公开(公告)号：US20210398868A1

公开(公告)日：2021-12-23

申请号：US17284307

申请日：2019-10-11

Applicant: University of Southampton

Inventor： Stephen Paul BEEBY ,  Michael John TUDOR ,  Menglong LI

IPC: H01L23/31 ,  H01L23/498 ,  H01L21/56 ,  H01L25/065 ,  D02G3/44

Abstract: An encapsulated assembly of electronic componentry, suitable for incorporation into a textile or a yarn, and the assembly comprising two flexible substrates (3, 4) which encapsulate the electronic componentry, at least one of the flexible substrates comprising at least one preformed relief region (3a), which provides a volume which at least in part accommodates the electronic componentry, and the componentry located substantially at a neutral axis (N) of the assembly.

公开(公告)号：US20210346498A1

公开(公告)日：2021-11-11

申请号：US17359496

申请日：2021-06-25

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： Mark Cragg ,  Martin Glennie ,  Ali Roghanian ,  Stephen Beers ,  Peter Johnson ,  Sean Lim ,  Björn Frendéus ,  Ingrid Teige

IPC: A61K39/395 ,  C07K16/28 ,  G01N33/68

Abstract: The invention provides a method of treating a patient having target cells that express FcγRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcγRIIb; in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcγRIIb; characterized in that the patient is selected on the basis that their target cells express an elevated level of FcγRIIb.

公开(公告)号：US20210299148A1

公开(公告)日：2021-09-30

申请号：US17262915

申请日：2019-07-30

Applicant: NZP UK LIMITED ,  THE UNIVERSITY OF SOUTHAMPTON

Inventor： Alexander Charles Weymouth-Wilson ,  Gemma Packer ,  Bruno Jan Pol Linclau ,  Dannielle Kydd-Sinclair ,  Kimberly Ann Watson

IPC: A61K31/64 ,  A61P1/16 ,  C07J41/00 ,  A61K31/575

Abstract: The invention relates to compounds of general formula (I): wherein R2a, R2b, R3a, R3b, R5, Y and R7 are as defined herein are selective agonists at the FXR receptor and are useful for the treatment or prevention of diseases and conditions including nonalcoholic steatohepatitis (NASH); primary biliary cirrhosis; primary sclerosing cholangitis; biliary atresia; cholestatic liver disease; hepatitis C infection; alcoholic liver disease; fibrosis; and liver damage arising from fibrosis.

公开(公告)号：US20210265798A1

公开(公告)日：2021-08-26

申请号：US17181472

申请日：2021-02-22

Applicant: University of Southampton

Inventor： Masaaki SAKAKURA ,  Yanhao YU ,  Peter KAZANSKY ,  Lei WANG

IPC: H01S3/00 ,  G02B27/09 ,  G02B5/30

Abstract: A method of delivering optical pulses to a substrate comprises directing a focused beam from a source of optical pulses along a propagation direction onto a substrate; moving the substrate relative to the beam in a plane substantially orthogonal to the propagation direction and continuously along a first direction that includes spaced apart row locations on the substrate, and delivering a plurality of optical pulses from source as the beam reaches each row location; and between delivering the optical pulses at consecutive row locations, moving the beam relative to the substrate in one or more successive discrete movements along a second direction in the plane orthogonal to the first direction, to direct the beam to one or more spaced apart column locations on the substrate, and delivering a plurality of optical pulses from the source at each column location.

公开(公告)号：US20210265797A1

公开(公告)日：2021-08-26

申请号：US17181414

申请日：2021-02-22

Applicant: University of Southampton

Inventor： Masaaki SAKAKURA ,  Yanhao YU ,  Peter KAZANSKY ,  Lei WANG

IPC: H01S3/00 ,  B23K26/0622

Abstract: A method of delivering optical energy to a substrate comprises applying a temporal group of optical pulses to a region of the substrate, wherein the temporal group comprises twenty or fewer pulses of a femtosecond pulse duration, arranged as a first subgroup of pulses comprising up to three pulses followed by a second subgroup of pulses comprising the remaining pulses in the temporal group; and wherein energies of the pulses are controlled such that pulses in the first subgroup have a first energy per pulse and pulses in a second subgroup of pulses have a second energy per pulse which is less than the first energy.

公开(公告)号：US10991585B2

公开(公告)日：2021-04-27

申请号：US16072013

申请日：2017-01-23

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： David John Thomson ,  Graham Trevor Reed ,  Robert Topley

IPC: H01L21/265 ,  G02B6/134 ,  H01L21/268 ,  H01L21/324 ,  H01L21/67 ,  H01L21/66 ,  G02B6/12

Abstract: A method of trimming the refractive index of material forming at least part of one or more structures integrated in one or more pre-fabricated devices, the method comprising: implanting one or more first regions of material of one or more pre-fabricated devices, encompassing at least partially one or more device structures, with ions to alter the crystal form of the material within the one or more first regions and change the refractive index of the material within the one or more first regions; and heat treating one or more second regions of material of the one or more devices, encompassing at least partially the one or more first regions, to alter the crystal form of the material within the one or more first regions encompassed by the one or more second regions and change the refractive index thereof, thereby trimming the refractive index of the material of at least part of the one or more device structures, such that the one or more device structures provide one or more predetermined device outputs.

公开(公告)号：US20210098865A1

公开(公告)日：2021-04-01

申请号：US16635410

申请日：2018-08-01

Applicant: University of Southampton

Inventor： Hywel Morgan ,  Shilong Lu ,  Ying Cheong

IPC: H01Q1/27 ,  A61B5/00 ,  H01Q7/00

Abstract: A wearable antenna is described, for wirelessly receiving sensor data generated by an implantable sensor device implanted in a uterus, the wearable antenna, in use, extending around the waist of the wearer's body, and having a downwardly extending portion for location at the front of the wearer's body. In this way, an improved electromagnetic interaction between the wearable antenna and the implantable sensor can be achieved. Further, the wearable antenna may have an undulating shape around at least a portion of the wearer's waist, to permit expansion and contraction of the wearable antenna about the wearer's waist.

公开(公告)号：US10960067B2

公开(公告)日：2021-03-30

申请号：US16062867

申请日：2016-12-15

Applicant: University of Southampton

Inventor： Jay Robert Laver ,  Robert Charles Read

IPC: A61K39/00 ,  A61K39/02 ,  A61K39/095 ,  C12N15/74

Abstract: The invention relates to a modified Neisseria lactamica, wherein the modified Neisseria lactamica is transformed with recombinant DNA encoding a heterologous protein; a method of prophylactic treatment for pathogenic infection of a subject comprising nasopharyngeal inoculation of a modified Neisseria lactamica; a method of reducing or preventing meningococcal colonisation of a subject; a method of modifying the microbiome of a subject; a wild-type Neisseria lactamica for use for the prophylactic treatment of meningococcal infection of a subject or reducing colonisation of a subject, wherein the prophylactic treatment comprises nasopharyngeal inoculation of the wild-type Neisseria lactamica; associated nucleic acid for mutagenesis of Neisseria lactamica; methods of mutagenesis; outer membrane vesicle (OMV) vaccines; and associated compositions and methods thereof.

公开(公告)号：US20200348371A1

公开(公告)日：2020-11-05

申请号：US16879575

申请日：2020-05-20

Applicant: University of Southampton

Inventor： Rand Ismaeel ,  Ali Masoudi ,  Martynas Beresna ,  Gilberto Brambilla

IPC: G01R33/032 ,  G02F1/01 ,  G02F1/00 ,  G02F1/095

Abstract: A magnetic field sensor comprises a magnetically responsive light propagating component configured to cause a polarization of light propagating inside the component to be rotated in response to an applied magnetic field, wherein the magnetically responsive light propagating component is formed of a bulk material doped with a dopant, the dopant including at least gadolinium, the dopant concentration being at a sufficiently low concentration such that the dopant is uniformly dispersed in the bulk material to provide a high Verdet constant. The magnetic field sensor also comprises a detector, and a polarization-maintaining light input device to couple the light into the magnetically responsive light propagating component. The detector is configured to measure a property of light output from the magnetically responsive light propagating component to determine a change in polarization of the light, the change caused by the presence of a magnetic field.

公开(公告)号：US10782473B2

公开(公告)日：2020-09-22

申请号：US15319964

申请日：2015-06-17

Applicant: University of Southampton

Inventor： Christopher Holmes ,  Peter George Robin Smith ,  James Christopher Gates ,  Lewis Glynn Carpenter

IPC: G02B6/36 ,  G02B6/122 ,  G02B6/34 ,  G02B6/12

Abstract: A method of forming an optical fibre assembly, comprises providing a planar substrate made of a first material; positioning an optical fibre with an outer layer of a first glass material on a surface of the substrate to form a pre-assembly; depositing a further glass material such as silica soot onto the pre-assembly, over at least a part of the optical fibre and adjacent parts of the substrate surface; and heating the pre-assembly to consolidate the further glass material into an amorphous volume in contact with at least parts of the surface of the substrate and the outer layer of the optical fibre, thereby bonding the optical fibre to the substrate to create the optical fibre assembly.