公开(公告)号：US20160122341A1

公开(公告)日：2016-05-05

申请号：US14895809

申请日：2014-06-04

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Alexandros VAKALOPOULOS ,  Markus FOLLMANN ,  Ingo HARTUNG ,  Philipp BUCHGRABER ,  Alexey GROMOV ,  Niels LINDNER ,  Frank WUNDER ,  Johannes-Peter STASCH ,  Gorden REDLICH ,  Volkhart Min-Jian LI

IPC分类号： C07D471/04 ,  A61K45/06 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/541 ,  A61K31/437 ,  A61K31/444

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06

摘要： The present application relates to novel 3-aryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

摘要翻译： 本申请涉及新的3-芳基取代的咪唑并[1,2-a]吡啶，其制备方法，其用途，单独或组合用于治疗和/或预防疾病，以及使用 用于生产用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。

公开(公告)号：US20220324865A1

公开(公告)日：2022-10-13

申请号：US17055190

申请日：2019-05-10

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Steffen MUELLER ,  Rudolf SCHOHE-LOOP ,  Nuria ORTEGA HERNANDEZ ,  Frank SUESSMEIER ,  Eloisa JIMENEZ NUNEZ ,  Thomas BRUMBY ,  Niels LINDNER ,  Christoph GERDES ,  Elisabeth POOK ,  Anja BUCHMUELLER ,  Fabienne Zdenka GAUGAZ ,  Dieter LANG ,  Stefanie ZIMMERMANN ,  Alexander Helmut Michael EHRMANN ,  Michael GERISCH ,  Lutz LEHMANN ,  Andreas TIMMERMANN ,  Martina SCHAEFER ,  Georg SCHMIDT ,  Karl-Heinz SCHLEMMER ,  Markus FOLLMANN ,  Elisabeth KERSTEN ,  Vivian WANG ,  Xiang GAO ,  Yafeng WANG

IPC分类号： C07D487/04 ,  A61P7/02

摘要： The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.

公开(公告)号：US20200316045A1

公开(公告)日：2020-10-08

申请号：US16756623

申请日：2018-10-17

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Marie-Pierre COLLIN-KROEPELIN ,  Peter KOLKHOF ,  Thomas NEUBAUER ,  Chantal FUERSTNER ,  Elisabeth POOK ,  Matthias Beat WITTWER ,  Klemens LUSTIG ,  Hanna TINEL ,  Niels LINDNER ,  Heiko SCHIRMER

IPC分类号： A61K31/4439 ,  A61K45/06 ,  C07D401/14 ,  A61K31/496 ,  C07D403/14 ,  C07D417/14 ,  A61K31/541 ,  A61K31/5377 ,  C07D413/14 ,  C07D409/14 ,  A61K31/4188 ,  C07D487/10 ,  A61K31/4196 ,  C07D403/06 ,  C07D405/14 ,  A61K31/551

摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

公开(公告)号：US20200055842A1

公开(公告)日：2020-02-20

申请号：US16341410

申请日：2017-10-09

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Anja GIESE ,  Jürgen KLAR ,  Alexander Helmut Michael EHRMANN ,  Jens WILLWACHER ,  David ENGEL ,  Andre Philippe DIESKAU ,  Antje KAHNERT ,  Alexey GROMOV ,  Carsten SCHMECK ,  Niels LINDNER ,  Thomas MÜLLER ,  Anna Lena ANDREEVSKI ,  Jan DREHER ,  Karl COLLINS

IPC分类号： C07D403/14 ,  C07D401/14 ,  C07D487/04 ,  C07D405/14 ,  C07D413/14

摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20160318866A1

公开(公告)日：2016-11-03

申请号：US15106285

申请日：2014-12-16

申请人： Bayer Pharma Aktiengesellschaft

发明人： Eva Maria BECKER-PELSTER ,  Philipp BUCHGRABER ,  Anja BUCHMÜLLER ,  Karen ENGEL ,  Mark Jean GNOTH ,  Herbert HIMMEL ,  Raimund KAST ,  Joerg KELDENICH ,  Jürgen KLAR ,  Andreas KNORR ,  Dieter LANG ,  Niels LINDNER ,  Carsten SCHMECK ,  Rudolf SCHOHE-LOOP ,  Hanna TINEL ,  Hubert TRÜBEL ,  Frank WUNDER

IPC分类号： C07D211/10 ,  C07D211/42 ,  C07D211/22 ,  A61K45/06 ,  C07D401/14 ,  C07D413/14 ,  C07D405/14 ,  C07D211/60 ,  A61K31/4545

CPC分类号： C07D211/10 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/16 ,  C07D211/22 ,  C07D211/42 ,  C07D211/60 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

摘要翻译： 本发明涉及新的取代的二哌啶基衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病溃疡，特别是用于促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。

公开(公告)号：US20140179672A1

公开(公告)日：2014-06-26

申请号：US14070180

申请日：2013-11-01

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Alexandros VAKALOPOULOS ,  Markus FOLLMANN ,  Ingo HARTUNG ,  Philipp BUCHGRABER ,  Rolf JAUTELAT ,  Jorma HAßFELD ,  Niels LINDNER ,  Alexey GROMOV ,  Frank WUNDER ,  Johannes-Peter STASCH ,  Gorden REDLICH ,  Volkhart Min-Jian LI ,  Eva Maria BECKER-PELSTER ,  Andreas KNORR

IPC分类号： A61K31/4985 ,  A61K45/06 ,  C07D471/04 ,  A61K31/437 ,  C07D471/08 ,  A61K31/439

CPC分类号： A61K31/437 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D471/08 ,  C07D519/00

摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

公开(公告)号：US20140128424A1

公开(公告)日：2014-05-08

申请号：US13789208

申请日：2013-03-07

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Alexandros VAKALOPOULOS ,  Ingo HARTUNG ,  Markus FOLLMANN ,  Rolf JAUTELAT ,  Alexander STRAUB ,  Jorma HASSFELD ,  Niels LINDNER ,  Dirk SCHNEIDER ,  Frank WUNDER ,  Johannes-Peter STASCH ,  Gorden REDLICH ,  Volkhart Min-Jian LI ,  Eva-Maria BECKER ,  Andreas KNORR

IPC分类号： A61K31/437 ,  A61K45/06 ,  C07D471/04

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/5377 ,  A61K45/06

摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。