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47 条记录 (耗时 0.029 秒)

    GLUCOPYRANOSIDE COMPOUND
    21.
    发明申请
    GLUCOPYRANOSIDE COMPOUND 有权
    葡萄糖苷化合物

    公开(公告)号：US20120058941A1

    公开(公告)日：2012-03-08

    申请号：US13174814

    申请日：2011-07-01

    申请人： Sumihiro NOMURA ,  Eiji Kawanishi ,  Kiichiro Ueta

    发明人： Sumihiro NOMURA ,  Eiji Kawanishi ,  Kiichiro Ueta

    IPC分类号： A61K31/7034 ,  A61K38/28 ,  A61K38/26 ,  A61P3/10 ,  A61P27/02 ,  A61P25/02 ,  A61P13/12 ,  A61P17/02 ,  A61P5/48 ,  A61P7/00 ,  A61P3/06 ,  A61P3/04 ,  A61P3/00 ,  A61P9/10 ,  A61P9/12 ,  A61P7/02 ,  A61K31/7056

    CPC分类号： C07H19/048 ,  A61K45/06 ,  C07D405/04 ,  C07D409/04 ,  C07D409/10 ,  C07H19/06

    摘要： A compound of the formula: wherein Ring A and Ring B are: (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring, (2) Ring A is an optionally substituted benzene ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring or an optionally substituted unsaturated fused heterobicyclic ring, or (3) Ring A is an optionally substituted unsaturated fused heterobicyclic ring, and Ring B are independently an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; X is a carbon atom or a nitrogen atom; Y is —(CH2)n— (n is 1 or 2); or a pharmaceutically acceptable salt thereof, or a prodrug thereof.

    摘要翻译： 下式的化合物：其中环A和环B是：（1）环A是任选取代的不饱和单环杂环，环B是任选取代的不饱和单环杂环，任选取代的不饱和稠合杂双环，或 任选取代的苯环，（2）环A是任选取代的苯环，环B是任选取代的不饱和单环杂环或任选取代的不饱和稠环杂双环，或（3）环A是任选取代的不饱和稠合杂双环 环和环B独立地是任选取代的不饱和单环杂环，任选取代的不饱和稠合杂双环或任选取代的苯环; X是碳原子或氮原子; Y为 - （CH 2）n - （n为1或2）; 或其药学上可接受的盐，或其前药。

    S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
    26.
    发明授权
    S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof 失效
    S型2-取代羟基-2-吲哚哩啶基丁酸酯化合物及其制备方法

    公开(公告)号：US06277992B1

    公开(公告)日：2001-08-21

    申请号：US09570172

    申请日：2000-05-12

    申请人： Takayuki Kawaguchi ,  Sumihiro Nomura ,  Kenji Tsujihara

    发明人： Takayuki Kawaguchi ,  Sumihiro Nomura ,  Kenji Tsujihara

    IPC分类号： C07D47112

    CPC分类号： C07D491/14 ,  C07B2200/07 ,  C07D209/42 ,  C07D217/26

    摘要： A process for preparing S type 2-substituted hydroxy-2-indolidinyl-butyric ester compound [II]: wherein R0 is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of “R”(in which the nitrogen atom is protected), R1 and R2 are lower alkyl group, and E is ester residue, which is useful as an intermediate for preparing camptothecin derivatives having antitumor activities, which comprises 2-ethylating 2-substituted hydroxy-2-indolidinylacetic ester compound [I]: wherein the symbols are as defined above.

    摘要翻译： 一种制备S型2-取代羟基-2-吲哚哩啶基 - 丁酸酯化合物[II]的方法：其中R 0是具有绝对构型“R”（其中保护氮原子）的含氮稠合杂环羧酸的残基， R 1和R 2为低级烷基，E为酯残基，其可用作制备具有抗肿瘤活性的喜树碱衍生物的中间体，其包括2-乙基化2-取代的羟基-2-吲哚哩啶基乙酸酯化合物[I]：其中 符号如上所述。