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    METHOD AND ARRANGEMENT FOR CONTROLLED ACTUATION OF A MICROSCOPE, IN PARTICULAR OF A LASER SCANNING MICROSCOPE
    2.
    发明申请
    METHOD AND ARRANGEMENT FOR CONTROLLED ACTUATION OF A MICROSCOPE, IN PARTICULAR OF A LASER SCANNING MICROSCOPE 有权
    用于控制微波激光的方法和装置，特别是激光扫描显微镜

    公开(公告)号：US20100097694A1

    公开(公告)日：2010-04-22

    申请号：US12578202

    申请日：2009-10-13

    申请人： Bernhard Zimmermann ,  Ralf Netz ,  Frank Hecht ,  Joerg-Michael Funk ,  Ralf Engelmann

    发明人： Bernhard Zimmermann ,  Ralf Netz ,  Frank Hecht ,  Joerg-Michael Funk ,  Ralf Engelmann

    IPC分类号： G02B21/06

    CPC分类号： G02B21/06 ,  G02B21/00 ,  G02B21/0032 ,  G02B21/0076 ,  G02B27/0972

    摘要： Method for actuation control of a microscope, in particular of a Laser Scanning Microscope, in which, at least one first illumination light, preferably moving at least in one direction, as well as at least one second illumination light moving at least in one direction, illuminate a sample through a beam combiner, a detection of the light coming from the sample takes place, whereby, at least one part of the illumination light is generated through the splitting of the light from a common illuminating unit, characterized in that, by means of a common control unit, a controlled splitting into the first and the second illumination light takes place, in which the intensity of the first illuminating light, specified by the user or specified automatically, is assigned a higher priority (is prioritized) compared to the specified value for the second illumination light, and an adjustment for the second illumination light takes place until a maximum value is obtained, which is determined by the value specified for the first illumination light.

    摘要翻译： 显微镜，特别是激光扫描显微镜的致动控制方法，其中至少一个至少在一个方向上移动的第一照明光以及至少沿一个方向移动的至少一个第二照明光， 通过光束组合器照射样品，发生来自样品的光的检测，由此通过从公共照明单元分离光而产生照明光的至少一部分，其特征在于，通过装置 发生公共控制单元的受控分割，进入第一和第二照明光，其中由用户指定或自动指定的第一照明光的强度被分配为比较高的优先级（优先化） 对于第二照明光的指定值，并且进行第二照明光的调整，直到获得最大值，其由v 为第一个照明灯指定。

    Method for the detection of fluorescent light
    4.
    发明授权
    Method for the detection of fluorescent light 有权
    检测荧光灯的方法

    公开(公告)号：US07119898B2

    公开(公告)日：2006-10-10

    申请号：US10763649

    申请日：2004-01-23

    申请人： Bernhard Zimmermann ,  Eva Simbuerger ,  Mary Dickinson

    发明人： Bernhard Zimmermann ,  Eva Simbuerger ,  Mary Dickinson

    IPC分类号： G01J3/30

    CPC分类号： G02B21/008 ,  G01N21/64 ,  G01N2021/6419 ,  G01N2021/6441 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/0084 ,  G02B21/16

    摘要： A method for the detection and evaluation of the light generated in a fluorescing specimen by a short pulse laser, wherein at least a first and a second fluorophore and/or a self-fluorescing specimen are separately irradiated with different wavelengths and the specimen light is recorded in a wavelength-dependent manner with at least one nondescanned detector as reference spectrum and a separation into individual spectra is carried out during the irradiation of at least two fluorophores and/or self-fluorescing specimens simultaneously from the measured spectrum and the reference spectra through regression analysis, wherein the wavelength of the short pulse laser is advantageously changed continuously in at least one wavelength region.

    摘要翻译： 一种用于通过短脉冲激光检测和评估在荧光样品中产生的光的方法，其中至少第一和第二荧光团和/或自发荧光样品被不同波长分开照射并且记录样本光 以至少一个非扫描检测器作为参考光谱的波长依赖性方式，并且在从测量的光谱和参考光谱通过回归同时从至少两个荧光团和/或自发荧光样品的照射期间进行分离成单个光谱 分析，其中短脉冲激光器的波长有利地在至少一个波长区域中连续地改变。

    Rheostatic device in a switching arrangement for electric tools
    6.
    发明授权
    Rheostatic device in a switching arrangement for electric tools 失效
    用于电动工具的开关装置中的变阻器

    公开(公告)号：US5453728A

    公开(公告)日：1995-09-26

    申请号：US962792

    申请日：1992-12-28

    申请人： Bernhard Zimmermann ,  Gerhard Niklewski

    发明人： Bernhard Zimmermann ,  Gerhard Niklewski

    IPC分类号： H01C10/30 ,  H01H9/06 ,  H05K1/18 ,  H01C10/36 ,  H01C10/50

    CPC分类号： H01C10/30 ,  H05K1/181 ,  H01H2011/0075 ,  H01H9/061 ,  H05K2201/10022 ,  H05K2201/10196 ,  H05K2201/10636 ,  Y02P70/611

    摘要： An electric tool rheostatic device in a switching arrangement is provided for regulating the speed of an electric motor in an electric tool. A circuit board for receiving electronic components is disposed in a switch housing. A potentiometer disposed within the switch housing includes a potentiometer slider operatively connected with a manually-operated actuating member and a resistance track that is constituted by a chip resistance element produced independently of the circuit board according to surface mounted device technology and mounted on the circuit board independently of the potentiometer slider. Upon assembly of the switching arrangement the potentiometer slide is adjustably located on the resistance track by the manually-operated actuating member for controlling resistance.

    摘要翻译： PCT No.PCT / DE91 / 00529 Sec。 371日期1992年12月28日 102（e）日期1992年12月28日PCT Filed 1991年6月27日PCT Pub。 出版物WO92 / 00594 日期1992年1月9日。设置有用于调节电动工具中的电动机的速度的开关装置中的电动工具变阻器。 用于接收电子部件的电路板设置在开关壳体中。 设置在开关壳体内的电位器包括与手动操作的致动构件可操作地连接的电位计滑块和由根据表面安装器件技术独立于电路板制造的芯片电阻元件构成的电阻轨迹，并安装在电路板上 独立于电位器滑块。 在组装开关装置时，电位器滑块通过用于控制电阻的手动操作的致动构件可调节地位于阻力轨道上。

    Non-invasive detection of fetal genetic traits
    7.
    发明授权
    Non-invasive detection of fetal genetic traits 有权
    非侵入性检测胎儿遗传性状

    公开(公告)号：US09580751B2

    公开(公告)日：2017-02-28

    申请号：US13029995

    申请日：2011-02-17

    申请人： Sinuhe Hahn ,  Wolfgang Holzgreve ,  Bernhard Zimmermann ,  Ying Li

    发明人： Sinuhe Hahn ,  Wolfgang Holzgreve ,  Bernhard Zimmermann ,  Ying Li

    IPC分类号： C12Q1/68 ,  C07H21/02

    CPC分类号： C12Q1/6883 ,  C12Q1/6806 ,  C12Q2600/156 ,  C12Q2565/125

    摘要： Blood plasma of pregnant women contains fetal and (generally >90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains ≦500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of

    摘要翻译： 孕妇的血浆含有胎儿和（一般> 90％）母体循环细胞外DNA。 大多数所述胎儿DNA含有≤500个碱基对，所述母体DNA具有更大的尺寸。 分离<500碱基对的循环细胞外DNA导致胎儿与母体DNA分离。 由于尺寸分离（例如通过色谱法，密度梯度离心或纳米技术方法），怀孕妇女血浆或血清样品的一小部分含有基本上包含≤500个碱基对的细胞外DNA，可用于非侵入性检测胎儿遗传 性状（包括胎儿RhD基因在妊娠中存在HDN风险;胎儿Y染色体特异性序列在X染色体相关疾病风险的妊娠中;染色体异常;遗传性孟德尔遗传疾病和相应的遗传标记;以及决定亲子鉴别的特征） 通过例如 PCR，配体链反应或探针杂交技术或核酸阵列。

    NON-INVASIVE DETECTION OF FETAL GENETIC TRAITS
    9.
    发明申请
    NON-INVASIVE DETECTION OF FETAL GENETIC TRAITS 有权
    非侵入性检测天然遗传基因

    公开(公告)号：US20080071076A1

    公开(公告)日：2008-03-20

    申请号：US11855558

    申请日：2007-09-14

    申请人： Sinuhe Hahn ,  Wolfgang Holzgreve ,  Bernhard Zimmermann ,  Ying Li

    发明人： Sinuhe Hahn ,  Wolfgang Holzgreve ,  Bernhard Zimmermann ,  Ying Li

    IPC分类号： C07H1/06

    CPC分类号： C12Q1/6883 ,  C12Q1/6806 ,  C12Q2600/156 ,  C12Q2565/125

    摘要： Blood plasma of pregnant women contains fetal and (generally>90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains .Itoreq.500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of .Itoreq.500 base pairs results in separation of fetal from maternal DNA. A fraction of a blood plasma or serum sample of a pregnant woman containing, due to size separation (e.g. by chromatography, density gradient centrifugation or nanotechnological methods), extracellular DNA substantially comprising .Itoreq.500 base pairs is useful for non-invasive detection of fetal genetic traits (including the fetal RhD gene in pregnancies at risk for HDN; fetal Y chromosome-specific sequences in pregnancies at risk for X chromosome-linked disorders; chromosomal aberrations; hereditary Mendelian genetic disorders and corresponding genetic markers; and traits decisive for paternity determination) by e.g. PCR, ligand chain reaction or probe hybridization techniques, or nucleic acid arrays.

    摘要翻译： 孕妇的血浆含有胎儿和（一般> 90％）母体循环细胞外DNA。 大多数所述胎儿DNA含有大约0.500个碱基对，所述母体DNA具有更大的尺寸。 分离的循环细胞外DNA，它们的碱基对，导致胎儿与母体DNA的分离。 由于尺寸分离（例如通过色谱法，密度梯度离心或纳米技术方法），怀孕妇女血浆或血清样品的一小部分含有基本上包含0.5个碱基对的细胞外DNA，可用于非侵入性检测 胚胎遗传特征（包括胎儿RhD基因在HDN风险的怀孕中;胎儿Y染色体特异性序列在X染色体相关疾病风险的怀孕中;染色体畸变;遗传性孟德尔遗传疾病和相应的遗传标记;性状决定性的亲子鉴定 确定） PCR，配体链反应或探针杂交技术或核酸阵列。