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公开(公告)号：US20120084873A1
公开(公告)日：2012-04-05
申请号：US13147856
申请日：2010-02-08
申请人： Andrew Sinclair , Craig Smith , Timothy James Doran , Robert John Moore , John William Lowenthal
发明人： Andrew Sinclair , Craig Smith , Timothy James Doran , Robert John Moore , John William Lowenthal
IPC分类号： A01K67/027 , G06Q90/00 , C07H21/02 , A61K31/7088 , C12N15/85
CPC分类号： A01K67/02 , A01K67/0275 , A01K2217/00 , A01K2217/058 , A01K2227/30 , A01K2267/02 , C07K14/465 , C12N15/8509 , C12N2799/027 , G06Q99/00
摘要： The present invention relates generally to the field of sex determination of animals. Provided are methods and agents to manipulate sex determination, particularly in avian animals such as chickens, through a male chromosome-linked testis (sex) regulatory gene. Expression or activity of the DMRT1 gene or protein is modulated to produce animals with displaying a phenotype sex that differs from their genotype.
摘要翻译： 本发明一般涉及动物的性别决定领域。 提供了通过雄性染色体连锁的睾丸（性别）调节基因来操作性别测定的方法和试剂，特别是在禽类动物如鸡中。 DMRT1基因或蛋白质的表达或活性被调节以产生具有不同于其基因型的表型性别的动物。
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公开(公告)号：US20120227119A1
公开(公告)日：2012-09-06
申请号：US13139163
申请日：2009-12-16
申请人： Timothy James Doran , Robert John Moore , John William Lowenthal , Craig Smith , Andrew Henrik Sinclair
发明人： Timothy James Doran , Robert John Moore , John William Lowenthal , Craig Smith , Andrew Henrik Sinclair
IPC分类号： A01K67/027 , A61K31/713
CPC分类号： C12N15/111 , A01K67/027 , A01K2207/05 , A01K2227/30 , A01K2267/02 , C07K14/4702 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to nucleic acids and methods for modulating the sex of avians. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to increase the production of female birds.
摘要翻译： 本发明涉及调节禽类性别的核酸和方法。 特别地，本发明涉及dsRNA分子，特别是siRNAs的卵内递送，以增加雌性鸟的产生。
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公开(公告)号：US20110209231A1
公开(公告)日：2011-08-25
申请号：US12451540
申请日：2008-05-16
申请人： Timothy James Doran , James Climie McKay , Robert John Moore , John William Lowenthal , Scott Geoffrey Tyack
发明人： Timothy James Doran , James Climie McKay , Robert John Moore , John William Lowenthal , Scott Geoffrey Tyack
CPC分类号： C12N15/85 , A01K2217/058 , A01K2227/105 , A01K2227/30 , A01K2267/0337 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/11 , C12N2760/16111 , C12N2800/90 , C12N2830/38 , C12N2830/90
摘要： The present invention relates to nucleic acid molecules comprising a double-stranded region, and nucleic acid constructs encoding therfor, that are useful for the treatment and/or prevention of influenza. In particular, the present invention relates to nucleic acid constructs encoding a double stranded RNA molecule(s) that can be used to produce transgenic poultry, for example chickens, such that they are at least less susceptible to an avian influenza infection. Also provided are nucleic acid molecules comprising a double-stranded region that can be used as a therapeutic to treat and/or prevent, for example, avian influenza in poultry.
摘要翻译： 本发明涉及包含双链区域的核酸分子和编码其的核酸构建体，其可用于治疗和/或预防流感。 特别地，本发明涉及编码可用于产生转基因家禽（例如鸡）的双链RNA分子的核酸构建体，使得它们至少不易受禽流感感染的影响。 还提供了包含双链区域的核酸分子，其可以用作治疗和/或预防家禽禽流感的治疗剂。
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公开(公告)号：US20100306869A1
公开(公告)日：2010-12-02
申请号：US12664097
申请日：2008-06-12
IPC分类号： A01K67/027 , C12N15/00 , C07H21/02 , C12N15/63 , C12N5/07
CPC分类号： C12N15/8509 , A01K2217/058 , A01K2227/30 , A01K2267/02 , C12N15/111 , C12N15/113 , C12N15/1136 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to methods of modulating traits, particularly production traits, in avians such as chickens. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to modify production traits in commercially important birds.
摘要翻译： 本发明涉及在禽类如鸡中调节特性，特别是生产性状的方法。 特别地，本发明涉及dsRNA分子，特别是siRNAs的ovo递送，以改变商业上重要的鸟类的生产性状。
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公开(公告)号：US20120198578A1
公开(公告)日：2012-08-02
申请号：US13378316
申请日：2010-06-18
申请人： John William Lowenthal , Timothy James Doran , Scott Geoffrey Tyack , Terry Glenn Wise , Scott McLeod
发明人： John William Lowenthal , Timothy James Doran , Scott Geoffrey Tyack , Terry Glenn Wise , Scott McLeod
CPC分类号： C12Q1/701 , A01K2227/30 , A01K2227/40 , A01K2267/02 , C12N2760/16011 , C12N2760/16111 , C12Q1/70 , C12Q2600/124
摘要： The present invention relates to an assay for detecting virus, in particular an assay for detecting viral replication in a tissue sample. The invention also relates to methods of determining the susceptibility of an animal to a virus, and methods of breeding animals with decreased susceptibility to a virus.
摘要翻译： 本发明涉及用于检测病毒的测定法，特别是用于检测组织样品中病毒复制的测定法。 本发明还涉及确定动物对病毒的易感性的方法，以及育种对病毒易感性降低的动物的方法。
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公开(公告)号：US6083724A
公开(公告)日：2000-07-04
申请号：US765381
申请日：1997-04-25
申请人： John William Lowenthal , Jennifer Joy York , Terri Ellen O'Neil , Stephen Rhodes , Matthew Robert Digby
发明人： John William Lowenthal , Jennifer Joy York , Terri Ellen O'Neil , Stephen Rhodes , Matthew Robert Digby
IPC分类号： A61K38/00 , A61K39/00 , A61K39/39 , C07K14/465 , C07K14/555 , C07K14/57 , C07K16/24 , C12N15/20 , C12N15/23 , A61K38/21
CPC分类号： A61K39/39 , C07K14/465 , C07K14/555 , C07K14/57 , C07K16/249 , A61K38/00 , A61K39/00
摘要： A cDNA corresponding to the chicken interferon-.gamma. (IFN-.gamma.) gene has been isolated. The invention thus provides avian IFN-.gamma. polypeptides, nucleic acids encoding them, and their recombinant production. The nucleic acids and polypeptides are useful as therapeutic agents and as adjuvants for the treatment of birds.
摘要翻译： PCT No.PCT / AU96 / 00114 Sec。 371日期1997年04月25日 102（e）日期1997年4月25日PCT 1996年3月5日PCT公布。 WO96 / 27666 PCT公开号 日期1996年9月12日已经分离了对应于鸡干扰素-γ（IFN-γ）基因的cDNA。 因此，本发明提供禽类IFN-γ多肽，编码它们的核酸及其重组生产。 核酸和多肽可用作治疗剂和用作鸟的治疗佐剂。
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公开(公告)号：US20110038834A1
公开(公告)日：2011-02-17
申请号：US12679003
申请日：2008-09-19
IPC分类号： A61K38/21 , A61P43/00 , C12Q1/68 , C12N15/63 , C07K14/555 , C07K16/24 , C07H21/00 , C07K19/00
CPC分类号： C07K16/249 , A61K38/00 , A61K2039/505 , C07K14/555 , C07K2317/76 , C07K2319/00
摘要： The present invention relates generally to novel recombinant polypeptides having avian cytokine properties and to genetic sequences encoding same. More particularly, the present invention is directed to recombinant avian Type III interferon polypeptides, and genetic sequences encoding same, together with cellular expression systems and uses for same. Even more particularly, the present invention is directed to avian interferon-λ (IFN-λ) and functional derivatives, homologues and fragments thereof and to methods of use thereof. The molecules and cells of the present invention are useful in a wide range of applications including, but not limited to, providing a means for the treatment and prophylaxis of disease conditions, in particular avian disease conditions, or for use as an immune response modulator. Also provided are diagnostic means for screening for immune response and screening means for identifying modulators of IFN-λ protein or nucleic acid functionality.
摘要翻译： 本发明一般涉及具有禽细胞因子性质的新型重组多肽和编码该重组多肽的遗传序列。 更具体地，本发明涉及重组禽III型干扰素多肽，以及编码它们的遗传序列，以及细胞表达系统及其用途。 更具体地，本发明涉及禽干扰素-λ（IFN-λ）及其功能衍生物，同系物及其片段及其使用方法。 本发明的分子和细胞可用于广泛的应用，包括但不限于提供用于治疗和预防疾病状况，特别是禽病疾病或用作免疫应答调节剂的手段。 还提供了用于筛选免疫应答的诊断方法和用于鉴定IFN-λ蛋白或核酸功能的调节剂的筛选方法。
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公开(公告)号：US09051369B2
公开(公告)日：2015-06-09
申请号：US12679003
申请日：2008-09-19
CPC分类号： C07K16/249 , A61K38/00 , A61K2039/505 , C07K14/555 , C07K2317/76 , C07K2319/00
摘要： The present invention relates generally to novel recombinant polypeptides having avian cytokine properties and to genetic sequences encoding same. More particularly, the present invention is directed to recombinant avian Type III interferon polypeptides, and genetic sequences encoding same, together with cellular expression systems and uses for same. Even more particularly, the present invention is directed to avian interferon-λ (IFN-λ) and functional derivatives, homologues and fragments thereof and to methods of use thereof. The molecules and cells of the present invention are useful in a wide range of applications including, but not limited to, providing a means for the treatment and prophylaxis of disease conditions, in particular avian disease conditions, or for use as an immune response modulator. Also provided are diagnostic means for screening for immune response and screening means for identifying modulators of IFN-λ protein or nucleic acid functionality.
摘要翻译： 本发明一般涉及具有禽细胞因子性质的新型重组多肽和编码该重组多肽的遗传序列。 更具体地，本发明涉及重组禽III型干扰素多肽，以及编码它们的遗传序列，以及细胞表达系统及其用途。 更具体地，本发明涉及禽干扰素-λ（IFN-λ）及其功能衍生物，同系物及其片段及其使用方法。 本发明的分子和细胞可用于广泛的应用，包括但不限于提供用于治疗和预防疾病状况，特别是禽病疾病或用作免疫应答调节剂的手段。 还提供了用于筛选免疫应答的诊断方法和用于鉴定IFN-λ蛋白或核酸功能的调节剂的筛选方法。
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