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    USE OF A GALECTIN-1-TARGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER
    21.
    发明申请
    USE OF A GALECTIN-1-TARGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 有权
    使用GALECTIN-1靶向基于RNAi的方法治疗癌症

    公开(公告)号：US20100120891A1

    公开(公告)日：2010-05-13

    申请号：US11911342

    申请日：2006-03-09

    申请人： Isabelle Camby ,  Patrick Henriet ,  Florence Lefranc ,  Pierre Courtoy ,  Robert Kiss

    发明人： Isabelle Camby ,  Patrick Henriet ,  Florence Lefranc ,  Pierre Courtoy ,  Robert Kiss

    IPC分类号： A61K31/7105 ,  C12N5/071 ,  C12N15/74 ,  A61K31/711 ,  A61P35/00 ,  A61P35/04

    CPC分类号： C12N15/1138 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.

    摘要翻译： 本发明涉及适于降低含有SEQ ID NO：1-33的任何序列，优选SEQ ID NO：2,3或4的序列的半乳凝素-1的表达的RNAi分子，并且涉及 或用于制备用于治疗和/或延迟癌症进展的药物，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤 。 本发明还涉及用于治疗和延迟癌症，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤的进展的组合物和方法，用于减少 肿瘤细胞，优选胶质瘤细胞，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，和/或用于增强癌症疗法治疗癌症的功效，优选神经胶质瘤， 胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，选自化疗，放射治疗，免疫治疗和/或基因治疗。

    Steroid compounds with anti-tumor activity
    25.
    发明申请
    Steroid compounds with anti-tumor activity 审中-公开
    具有抗肿瘤活性的类固醇化合物

    公开(公告)号：US20060149045A1

    公开(公告)日：2006-07-06

    申请号：US10538993

    申请日：2003-12-18

    申请人： Jean-Claude Braekman ,  Eric Quaquebeke ,  Laurent Ingrassia ,  Janique Dewelle ,  Robert Kiss ,  Francis Darro

    发明人： Jean-Claude Braekman ,  Eric Quaquebeke ,  Laurent Ingrassia ,  Janique Dewelle ,  Robert Kiss ,  Francis Darro

    IPC分类号： C07J41/00 ,  C07J17/00 ,  C07J43/00

    CPC分类号： C07J17/00 ,  A61K31/57 ,  A61K31/575 ,  C07J7/00 ,  C07J9/00 ,  C07J41/00 ,  C07J43/00

    摘要： The present invention relates to novel steroid compounds of Formula (IB) having anti-tumor activity. The present invention also relates to a method for the preparation of said steroid compounds. The invention further relates to a pharmaceutical composition comprising an effective amount of said steroid compounds. Furthermore, the present invention concerns the use of said steroid compounds as a medicament and in the preparation of a medicament for the treatment of cancer. The present invention also relates to the use of a steroid compound or a pharmaceutical composition comprising said steroid compound according to the invention in the treatment of cancer.

    摘要翻译： 本发明涉及具有抗肿瘤活性的式（IB）的新型类固醇化合物。 本发明还涉及一种制备所述类固醇化合物的方法。 本发明还涉及包含有效量的所述类固醇化合物的药物组合物。 此外，本发明涉及所述类固醇化合物作为药物和制备用于治疗癌症的药物的用途。 本发明还涉及包含根据本发明的所述类固醇化合物的类固醇化合物或药物组合物在治疗癌症中的用途。