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1.发明申请Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof 审中-公开芳基硫代芳基烷基取代的咪唑烷-2,4-二酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20110053947A1
公开(公告)日：2011-03-03
申请号：US12852216
申请日：2010-08-06
IPC分类号： A61K31/4985 , C07D241/04 , C07D233/40 , C07D401/04 , A61K31/497 , A61K31/4166 , A61K31/4439 , A61P25/18 , A61P25/28
CPC分类号： C07D233/74
摘要： The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.
摘要翻译： 本发明涉及式（I）化合物，其中基团R和R'，A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物。
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2.发明授权
公开(公告)号：US5789383A
公开(公告)日：1998-08-04
申请号：US366598
申请日：1994-12-29
申请人： Klaus Wirth , Irvin Winkler , Fred Lembeck , Gerhard Breipohl , Stephan Henke , Jochen Knolle
发明人： Klaus Wirth , Irvin Winkler , Fred Lembeck , Gerhard Breipohl , Stephan Henke , Jochen Knolle
CPC分类号： A61K38/043
摘要： Bradykinin antagonists and their physiologically tolerated salts are suitable for the treatment or prophylaxis of virus diseases.
摘要翻译： 缓激肽拮抗剂及其生理耐受盐适用于治疗或预防病毒病。
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3.发明授权Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses 失效用于治疗病毒引起的疾病的苯并恶唑酸衍生物的应用
公开(公告)号：US5242908A
公开(公告)日：1993-09-07
申请号：US648622
申请日：1991-02-01
申请人： Anuschirwan Peyman , Eugen Uhlmann , Karlheinz Budt , Jochen Knolle , Irvin Winkler , Matthias Helsberg
发明人： Anuschirwan Peyman , Eugen Uhlmann , Karlheinz Budt , Jochen Knolle , Irvin Winkler , Matthias Helsberg
IPC分类号： A61K31/66 , A61P31/12 , C07F9/38 , C07F9/40 , C07F9/6574
CPC分类号： C07F9/65742 , C07F9/3882 , C07F9/4056
摘要： The use of a compound of the formula I ##STR1## in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, aryl, aralkyl or carboalkoxy group, R.sup.1 and R.sup.2 are an alkyl, alkenyl, alkynyl, cycloalkyl or halogenoalkyl group, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium or hydrogen, R.sup.1 and R.sup.2 together form a cyclic diester, R.sup.3 and R.sup.4 are an alkyl, alkenyl, alkynyl, carboalkoxy, cycloalkyl or alkoxy group, hydrogen, fluorine, chlorine, bromine or iodine and X, Y and Z are oxygen or sulfur, for the treatment of diseases caused by DNA viruses or RNA viruses is described.
摘要翻译： 使用其中V为烷基，氟，氯，溴或碘的式I化合物I，其为1至5的整数，W为烷基，烯基，炔基或烷氧基 ，氰基，硝基，羧基，氢或环烷基，芳基，芳烷基或烷氧基，R1和R2是烷基，烯基，炔基，环烷基或卤代烷基，钠，钾，钙，镁，铝，锂，铵， 或氢，R1和R2一起形成环状二酯，R3和R4是烷基，烯基，炔基，烷氧羰基，环烷基或烷氧基，氢，氟，氯，溴或碘，X，Y和Z是氧或硫， 描述了用于治疗由DNA病毒或RNA病毒引起的疾病。
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公开(公告)号：US08476222B2
公开(公告)日：2013-07-02
申请号：US12417307
申请日：2009-04-02
申请人： Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
发明人： Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
摘要： The disclosure relates to a compound of the formula (I) wherein R1 is H, C(O)—(C1-C6)alkyl or C(O)—O—(C1-C6)alkyl; R2 is OH, NH2, NH—(C1-C6)alkyl, NH—(C1-C4)alkylene-phenyl or NH—(C1-C4)alkylene-pyridyl; R3 and R4 are independently of each other H or OH, or R3 and R4 together are ═O; and m and n are independently of one another 0, 1 or 2; in any stereochemical form, or a mixture of any stereochemical forms in any ratio, or a physiologically acceptable salt thereof, obtainable from Actinomadura namibiensis (DSM 6313), and its use for the treatment of bacterial infections, viral infections and/or pain, and pharmaceutical composition comprising it.
摘要翻译： 本发明涉及式（I）化合物，其中R 1是H，C（O） - （C 1 -C 6）烷基或C（O）-O-（C 1 -C 6）烷基; R2是OH，NH2，NH-（C1-C6）烷基，NH-（C1-C4）亚烷基 - 苯基或NH-（C1-C4）亚烷基 - 吡啶基; R3和R4彼此独立地为H或OH，或R3和R4一起为= O; m和n彼此独立地为0,1或2; 任何立体化学形式，或任何比例的任何立体化学形式的混合物，或其生理学上可接受的盐，可从放线杆菌素（DSM 6313）获得，以及其用于治疗细菌感染，病毒感染和/或疼痛的用途，以及 包含它的药物组合物。
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5.发明申请Substituted imidazoline-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof 审中-公开取代的咪唑啉-2,4-二酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20110112097A1
公开(公告)日：2011-05-12
申请号：US12852084
申请日：2010-08-06
申请人： Gerhard Jaehne , Peter Below , Siegfried Stengelin , Matthias Gossel , Thomas Klabunde , Irvin Winkler
发明人： Gerhard Jaehne , Peter Below , Siegfried Stengelin , Matthias Gossel , Thomas Klabunde , Irvin Winkler
IPC分类号： A61K31/5377 , C07D233/72 , A61K31/415 , C07D413/10 , C07D471/10 , A61K31/438 , C07D487/10 , C07D401/04 , A61K31/4439 , A61P3/00 , A61P3/10 , A61P3/04 , A61P25/34 , A61P25/32 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D401/04 , C07D233/74 , C07D235/02 , C07D405/04 , C07D409/04 , C07D471/04
摘要： The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.
摘要翻译： 本发明涉及式（I）化合物，其中基团R和R'，A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物。
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公开(公告)号：US20090298904A1
公开(公告)日：2009-12-03
申请号：US12417307
申请日：2009-04-02
申请人： Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
发明人： Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
IPC分类号： A61K31/40 , C07D513/18 , C12P17/18
摘要： The disclosure relates to a compound of the formula (I) wherein m and n are independently of one another 0, 1 or 2, obtainable from Actinomadura namibiensis (DSM 6313), its use for the treatment of bacterial infections, viral infections and/or pain, and pharmaceutical composition comprising it.
摘要翻译： 本公开涉及式（I）的化合物，其中m和n彼此独立地为0,1或2，可从放线菌素（DSM 6313）获得，其用于治疗细菌感染，病毒感染和/或 疼痛和包含它的药物组合物。
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7.发明授权3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use 失效具有非核苷酸分组的3'-衍生的寡核苷酸类似物，其制备和用途
公开(公告)号：US5646261A
公开(公告)日：1997-07-08
申请号：US5283
申请日：1993-01-19
IPC分类号： A61K31/70 , A61K31/7125 , A61K48/00 , A61P31/12 , A61P35/00 , C07F9/24 , C07F9/44 , C07H21/00 , C07H21/04 , C12Q1/68
CPC分类号： C07H21/00
摘要： The present invention relates to novel oligonucleotide analogs with valuable physical, biological and pharmacological properties, and a process for their preparation.
摘要翻译： 本发明涉及具有宝贵的物理，生物和药理学性质的新型寡核苷酸类似物及其制备方法。
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8.发明授权N1-substituted 1H-1,2,3-triazolo[4,5,-D]pyrimidines, a process for their preparation and their use as antiviral agents 失效N1取代的1H-1,2,3-三唑并[4,5，-D]嘧啶，其制备方法及其作为抗病毒剂的用途
公开(公告)号：US5457091A
公开(公告)日：1995-10-10
申请号：US125195
申请日：1993-09-23
IPC分类号： A61K31/505 , A61P31/12 , C07D487/04 , C07F9/6561 , C07D239/00
CPC分类号： C07D487/04
摘要： N1-Substituted 1H-1,2,3-triazolo[4,5-d]pyrimidine compounds of the formula I ##STR1## in which the substituents X, Y, R.sup.1, R.sup.2 and R.sup.3 have the meanings recited in the specification, are described as pharmaceutical compositions containing them and processes for their preparation. The compounds are effective antiviral agents.
摘要翻译： 取代基X，Y，R 1，R 2和R 3具有式I（I）中所述的取代基的N 1 - 取代的1 H-1,2,3-三唑并[4,5-d]嘧啶化合物 描述为含有它们的药物组合物及其制备方法。 这些化合物是有效的抗病毒剂。
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公开(公告)号：US5055457A
公开(公告)日：1991-10-08
申请号：US226250
申请日：1988-07-29
IPC分类号： C07D473/06 , A61K20060101 , A61K31/52 , A61K31/70 , A61K31/715 , A61P31/12 , C07D20060101 , C07D473/04 , C08B20060101 , C08B37/00
CPC分类号： A61K31/715
摘要： A pharmaceutical combination product containing or composed ofa) at least one sulfated polysaccharide andb) at least one xanthine derivative.The product is suitable for controlling and preventing virus diseases, especially those caused by retroviruses.
摘要翻译： 含有或由a）至少一种硫酸化多糖和b）至少一种黄嘌呤衍生物组成的药物组合产品。 该产品适用于控制和预防病毒性疾病，特别是由逆转录病毒引起的病毒。
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10.发明申请Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof 审中-公开新的苯基取代的咪唑啉，其制备方法，包含所述化合物的药物及其用途公开(公告)号：US20110178134A1
公开(公告)日：2011-07-21
申请号：US12852038
申请日：2010-08-06
申请人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI
发明人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI
IPC分类号： A61K31/4439 , C07D233/02 , C07D401/06 , A61K31/4166 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/32 , A61P25/34 , A61P25/18
CPC分类号： C07D233/72 , C07D401/06
摘要： The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.
摘要翻译： 本发明涉及其中基团具有所述含义的式（I）化合物及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物和治疗心脏代谢综合征。
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