Anti-glypican-3 antibody
    24.
    发明授权
    Anti-glypican-3 antibody 有权
    抗磷脂酰肌醇蛋白聚糖-3抗体

    公开(公告)号:US09102739B2

    公开(公告)日:2015-08-11

    申请号:US12089957

    申请日:2006-10-11

    摘要: An anti-glypican-3 antibody comprising one or more amino acid substitutions introduced in the Fc region is disclosed. Preferably, in the anti-glypican-3 antibody, one or more of the amino acid residues at the positions 239, 298, 326, 330 and 332 in the Fc region are substituted with other amino acid residues. Since the Fc-modified anti-glypican-3 antibody of the invention exhibit enhanced ADCC activity, it is useful in treating cancers, such as hepatic cancer. Also disclosed are an anticancer agent comprising the anti-glypican-3 antibody of the invention and a pharmaceutically acceptable carrier, as well as a method of treating a patient with cancer comprising administering to the patient the anticancer agent of the invention.

    摘要翻译: 公开了包含在Fc区中引入的一个或多个氨基酸取代的抗磷脂酰肌醇蛋白聚糖-3抗体。 优选地,在抗磷脂酰肌醇蛋白聚糖-3抗体中,Fc区中位置239,298,326,330和332处的一个或多个氨基酸残基被其它氨基酸残基取代。 由于本发明的Fc修饰的抗磷脂酰肌醇蛋白聚糖-3抗体表现出增强的ADCC活性,因此可用于治疗诸如肝癌的癌症。 还公开了包含本发明的抗磷脂酰肌醇蛋白聚糖-3抗体和药学上可接受的载体的抗癌剂,以及治疗患有癌症的患者的方法,包括向患者施用本发明的抗癌剂。

    TNF-αvariants
    30.
    发明授权
    TNF-αvariants 失效
    TNF-变应性

    公开(公告)号:US07101974B2

    公开(公告)日:2006-09-05

    申请号:US09981289

    申请日:2001-10-15

    IPC分类号: C07K17/00 G01N33/53

    CPC分类号: A61K38/191 C07K14/525

    摘要: The invention relates to novel proteins with TNF-α antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-α related disorders, such as rheumatoid arthritis.

    摘要翻译: 本发明涉及具有TNF-α拮抗剂活性的新型蛋白质和编码这些蛋白质的核酸。 本发明还涉及新型蛋白质在治疗TNF-α相关疾病如类风湿性关节炎中的用途。