公开(公告)号：US20130345583A1

公开(公告)日：2013-12-26

申请号：US13923006

申请日：2013-06-20

Applicant: Boston Scientific Scimed, Inc.

Inventor： Pramodsingh Hirasingh Thakur ,  Barun Maskara ,  Allan C. Shuros ,  Sunipa Saha ,  Shibaji Shome

IPC: A61B5/04

CPC classification number: A61B5/04017 ,  A61B5/0422 ,  A61B5/6859 ,  A61B5/7235 ,  A61B8/0883 ,  A61B8/5215 ,  A61B18/1492 ,  A61B2017/00053 ,  A61B2018/00267 ,  A61B2018/00839

Abstract: Electrical activity propagation along an electrode array within a cardiac chamber is reconstructed. Signals from the electrode array are sampled, and the signals are plotted in multi-dimensional space with each axis corresponding to a channel in the electrode array. A covariance matrix of the plotted signals is decomposed to characterize the spread of a data cloud of the signals in the multi-dimensional space. The data cloud is then decorrelated, such as through whitening, to suppress excursions along correlated directions (global activation) and enhance excursions along each axis (local activation).

Abstract translation: 重建沿心室内电极阵列的电活动传播。 来自电极阵列的信号被采样，并且将信号绘制在多维空间中，每个轴对应于电极阵列中的通道。 绘制的信号的协方差矩阵被分解以表征多维空间中的信号的数据云的扩展。 然后将数据云解相关，例如通过白化，以抑制沿着相关方向的偏移（全局激活）并增强沿着每个轴的偏移（局部激活）。

公开(公告)号：US20130345537A1

公开(公告)日：2013-12-26

申请号：US13923020

申请日：2013-06-20

Applicant: Boston Scientific Scimed, Inc.

Inventor： Pramodsingh Hirasingh Thakur ,  Barun Maskara ,  Allan C. Shuros ,  Sunipa Saha ,  Shibaji Shome

IPC: A61B5/042 ,  A61B5/04

CPC classification number: A61B5/0422 ,  A61B5/0044 ,  A61B5/04007 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/6859 ,  A61B18/1492

Abstract: Electrical activity propagation along an electrode array within a cardiac chamber is reconstructed. Signals are sampled from the electrode array and the signals are plotted in multi-dimensional space with each axis corresponding to a channel in the electrode array. An excursion direction of global activation in the multi-dimensional space is estimated and a change in vectors of the sampled signals over time is determined. Signals with vectors that change over time in the excursion direction are suppressed.

Abstract translation: 重建沿心室内电极阵列的电活动传播。 信号从电极阵列中采样，并且信号绘制在多维空间中，每个轴对应于电极阵列中的通道。 估计多维空间中全局激活的偏移方向，并确定采样信号随时间的向量变化。 具有沿偏移方向随时间变化的矢量的信号被抑制。

公开(公告)号：US10595739B2

公开(公告)日：2020-03-24

申请号：US15651211

申请日：2017-07-17

Applicant: Boston Scientific Scimed Inc.

Inventor： Pramodsingh Hirasingh Thakur ,  Shibaji Shome ,  Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Barun Maskara ,  Sunipa Saha

IPC: A61B5/04 ,  A61B5/042 ,  A61B5/00 ,  G16H50/20 ,  G06N5/04

Abstract: An anatomical mapping system including a plurality of mapping electrodes disposed in or near an anatomical structure and configured to detect activation signals of physiological activity, each of the plurality of mapping electrodes having an electrode location, and a processing system associated with the plurality of mapping electrodes, and configured to record the detected activation signals and associate one of the plurality of mapping electrodes with each recorded activation signal. The processing system further configured to determine a dominant frequency at each electrode location, and determine a wavefront vector at each electrode location based on a difference between the dominant frequency at a first electrode location and the dominant frequency at neighboring electrode locations.

公开(公告)号：US20180153426A1

公开(公告)日：2018-06-07

申请号：US15890110

申请日：2018-02-06

Applicant: Boston Scientific Scimed Inc.

Inventor： Pramodsingh H. Thakur ,  Shibaji Shome ,  Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Barun Maskara ,  Sunipa Saha

IPC: A61B5/04 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/00 ,  G06K9/00 ,  A61B18/14 ,  A61B18/00

Abstract: A method and system for mapping an anatomical structure includes sensing activation signals of intrinsic physiological activity with a plurality of mapping electrodes disposed in or near the anatomical structure, each of the plurality of mapping electrodes having an electrode location. A vector field map which represents a direction of propagation of the activation signals at each electrode location is generated to identify a signature pattern and a location in the vector field map according to at least one vector field template. A target location of the identified signature pattern is identified according to a corresponding electrode location.

公开(公告)号：US09918649B2

公开(公告)日：2018-03-20

申请号：US14120369

申请日：2014-05-14

Applicant: Boston Scientific Scimed Inc.

Inventor： Pramodsingh H. Thakur ,  Shibaji Shome ,  Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Barun Maskara ,  Sunipa Saha

IPC: A61B5/04 ,  A61N1/00 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0402 ,  A61B5/00 ,  A61B5/0452 ,  G06K9/00 ,  A61B18/14 ,  A61B18/00

CPC classification number: A61B5/04011 ,  A61B5/04012 ,  A61B5/04023 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/04525 ,  A61B5/6852 ,  A61B5/6858 ,  A61B5/6859 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7246 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  G06K9/00496

Abstract: A method and system for mapping an anatomical structure includes sensing activation signals of intrinsic physiological activity with a plurality of mapping electrodes disposed in or near the anatomical structure, each of the plurality of mapping electrodes having an electrode location. A vector field map which represents a direction of propagation of the activation signals at each electrode location is generated to identify a signature pattern and a location in the vector field map according to at least one vector field template. A target location of the identified signature pattern is identified according to a corresponding electrode location.

公开(公告)号：US20160345853A1

公开(公告)日：2016-12-01

申请号：US15232732

申请日：2016-08-09

Applicant: Boston Scientific Scimed Inc.

Inventor： Pramodsingh H. Thakur ,  Shantha Arcot-Krishnamurthy ,  Barun Maskara ,  Sunipa Saha ,  Allan C. Shuros ,  Shibaji Shome

IPC: A61B5/0452 ,  A61B5/0456 ,  A61B18/12 ,  A61B5/04 ,  A61B18/14 ,  A61B5/042 ,  A61B5/00

CPC classification number: A61B5/0452 ,  A61B5/04014 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/6858 ,  A61B5/7203 ,  A61B5/725 ,  A61B5/7282 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00595 ,  A61B2018/00642 ,  A61B2018/00839 ,  A61N1/056 ,  A61N1/3702

Abstract: A method for mapping a cardiac chamber includes sensing activation signals of intrinsic physiological activity with a plurality of electrodes disposed in or near the cardiac chamber, the activation signals including a near-field activation signal component and a far-field activation signal component, isolating R-wave events in the activation signals, generating a far-field activation template representative of the far-field activation signal component based on the R-wave events, and filtering the far-field activation template from the activation signals to identify the near-field activation signal components in the activation signals.

Abstract translation: 用于映射心室的方法包括利用布置在心室中或附近的多个电极来感测内在生理活动的激活信号，激活信号包括近场激活信号分量和远场激活信号分量，将R - 激活信号中的波事件，基于R波事件产生表示远场激活信号分量的远场激活模板，以及从激活信号过滤远场激活模板以识别近场 激活信号中的激活信号分量。

公开(公告)号：US20160331267A1

公开(公告)日：2016-11-17

申请号：US15220066

申请日：2016-07-26

Applicant: Boston Scientific Scimed Inc.

Inventor： Barun Maskara ,  Pramodsingh H. Thakur ,  Shantha Arcot-Krishnamurthy ,  Shibaji Shome ,  Sunipa Saha ,  Allan C. Shuros ,  Scott A. Meyer

IPC: A61B5/053 ,  A61B18/14 ,  A61B5/00 ,  A61B5/044 ,  A61B5/042

CPC classification number: A61B5/0538 ,  A61B5/0422 ,  A61B5/0424 ,  A61B5/044 ,  A61B5/6858 ,  A61B5/6885 ,  A61B18/1492 ,  A61B2017/00044 ,  A61B2017/00053 ,  A61B2018/00267 ,  A61B2018/00678 ,  A61B2018/00839 ,  A61B2090/065

Abstract: A catheter system includes a mapping catheter including a plurality of mapping electrodes, each mapping electrode configured to sense signals associated with an anatomical structure. The catheter system further includes a processor operatively coupled to the plurality of mapping electrodes and configured to receive the signals sensed by the plurality of mapping electrodes, characterize the signals sensed by the plurality of mapping electrodes based on a signal parameter of the sensed signals, and generate an output of a quality of contact of the plurality of mapping electrodes with the anatomical structure based on the signal characterization.

Abstract translation: 导管系统包括包括多个映射电极的映射导管，每个映射电极被配置为感测与解剖结构相关联的信号。 所述导管系统还包括可操作地耦合到所述多个映射电极并且被配置为接收由所述多个映射电极感测的信号的处理器，基于所述感测信号的信号参数表征由所述多个映射电极感测的信号，以及 基于信号表征，产生多个映射电极与解剖结构的接触质量的输出。

公开(公告)号：US09186080B2

公开(公告)日：2015-11-17

申请号：US14272292

申请日：2014-05-07

Applicant: Boston Scientific Scimed Inc.

Inventor： Allan C. Shuros ,  Pramodsingh H. Thakur ,  Shibaji Shome ,  Barun Maskara ,  Shantha Arcot-Krishnamurthy ,  Sunipa Saha ,  Jacob Laughner

IPC: A61B5/04 ,  A61B5/00 ,  A61B5/042 ,  A61B5/046

CPC classification number: A61B5/04012 ,  A61B5/0422 ,  A61B5/046 ,  A61B5/6858 ,  A61B5/7246

Abstract: A method and system for mapping an anatomical structure includes sensing activation signals of intrinsic physiological activity with a plurality of mapping electrodes disposed in or near the anatomical structure. The activation signals are used to determine a dominant frequency for each electrode from which a wavefront vector for each electrode is determined based on a difference between the dominant frequency at a first electrode location and the dominant frequency at neighboring electrodes. An anatomical map is generated based on the determined wavefront vectors.

Abstract translation: 用于映射解剖结构的方法和系统包括用设置在解剖结构中或附近的多个映射电极来感测内在生理活动的激活信号。 激活信号用于确定每个电极的主频率，根据第一电极位置处的主频与相邻电极处的主频率之间的差，确定每个电极的波前矢量。 基于所确定的波前矢量生成解剖图。

公开(公告)号：US09089272B2

公开(公告)日：2015-07-28

申请号：US14133242

申请日：2013-12-18

Applicant: Boston Scientific Scimed, Inc.

Inventor： Pramodsingh H. Thakur ,  Barun Maskara ,  Shantha Arcot-Krishnamurthy ,  Shibaji Shome ,  Sunipa Saha ,  Allan C. Shuros

IPC: A61B5/04 ,  A61B5/0452 ,  A61B5/00 ,  A61B5/042 ,  A61B18/14 ,  A61B18/00

CPC classification number: A61B5/0452 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/6858 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577

Abstract: A method for mapping an anatomical structure includes sensing activation signals of physiological activity with a plurality of electrodes disposed in or near the anatomical structure, each activation signal having an associated cycle length, estimating an action potential duration and diastolic interval for each cycle length, generating a restitution curve based on the estimated action potential duration and diastolic interval from a preceding cycle length, iteratively optimizing each estimated action potential duration and corresponding diastolic interval to maximize a functional relationship between the estimated action potential duration and estimated diastolic interval from preceding cycle length, and generating an action potential duration restitution curve based on the optimized action potential durations and diastolic intervals.

Abstract translation: 用于映射解剖结构的方法包括用设置在解剖结构中或附近的多个电极感测生理活动的激活信号，每个激活信号具有相关联的周期长度，估计每个周期长度的动作电位持续时间和舒张期间隔，产生 基于来自前一周期长度的估计动作电位持续时间和舒张期间隔的恢复曲线，迭代地优化每个估计动作电位持续时间和相应的舒张期间隔，以使估计的动作电位持续时间与前一周期长度的估计的舒张期之间的功能关系最大化， 并基于优化的动作电位持续时间和舒张期间隔产生动作电位持续时间恢复曲线。

公开(公告)号：US20140343388A1

公开(公告)日：2014-11-20

申请号：US14120369

申请日：2014-05-14

Applicant: Boston Scientific Scimed Inc.

Inventor： Pramodsingh H. Thakur ,  Shibaji Shome ,  Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Barun Maskara ,  Sunipa Saha

IPC: A61B5/04 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044

CPC classification number: A61B5/04011 ,  A61B5/04012 ,  A61B5/04023 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/04525 ,  A61B5/6852 ,  A61B5/6858 ,  A61B5/6859 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7246 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  G06K9/00496

Abstract: A method and system for mapping an anatomical structure includes sensing activation signals of intrinsic physiological activity with a plurality of mapping electrodes disposed in or near the anatomical structure, each of the plurality of mapping electrodes having an electrode location. A vector field map which represents a direction of propagation of the activation signals at each electrode location is generated to identify a signature pattern and a location in the vector field map according to at least one vector field template. A target location of the identified signature pattern is identified according to a corresponding electrode location.

Abstract translation: 用于映射解剖结构的方法和系统包括用设置在解剖结构中或附近的多个映射电极感测内在生理活动的激活信号，多个映射电极中的每一个具有电极位置。 生成表示每个电极位置处的激活信号的传播方向的矢量场图，以根据至少一个矢量场模板来识别矢量场地图中的特征图案和位置。 根据相应的电极位置识别所识别的签名图案的目标位置。