公开(公告)号：US08790637B2

公开(公告)日：2014-07-29

申请号：US12054718

申请日：2008-03-25

申请人： Sanjay Mistry ,  Darin Messina

发明人： Sanjay Mistry ,  Darin Messina

IPC分类号： A01N63/00 ,  C12N5/071

CPC分类号： A61K35/51 ,  A61K9/0048 ,  A61K35/12 ,  C12N5/0605 ,  C12N5/0607 ,  C12N5/0618 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/025 ,  C12N2506/03 ,  C12N2506/08 ,  C12N2509/00 ,  C12N2533/50

摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.

摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞再生或修复眼组织的药物组合物，装置和方法。

公开(公告)号：US20060069009A1

公开(公告)日：2006-03-30

申请号：US10952065

申请日：2004-09-28

申请人： Darin Messina ,  Sanjay Mistry

发明人： Darin Messina ,  Sanjay Mistry

IPC分类号： A61K38/18

CPC分类号： A61K38/1875 ,  A61K38/1709 ,  A61K38/1825 ,  A61K2300/00

摘要： The present invention is directed to methods of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human by administering BMP7 to the striatum or substanta nigra pars compacta of a human in amounts effective to induce cell populations having the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards a dopaminergic phenotype, and to neurotrophic compositions and matrices suitable for use in such treatments.

摘要翻译： 本发明涉及通过将BMP7施用于人的纹状体或黑质块状物，以有效诱导具有该细胞群的细胞群的量，将治疗由纹状体或黑质致密结构引起的损伤或疾病的神经功能缺损 区分多巴胺能表型的能力实际上分化为多巴胺能表型，以及适合用于这种治疗的神经营养组合物和基质。

公开(公告)号：US20060153818A1

公开(公告)日：2006-07-13

申请号：US11321864

申请日：2005-12-29

申请人： Sridevi Dhanaraj ,  Alexander Harmon ,  Darin Messina

发明人： Sridevi Dhanaraj ,  Alexander Harmon ,  Darin Messina

IPC分类号： A61K35/12 ,  C12N5/08

CPC分类号： A61K35/51 ,  A01N1/0226 ,  A61K35/12 ,  A61K35/50 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/19 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/27 ,  A61K45/06 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0607 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2509/00 ,  C12N2509/10 ,  C12N2533/50

摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

摘要翻译： 源自产后组织的细胞及其分离和诱导分化成软骨形成或成骨表型细胞的方法由本发明提供。 本发明进一步提供产后来源细胞的培养物和组合物及其相关的产品。 本发明的产后衍生细胞及其相关产品具有多种用途，包括但不限于研究，诊断和治疗应用，例如用于治疗骨和软骨病症。

公开(公告)号：US20050125848A1

公开(公告)日：2005-06-09

申请号：US11036004

申请日：2005-01-14

申请人： Margot Mayer-Proschel ,  Mahendra Rao ,  Patrick Tresco ,  Darin Messina

发明人： Margot Mayer-Proschel ,  Mahendra Rao ,  Patrick Tresco ,  Darin Messina

IPC分类号： A61K35/12 ,  C12N5/0797 ,  A01K67/033 ,  C12N5/08 ,  A01K67/00

CPC分类号： A61K35/54 ,  A61K35/12 ,  C12N5/0623

摘要： A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.