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公开(公告)号：US20240166652A1
公开(公告)日：2024-05-23
申请号：US18324901
申请日：2023-05-26
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei Zhang , SeungWon Chung , Zhaoming Xiong , Ramzi Farah Sweis , Michael J. Dart , Brian S. Brown , Kathleen J. Murauski
IPC: C07D487/04 , C07C235/22 , C07D213/30 , C07D213/643 , C07D213/73 , C07D231/56 , C07D241/18 , C07D261/20 , C07D271/07 , C07D271/113
CPC classification number: C07D487/04 , C07C235/22 , C07D213/30 , C07D213/643 , C07D213/73 , C07D231/56 , C07D241/18 , C07D261/20 , C07D271/07 , C07D271/113
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US11939320B2
公开(公告)日：2024-03-26
申请号：US16761365
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Jennifer M. Frost , Lei Shi , Yunsong Tong , Michael J. Dart , Kathleen J. Murauski
IPC: C07D405/12 , A61K45/06 , C07D205/04 , C07D207/08 , C07D213/40 , C07D213/75 , C07D235/14 , C07D263/32 , C07D309/14 , C07D413/14 , C07D487/04
CPC classification number: C07D405/12 , A61K45/06 , C07D205/04 , C07D207/08 , C07D213/40 , C07D213/75 , C07D235/14 , C07D263/32 , C07D309/14 , C07D413/14 , C07D487/04
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210363136A1
公开(公告)日：2021-11-25
申请号：US16863737
申请日：2020-04-30
Applicant: Calico Life Sciences LLC , AbbVie Inc. , SYGNATURE DISCOVERY LIMITED
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei I Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph , Hanae Benelkebir
IPC: C07D413/12 , C07D317/68 , C07D311/24 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D319/20 , C07D493/04 , C07D405/12 , C07D417/12 , C07D493/08 , C07D405/14
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20210171508A1
公开(公告)日：2021-06-10
申请号：US16761365
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Lei Shi , Yunsong Tong , Michael J. Dart , Kathleen J. Murauski
IPC: C07D405/12 , C07D213/40 , C07D487/04 , C07D213/75 , C07D309/14 , C07D235/14 , C07D207/08 , C07D263/32 , C07D413/14 , C07D205/04 , A61K45/06
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210113532A1
公开(公告)日：2021-04-22
申请号：US16885766
申请日：2020-05-28
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC: A61K31/42 , C07D271/10 , C07D471/04 , C07D271/06 , C07D401/12 , C07D233/64 , C07D413/12 , A61P3/08 , A61P25/28 , A61P9/00 , A61P35/00
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Patent Agency Ranking
公开(公告)号：US20190144440A1
公开(公告)日：2019-05-16
申请号：US16098675
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC: C07D471/04 , A61P25/28 , C07D213/30 , C07D213/64 , C07D213/66 , C07D213/73 , C07D231/56 , C07D241/18 , C07D261/08 , C07D271/113 , C07D261/20 , C07D317/64 , C07D401/04 , C07D405/08
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US08969325B2
公开(公告)日：2015-03-03
申请号：US13716862
申请日：2012-12-17
Applicant: AbbVie Inc.
Inventor： Michael J. Dart , Philip R. Kym , Eric A. Voight , Anurupa Shrestha , Jerome F. Daanen , Tammie K. Jinkerson , Ryan G. Keddy , Sridhar Peddi , Arthur Gomtsyan , Michael E. Kort , Gregory A. Gfesser , Kevin R. Woller , Derek W. Nelson
IPC: C07D405/12 , C07D215/38 , C07D239/80 , C07D413/12 , C07D491/052 , A61K31/192 , A61K31/4704 , A61K31/4709 , A61K31/517 , A61K31/538 , A61K45/06 , C07D413/14 , C07D215/227 , C07D265/36
CPC classification number: C07D405/12 , A61K31/192 , A61K31/4704 , A61K31/4709 , A61K31/517 , A61K31/538 , A61K45/06 , C07D215/227 , C07D215/38 , C07D239/80 , C07D265/36 , C07D413/12 , C07D413/14 , C07D491/052
Abstract: Disclosed herein are compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein X1, L, Rx, Ry, G, Z, A, m, n, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）的化合物或其药学上可接受的盐，其中X1，L，Rx，Ry，G，Z，A，m，n和p如说明书中所定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20140080803A1
公开(公告)日：2014-03-20
申请号：US13658355
申请日：2012-10-23
Applicant: ABBVIE INC.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Michael J. Dart , Gregory A. Gfesser , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Eric A. Voight
IPC: A61K31/505 , A61K31/4418 , C07D213/34 , C07D213/38 , A61K31/444 , C07D239/26 , A61K31/4433 , C07D401/06 , A61K31/4427 , C07D405/08 , A61K31/443 , C07D417/08 , A61K31/4439 , A61K45/06 , A61K31/192 , C07D213/30
CPC classification number: C07D213/38 , A61K31/192 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/34 , C07D213/72 , C07D215/14 , C07D221/04 , C07D239/26 , C07D311/04 , C07D401/06 , C07D405/06 , C07D405/08 , C07D405/10 , C07D417/08 , A61K2300/00
Abstract: Disclosed herein are modulators of TRPV3 of Formula (I) wherein p is 1, 2, 3, or 4, and G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中p为1,2,3或4，并且G1，X1，X2，X3，X4，X5，G2，Z1，Ra，Rb和u如 规格。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20130131036A1
公开(公告)日：2013-05-23
申请号：US13658374
申请日：2012-10-23
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Michael J. Dart , Gregory A. Gfesser , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Eric A. Voight
IPC: A61K31/435 , A61K31/444 , C07D239/26 , A61K31/505 , C07D405/10 , A61K31/4433 , C07D405/06 , A61K31/443 , A61K31/4427 , C07D213/72 , C07D401/06 , A61K31/4545 , C07D215/14 , A61K31/47 , C07D221/04 , A61K31/4439 , A61K45/06 , C07D213/30
CPC classification number: C07D213/38 , A61K31/192 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/34 , C07D213/72 , C07D215/14 , C07D221/04 , C07D239/26 , C07D311/04 , C07D401/06 , C07D405/06 , C07D405/08 , C07D405/10 , C07D417/08 , A61K2300/00
Abstract: Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（II）的TRPV3的调节剂：其中G1，X1，X2，X3，X4，X5，G2，Ra，Rb和u如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20250122188A1
公开(公告)日：2025-04-17
申请号：US18648195
申请日：2024-04-26
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC: C07D471/04 , A61P25/28 , C07C235/22 , C07C311/13 , C07C311/24 , C07C317/22 , C07D213/30 , C07D213/64 , C07D213/66 , C07D213/73 , C07D231/56 , C07D237/14 , C07D237/16 , C07D241/18 , C07D261/08 , C07D261/20 , C07D271/113 , C07D317/64 , C07D401/04 , C07D405/08
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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