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    Functional nano-scale gels
    23.
    发明申请
    Functional nano-scale gels 审中-公开
    功能纳米级凝胶

    公开(公告)号：US20060014003A1

    公开(公告)日：2006-01-19

    申请号：US11141339

    申请日：2005-05-31

    Applicant: Matthew Libera ,  Svetlana Sukhishvili ,  Peter Krsko ,  Ye Hong

    Inventor： Matthew Libera ,  Svetlana Sukhishvili ,  Peter Krsko ,  Ye Hong

    IPC: C12M3/00

    CPC classification number: A61K47/6903 ,  Y10T428/24802

    Abstract: Nanometer-scale hydrogels are formed from a polymer film by exposing said film to a focused electron beam of 1 to 10 nm diameter. The hydrogels may be formed in regular patterns, such as arrays, or in irregular patterns. The hydrogels have a plurality of functional groups that can form covalent bonds with proteins while preserving the natural functionality of the proteins. Such functionalized nanohydrogels may serve as a substrate for attachment of other proteins or cells, or may be used in other biological applications.

    Abstract translation: 通过将所述膜暴露于1至10nm直径的聚焦电子束，由聚合物膜形成纳米级水凝胶。 水凝胶可以以规则的图案形成，例如阵列，或以不规则图案形成。 水凝胶具有多个可与蛋白形成共价键的官能团，同时保留蛋白质的天然功能。 这样的官能化纳米水凝胶可以用作其它蛋白质或细胞附着的底物，或者可以用于其它生物学应用。

    Wettable silicone hydrogel contact lenses
    24.
    发明授权
    Wettable silicone hydrogel contact lenses 有权
    可湿性硅酮水凝胶隐形眼镜

    公开(公告)号：US09164298B2

    公开(公告)日：2015-10-20

    申请号：US13983577

    申请日：2012-02-23

    Applicant: Ye Hong ,  Li Yao ,  Yuwen Liu ,  Charlie Chen ,  Arthur Back

    Inventor： Ye Hong ,  Li Yao ,  Yuwen Liu ,  Charlie Chen ,  Arthur Back

    IPC: G02C7/04 ,  G02B1/04 ,  C08L83/12

    CPC classification number: G02C7/049 ,  C08L83/12 ,  G02B1/043 ,  C08L101/14 ,  C08L83/04 ,  C08L51/085

    Abstract: Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent, wherein the polymerizable composition has a molar ratio of total amount of hydrophilic vinyl-containing monomer to total amount of acrylate-containing siloxane monomer of from 5:1 to 30:1, respectively. The silicone hydrogel contact lenses have good manufacturing processability, can be manufactured without the use of alcohol solvents, and have excellent surface wettability.

    Abstract translation: 硅氧烷水凝胶隐形眼镜由包含至少一种含丙烯酸酯的硅氧烷单体，至少一种亲水性含乙烯基单体和至少一种含乙烯基交联剂的可聚合组合物的反应产物形成，其中可聚合组合物具有 亲水性含乙烯基单体的总量与含丙烯酸酯的硅氧烷单体的总量的摩尔比分别为5:1至30:1。 硅酮水凝胶隐形眼镜具有良好的制造加工性，可以在不使用醇溶剂的情况下制造，并且具有优异的表面润湿性。

    Silicone hydrogel contact lenses
    25.
    发明授权
    Silicone hydrogel contact lenses 有权
    硅胶水凝胶隐形眼镜

    公开(公告)号：US09057822B2

    公开(公告)日：2015-06-16

    申请号：US13983774

    申请日：2012-02-23

    Applicant: Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

    Inventor： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

    IPC: G02B1/04 ,  C08F283/12 ,  C08F236/20 ,  C08F226/00 ,  C08F283/06 ,  C08L51/08 ,  C08J11/02

    CPC classification number: G02B1/043 ,  C08F226/00 ,  C08F236/20 ,  C08F283/065 ,  C08F283/126 ,  C08J11/02 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

    Abstract: Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.

    Abstract translation: 衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。 和至少一种含乙烯基醚的交联剂。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。 在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

    Silicone Hydrogel Contact Lenses
    26.
    发明申请
    Silicone Hydrogel Contact Lenses 有权
    硅胶水凝胶隐形眼镜

    公开(公告)号：US20140016086A1

    公开(公告)日：2014-01-16

    申请号：US13983774

    申请日：2012-02-23

    Applicant: Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

    Inventor： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

    IPC: G02C7/04

    CPC classification number: G02B1/043 ,  C08F226/00 ,  C08F236/20 ,  C08F283/065 ,  C08F283/126 ,  C08J11/02 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

    Abstract: Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.

    Abstract translation: 衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。 和至少一种含乙烯基醚的交联剂。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。 在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

    Silicone Hydrogel Contact Lenses
    27.
    发明申请
    Silicone Hydrogel Contact Lenses 有权
    硅胶水凝胶隐形眼镜

    公开(公告)号：US20140016085A1

    公开(公告)日：2014-01-16

    申请号：US13982032

    申请日：2012-02-23

    Applicant: Junhao Ge ,  Yuwen Liu ,  Charlie Chen ,  Yuan Xu ,  Ye Hong ,  Hongjin Qiu

    Inventor： Junhao Ge ,  Yuwen Liu ,  Charlie Chen ,  Yuan Xu ,  Ye Hong ,  Hongjin Qiu

    IPC: G02C7/04

    CPC classification number: G02C7/049 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

    Abstract: Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one hydrophilic vinyl amide-containing monomer, at least one acrylate-containing siloxane monomer, and at least one hydrophilic vinyl ether-containing monomer. The contact lenses have ophthalmically-acceptable surface wettability and can be manufactured without the use of volatile organic solvents.

    Abstract translation: 硅氧水凝胶隐形眼镜由包含至少一种含亲水性乙烯基酰胺的单体，至少一种含丙烯酸酯的硅氧烷单体和至少一种含亲水性乙烯基醚的单体的可聚合组合物的反应产物形成。 隐形眼镜具有眼科可接受的表面润湿性，并且可以在不使用挥发性有机溶剂的情况下制造。

    Wettable Silicone Hydrogel Contact Lenses and Related Compositions and Methods
    30.
    发明申请
    Wettable Silicone Hydrogel Contact Lenses and Related Compositions and Methods 有权
    可湿性硅胶水凝胶隐形眼镜及相关成分及方法

    公开(公告)号：US20090264553A1

    公开(公告)日：2009-10-22

    申请号：US12496228

    申请日：2009-07-01

    Applicant: Charlie Chen ,  Ye Hong ,  Nick Manesis

    Inventor： Charlie Chen ,  Ye Hong ,  Nick Manesis

    IPC: B29D11/00 ,  C08G77/04 ,  C08L83/06

    CPC classification number: C08L83/14 ,  G02B1/043

    Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.

    Abstract translation: 具有眼科可接受的表面润湿性的硅酮水凝胶隐形眼镜由具有相对大量的可移除或可萃取材料的预提取聚合的硅氧水凝胶隐形眼镜产品获得。 硅酮水凝胶隐形眼镜可以从非极性树脂基隐形眼镜模具获得，而不用表面处理或聚合润湿剂的互穿聚合物网络获得。 还描述了相关的透镜产品，可聚合组合物和方法。

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