公开(公告)号：US20240077460A1

公开(公告)日：2024-03-07

申请号：US18369739

申请日：2023-09-18

申请人： Agilent Technologies, Inc.

发明人： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC分类号： G01N30/20 ,  G01N30/32

CPC分类号： G01N30/20 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/328

摘要： An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

公开(公告)号：US20240027407A1

公开(公告)日：2024-01-25

申请号：US18265923

申请日：2021-12-07

申请人： Agilent Technologies, Inc.

发明人： Konstantin Shoykhet ,  Thomas Ortmann

IPC分类号： G01N30/20 ,  B01D15/14

CPC分类号： G01N30/20 ,  B01D15/14 ,  G01N2030/027

摘要： A fluid valve, for a sample separation device such as for liquid chromatography, includes a rotor, a stator, and external terminals for fluidically connecting one or more components. By rotating the rotor, different fluidic coupling and/or decoupling states between components are adjustable. Ports are connectable with one or more external terminals. A first channel is formed along a first circular path. A second channel includes a first coupling point located on the first circular path and a second coupling point located on a second circular path. By rotating the rotor, a fluidic coupling between a first port and a second port can be established, by the first channel being connected with the first port and at least the first coupling point with the second channel, and by the second channel being connected at least via the second coupling point with the second port.

公开(公告)号：US11773999B2

公开(公告)日：2023-10-03

申请号：US16480600

申请日：2018-01-23

申请人： Agilent Technologies, Inc.

发明人： Tony Ziegler ,  Darijo Zeko ,  Thomas Ortmann

IPC分类号： F16K3/04 ,  F16K25/00 ,  F16K11/074 ,  G01N30/20

CPC分类号： F16K25/005 ,  F16K3/04 ,  F16K11/0743 ,  G01N30/20 ,  G01N2030/201

摘要： A fluid valve for a sample separation apparatus includes a first valve component and a second valve component, which are adjacent to one another and movable relative to one another. The valve components are configured such that, in at least one switching state, at least one switchable fluid channel is formed between the valve components, and at least one part of a surface of at least one of the first valve component and the second valve component is provided with a coating containing gold and/or platinum.

公开(公告)号：US20230085894A1

公开(公告)日：2023-03-23

申请号：US17801767

申请日：2021-02-26

申请人： Agilent Technologies, Inc.

发明人： Blasius Nocon ,  Thomas Ortmann

IPC分类号： B01D15/12 ,  G01N30/16 ,  G01N30/14

摘要： A sample injector is provided for a chromatography system that includes a mobile phase drive and a separation unit. The mobile phase drive is configured for driving a mobile phase through the separation unit, and the separation unit is configured for chromatographically separating compounds of a sample fluid in the mobile phase. The sample injector is configured for injecting the sample fluid into the mobile phase and comprises a needle and a handling unit configured for positioning the needle. Operating the sample injector includes providing a receptacle that includes a filtration unit configured for filtering a sample fluid comprised within the receptacle, moving the filtration unit within the receptacle in order to filter at least a portion of the sample fluid contained in the receptacle, operating the handling unit to position the needle into the receptacle, and aspirating a volume of the filtered sample fluid.

公开(公告)号：US20220128519A1

公开(公告)日：2022-04-28

申请号：US17312888

申请日：2018-12-14

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann

IPC分类号： G01N30/24 ,  F16K11/074 ,  G01N30/06 ,  G01N30/18 ,  G01N30/20 ,  G01N30/22 ,  G01N30/32

摘要： A configurable injector for injecting a fluidic sample in a separation path of a sample separation apparatus includes a sample accommodation volume for accommodating the fluidic sample to be injected into the separation path, a valve arrangement fluidically couplable with the separation path, fluidically coupled with the sample accommodation volume, and being controllable for injecting the fluidic sample into the separation path, an input interface configured for receiving input data indicative of an injection profile of an injector to be emulated by the configurable injector, and a control unit configured for controlling the configurable injector, in particular the valve arrangement, so that the configurable injector is operated in accordance with the injection profile to thereby emulate the injector to be emulated.

公开(公告)号：US20220120719A1

公开(公告)日：2022-04-21

申请号：US17566330

申请日：2021-12-30

申请人： Agilent Technologies, Inc.

发明人： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC分类号： G01N30/20 ,  G01N30/32

摘要： An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

公开(公告)号：US20210033572A1

公开(公告)日：2021-02-04

申请号：US16943868

申请日：2020-07-30

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Thomas Glauner

IPC分类号： G01N30/20 ,  G01N30/38

摘要： A sample dispatcher for a fluid separation apparatus includes a sampling path including a sampling volume, a sampling unit, and a retaining unit. The sampling unit receives a fluidic sample, and the sampling volume temporarily stores an amount of the received sample. The retaining unit receives and retains from the sampling volume at least a portion of the stored sample, and has different retention characteristics for different components of the sample. A switching unit is coupled to the sampling path, a sampling fluid drive, a mobile phase drive, and a separating device. In a feed injection configuration of the switching unit, the mobile phase drive, the separating device, and the sampling path are coupled together in a coupling point for combining a flow from the sampling fluid drive containing the fluidic sample retained by the retaining unit with a flow of the mobile phase from the mobile phase drive.

公开(公告)号：US20200340956A1

公开(公告)日：2020-10-29

申请号：US16760429

申请日：2018-10-26

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Konstantin Shoykhet

IPC分类号： G01N30/20 ,  G01N30/08 ,  G01N30/32 ,  G01N30/36

摘要： Injector (40) for injecting a fluidic sample into a mobile phase in a sample separation apparatus (10), the injector (40) comprising a main flow path (100) between a fluid drive (20) and a sample separation device (30), wherein the fluid drive (20) is adapted to drive the mobile phase and the sample separation device (30) is adapted to separate the fluidic sample that is injected into the mobile phase, a discharge device (104) for discharging an, in particular predetermined, amount of the mobile phase from the main flow path (100), and a supply device (102) for supplying an, in particular predetermined, amount of the fluidic sample and/or of a solvent into the main flow path (100), wherein the discharged amount and the supplied amount compensate each other at least partially.

公开(公告)号：US20200333300A1

公开(公告)日：2020-10-22

申请号：US16917908

申请日：2020-07-01

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Daniel Thielsch ,  Dominik Ruf

IPC分类号： G01N30/20 ,  B01D15/14 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36

摘要： A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

公开(公告)号：US20170343520A1

公开(公告)日：2017-11-30

申请号：US15608888

申请日：2017-05-30

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Daniel Thielsch

IPC分类号： G01N30/32 ,  G01N30/36 ,  G01N30/04 ,  G01N30/10

CPC分类号： G01N30/20 ,  B01D15/14 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  G01N2030/324 ,  G01N2030/326 ,  G01N2030/328

摘要： A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured to adjust a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.