摘要:
Cell-free extracts, methods for producing these extracts, methods for using these extracts, compositions that facilitate production of these extracts and kits that contain these extracts are provided. By increasing or decreasing certain gene products through, for example, the use of siRNA or mimics, one can develop mammalian cell-free extracts that have desired levels of efficiency.
摘要:
The present invention relates to nucleic acids and methods for modulating the sex of avians. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to increase the production of female birds.
摘要:
The present invention relates generally to the field of sex determination of animals. Provided are methods and agents to manipulate sex determination, particularly in avian animals such as chickens, through a male chromosome-linked testis (sex) regulatory gene. Expression or activity of the DMRT1 gene or protein is modulated to produce animals with displaying a phenotype sex that differs from their genotype.
摘要:
A vehicle includes a front seat, provided to the rear, in the forward/back direction of the vehicle, of a front panel, and having a seat cushion portion, a backrest portion that is provided integrally with the seat cushion portion, and a headrest portion that is provided integrally with the backrest portion, wherein at least the backrest portion and the headrest portion are fabricated independently for the left and the right, and wherein the left and right headrest portions are fabricated so that the widths thereof, in the direction of width of the vehicle, are narrower than the widths of, in the direction of width of the vehicle, of the left and right backrest portions.
摘要:
A vehicle comprising a front seat 7, provided to the rear, in the forward/back direction of the vehicle, of a front panel 5, and having a seat cushion portion 7a, a backrest portion 7b that is provided at integrally with the seat cushion portion 7a, and a headrest portion 7c that is provided integrally with the backrest portion 7b, wherein at least the backrest portion 7b and the headrest portion 7c are fabricated independently for the left and the right, and wherein the left and right headrest portions 7c are fabricated so that the widths thereof, in the direction of width of the vehicle, are narrower than the widths of, in the direction of width of the vehicle, of the left and right backrest portions.
摘要:
A camera has a body and an electronic capture unit mounted in the body. The electronic capture unit selectively captures and stores a scene image as a representational electronic image having a first array of pixels. A control system is mounted in the body. The control system provides a remapped electronic image having a second array of pixels. A memory unit is disposed in the body. The memory unit stores a data-set defining an non-uniform mapping between a plurality of primary input coordinates mappable on said first array of pixels and plurality of primary output coordinates mappable on said second array of pixels. The control system uses the data-set to remap the pixels of the input electronic image to provide the remapped electronic image.
摘要:
A vehicle seat latch (24) includes a latch member (40) and a blocking member (70) that each have associated first and second blocking surfaces (80, 82 and 88, 90) for holding the latch member in a latched position with the blocking member in a blocking position. The first blocking surfaces (80 and 88) of the latch member and blocking member have a pressure angle between 4.6 and 6.6 degrees while the second blocking surfaces (82 and 90) have a zero degree pressure angle and are slightly spaced from each other. A deformable blocking portion (84) of the blocking member (70) defines its first blocking surface (88) and is deformed by excessive loading so that the zero degree pressure angle second blocking surfaces (82 and 90) then contact each other to hold the latch member in its latched position.
摘要:
The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.
摘要:
Fusion proteins having a tumor necrosis factor receptor (TNF-R) polypeptide and at least one additional polypeptide covalently fused thereto and selected from an interleukin-1 receptor (IL-1R) and a second TNF-R polypeptide. The receptor polypeptides are preferably fused together by a peptidyl linker. Suitable fusions include, for example, TNF-R-linker-TNF-R; TNF-R-linker-IL-1R; and TNF-R-linker-TNF-R-linker-IL-1R molecules.
摘要:
A method for detecting a target biomolecule directly in a polyacrylamide gel in which it has been separated from other substances. Prior to binding the target to a probe and while the target biomolecule remains in the gel, the gel is immersed in a water miscible aqueous extracting medium containing a base to shrink the gel by at least about ten percent, and then the gel is washed with water to restore the gel to substantially its original size.