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公开(公告)号：US20160318901A1
公开(公告)日：2016-11-03
申请号：US15106284
申请日：2014-12-16
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Volker GEISS , Andreas GÖLLER , Herbert HIMMEL , Raimund KAST , Andreas KNORR , Dieter LANG , Gorden REDLICH , Carsten SCHMECK , Hanna TINEL , Frank WUNDER
IPC分类号： C07D401/14 , A61K45/06 , A61K31/5377 , A61K31/541 , C07D413/14 , A61K31/506 , C07D491/107
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
摘要翻译： 本申请涉及新的取代的哌啶基四氢喹啉，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病性溃疡，特别是促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，周围循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。
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公开(公告)号：US20160318866A1
公开(公告)日：2016-11-03
申请号：US15106285
申请日：2014-12-16
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Mark Jean GNOTH , Herbert HIMMEL , Raimund KAST , Joerg KELDENICH , Jürgen KLAR , Andreas KNORR , Dieter LANG , Niels LINDNER , Carsten SCHMECK , Rudolf SCHOHE-LOOP , Hanna TINEL , Hubert TRÜBEL , Frank WUNDER
IPC分类号： C07D211/10 , C07D211/42 , C07D211/22 , A61K45/06 , C07D401/14 , C07D413/14 , C07D405/14 , C07D211/60 , A61K31/4545
CPC分类号： C07D211/10 , A61K31/4545 , A61K45/06 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/60 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
摘要翻译： 本发明涉及新的取代的二哌啶基衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病溃疡，特别是用于促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。
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公开(公告)号：US20160122325A1
公开(公告)日：2016-05-05
申请号：US14930157
申请日：2015-11-02
发明人： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KOLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC分类号： C07D403/06 , A61K45/06 , A61K31/4196
CPC分类号： C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
摘要翻译： 本发明涉及新的5-（羟基烷基）-1-苯基-1,2,4-三唑衍生物，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物或组合物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管和肾脏疾病。
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公开(公告)号：US20230265072A1
公开(公告)日：2023-08-24
申请号：US18134378
申请日：2023-04-13
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK , Thomas MONDRITZKI
IPC分类号： C07D401/14 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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公开(公告)号：US20240109864A1
公开(公告)日：2024-04-04
申请号：US18256645
申请日：2021-12-09
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK
IPC分类号： C07D401/14 , A61P9/12 , C07D401/04
CPC分类号： C07D401/14 , A61P9/12 , C07D401/04
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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公开(公告)号：US20240051935A1
公开(公告)日：2024-02-15
申请号：US18256647
申请日：2021-12-09
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK , Thomas MONDRITZKI
IPC分类号： C07D401/04 , A61P9/12 , A61P9/00
CPC分类号： C07D401/04 , A61P9/12 , A61P9/00
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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公开(公告)号：US20230115270A1
公开(公告)日：2023-04-13
申请号：US17774459
申请日：2020-11-05
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Lisa DIETZ , Magdalena PLATZK , Daniel MEIBOM , Philipp BUCHGRABER , Niels LINDNER , Eva Maria BECKER-PELSTER , Carsten SCHMECK
IPC分类号： C07D417/12 , C07D413/12 , C07D277/28
摘要： The present application relates to novel substituted heterocyclic carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of breathing difficulties including sleep-induced breathing difficulties such as central and obstructive sleep apnoea, snoring (primary and obstructive snoring), dysphagia, peripheral and cardiac vascular disorders including diabetic microangiopathies and disorders of the peripheral and central nervous system including neurodegenerative and neuroinflammatory disorders.
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公开(公告)号：US20200230136A1
公开(公告)日：2020-07-23
申请号：US16608710
申请日：2018-04-19
IPC分类号： A61K31/506 , A61K31/541 , A61K31/5377 , A61P9/10
摘要： The invention relates to selective adrenoreceptor α2C receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (PAD) and/or critical limb ischemia (CLI).
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公开(公告)号：US20240101528A1
公开(公告)日：2024-03-28
申请号：US18256650
申请日：2021-12-09
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK
IPC分类号： C07D401/04 , C07D405/14 , C07D401/14 , A61P9/12 , A61P9/08
CPC分类号： C07D401/04 , C07D405/14 , C07D401/14 , A61P9/12 , A61P9/08
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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公开(公告)号：US20220274958A1
公开(公告)日：2022-09-01
申请号：US17667410
申请日：2022-02-08
发明人： Alexandros VAKALOPOULOS , Marie-Pierre COLLIN-KRÖPELIN , Nuria ORTEGA HERNANDEZ , Andre DIESKAU , Melissa BOULTADAKIS-ARAPINIS , Lisa CANDISH , Timo STELLFELD , Ilka MATHAR , Lucas Hudson HOFMEISTER , Peter SANDNER , Frank WUNDER , Lisa DIETZ , Robert Alan WEBSTER , Carsten SCHMECK , Thomas MONDRITZKI
IPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
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