-
公开(公告)号：US20190192641A1
公开(公告)日：2019-06-27
申请号：US16271689
申请日：2019-02-08
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
Abstract: The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
-
公开(公告)号：US20180207244A1
公开(公告)日：2018-07-26
申请号：US15820080
申请日：2017-11-21
Applicant: Bioverativ Therapeutics Inc.
Inventor： Glenn PIERCE , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC: A61K38/48 , A61K47/64 , C12N9/64 , C12N9/96 , A61K9/00 , A61K38/38 , A61K39/395 , C07K16/18 , C07K14/76
Abstract: The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
-
公开(公告)号：US12186375B2
公开(公告)日：2025-01-07
申请号：US17112280
申请日：2020-12-04
Applicant: Bioverativ Therapeutics Inc.
Inventor： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert T. Peters
IPC: A61K38/37 , A61K47/60 , A61K47/68 , C07K14/755 , G01N33/86
Abstract: The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
-
Patent Agency Ranking
公开(公告)号：US11747351B2
公开(公告)日：2023-09-05
申请号：US16848445
申请日：2020-04-14
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Jurg Sommer , Haiyan Jiang , Xin Zhang , Buyue Yang , Glenn Pierce
CPC classification number: G01N33/86 , C12N9/644 , G01N2333/755 , G01N2333/9645 , G01N2333/974
Abstract: The present invention provides methods of dosing Factor VIII or Factor IX chimeric and hybrid polypeptides. The present invention further provides high-sensitivity methods of quantifying an amount of activated FIX protein in a test sample.
-
公开(公告)号：US11370827B2
公开(公告)日：2022-06-28
申请号：US14371948
申请日：2013-01-12
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Ekta Seth Chhabra , Tongyao Liu , Robert T Peters , Haiyan Jiang
IPC: A61K38/37 , C07K14/755 , A61K47/62 , C07K16/00
Abstract: The present invention provides a VWF fragment comprising the D′ domain and D3 domain of VWF, a chimeric protein comprising the VWF fragment and a heterologous moiety, or a chimeric protein comprising the VWF fragment and a FVIII protein and methods of using the same. A polypeptide chain comprising a VWF fragment of the invention binds to or is associated with a polypeptide chain comprising a FVIII protein and the polypeptide chain comprising the VWF fragment can prevent or inhibit binding of endogenous VWF to the FVIII protein. By preventing or inhibiting binding of endogenous VWF to the FVIII, which is a half-life limiting factor for FVIII, the VWF fragment can induce extension of half-life of the FVIII protein. The invention also includes nucleotides, vectors, host cells, methods of using the VWF fragment, or the chimeric proteins.
-
公开(公告)号：US10325687B2
公开(公告)日：2019-06-18
申请号：US15101756
申请日：2014-12-06
Applicant: Bioverativ Therapeutics Inc.
Inventor： Haiyan Jiang
Abstract: The present invention is directed to computer based pharmacokinetics systems, such as. web-based pharmacokinetics systems, and their use to predict a dose and a dosing interval for a patient in need of a clotting factor therapy.
-
公开(公告)号：US09629903B2
公开(公告)日：2017-04-25
申请号：US15043457
申请日：2016-02-12
Applicant: Bioverativ Therapeutics Inc.
Inventor： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC: A61K38/37 , A61K38/48 , A61K39/395 , C12N9/96 , A61K38/38 , C07K16/18 , C12N9/64 , C07K14/76 , A61K9/00 , A61K47/48
CPC classification number: A61K38/4846 , A61K9/0019 , A61K38/38 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K47/643 , C07K14/76 , C07K16/18 , C07K2317/21 , C07K2317/90 , C07K2317/94 , C07K2319/30 , C07K2319/31 , C07K2319/33 , C12N9/644 , C12N9/96 , C12Y304/21022
Abstract: The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
-
公开(公告)号：US09623091B2
公开(公告)日：2017-04-18
申请号：US15043455
申请日：2016-02-12
Applicant: Bioverativ Therapeutics Inc.
Inventor： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC: A61K38/36 , A61K38/48 , A61K39/395 , C12N9/96 , A61K38/38 , C07K16/18 , C12N9/64 , C07K14/76 , A61K9/00 , A61K47/48
CPC classification number: A61K38/4846 , A61K9/0019 , A61K38/38 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K47/643 , C07K14/76 , C07K16/18 , C07K2317/21 , C07K2317/90 , C07K2317/94 , C07K2319/30 , C07K2319/31 , C07K2319/33 , C12N9/644 , C12N9/96 , C12Y304/21022
Abstract: The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
-
-
-
-
-
-
-
Search Results
28
records
(took 0.031 seconds)
