公开(公告)号：US09567401B2

公开(公告)日：2017-02-14

申请号：US14165400

申请日：2014-01-27

Applicant: Baylor Research Institute

Inventor： Jacques F. Banchereau ,  Gerard Zurawski ,  Sandra Zurawski ,  SangKon Oh

IPC: A61K39/395 ,  C07K16/28 ,  C07K14/005 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K39/00 ,  A61K2039/6056 ,  C07K14/005 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/74 ,  C07K2317/80 ,  C07K2319/00 ,  C12N2740/16222 ,  C12N2740/16322

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

Abstract translation: 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。

公开(公告)号：US09339556B2

公开(公告)日：2016-05-17

申请号：US13927437

申请日：2013-06-26

Applicant: Baylor Research Institute

Inventor： Jacques F. Banchereau ,  SangKon Oh ,  Gerard Zurawski ,  Sandra Zurawski ,  Dapeng Li

IPC: C07K16/00 ,  C07K17/00 ,  C07K17/14 ,  C12P21/08 ,  A61K47/48 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K47/48369 ,  A61K2039/5154 ,  A61K2039/55516 ,  C07K16/28 ,  C07K2317/92 ,  C07K2319/01 ,  C07K2319/33

Abstract: The present invention includes compositions and methods for targeting the LOX-1 receptor on immune cells and uses for the anti-LOX-1 antibodies.

公开(公告)号：US10993990B2

公开(公告)日：2021-05-04

申请号：US15311572

申请日：2015-05-15

Applicant: Baylor Research Institute

Inventor： SangKon Oh ,  Sandra Zurawski ,  Hyemee Joo ,  Gerard Zurawski

IPC: A61K38/20 ,  C07K14/54 ,  A61K39/00 ,  C07K16/28

Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.

公开(公告)号：US10980869B2

公开(公告)日：2021-04-20

申请号：US15703685

申请日：2017-09-13

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Peter Klucar ,  Keiko Akagawa ,  Sandra Zurawski ,  SangKon Oh

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/28 ,  C07K14/435

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20180094071A1

公开(公告)日：2018-04-05

申请号：US15787425

申请日：2017-10-18

Applicant: Baylor Research Institute

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  G01N33/68 ,  C07K14/005

CPC classification number: C07K16/2878 ,  A61K39/00 ,  A61K39/385 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/005 ,  C07K16/00 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/40 ,  C07K2319/91 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2760/16122 ,  C12N2770/24222 ,  C12N2770/24234 ,  G01N33/6863 ,  Y02A50/39 ,  Y02A50/464 ,  Y02A50/466

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20170095573A1

公开(公告)日：2017-04-06

申请号：US15316040

申请日：2015-06-02

Applicant: Baylor Research Institute

Inventor： SangKon OH ,  Bob Kane ,  Gerard Zurawski

IPC: A61K51/00 ,  C07K16/28

CPC classification number: A61K47/543 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/577 ,  C07K16/2851 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/75 ,  C07K2317/76

Abstract: Described herein are therapeutic approaches with immune modifiers of the Th2 pathway for the treatment of allergic and inflammatory diseases. Aspects of the disclosure relate to methods for decreasing Th2-type cell responses in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an anti-Dectin-1 antibody or antigen binding fragment thereof operatively linked to a TLR agonist.

公开(公告)号：US20160296609A1

公开(公告)日：2016-10-13

申请号：US14901617

申请日：2014-06-27

Applicant: Baylor Research Institute

Inventor： SangKon Oh ,  Gerard Zurawski

IPC: A61K39/00 ,  C07K14/46 ,  C07K16/28

CPC classification number: A61K39/0008 ,  A61K2039/505 ,  A61K2039/577 ,  C07K14/46 ,  C07K16/28 ,  C07K2319/33

Abstract: Methods and compositions for treating multiple sclerosis using dendritic cell anti-ASGPR antibodies fused to myelin basic protein or myelin oligodendrocyte glycoprotein provided.

Abstract translation: 使用与髓磷脂碱性蛋白或髓鞘少突胶质细胞糖蛋白融合的树突状细胞抗ASGPR抗体治疗多发性硬化症的方法和组合物。

公开(公告)号：US20160022792A1

公开(公告)日：2016-01-28

申请号：US14819909

申请日：2015-08-06

Applicant: Baylor Research Institute

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Peter Klucar ,  Keiko Akagawa ,  Sandra Zurawski ,  SangKon Oh

IPC: A61K39/00 ,  C07K14/435 ,  C07K16/28

CPC classification number: A61K39/0011 ,  A61K2039/6056 ,  C07K14/435 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/91 ,  Y02A50/39 ,  Y02A50/466

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

Abstract translation: 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。

公开(公告)号：US20140199763A1

公开(公告)日：2014-07-17

申请号：US14152448

申请日：2014-01-10

Applicant: Institut National de la Sante et de la Recherche Medicale ( INSERM) ,  Baylor Research Institute

Inventor： Helene Dutartre ,  Yves Levy ,  Jacques Banchereau ,  Gerard Zurawski

IPC: C12N5/0784

CPC classification number: C12N5/0639 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/6056 ,  C07K14/005 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/33 ,  C12N2770/24222 ,  C12N2770/24234

Abstract: Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to heavy and/or light chain of antibodies, or fragments thereof specific for dendritic cells (DCs) are described herein. Included herein are immunostimulatory compositions (HCV vaccines, HCV antigen presenting dendritic cells, etc.) and methods for increasing effectiveness of HCV antigen presentation by an antigen presenting cell, for a treatment, a prophylaxis or a combination thereof against hepatitis C in a human subject, and methods of providing immunostimulation by activation of one or more dendritic cells, methods to treat or prevent hepatitis C.

Abstract translation: 本文描述了包含与针对树突状细胞（DC）特异性的抗体的重链和/或轻链或其片段融合的丙型肝炎病毒（HCV）蛋白或其片段的病毒抗原和抗原肽的组合物。 本文包括免疫刺激组合物（HCV疫苗，呈递树突细胞的HCV抗原等）以及用于增加抗原呈递细胞的HCV抗原呈递的有效性的方法，用于治疗，预防或其组合以抗人类受试者中的丙型肝炎 ，以及通过激活一种或多种树突状细胞提供免疫刺激的方法，治疗或预防丙型肝炎的方法。

公开(公告)号：US12186379B2

公开(公告)日：2025-01-07

申请号：US17447607

申请日：2021-09-14

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Sangkon Oh ,  Gerard Zurawski

IPC: A61K39/00 ,  A61P25/00 ,  A61P25/28 ,  A61P37/02 ,  C07K14/46 ,  C07K16/28

Abstract: Methods and compositions for treating multiple sclerosis using dendritic cell anti-ASGPR antibodies fused to myelin basic protein or myelin oligodendrocyte glycoprotein are provided.