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公开(公告)号：US20150010491A1
公开(公告)日：2015-01-08
申请号：US14493197
申请日：2014-09-22
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Syed Hossainy , Stephen Pacetti , Jessica DesNoyer
IPC: A61K47/48 , A61K31/727
CPC classification number: A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
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公开(公告)号：US20140120053A1
公开(公告)日：2014-05-01
申请号：US14149533
申请日：2014-01-07
Applicant: Abbott Cardiovascular Systems Inc
Inventor： Lothar W. Kleiner , Syed Hossainy , Stephen Pacetti , Jessica DesNoyer
IPC: A61K47/48
CPC classification number: A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
Abstract translation: 本文描述了由特定类型的聚（酯酰胺）（PEA），治疗剂和水混溶性溶剂形成的治疗剂递送系统。 通过将由PEA聚合物，治疗剂和水混溶性溶剂形成的治疗剂递送系统递送到生理环境来递送治疗剂递送系统的方法，并分离治疗剂递送系统的相以形成膜 还描述了在生理环境中含有治疗剂的聚合物。 另外公开了一种试剂盒，其包括注射器内的注射器和治疗剂递送系统。
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公开(公告)号：US10555825B2
公开(公告)日：2020-02-11
申请号：US15807963
申请日：2017-11-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Victoria M. Gong , Stephen Pacetti
Abstract: A medical device includes a balloon expanded scaffold crimped to a balloon catheter. The scaffold has a network of rings formed by struts connected at crowns and links connecting adjacent rings. The scaffold has a polymer coating and is crimped to the balloon. The scaffold is rotated, or allowed to rotate during crimping to improve results from crimping, such as reduced damage to the coating.
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公开(公告)号：US09999527B2
公开(公告)日：2018-06-19
申请号：US14620096
申请日：2015-02-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti , Joan Bei , Karen Wang , Annie Liu
CPC classification number: A61F2/82 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0004 , A61F2210/0071 , A61F2240/001 , A61F2250/0098 , A61L31/04 , A61L31/18
Abstract: A scaffold includes a radiopaque marker connected to a strut. The marker is retained within the strut by one or more of a mechanical interference fit, a polymer coating or melt, and/or by friction. The marker can take the form of a bead, rivet or snap-in marker, or a tube deformed when attached to the strut. The strut is made from a tube. The strut has a thickness of about 100 microns.
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25.发明申请公开(公告)号：US20170065443A1
公开(公告)日：2017-03-09
申请号：US15356930
申请日：2016-11-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti
CPC classification number: A61F2/90 , A61F2/89 , A61F2/915 , A61F2002/91566 , A61F2230/0069 , A61F2240/001 , A61F2250/0067 , A61F2250/0068 , A61F2250/0098 , A61K49/04 , A61L31/022 , A61L31/16 , A61L31/18
Abstract: An implantable prosthesis can comprise a strut having a lumen, radiopaque particles within the lumen, and a polymer binder. The polymer binder retains the radiopaque particles within the lumen. The strut may have side holes through which a therapeutic agent may pass and through which the radiopaque particles are incapable of passing. The polymer binder may be absent or optional. The radiopaque particles can have sizes that prevent them from escaping out of the lumen through the side holes. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure.
Abstract translation: 可植入假体可以包括具有内腔，管腔内的不透射线颗粒的支柱和聚合物粘合剂。 聚合物粘合剂将不透射线的颗粒保留在管腔内。 支柱可以具有侧孔，治疗剂通过该侧孔，不透射线的颗粒不能通过。 聚合物粘合剂可以不存在或任选。 不透射线的颗粒可以具有防止它们通过侧孔从管腔逸出的尺寸。 放置在内腔内的不透射线颗粒可以改善植入术期间假体的可视化。
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Patent Agency Ranking
公开(公告)号：US20160228267A1
公开(公告)日：2016-08-11
申请号：US14620096
申请日：2015-02-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti , Joan Bei , Karen Wang , Annie Liu
IPC: A61F2/82
CPC classification number: A61F2/82 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0004 , A61F2210/0071 , A61F2240/001 , A61F2250/0098 , A61L31/04 , A61L31/18
Abstract: A scaffold includes a radiopaque marker connected to a strut. The marker is retained within the strut by one or more of a mechanical interference fit, a polymer coating or melt, and/or by friction. The marker can take the form of a bead, rivet or snap-in marker, or a tube deformed when attached to the strut. The strut is made from a tube. The strut has a thickness of about 100 microns.
Abstract translation: 支架包括连接到支柱的不透射线标记。 标记物通过机械干涉配合，聚合物涂层或熔体中的一种或多种和/或通过摩擦保持在支柱内。 标记可以采取珠，铆钉或卡入式标记的形式，或连接到支柱时变形的管。 支柱由管制成。 支柱具有约100微米的厚度。
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公开(公告)号：US09375876B2
公开(公告)日：2016-06-28
申请号：US14928823
申请日：2015-10-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yung-Ming Chen , Jason Van Sciver , Syed F. A. Hossainy , Stephen Pacetti
IPC: A61F2/06 , B05D3/02 , B29C65/76 , A61F2/91 , B05D3/04 , B05D1/38 , A61F2/82 , A61F2/86 , B29C65/10 , A61L31/14 , B29K67/00 , B29K105/00 , B29L31/00
CPC classification number: B29C65/76 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61F2310/00389 , A61L31/14 , A61L31/148 , A61L2420/02 , B05D1/38 , B05D3/0254 , B05D3/0473 , B29C65/10 , B29K2067/046 , B29K2105/258 , B29L2031/7534
Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.
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公开(公告)号：US09204981B2
公开(公告)日：2015-12-08
申请号：US14659276
申请日：2015-03-16
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yung-Ming Chen , Jason Van Sciver , Syed F. A. Hossainy , Stephen Pacetti
CPC classification number: B29C65/76 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61F2310/00389 , A61L31/14 , A61L31/148 , A61L2420/02 , B05D1/38 , B05D3/0254 , B05D3/0473 , B29C65/10 , B29K2067/046 , B29K2105/258 , B29L2031/7534
Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.
Abstract translation: 本文描述了用于涂覆支架的方法的各种实施例。 公开了将包含聚合物组分和溶剂的组合物施用到支架基底，然后将聚合物组分暴露于等于或大于聚合物组分的Tg的温度。 重复施加和暴露一次或多次以形成涂层，结果是在最终曝光步骤之后涂层的溶剂含量处于适合成品支架的水平。
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公开(公告)号：US20140364935A1
公开(公告)日：2014-12-11
申请号：US13910998
申请日：2013-06-05
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Erik David Eli , Syed Hossainy , Mikael Trollsas , Michael H. Ngo , Stephen Pacetti , Michael Green , John Papp
IPC: A61F2/07
CPC classification number: A61F2/915 , A61F2/91 , A61F2/958 , A61F2002/828 , A61F2002/91575 , A61F2002/91591 , A61F2210/0004 , A61F2220/0075 , A61F2220/0091
Abstract: A scaffold is formed by several segments joined or connected to each other by only at least one coupling. The coupling decouples the segments in the axial direction over a finite distance of axial displacement. The scaffold when implanted in a peripheral vessel reduces loading on rings of a segment due to the decoupling of the segments in the axial direction over the finite distance.
Abstract translation: 支架由仅通过至少一个联接件彼此连接或连接的若干段形成。 联轴器在轴向方向上在轴向位移的有限距离上使分段解耦。 当支架植入外周血管时，由于在有限的距离上沿着轴向方向的分段，分段的环上的载荷减小。
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30.发明申请CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING 审中-公开控制用于熔融加工的可生物降解聚合物的水分和塑化公开(公告)号：US20140298675A1
公开(公告)日：2014-10-09
申请号：US14311175
申请日：2014-06-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
IPC: B29B13/06
CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/1018 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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