公开(公告)号：US20180280414A1

公开(公告)日：2018-10-04

申请号：US15765756

申请日：2016-10-12

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  Sorbonne Universite ,  Universite Paris Diderot - Paris 7 ,  Fondation Asile des Aveugles

Inventor： Francine BEHAR-COHEN ,  Min ZHAO

IPC: A61K31/585 ,  A61P27/02 ,  A61K45/06 ,  A61K9/00 ,  A61K9/16

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of choroidal neovascularisation. In particular, the present invention relates to a method of treating choroidal neovascularisation in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a mineralocorticoid receptor antagonist.

公开(公告)号：US20180264075A1

公开(公告)日：2018-09-20

申请号：US15761825

申请日：2016-09-21

Applicant: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  UNIVERSITE PARIS DESCARTES ,  INSERM PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Jean-Philippe WOLF ,  Anne LOMBES ,  Morgane BOMSEL

IPC: A61K38/12 ,  C07K5/087 ,  A61K9/00 ,  A61P15/08

CPC classification number: A61K38/12 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/0048 ,  A61P15/08 ,  B63B21/00 ,  B63B2021/004 ,  C07K5/0812 ,  C07K7/64 ,  C07K14/705

Abstract: The present invention relates to the use of a cyclic peptide comprising the tripeptide reproducing a binding site of fertilin beta to the oocyte integrin, for improving cellular energy metabolism. More particularly, the invention concerns the use of a cyclic peptide comprising the tripeptide FEEc for stimulating the energy metabolism of gametes or embryonic cells in the context of medically assisted procreation (MAP) protocols, in particular promoting the in vitro maturation of the oocyte, the fertilization rate and the birth rate.

公开(公告)号：US20180251552A1

公开(公告)日：2018-09-06

申请号：US15759850

申请日：2016-10-11

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  Universite Paris Descartes ,  Assistance Publique-Hopitaux de Paris (APHP)

Inventor： Hafid AIT-OUFELLA

IPC: C07K16/28 ,  A61K47/68

CPC classification number: C07K16/2815 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/73

Abstract: The present invention relates to a method for treating MI or AMI in a subject in need thereof comprising a step of administering to said subject a therapeutically effective amount of an agent capable of depleting CD8 T cells. More particularly, this present invention relates to a method for treating acute myocardial infarction by reducing the size of necrosis and limiting 10 the post ischemic left ventricular remodeling.

公开(公告)号：US20180221313A1

公开(公告)日：2018-08-09

申请号：US15750143

申请日：2016-08-08

Applicant: CENTRE HOSPITALIER NATIONAL D'OPHTALMOLOGIE QUINZE-VINGTS ,  NSTITUT NATINONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  MAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  UNIVERSITE PARIS DESCARTES

Inventor： Yves COLIN ,  Jean-Francois GIRMENS ,  Olivier HERMINE ,  Emmanuel HERON ,  Michel PAQUES

IPC: A61K31/17 ,  A61P9/14 ,  A61P27/02

CPC classification number: A61K31/17 ,  A61P9/14 ,  A61P27/02

Abstract: The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.

公开(公告)号：US20180207250A1

公开(公告)日：2018-07-26

申请号：US15745273

申请日：2016-07-13

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITE PARIS DIDEROT - PARIS 7 ,  UNIVERSITÉ PARIS-SUD ,  SORBONNE UNIVERSITE

Inventor： Roberto MALLONE ,  Slobodan CULINA ,  Nimesh GUPTA ,  Sebastien LACROIX-DESMAZES

IPC: A61K39/00 ,  A61P37/06

CPC classification number: A61K39/0008 ,  A61K2039/542 ,  A61K2039/577 ,  A61K2039/6056 ,  A61P37/06

Abstract: The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. In particular, the present invention relates to a method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.

公开(公告)号：US20180185476A1

公开(公告)日：2018-07-05

申请号：US15861070

申请日：2018-01-03

Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Fondation Imagine ,  Universite Paris Descartes ,  Assistance Publique-Hopitaux de Paris (APHP) ,  The University of Manchester

Inventor： Sylvain LATOUR ,  Alain FISCHER ,  Emmanuel MARTIN ,  Peter ARKWRIGHT

IPC: A61K39/395 ,  G01N33/50 ,  A61K31/185 ,  A61K45/06 ,  A61K38/13 ,  A61K31/713 ,  A61K31/7072 ,  A61K31/7068 ,  A61K31/655 ,  A61K31/5377 ,  A61K31/52 ,  A61K31/436 ,  A61K31/42 ,  A61K31/404 ,  A61K31/4015 ,  A61K31/353 ,  A61K31/215

CPC classification number: A61K39/3955 ,  A61K31/185 ,  A61K31/215 ,  A61K31/353 ,  A61K31/4015 ,  A61K31/404 ,  A61K31/42 ,  A61K31/436 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/655 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/713 ,  A61K38/13 ,  A61K45/06 ,  G01N33/5023 ,  G01N33/505

Abstract: The present invention relates to methods and pharmaceutical compositions for inhibiting lymphocyte proliferation in a subject in need thereof. In particular, the invention relates to a CTP synthase 1 (CTPS1) inhibitor for use in a method for inhibiting lymphocyte proliferation in a subject in need thereof. The invention also relates to a method for screening a plurality of test substances useful for inhibiting lymphocyte proliferation in a subject in need thereof comprising the steps consisting of i) testing each of the test substances for its ability to inhibit CTPS1 activity or expression and ii) identifying the test substance which inhibits CTPS1 activity or expression thereby to identify a test substance useful for inhibiting lymphocyte proliferation in a subject in need thereof.

公开(公告)号：US09874560B2

公开(公告)日：2018-01-23

申请号：US15291120

申请日：2016-10-12

Applicant: INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PARIS DESCARTES ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS

Inventor： Claire Poyart ,  Marie-Cecile Lamy ,  Shaynoor Dramsi ,  Elisabeth Sauvage ,  Philippe Glaser ,  Patrick Trieu-Cuot

IPC: C07K16/00 ,  G01N33/53 ,  G01N33/569 ,  C12Q1/68 ,  C07K16/12

CPC classification number: G01N33/56944 ,  C07K16/1275 ,  C12Q1/6883 ,  C12Q1/689 ,  G01N2333/315

Abstract: The present invention relates to polynucleotides enabling the rapid, simple and specific detection of Group B Streptococcus highly-virulent ST-17 clones.The present invention also relates to the polypeptides encoded by said polynucleotides, as well as to antibodies directed or raised against said polypeptides.The present invention also relates to kits and methods for the specific detection of Group B Streptococcus highly-virulent ST-17 clones, using the polynucleotides, the polypeptides or the antibodies according to the invention.

公开(公告)号：US20170335276A1

公开(公告)日：2017-11-23

申请号：US15538184

申请日：2015-12-23

Applicant: INSTITUT PASTEUR ,  FONDATION IMAGINE ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  UNIVERSITE PARIS DESCARTES ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： EBERL Gerard ,  BIKARD David ,  SCHNUPF Pamela ,  CERF BENSUSSAN Nadine ,  GABORIAU-ROUTHIAU Valerie ,  SANSONETTI Philippe

IPC: C12N1/20 ,  C12N13/00

CPC classification number: C12N1/20 ,  C12N13/00 ,  C12N15/74 ,  C12N2502/23

Abstract: The present invention relates to an in vitro method of culturing a segmented filamentous bacterium strain, comprising co-culturing said segmented filamentous bacterium strain with a eukaryotic host cell, wherein the culture is performed at an O2 level inferior to 5% in a rich tissue culture liquid medium containing bacterial medium components including iron. The present invention also relates to methods for genetically modifying a segmented filamentous bacterium strain comprising a step a culturing the strain in vitro.

公开(公告)号：US20170209488A1

公开(公告)日：2017-07-27

申请号：US15324946

申请日：2015-07-16

Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite Paris Descartes ,  Universite Paris Diderot - Paris 7

Inventor： Laure Strochlic ,  Julien Messeant ,  Perrine Delers ,  Alexandre Dobbertin ,  Claire Legay

IPC: A61K33/14 ,  A61K31/433

CPC classification number: A61K33/14 ,  A61K31/00 ,  A61K31/433 ,  Y02A50/469

Abstract: The present invention relates to methods for treating neuromuscular junction-related diseases. In particular, the present invention relates to a method of treating a neuromuscular junction-related disease in a subject in need thereof comprising ad ministering the subject with a therapeutically effective amount of at least one inhibitor of glycogen synthase kinase 3 (GSK3).

公开(公告)号：US20170202367A1

公开(公告)日：2017-07-20

申请号：US15326843

申请日：2015-07-16

Applicant: Universite Paris Descartes ,  Centre National de la Recherche Scientifique (CNRS) ,  Ecole Pratique Des Hautes Etudes ,  San Francisco State University

Inventor： Marianne Barbu-Roth ,  Vincent Forma ,  Caroline Teulier ,  David Anderson ,  Joëlle Provasi ,  Benoist Schaal

IPC: A47D13/08 ,  G09B19/00

CPC classification number: A47D13/08 ,  G09B19/003

Abstract: Device for assisting crawling of an infant (2) on a training surface comprising: —a platform (1) comprising a chest supporting surface for supporting a chest of the infant (2) resting on the platform (1) in a prone position, and —rolling elements (9) rotatably mounted on the platform in such a way they can rotate 360 degrees (1) and arranged to be located between the platform (1) and the training surface, wherein the platform (1) is shaped so that, when the rolling elements (9) are in contact with the training surface, the chest supporting surface of the platform (1) is inclined relative to the training surface, so that the pelvis and the legs of the infant (2) are in contact with the training surface.