利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

155 records (took 0.035 seconds)

    Encoded beads having oligonucleotides attached in arrays on a patterned surface
    2.
    发明授权
    Encoded beads having oligonucleotides attached in arrays on a patterned surface 有权
    具有寡核苷酸的编码珠在阵列上附着在图案化表面上

    公开(公告)号：US08124402B2

    公开(公告)日：2012-02-28

    申请号：US11436717

    申请日：2006-05-17

    Applicant: Michael Seul

    Inventor： Michael Seul

    IPC: C12M1/36 ,  G01N15/06 ,  C07H21/04

    CPC classification number: C40B50/18 ,  B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00448 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B60/14 ,  C12Q2565/501 ,  C12Q2563/155 ,  C12Q2565/607

    Abstract: A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.

    Abstract translation: 一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面上操纵胶体颗粒和生物分子的方法和装置。 表面附近颗粒的光控电动组装取决于三个功能元件的组合：交流电场引起的平面聚集体的组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。 本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。 本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。 此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装的光学部件的程序。

    ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES
    3.
    发明申请
    ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US20110251093A1

    公开(公告)日：2011-10-13

    申请号：US13084869

    申请日：2011-04-12

    Applicant: Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    Inventor： Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    IPC: C40B30/04

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    Analysis, secure access to, and transmission of array images
    4.
    发明授权
    Analysis, secure access to, and transmission of array images 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US07940968B2

    公开(公告)日：2011-05-10

    申请号：US11439599

    申请日：2006-05-23

    Applicant: Michael Seul ,  Xiongwu Xia ,  Chiu Chau

    Inventor： Michael Seul ,  Xiongwu Xia ,  Chiu Chau

    IPC: G06K9/00

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    Correcting an assay image of an array of signals generated from a multiplexed hybridization-mediated assay
    6.
    发明授权
    Correcting an assay image of an array of signals generated from a multiplexed hybridization-mediated assay 有权
    校正由多重杂交介导的测定产生的信号阵列的测定图像

    公开(公告)号：US07771939B2

    公开(公告)日：2010-08-10

    申请号：US11439694

    申请日：2006-05-23

    Applicant: Ghazala Hashmi ,  Michael Seul

    Inventor： Ghazala Hashmi ,  Michael Seul

    IPC: C12Q1/68 ,  C12M1/34 ,  G01N33/00 ,  G01N33/53 ,  C07H21/04 ,  G01N33/50

    CPC classification number: C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6837 ,  C12Q2600/156 ,  C12Q2600/16 ,  Y10S436/80 ,  Y10S436/805 ,  Y10T436/143333 ,  C12Q2565/543 ,  C12Q2563/107 ,  C12Q2565/501

    Abstract: Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is complementary to a corresponding wild type allele), with probes bound to encoded particles (e.g., beads) wherein the encoding allows identification of the attached probe. The methods relate to avoiding cross-hybridization by selection of probes and amplicons, as well as separation of reactions of certain probes and amplicons where a homology threshold is exceeded. Methods of correcting a fluorescent image using a background map, where the particles also contain an optical encoding system, are also disclosed.

    Abstract translation: 描述了测定设计和测定图像校正的方法，其可用于使用探针对阵列（在一个方面中，其中一个成员与特定突变体互补的突变和多态性）的多重遗传筛选（包括CF相关突变体和多态性） 多态等位基因和另一个成员与相应的野生型等位基因互补），其中探针与编码的颗粒结合（例如，珠粒），其中编码允许鉴定附着的探针。 该方法涉及通过选择探针和扩增子来避免交叉杂交，以及分离某些探针和扩增子的反应，其中超过同源性阈值。 还公开了使用背景图校正荧光图像的方法，其中颗粒还包含光编码系统。

    Concurrent Optimization In Selection of Primer and Capture Probe Sets for Nucleic Acid Analysis
    7.
    发明申请
    Concurrent Optimization In Selection of Primer and Capture Probe Sets for Nucleic Acid Analysis 有权
    选择用于核酸分析的引物和捕获探针组的并行优化

    公开(公告)号：US20100021909A1

    公开(公告)日：2010-01-28

    申请号：US12502725

    申请日：2009-07-14

    Applicant: Michael Seul ,  Tatiana Vener ,  XiongWu Xia

    Inventor： Michael Seul ,  Tatiana Vener ,  XiongWu Xia

    IPC: C12Q1/68

    CPC classification number: C12Q1/6876 ,  C12Q2600/16 ,  G06F19/20 ,  G06F19/22

    Abstract: Disclosed is a method of iteratively optimizing two (or more) interrelated sets of probes for the multi-step analysis of sets of designated sequences, each such sequence requiring, for conversion, at least one conversion probe (“primer”), and each converted sequence requiring, for detection, at least one capture probe. The iterative method disclosed herein for the concurrent optimization of primer and probe selection invokes fast logical string matching functions to perform a complete cross-correlation of probe sequences and target sequences. The score function assigns to each probe-target alignment a “degree of matching” score on the basis of position-weighted Hamming distance functions introduced herein. Pairs of probes in the final selection may differ in several positions, while other pairs of probes may differ in only a single position. Not all such positions are of equal importance, and a score function is introduced, reflecting the position of the mismatch within the probe sequence.

    Abstract translation: 公开了一种迭代优化两个（或多个）相互关联的探针组的方法，用于多步分析指定序列组，每个这样的序列需要用于转化的至少一个转化探针（“引物”），并且每个转化 用于检测至少一个捕获探针的序列。 本文公开的用于并行优化引物和探针选择的迭代方法调用快速逻辑串匹配函数来执行探针序列和靶序列的完全互相关。 得分函数根据本文介绍的位置加权汉明距离函数将每个探针 - 目标对准分配给“匹配度”得分。 最终选择中的一对探针在几个位置可能有所不同，而其他探针对只能在一个位置上不同。 并不是所有这样的位置都是同等重要的，并且引入了分数函数，反映了探针序列内不匹配的位置。

    Fulfilling Demand for Particular Blood Group Types
    8.
    发明申请
    Fulfilling Demand for Particular Blood Group Types 审中-公开
    满足特殊血型的需求

    公开(公告)号：US20090313042A1

    公开(公告)日：2009-12-17

    申请号：US12546234

    申请日：2009-08-24

    Applicant: Yi Zhang ,  Michael Seul

    Inventor： Yi Zhang ,  Michael Seul

    IPC: G06Q50/00 ,  G06Q10/00

    CPC classification number: G16H40/20 ,  G06Q30/02 ,  G06Q30/0202 ,  G06Q50/22 ,  G06Q50/24

    Abstract: Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors.

    Abstract translation: 公布了候选人输血捐助者的登记册，该登记处援引了库存管理政策，以创建和主动管理候选人捐助者名单，以便最大限度地减少多个地区和多个捐助者和接受者之间的需求与供应之间的不平衡。 与基因分型实验室一起，注册管理机构确实针对招募潜在的捐赠者，这些捐赠者是针对一系列与临床相关抗原相关的遗传标记，包括人类红细胞抗原（HEA）的突变，Rh的遗传变体和可能的其他抗原如HLA 和HPA。 注册管理机监测输血抗原基因型的输入需求，最好将需求分为一组代表稳定亚群体的类别，并将应用本文所披露的策略来调整候选捐献者名单的组成以匹配需求，从而避免过多和不必要的 ，候选人捐款人的打字。

Patent Agency Ranking