公开(公告)号：US11432731B2

公开(公告)日：2022-09-06

申请号：US16303190

申请日：2017-05-26

Applicant: University of Pittsburgh-Of the Commonwealth System of Higher Education ,  Virginia Commonwealth University

Inventor： Young Jae Chun ,  Brian T. Jankowitz ,  Sung Kwon Cho ,  Yanfei Chen ,  Woon-Hong Yeo ,  Yongkuk Lee ,  Connor Howe

IPC: A61B5/026 ,  A61B5/021 ,  A61B5/00

Abstract: The invention relates to endovascular medical implant devices, systems and methods that including a sensing device and a flow diverter device, which are effective to monitor intra-/post-operative hemodynamic properties in the location of a cerebral aneurysm and, hemodynamic alterations following placement of the system for treating ischemic diseases in carotid, coronary and peripheral arteries. The sensing device includes wireless, non-thrombogenic, highly stretchable, ultra-low profile flow sensors.

公开(公告)号：US20220274834A1

公开(公告)日：2022-09-01

申请号：US17625511

申请日：2020-07-09

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  UNIVERSITY OF MASSACHUSETTS

Inventor： Puru JENA ,  Hong FANG ,  Joel THERRIEN

IPC: C01B32/05 ,  C23C16/26 ,  B01J37/02 ,  B01J23/50 ,  B01J23/52 ,  B01J23/755 ,  B01J23/72 ,  B01J27/24

Abstract: A 3-dimensional crystalline carbon material that is magnetic and metallic under ambient conditions is provided. The material, denominated U-carbon, has been synthesized using the molecular precursor, 3, 3-dimethyl-1-butene (C6H12). Depending on the atomic connections made between the carbon atoms of the material, U-Carbon forms structures that exhibit semiconducting and nonmagnetic to metallic and ferromagnetic behaviors. The use of selected molecular precursors (such as 3, 3-dimethyl-1-butene C6H12) that support crystal growth based on clustered rather than individual atoms is a paradigm shift in materials development. Rationally designed metastable materials with desirable properties, including U-Carbon, can have many scientific and technological applications.

公开(公告)号：US20220273661A1

公开(公告)日：2022-09-01

申请号：US17631995

申请日：2020-08-05

Applicant: PTC Therapeutics MP, Inc. ,  Virginia Commonwealth University

Inventor： Eleonora MEZZAROMA ,  Christopher RABENDER ,  Ross MIKKELSEN ,  Vasily YAKOVLEV ,  Neil SMITH

IPC: A61K31/519 ,  A61P39/00

Abstract: The invention provides methods for treating radiation exposure in a subject by administering sepiapterin, tetrahydrobiopterin, or dihydrobiopterin.

公开(公告)号：US20220241605A1

公开(公告)日：2022-08-04

申请号：US17577887

申请日：2022-01-18

Applicant: Virginia Commonwealth University

Inventor： Ivan C. Carmona Tortolero ,  Ravi L. Hadimani ,  Mark S. Baron ,  Deepak Kumbhare

IPC: A61N2/02 ,  A61N2/00

Abstract: An example method includes positioning above the transcranial region, an arrangement of solenoids, and selecting a target zone from among a plurality of zones. A zone-specific set of Q solenoids is identified from the arrangement of solenoids, based on the target zone. The zone-specific set includes a pair of mutually adjacent ones of the solenoids. A Q-element solenoid feed modulation state vector is generated, which defines a Q-current element feed current modulation state. The Q-current element feed current modulation state is configured to cause the zone-specific set of Q solenoids to generate Q individual, spatially configured, time-varying magnetic fields that, in combination, establish a transcranial magnetic stimulation (TMS) inducing time-varying magnetic field, which induces a target hotspot TMS electric field. The hotspot TMS electric field is focalized to the target zone.

公开(公告)号：US20220218850A1

公开(公告)日：2022-07-14

申请号：US17574790

申请日：2022-01-13

Applicant: Virginia Commonwealth University

Inventor： Paul B. Fisher ,  Luni Emdad ,  Praveen Bhoopathi ,  Anjan K. Pradhan ,  Swadesh K. Das ,  Alexander L. Klibanov

IPC: A61K49/22 ,  A61K45/06 ,  A61K31/7115

Abstract: In various aspects, the present disclosure provides methods, compositions, and kits for treating a target tissue with one or more active agents. In embodiments, delivering an active agent to a target tissue comprises administration of microbubbles and ultrasound.

公开(公告)号：US20220205106A1

公开(公告)日：2022-06-30

申请号：US17604512

申请日：2020-02-27

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Gary TEPPER ,  Gilbert ANNOHENE

IPC: C23C18/12 ,  H01L51/42

Abstract: Crystallization of perovskite films was performed in supercritical carbon dioxide with and without organic co-solvents. Post deposition crystallization of the films was performed in a binary, single phase supercritical fluid at constant conditions (45° C., 1200 psi) but with varying organic co-solvent volume fractions up to 2%. The co-solvents can provide selective interactions with one or both of the perovskite precursor compounds resulting in different film morphologies ranging from uniform films containing large grains to films exhibiting large cubic or hexagonal crystals or preferential crystallographic orientations. The use of supercritical fluids to enhance or tune crystallization in solid-state thin films could have broad applications toward the realization of high efficiency photovoltaic devices.

公开(公告)号：US11167131B2

公开(公告)日：2021-11-09

申请号：US17306049

申请日：2021-05-03

Applicant: BioCircuit Technologies, Inc. ,  Virginia Commonwealth University

Inventor： Jonathan Isaacs ,  Isaac Perry Clements ,  Andrew Willsie ,  James David Ross ,  Alex Weidenbach

IPC: A61B17/11 ,  A61N1/05 ,  A61B5/00 ,  A61B5/24 ,  A61N1/36

Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.

公开(公告)号：US20210301135A1

公开(公告)日：2021-09-30

申请号：US17207991

申请日：2021-03-22

Applicant: Virginia Commonwealth University

Inventor： Xuewei Wang ,  Hong Zhao ,  Yuanhang Yang ,  Wuwei Li

IPC: C08L83/04 ,  B33Y70/00 ,  B29C64/112 ,  B33Y10/00 ,  B33Y80/00 ,  C08K5/43 ,  C08G77/08

Abstract: A nitric oxide-releasing 3D printing ink is described for its composition and uses in fabricating a plurality of types of nitric oxide-releasing medical devices. The printing ink composition comprises a mixture of at least one nitric oxide donor and at least one polymer. The nitric oxide-releasing medical device is manufactured by 3D printing technology and provides antimicrobial and/or antithrombus effects by releasing nitric oxide in the presence of moisture.

公开(公告)号：US11104632B1

公开(公告)日：2021-08-31

申请号：US16872466

申请日：2020-05-12

Applicant: King Abdulaziz University ,  Virginia Commonwealth University

Inventor： Abdelsattar Mansour Ebeid Omar ,  Moustafa El-Sayed El-Araby ,  Martin K. Safo

IPC: C07C47/58 ,  C07C49/84 ,  A61P7/00 ,  C07C69/738 ,  C07C233/11 ,  C07D309/12

Abstract: Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.

公开(公告)号：US20210253800A1

公开(公告)日：2021-08-19

申请号：US17284595

申请日：2019-10-11

Applicant: Virginia Commonwealth University

Inventor： Kenneth J. Wynne ,  Ashraf KAYESH

IPC: C08G77/388 ,  C08G77/20 ,  C08G77/12 ,  C09D183/08

Abstract: A surface-modified poly(dimethylsiloxane) is provided, comprising a Pt-cured poly(dimethylsiloxane) elastomer, having a surface; and a plurality of —CH2—CH2—R groups covalently bound to the surface; wherein R is a substituted or unsubstituted, branched or unbranched alkyl, aryl, aralkyl, alkylsilyl, silyl, alkyl ether, alkyl amine, quaternary alkyl amine, or alkylcarbonyloxy group. Methods of making and using the surface-modified poly(dimethylsiloxane) are also provided.