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1.发明申请FURO-3-CARBOXAMIDE DERIVATIVES AND METHODS OF USE 有权FURO-3-CARBOXAMIDE DORIVATIVES AND METHODS OF USE公开(公告)号：US20150210720A1
公开(公告)日：2015-07-30
申请号：US14603043
申请日：2015-01-22
Applicant: AbbVie Inc.
Inventor： Robert J. Altenbach , Huaqing Liu , Bruce Clapham , Ana L. Aguirre , Marlon Cowart , John R. Koenig , Katerina Sarris , Marc J. Scanio , Kerren K. Swinger , Anil Vasudevan , Clara I. Villamil , Kevin R. Woller
IPC: C07D519/00 , C07D493/10 , C07D405/12 , C07D491/20 , C07D307/83 , C07D491/048 , C07D491/107
CPC classification number: C07D519/00 , C07D307/83 , C07D405/12 , C07D407/12 , C07D491/048 , C07D491/107 , C07D491/20 , C07D493/10
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
Abstract translation: 式（I）化合物及其药学上可接受的盐，酯，酰胺或放射性标记形式，其中R1，Z1，Z2和n如说明书中所定义，可用于治疗由Tropomysin受体阻止或改善的病症或病症 激酶（Trk）。 公开了制备化合物的方法。 还公开了式（I）化合物的药物组合物，以及使用这些化合物和组合物的方法。
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公开(公告)号：US20190119200A1
公开(公告)日：2019-04-25
申请号：US16091919
申请日：2017-04-06
Applicant: AbbVie Inc.
Inventor： Lawrence A. Black , William H. Bunnelle , Da Chen , Bruce Clapham , David A. Degoey , Xiangjun Deng , Liqiang Fu , Lisa A. Hazelwood , Linglong Kong , Qingyu Lang , Chih-Hung Lee , Mingfeng Li , Greta L. Lundgaard , Meena V. Patel , Ruihong Tao , Lin Zhang , Qingwei Zhang , Qiangang Zheng , Wei Zhu
IPC: C07C235/34 , C07D213/69 , C07D321/10 , C07D307/86 , C07D317/46 , C07D333/24 , C07C323/52 , C07F9/38 , C07C313/04 , C07D209/20 , C07C311/32 , C07D305/06 , C07D213/71 , C07C311/51 , C07D239/72 , C07D239/52 , C07D257/06 , C07D215/50 , C07D217/26 , C07D498/04 , C07D307/33
Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
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公开(公告)号：US20140080803A1
公开(公告)日：2014-03-20
申请号：US13658355
申请日：2012-10-23
Applicant: ABBVIE INC.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Michael J. Dart , Gregory A. Gfesser , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Eric A. Voight
IPC: A61K31/505 , A61K31/4418 , C07D213/34 , C07D213/38 , A61K31/444 , C07D239/26 , A61K31/4433 , C07D401/06 , A61K31/4427 , C07D405/08 , A61K31/443 , C07D417/08 , A61K31/4439 , A61K45/06 , A61K31/192 , C07D213/30
CPC classification number: C07D213/38 , A61K31/192 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/34 , C07D213/72 , C07D215/14 , C07D221/04 , C07D239/26 , C07D311/04 , C07D401/06 , C07D405/06 , C07D405/08 , C07D405/10 , C07D417/08 , A61K2300/00
Abstract: Disclosed herein are modulators of TRPV3 of Formula (I) wherein p is 1, 2, 3, or 4, and G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中p为1,2,3或4，并且G1，X1，X2，X3，X4，X5，G2，Z1，Ra，Rb和u如 规格。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20130131036A1
公开(公告)日：2013-05-23
申请号：US13658374
申请日：2012-10-23
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Michael J. Dart , Gregory A. Gfesser , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Eric A. Voight
IPC: A61K31/435 , A61K31/444 , C07D239/26 , A61K31/505 , C07D405/10 , A61K31/4433 , C07D405/06 , A61K31/443 , A61K31/4427 , C07D213/72 , C07D401/06 , A61K31/4545 , C07D215/14 , A61K31/47 , C07D221/04 , A61K31/4439 , A61K45/06 , C07D213/30
CPC classification number: C07D213/38 , A61K31/192 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/34 , C07D213/72 , C07D215/14 , C07D221/04 , C07D239/26 , C07D311/04 , C07D401/06 , C07D405/06 , C07D405/08 , C07D405/10 , C07D417/08 , A61K2300/00
Abstract: Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（II）的TRPV3的调节剂：其中G1，X1，X2，X3，X4，X5，G2，Ra，Rb和u如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20180243298A1
公开(公告)日：2018-08-30
申请号：US15563888
申请日：2016-03-30
Applicant: AbbVie Inc.
Inventor： Lawrence Black , Brian S. Brown , Bruce Clapham , Marlon D. Cowart , Michael J. Dart , Ramin Faghih , Jennifer Frost , Arthur R. Gomtsyan , Philip R. Kym , Huaqing Liu , Robert G. Schmidt , Lei Shi , Anurupa Shrestha , Kevin Sippy
IPC: A61K31/506 , A61P17/06 , A61P17/04
CPC classification number: A61K31/506 , A61P17/04 , A61P17/06 , C07D417/12 , C07D417/14 , C07D491/048 , C07D491/107
Abstract: A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis, eczema, itch or psoriasis, is disclosed. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
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Patent Agency Ranking
公开(公告)号：US09156788B2
公开(公告)日：2015-10-13
申请号：US13761862
申请日：2013-02-07
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Eric A. Voight
IPC: A61K31/444 , C07D213/30 , C07D239/26 , C07D401/04 , C07D405/12 , C07D213/50 , C07D401/12
CPC classification number: C07D213/30 , C07D213/50 , C07D239/26 , C07D401/12 , C07D405/12
Abstract: Disclosed herein are modulators of TRPV3 of formula (I) wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中G1，X1，X2，X3，X4，X5，G2，Z1，Ra，Rb，u和p如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20130150409A1
公开(公告)日：2013-06-13
申请号：US13761862
申请日：2013-02-07
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Eric A. Voight
IPC: A61K31/44 , C07D401/04 , A61K31/444
CPC classification number: C07D213/30 , C07D213/50 , C07D239/26 , C07D401/12 , C07D405/12
Abstract: Disclosed herein are modulators of TRPV3 of formula (I) wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中G1，X1，X2，X3，X4，X5，G2，Z1，Ra，Rb，u和p如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US09777020B2
公开(公告)日：2017-10-03
申请号：US14603043
申请日：2015-01-22
Applicant: AbbVie Inc.
Inventor： Robert J. Altenbach , Huaqing Liu , Bruce Clapham , Ana L. Aguirre , Marlon Cowart , John R. Koenig , Kathy Sarris , Marc J. Scanio , Kerren K. Swinger , Anil Vasudevan , Clara I. Villamil , Kevin R. Woller
IPC: C07D407/12 , C07D491/048 , C07D491/20 , C07D519/00 , C07D307/83 , C07D405/12 , C07D491/107 , C07D493/10
CPC classification number: C07D519/00 , C07D307/83 , C07D405/12 , C07D407/12 , C07D491/048 , C07D491/107 , C07D491/20 , C07D493/10
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
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公开(公告)号：US08772500B2
公开(公告)日：2014-07-08
申请号：US13658374
申请日：2012-10-23
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Michael J. Dart , Gregory A. Gfesser , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt
IPC: C07D213/00 , C07D213/28 , C07D211/74 , C07D421/00 , C07D401/00
CPC classification number: C07D213/38 , A61K31/192 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/34 , C07D213/72 , C07D215/14 , C07D221/04 , C07D239/26 , C07D311/04 , C07D401/06 , C07D405/06 , C07D405/08 , C07D405/10 , C07D417/08 , A61K2300/00
Abstract: Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（II）的TRPV3的调节剂：其中G1，X1，X2，X3，X4，X5，G2，Ra，Rb和u如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US08772499B2
公开(公告)日：2014-07-08
申请号：US13658355
申请日：2012-10-23
Applicant: AbbVie Inc.
Inventor： Erol K. Bayburt , Bruce Clapham , Phil B. Cox , Jerome F. Daanen , Michael J. Dart , Gregory A. Gfesser , Arthur Gomtsyan , Michael E. Kort , Philip R. Kym , Robert G. Schmidt , Eric A. Voight
IPC: C07D213/00 , C07D213/28 , C07D211/74 , C07D421/00 , C07D401/00
CPC classification number: C07D213/38 , A61K31/192 , A61K31/435 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/34 , C07D213/72 , C07D215/14 , C07D221/04 , C07D239/26 , C07D311/04 , C07D401/06 , C07D405/06 , C07D405/08 , C07D405/10 , C07D417/08 , A61K2300/00
Abstract: Disclosed herein are modulators of TRPV3 of Formula (I) wherein p is 1, 2, 3, or 4, and G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中p为1,2,3或4，并且G1，X1，X2，X3，X4，X5，G2，Z1，Ra，Rb和u如 规格。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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