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21.发明授权Pyrrolidinone derivatives as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders 有权吡咯烷酮衍生物作为治疗糖尿病，肥胖，血脂异常和相关疾病的GPR119调节剂公开(公告)号：US08853412B2
公开(公告)日：2014-10-07
申请号：US14048425
申请日：2013-10-08
Applicant: Lothar Schwink , Martin Bossart , Heiner Glombik , Matthias Gossel , Dieter Kadereit , Thomas Klabunde , Thomas Maier , Siegfried Stengelin
Inventor： Lothar Schwink , Martin Bossart , Heiner Glombik , Matthias Gossel , Dieter Kadereit , Thomas Klabunde , Thomas Maier , Siegfried Stengelin
IPC: C07D401/00 , A61K31/44 , A61K31/497 , C07D401/12 , A61K31/4545 , C07D413/14 , A61K31/4439 , C07D401/14 , C07D407/14 , C07D417/14 , C07D207/12 , C07D405/14 , A61K31/444 , A61K31/4015
CPC classification number: A61K31/497 , A61K31/4015 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K45/06 , A61K48/00 , C07D207/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to pyrrolidinone derivatives. The pyrrolidinone derivatives are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The invention furthermore relates to the use of pyrrolidinone derivatives as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
Abstract translation: 本发明涉及吡咯烷酮衍生物。 吡咯烷酮衍生物是GPR119调节剂，可用于预防和/或治疗糖尿病，肥胖，血脂异常和相关疾病。 本发明还涉及吡咯烷酮衍生物作为药物中的活性成分的用途，以及包含它们的药物组合物。
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22.发明授权Use of substituted pyranone acid derivatives for the treatment of metabolic syndrome 有权使用取代的吡喃酮酸衍生物治疗代谢综合征公开(公告)号：US08748483B2
公开(公告)日：2014-06-10
申请号：US12504198
申请日：2009-07-16
Applicant: Harm Brummerhop , Siegfried Stengelin , Hubert Heuer , Susanne Kilp , Andreas Herling , Thomas Klabunde , Dieter Kadereit , Matthias Urmann
Inventor： Harm Brummerhop , Siegfried Stengelin , Hubert Heuer , Susanne Kilp , Andreas Herling , Thomas Klabunde , Dieter Kadereit , Matthias Urmann
IPC: A01N43/16 , A61K31/35 , C09B3/00 , C07D209/80 , C09B7/00
CPC classification number: A61K31/351
Abstract: The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome.
Abstract translation: 本发明涉及取代的吡喃酮酸衍生物及其生理学上可接受的盐用于制备用于治疗代谢综合征的药物的用途。
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23.发明授权Urea- and urethane-substituted acylureas, process for their preparation and their use 有权尿素和氨基甲酸酯取代的酰基脲，其制备方法及其用途公开(公告)号：US08247452B2
公开(公告)日：2012-08-21
申请号：US11845242
申请日：2007-08-27
Applicant: Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
Inventor： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
IPC: C07C275/24 , A61K31/277
CPC classification number: C07C275/54 , C07D213/75 , C07D239/96 , C07D295/135
Abstract: The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.
Abstract translation: 本发明涉及脲和氨基甲酸酯取代的酰基脲及其生理上耐受的盐和生理功能衍生物。 特别地，本发明涉及式I化合物，其中基团具有本文所述的含义及其生理学耐受的盐及其制备方法。 该化合物例如适用于抗糖尿病药。
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24.发明授权(Cyclopropylphenyl)phenyloxamides, method for the production thereof, and use of same as a medicament 有权（环丙基苯基）苯氧基酰胺，其制备方法及其作为药物的用途公开(公告)号：US08148375B2
公开(公告)日：2012-04-03
申请号：US12724517
申请日：2010-03-16
Applicant: Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
Inventor： Elisabeth Defossa , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Johanna Kuhlmann-Gottke , Stefan Bartoschek
IPC: A61K31/53 , A61K36/328
CPC classification number: C07C233/56 , C07C233/88
Abstract: The invention relates to (cyclopropylphenyl) phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
Abstract translation: 本发明涉及（环丙基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
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25.发明申请SPIROCYCLICALLY SUBSTITUTED 1,3-PROPANE DIOXIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 有权螺旋取代的1,3-丙二酮衍生物，其制备方法及其作为药物的用途公开(公告)号：US20120004187A1
公开(公告)日：2012-01-05
申请号：US13176333
申请日：2011-07-05
Applicant: Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
Inventor： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC: A61K38/16 , A61K31/337 , A61P3/10 , C07D213/64 , C07D305/04 , C07C59/68 , A61K31/44 , A61K31/19
CPC classification number: C07C59/72 , C07D213/64 , C07D213/65 , C07D305/06
Abstract: The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives, and to the physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, A and X are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
Abstract translation: 本发明涉及螺环取代的1,3-丙二醇衍生物及其与生理相容的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，A和X各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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Patent Agency Ranking
26.发明申请Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof 审中-公开芳基硫代芳基烷基取代的咪唑烷-2,4-二酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20110046185A1
公开(公告)日：2011-02-24
申请号：US12852188
申请日：2010-08-06
Applicant: Gerhard JAEHNE , Peter BELOW , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER
Inventor： Gerhard JAEHNE , Peter BELOW , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER
IPC: A61K31/4439 , C07D233/72 , A61K31/4166 , A61P3/10 , A61P3/04 , A61P25/32 , A61P25/34 , A61P25/18 , A61P25/28 , C07D401/04 , C07D409/04 , C07D417/10 , A61K31/428
CPC classification number: C07D233/72 , C07D401/04 , C07D405/04 , C07D409/04
Abstract: The invention relates to compounds of formula (I) wherein the groups R and R′ A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.
Abstract translation: 本发明涉及式（I）化合物，其中基团R和R'A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物。
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27.发明申请Heterocycle-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising them and use thereof 审中-公开杂环取代的咪唑烷-2,4-二酮，其制备方法，包含它们的药物及其用途公开(公告)号：US20110046105A1
公开(公告)日：2011-02-24
申请号：US12852233
申请日：2010-08-06
Applicant: Gerhard Jaehne , Siegfried Stengelin , Matthias Gossel , Thomas Klabunde , Irvin Winkler
Inventor： Gerhard Jaehne , Siegfried Stengelin , Matthias Gossel , Thomas Klabunde , Irvin Winkler
IPC: A61K31/4178 , C07D401/12 , A61K31/497 , A61P3/04 , A61P3/10 , A61P25/28 , A61P25/18 , A61P25/32 , A61P25/34 , A61K31/4184 , A61K31/501 , C07D413/14 , A61K31/5355 , A61K31/454
CPC classification number: C07D233/72 , C07D401/12 , C07D403/12 , C07D405/12
Abstract: The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.
Abstract translation: 本发明涉及式（I）化合物，其中基团R和R'，A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物。
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28.发明授权4,5-diphenyl-pyrimidinylamino substituted carboxylic acids, method for the production and use thereof as medicaments 有权4,5-二苯基 - 嘧啶基氨基取代的羧酸，其制备方法和用作药物公开(公告)号：US07713988B2
公开(公告)日：2010-05-11
申请号：US12267918
申请日：2008-11-10
Applicant: Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
Inventor： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC: C07D239/42 , A61K31/505
CPC classification number: C07D239/42
Abstract: This invention relates to a compound of formula I, wherein R1, R2, R3, m, n, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
Abstract translation: 本发明涉及式I化合物，其中R 1，R 2，R 3，m，n，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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29.发明申请4,5-DIPHENYL-PYRIMIDINYLAMINO SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS 有权4,5-二苯基 - 吡啶基氨基取代的羧酸，用于生产和使用其作为药物的方法公开(公告)号：US20090149487A1
公开(公告)日：2009-06-11
申请号：US12267918
申请日：2008-11-10
Applicant: Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
Inventor： Elisabeth Defossa , Jochen Goerlitzer , Thomas Klabunde , Viktoria Dietrich , Siegfried Stengelin , Guido Haschke , Andreas Herling , Stefan Bartoschek
IPC: A61K31/505 , C07D239/42 , A61P3/10
CPC classification number: C07D239/42
Abstract: This invention relates to a compound of formula I, wherein R1, R2, R3, m, n, W, X and Y are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition and use for lowering blood glucose, treating diabetes, or increasing insulin release.
Abstract translation: 本发明涉及式I化合物，其中R 1，R 2，R 3，m，n，W，X和Y如本文所定义，或其生理耐受盐，其药物组合物和降血糖用途，治疗糖尿病 ，或增加胰岛素释放。
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30.发明授权Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use 有权取代的苯甲酰脲基吡啶基哌啶和吡咯烷羧酸衍生物，其制备方法及其应用公开(公告)号：US07501440B2
公开(公告)日：2009-03-10
申请号：US10795863
申请日：2004-03-08
Applicant: Karl Schoenafinger , Dieter Kadereit , Elisabeth Defossa , Andreas Herling , Thomas Klabunde
Inventor： Karl Schoenafinger , Dieter Kadereit , Elisabeth Defossa , Andreas Herling , Thomas Klabunde
IPC: A61K31/4545 , C07D401/04
CPC classification number: C07D401/04
Abstract: The invention relates to compounds of the formula I where the radicals are as defined, and their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
Abstract translation: 本发明涉及式Ⅰ化合物，其中基团如所定义，及其生理上耐受的盐。 该化合物例如可用作预防和治疗2型糖尿病的药物。
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