公开(公告)号：US20170138913A1

公开(公告)日：2017-05-18

申请号：US15300267

申请日：2014-03-31

申请人： Agilent Technologies, Inc.

发明人： Blasius Nocon ,  Joachim-Richard Wagner ,  Karsten Lehradt

IPC分类号： G01N30/32 ,  F04B53/16 ,  F16J1/06

摘要： A piston member for a high-pressure pump for pumping fluid in a sample separation apparatus, wherein the piston member comprises a piston configured for being mountable to reciprocate in a piston chamber for displacing fluid, and a sealing for sealing between the piston member and the piston chamber when the piston member is mounted in the piston chamber to reciprocate, wherein the sealing is mounted on the piston so as to reciprocate together with the piston.

公开(公告)号：US20240272185A1

公开(公告)日：2024-08-15

申请号：US18437876

申请日：2024-02-09

申请人： Agilent Technologies, Inc.

发明人： Blasius Nocon ,  Christoph Geiger

IPC分类号： G01N35/00 ,  G01N35/02

CPC分类号： G01N35/0099 ,  G01N35/026

摘要： A sample handling device for handling a sample container, in particular for an analysis device for analyzing a fluidic sample in the sample container, includes: i) a push-push mechanism for fixing and releasing the sample container; and ii) a coupling region for releasably coupling to a sample moving device. The sample handling device is a passive device which is adapted to perform the fixing and the releasing free of a drive, in particular a motor. Furthermore, a related sample handling arrangement, an analysis device, and a method are described.

公开(公告)号：US20230296571A1

公开(公告)日：2023-09-21

申请号：US18018540

申请日：2021-07-29

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Blasius Nocon ,  Armin Steinke ,  Christian Daniel Ruf

IPC分类号： G01N30/20

CPC分类号： G01N30/20 ,  G01N2030/027

摘要： A valve may be utilized in a high-performance chromatography system for separating components of a sample liquid introduced into a mobile phase. The valve has a first valve element and a second valve element. By a movement of one valve element relative to the other, a first effective surface of the first valve element is brought into connection with a second effective surface of the second valve element, and a flow path may be produced or suppressed. The second valve element has an elastic region to compensate for an axial angle between the first valve element and the second valve element, such that the first effective surface and the second effective surface may be oriented parallel to each other. This may favorably influence a fluidic leak tightness and/or longevity of the valve.

公开(公告)号：US10591446B2

公开(公告)日：2020-03-17

申请号：US15300267

申请日：2014-03-31

申请人： Agilent Technologies, Inc.

发明人： Blasius Nocon ,  Joachim-Richard Wagner ,  Karsten Lehradt

IPC分类号： G01N30/32 ,  F04B9/00 ,  F04B9/06 ,  F04B9/02 ,  F04B37/12 ,  F04B13/00 ,  F04B53/14 ,  F04B53/16 ,  F16J1/04 ,  F16J1/00 ,  F16J1/06

摘要： A piston member for a high-pressure pump for pumping fluid in a sample separation apparatus, wherein the piston member comprises a piston configured for being mountable to reciprocate in a piston chamber for displacing fluid, and a sealing for sealing between the piston member and the piston chamber when the piston member is mounted in the piston chamber to reciprocate, wherein the sealing is mounted on the piston so as to reciprocate together with the piston.

公开(公告)号：US11519885B2

公开(公告)日：2022-12-06

申请号：US17239238

申请日：2021-04-23

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Michael Lang ,  Blasius Nocon

IPC分类号： G01N30/22 ,  G01N30/02

摘要： A sample injector for a chromatography system is configured for injecting a sample fluid into a mobile phase, and includes a needle and a conduit. The needle is configured for aspirating the sample fluid and includes a needle tip, a needle channel through the needle for guiding the aspirated sample fluid, and a needle opening at the needle tip into which the needle channel opens. The conduit is configured for fluidically coupling with the needle and includes a conduit tip, and a conduit channel through the conduit for guiding fluid and having a conduit opening at the conduit tip. The conduit tip and the needle tip are configured to be pressed against each other for fluidically coupling the conduit channel with the needle channel, with at least a portion of the conduit tip penetrating into the needle opening for providing the fluidic coupling between the conduit and needle channels.

公开(公告)号：US20210333247A1

公开(公告)日：2021-10-28

申请号：US17239238

申请日：2021-04-23

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Michael Lang ,  Blasius Nocon

IPC分类号： G01N30/22

摘要： A sample injector for a chromatography system is configured for injecting a sample fluid into a mobile phase, and includes a needle and a conduit. The needle is configured for aspirating the sample fluid and includes a needle tip, a needle channel through the needle for guiding the aspirated sample fluid, and a needle opening at the needle tip into which the needle channel opens. The conduit is configured for fluidically coupling with the needle and includes a conduit tip, and a conduit channel through the conduit for guiding fluid and having a conduit opening at the conduit tip. The conduit tip and the needle tip are configured to be pressed against each other for fluidically coupling the conduit channel with the needle channel, with at least a portion of the conduit tip penetrating into the needle opening for providing the fluidic coupling between the conduit and needle channels.

公开(公告)号：US20240125744A1

公开(公告)日：2024-04-18

申请号：US18379930

申请日：2023-10-13

申请人： Agilent Technologies, Inc.

发明人： Blasius Nocon ,  Lena Höninger ,  Christoph Geiger ,  Axel Reichert ,  Dirk Göger

IPC分类号： G01N30/30 ,  G01N30/12

CPC分类号： G01N30/30 ,  G01N30/12 ,  G01N2030/027

摘要： A thermostat arrangement for a sample separation device for separating a fluidic sample includes a separation unit thermostat unit for adjusting a temperature of a separation unit for separating the fluidic sample in a mobile phase, a sample handling unit thermostat unit for adjusting the temperature of a sample handling unit for handling the fluidic sample, and a thermal coupling unit for thermally coupling the separation unit thermostat unit with the sample handling unit thermostat unit.

公开(公告)号：US20230085894A1

公开(公告)日：2023-03-23

申请号：US17801767

申请日：2021-02-26

申请人： Agilent Technologies, Inc.

发明人： Blasius Nocon ,  Thomas Ortmann

IPC分类号： B01D15/12 ,  G01N30/16 ,  G01N30/14

摘要： A sample injector is provided for a chromatography system that includes a mobile phase drive and a separation unit. The mobile phase drive is configured for driving a mobile phase through the separation unit, and the separation unit is configured for chromatographically separating compounds of a sample fluid in the mobile phase. The sample injector is configured for injecting the sample fluid into the mobile phase and comprises a needle and a handling unit configured for positioning the needle. Operating the sample injector includes providing a receptacle that includes a filtration unit configured for filtering a sample fluid comprised within the receptacle, moving the filtration unit within the receptacle in order to filter at least a portion of the sample fluid contained in the receptacle, operating the handling unit to position the needle into the receptacle, and aspirating a volume of the filtered sample fluid.