公开(公告)号：US20060213405A1

公开(公告)日：2006-09-28

申请号：US11207215

申请日：2005-08-19

申请人： Bernhard Zimmermann

发明人： Bernhard Zimmermann

IPC分类号： F23K3/08 ,  F23K3/18

CPC分类号： F27D5/0006 ,  C21D9/0025 ,  F23G5/002 ,  F23H9/02 ,  F23H17/12

摘要： A grate covering for an incineration grate of an incineration furnace having a combustion chamber, includes a plurality of metal grate bars, each having a surface facing the combustion chamber that includes a layer made of a temperature-resistant, corrosion-resistant and abrasion-resistant non-metallic material, wherein a thickness of the layer is minimally sufficient to bear pressure and thrust loading. The thickness of the layer is about 10 mm to 15 mm. For a forward feed grate, the layer on each metal grate bar is present only in a zone of contact with an adjacent metal grate bar, and for a roller grate, and wherein the layer is present on the entire surface facing the combustion chamber.

摘要翻译： 具有燃烧室的焚化炉的焚烧炉的炉篦包括多个金属炉排棒，每个金属炉排条具有面向燃烧室的表面，该表面包括由耐温，耐腐蚀和耐磨的层 非金属材料，其中该层的厚度最小地足以承受压力和推力载荷。 该层的厚度为约10mm至15mm。 对于正向进料格栅，每个金属格栅条上的层仅存在于与相邻金属格栅条和与辊格栅接触的区域中，并且其中该层存在于面向燃烧室的整个表面上。

公开(公告)号：US20060012874A1

公开(公告)日：2006-01-19

申请号：US10967324

申请日：2004-10-19

申请人： Joerg-Michael Funk ,  Ralf Wolleschensky ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Ralf Engelmann

发明人： Joerg-Michael Funk ,  Ralf Wolleschensky ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Ralf Engelmann

IPC分类号： G02B21/06

CPC分类号： G02B21/0032 ,  G02B21/0048 ,  G02B21/32

摘要： Raster Scanning Light Microscope with punctiform light source distribution with at least one illumination module, in which the means to achieve a variable partition of the laser light into least two illumination channels are envisioned and joint illumination of a sample takes place at the same or at different areas of the sample.

摘要翻译： 具有点状光源分布的光栅扫描光显微镜具有至少一个照明模块，其中实现将激光可变分割成至少两个照明通道的手段，并且样品的联合照明在相同或不同的位置发生 样品区域。

公开(公告)号：US10017812B2

公开(公告)日：2018-07-10

申请号：US13300235

申请日：2011-11-18

申请人： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

发明人： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

IPC分类号： G01N33/48 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58 ,  C12Q1/6869 ,  C12Q1/6827 ,  G06F19/18 ,  C12Q1/6883 ,  C12Q1/6862 ,  G06F19/24

CPC分类号： C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6862 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06F19/34 ,  G16B20/00 ,  G16B40/00 ,  C12Q2537/161 ,  C12Q2537/165 ,  C12Q2537/143

摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

公开(公告)号：US20140065621A1

公开(公告)日：2014-03-06

申请号：US13793316

申请日：2013-03-11

申请人： Ravi Mhatre ,  Johan Baner ,  Bernhard Zimmermann ,  Matthew Hill ,  Zachary Demko

发明人： Ravi Mhatre ,  Johan Baner ,  Bernhard Zimmermann ,  Matthew Hill ,  Zachary Demko

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  A23D9/00 ,  C12Q2600/118 ,  C12Q2600/156

摘要： The invention provides methods of increasing the fetal fraction in maternal blood and plasma. This increase in fetal fraction improves the accuracy and decreases the “no call” rate for prenatal testing that measures fetal DNA in maternal blood.

摘要翻译： 本发明提供了增加母体血液和血浆中胎儿分数的方法。 胎儿分数的这种增加提高了准确性，降低了测量母体血液胎儿DNA的产前测试的“无呼叫”率。

公开(公告)号：US07688442B2

公开(公告)日：2010-03-30

申请号：US10560426

申请日：2004-06-09

申请人： Ralf Wolleschensky ,  Bernhard Zimmermann ,  Richard Ankerhold

发明人： Ralf Wolleschensky ,  Bernhard Zimmermann ,  Richard Ankerhold

IPC分类号： G01N21/64

CPC分类号： G01N21/6458 ,  G01N21/6402 ,  G01N2021/6417 ,  G02B21/0024 ,  G02B21/16

摘要： A method using fluorescence microscopy for image evaluation using a laser scanning microscope in which an at least partially spectrally resolved detection of the fluorescence spectrum occurs. Reference spectra are used for spectral demixing. Temporally and/or spectrally variable dyes and/or dye combinations are employed for recording of the reference spectra. Finally, the recorded reference spectra are inspected for image evaluation.

摘要翻译： 使用激光扫描显微镜使用荧光显微镜进行图像评估的方法，其中发生荧光光谱的至少部分光谱分辨检测。 参考光谱用于光谱分层。 使用时间和/或光谱变化的染料和/或染料组合来记录参考光谱。 最后，对记录的参考光谱进行图像评估。

公开(公告)号：US07459698B2

公开(公告)日：2008-12-02

申请号：US11590851

申请日：2006-11-01

申请人： Ralf Engelmann ,  Joerg-Michael Funk ,  Joerg Steinert ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Joerg Engel ,  Ulrich Meisel

发明人： Ralf Engelmann ,  Joerg-Michael Funk ,  Joerg Steinert ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Joerg Engel ,  Ulrich Meisel

IPC分类号： G01N21/64

CPC分类号： G02B21/0076 ,  G02B21/0048

摘要： Process for the observation of at least one sample region with a light raster microscope by a relative movement between the illumination light and sample via a first scanner along at least one scanning axis essentially perpendicular to the illumination axis wherein at an angle to the plane of the relative movement, preferably perpendicular thereto a second scanner is moved and an image acquisition takes place by the movement of the first and second scanners being coupled and a three-dimensional sampling movement being done by the illumination of the sample wherein the second scanner is coupled to the movement of the first scanner in such a manner that straight and/or curved lines and/or plane and/or curved surfaces are scanned which are extended along at least one scanning direction of the first scanner as well as along the scanning direction of the second scanner.

摘要翻译： 用于利用光栅显微镜通过第一扫描器沿着基本上垂直于照明轴的至少一个扫描轴的照明光和样本之间的相对运动来观察至少一个样本区域的过程，其中， 相对运动，优选地垂直于其，第二扫描器被移动，并且通过被耦合的第一和第二扫描器的运动而进行图像采集，并且三维采样运动是通过样本的照射进行的，其中第二扫描器耦合到 第一扫描器的运动以这样的方式扫描直线和/或曲线和/或平面和/或曲面，其沿着第一扫描仪的至少一个扫描方向以及沿着第一扫描仪的扫描方向延伸 第二台扫描仪

公开(公告)号：US20080068709A1

公开(公告)日：2008-03-20

申请号：US11783290

申请日：2007-04-06

申请人： Bernhard Zimmermann ,  Ralf Netz ,  Frank Hecht ,  Joerg-Michael Funk ,  Ralf Engelmann

发明人： Bernhard Zimmermann ,  Ralf Netz ,  Frank Hecht ,  Joerg-Michael Funk ,  Ralf Engelmann

IPC分类号： G02B21/06

CPC分类号： G02B21/06 ,  G02B21/00 ,  G02B21/0032 ,  G02B21/0076 ,  G02B27/0972

摘要： Method for actuation control of a microscope, in particular of a Laser Scanning Microscope, in which, at least one first illumination light, preferably moving at least in one direction, as well as at least one second illumination light moving at least in one direction, illuminate a sample through a beam combination, a detection of the light coming from the sample takes place, whereby, at least one part of the illumination light is generated through the splitting of the light from a common illuminating unit, characterized in that, by means of a common control unit, a controlled splitting into the first and the second illumination light takes place, in which the intensity of the first illuminating light, specified by the user or specified automatically, is assigned a higher priority (is prioritized) compared to the specified value for the second illumination light, and an adjustment for the second illumination light takes place until a maximum value is obtained, which is determined by the value specified for the first illumination light.

摘要翻译： 显微镜，特别是激光扫描显微镜的致动控制方法，其中至少一个至少在一个方向上移动的第一照明光以及至少沿一个方向移动的至少一个第二照明光， 通过光束组合照射样品，发生来自样品的光的检测，由此通过从公共照明单元分离光而产生照明光的至少一部分，其特征在于，通过装置 发生公共控制单元的受控分割，进入第一和第二照明光，其中由用户指定或自动指定的第一照明光的强度被分配为比较高的优先级（优先化） 对于第二照明光的指定值，并且进行第二照明光的调整，直到获得由th确定的最大值 为第一个照明灯指定的e值。

公开(公告)号：US20070066639A1

公开(公告)日：2007-03-22

申请号：US10595065

申请日：2004-08-12

申请人： Tushar Kshirsagar ,  David Amos ,  Joseph Dellaria Jr ,  Philip Heppner ,  Scott Langer ,  Bernhard Zimmermann

发明人： Tushar Kshirsagar ,  David Amos ,  Joseph Dellaria Jr ,  Philip Heppner ,  Scott Langer ,  Bernhard Zimmermann

IPC分类号： A61K31/4745 ,  C07D471/14 ,  C07D471/02

CPC分类号： C07D471/04 ,  C07D471/14

摘要： Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

摘要翻译： 在1位具有肟取代基的含咪唑的化合物（例如咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有这些化合物的化合物，中间体和使用这些化合物作为免疫调节剂的方法用于在动物中诱导细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：US07009699B2

公开(公告)日：2006-03-07

申请号：US10057571

申请日：2002-01-24

申请人： Ralf Wolleschensky ,  Bernhard Zimmermann ,  Sesbastian Tille

发明人： Ralf Wolleschensky ,  Bernhard Zimmermann ,  Sesbastian Tille

IPC分类号： G01N21/64

CPC分类号： G01N21/6458 ,  G01J3/2803 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N2021/6421 ,  G01N2021/6423 ,  G01N2021/6441 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/0084

摘要： A method for investigating specimens, wherein a spectral splitting of the radiation coming from the specimen is carried out for specimen points or point distributions, for the operation of a laser scanning microscope or a fluorescence screening arrangement or a flow cylinder comprising the steps of generating a λ-stack so that the spectral distribution is measured by individual detection channels and storing the signals so as to be correlated to the detection signals with at least one of the spatial coordinates x, y and z and/or so as to be correlated to the measurement time t.

摘要翻译： 一种用于检查样本的方法，其中对于样本点或点分布进行来自样本的辐射的光谱分裂，用于激光扫描显微镜或荧光屏蔽装置或流动筒的操作，包括以下步骤：产生 λ层叠，使得通过各个检测通道测量光谱分布并存储信号以便与具有至少一个空间坐标x，y和z的检测信号相关联和/或等于与 测量时间t。

公开(公告)号：US20060012864A1

公开(公告)日：2006-01-19

申请号：US10967316

申请日：2004-10-19

申请人： Joerg-Michael Funk ,  Ralf Wolleschensky ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Ralf Engelmann

发明人： Joerg-Michael Funk ,  Ralf Wolleschensky ,  Bernhard Zimmermann ,  Stefan Wilhelm ,  Ralf Engelmann

IPC分类号： G02B21/06

CPC分类号： G02B21/002 ,  G02B21/0032

摘要： Raster Scanning Light Microscope with line pattern scanning with at least one illumination module, in which the means to achieve a variable partition of the laser light into least two illumination channels are envisioned and joint illumination of a sample takes place at the same or at different areas of the sample.

摘要翻译： 光栅扫描光显微镜，其具有至少一个照明模块的线图案扫描，其中实现将激光可变分割成最少两个照明通道的手段，并且在相同或不同的区域发生样品的联合照明 的样品。