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公开(公告)号：US07407814B2
公开(公告)日：2008-08-05
申请号：US09927779
申请日：2001-08-09
IPC分类号： G01N33/543
CPC分类号： G01N29/036 , B82Y5/00 , B82Y35/00 , G01N33/54373 , G01N2291/0257
摘要： A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the mechanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalized nanoelectromechanical devices and a method for utilizing the biofunctionalized nanoelectromechanical device of the present invention are also provided.
摘要翻译： 提供了一种生物功能化的纳米机电装置（BioNEMS），用于通过在绑定事件期间测量BioNEMS装置的机械位移的变化来感测溶液中的单分子。 根据本发明的生物功能化纳米机电装置通常包括纳米机械机械谐振器，与用于测量谐振器的机械位移的机械谐振器集成的检测器，以及连接到检测器的电子装置，用于将结果传达给用户。 还提供了一种生物功能化的纳米机电装置系统和利用本发明的生物功能化纳米机电装置的方法。
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22.发明申请公开(公告)号：US20130043143A1
公开(公告)日：2013-02-21
申请号：US13497962
申请日：2010-09-24
CPC分类号： G01N29/036 , G01N29/022 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426
摘要： The present invention concerns a device for detecting gases or volatile organic compounds (VOC) comprising an electrically conducting or semiconducting zone f unctionalized with an organic film resulting from the polymerization of aromatic diazonium salt derived monomer.
摘要翻译： 本发明涉及一种用于检测气体或挥发性有机化合物（VOC）的装置，其包括由芳族重氮盐衍生的单体的聚合产生的有机膜的导电或半导电区域。
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公开(公告)号：US20110260802A1
公开(公告)日：2011-10-27
申请号：US13095692
申请日：2011-04-27
申请人： Luis Guillermo Villanueva Torrijo , Rassul Karabalin , Matthew Matheny , Philip X.L Feng , Michael C. Cross , Michael L. Roukes
发明人： Luis Guillermo Villanueva Torrijo , Rassul Karabalin , Matthew Matheny , Philip X.L Feng , Michael C. Cross , Michael L. Roukes
IPC分类号： H03B5/36
CPC分类号： H03B5/326
摘要： A parametric feedback oscillator includes a resonator which has at least one transduction element and at least one electromechanical resonating element. The resonator is configured to accept as input a parametric excitation signal at a frequency 2ω0 and to provide a resonating output signal at a frequency ω0. A cascaded feedback path in any electrically coupled cascade order includes at least one non-linear element, at least one phase shifter electrically, and at least one amplifier. The cascade feedback path is configured to receive as input the resonating output signal at a frequency ω0 and configured to provide as output a feedback path signal as the parametric excitation signal at a frequency 2ω0 to the resonator. A parametric feedback oscillator output terminal is configured to provide the resonating output signal at the frequency ω0 as an output signal. A method of causing a parametric feedback oscillation is also described.
摘要翻译： 参数反馈振荡器包括具有至少一个换能元件和至少一个机电谐振元件的谐振器。 谐振器被配置为以频率2ω0接受参量激励信号作为输入，并且以频率ω0提供谐振输出信号。 任何电耦合级联阶段中的级联反馈路径包括至少一个非线性元件，至少一个移相器和至少一个放大器。 级联反馈路径被配置为接收频率为ω0的谐振输出信号作为输入，并且被配置为向谐振器提供作为频率为2ω0的参量激励信号作为输出的反馈路径信号。 参数反馈振荡器输出端子被配置为以频率ω0提供作为输出信号的谐振输出信号。 还描述了引起参数反馈振荡的方法。
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24.发明授权公开(公告)号：US08044556B2
公开(公告)日：2011-10-25
申请号：US11830653
申请日：2007-07-30
IPC分类号： H01L41/04
CPC分类号： H03H9/02259 , B81B3/0021 , B81B2201/0271 , H03H2009/02511
摘要： A nanoelectromechanical systems (NEMS) device and method for using the device provide for a movable member that includes a region of low conductivity over which an electric field is developed. A region width is within a factor of ten (10) of a thickness of the NEMS device. The region is formed between a junction that incorporates piezoelectric material. A first voltage is applied across the region which alters a width of an active portion of the region thereby adjusting a movement of the movable member induced by a second voltage. The second voltage is applied across the region to produce a strain on the active portion of the region. The strain results in a defined movement of the movable member.
摘要翻译： 纳米机电系统（NEMS）器件和使用该器件的方法提供了一种可移动部件，该可移动部件包括在其上产生电场的低导电性区域。 区域宽度在NEMS设备的厚度的十分之一的范围内。 该区域形成在包含压电材料的接合部之间。 跨越区域施加第一电压，其改变区域的有效部分的宽度，从而调节由第二电压引起的可动构件的移动。 第二电压施加在该区域上以在该区域的有源部分上产生应变。 该应变导致可动构件的限定运动。
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25.发明申请DEVICE AND METHOD FOR SINGLE CELL AND BEAD CAPTURE AND MANIPULATION BY DIELECTROPHORESIS 审中-公开用于单细胞和珠粒捕获的装置和方法以及由电介质进行的操作公开(公告)号：US20100170797A1
公开(公告)日：2010-07-08
申请号：US12684357
申请日：2010-01-08
申请人： Jessica L. Arlett , Ji Hun Kim , Michael L. Roukes
发明人： Jessica L. Arlett , Ji Hun Kim , Michael L. Roukes
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , B01L3/502761 , B01L2200/0668 , B01L2400/0424 , B01L2400/046 , B03C5/005 , B03C5/026
摘要： A rapid and robust device and method for the capture and manipulation of single cells and beads in a microfluidic environment using positive dielectrophoresis (pDEP) is provided. The capture device uses a highly localized and non-uniform pDEP electric field gradient to allow for the simultaneous capture and manipulation of single cells and beads in standard cell growth media.
摘要翻译： 提供了使用正介电电泳（pDEP）在微流体环境中捕获和操纵单细胞和珠的快速且鲁棒的装置和方法。 捕获装置使用高度局部化和不均匀的pDEP电场梯度，以允许在标准细胞生长培养基中同时捕获和操纵单个细胞和珠粒。
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公开(公告)号：US20090054267A1
公开(公告)日：2009-02-26
申请号：US12216062
申请日：2008-06-27
IPC分类号： C40B60/12
CPC分类号： G01N29/036 , B82Y5/00 , B82Y35/00 , G01N33/54373 , G01N2291/0257
摘要： A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the mechanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalized nanoelectromechanical devices and a method for utilizing the biofunctionalized nanoelectromechanical device of the present invention are also provided.
摘要翻译： 提供了一种生物功能化的纳米机电装置（BioNEMS），用于通过在绑定事件期间测量BioNEMS装置的机械位移的变化来感测溶液中的单分子。 根据本发明的生物功能化纳米机电装置通常包括纳米机械机械谐振器，与用于测量谐振器的机械位移的机械谐振器集成的检测器，以及连接到检测器的电子装置，用于将结果传达给用户。 还提供了一种生物功能化的纳米机电装置系统和利用本发明的生物功能化纳米机电装置的方法。
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27.发明申请ULTRA-HIGH FREQUENCY SELF-SUSTAINING OSCILLATORS, COUPLED OSCILLATORS, VOLTAGE-CONTROLLED OSCILLATORS, AND OSCILLATOR ARRAYS BASED ON VIBRATING NANOELECTROMECHANICAL RESONATORS 有权超高频自恢复振荡器，耦合振荡器，电压控制振荡器和基于振荡纳米电子谐振器的振荡器阵列公开(公告)号：US20080204152A1
公开(公告)日：2008-08-28
申请号：US12030815
申请日：2008-02-13
IPC分类号： H03L7/00
摘要： A self-sustaining ultra-high frequency oscillator and method enable the ability to oscillate and output a signal. A balanced bridge circuit is utilized to null an embedding background response. A first vibrating nanoelectromechanical (NEMS) beam resonator is part of one of the branches of the balanced bridge circuit and determines the frequency of the oscillator's output signal. A feedback loop establishes and sets oscillation conditions of the oscillator's signal. Further, the feedback loop connects an output of the first resonator to an input of the balanced bridge circuit.
摘要翻译： 自持式超高频振荡器和方法能够振荡和输出信号。 使用平衡桥电路来消除嵌入背景响应。 第一个振动纳米机电（NEMS）光束谐振器是平衡桥接电路的一个分支的一部分，并确定振荡器输出信号的频率。 反馈回路建立并设置振荡器信号的振荡条件。 此外，反馈环路将第一谐振器的输出连接到平衡桥式电路的输入端。
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公开(公告)号：US06910382B2
公开(公告)日：2005-06-28
申请号：US10602548
申请日：2003-06-23
申请人： Hongxing Tang , Michael L. Roukes
发明人： Hongxing Tang , Michael L. Roukes
CPC分类号： G01L9/0042 , G01L9/16
摘要： Ferromagnetic semiconductor-based sensor devices, including sensors for detecting pressure changes and sensors for detecting magnetic fields, such as switching events in a magnetic recording medium. The pressure sensors of the present invention detect pressure changes using magnetoresistive measurement techniques, and in particular GPHE techniques. Magnetic field detection sensors such as magnetic switching detection sensors include ferromagnetic semiconductor-based materials that provide enhanced sensitivity relative to known materials and techniques. Such magnetic switching detection sensors according to the present invention are particularly useful as a read head sensor for HDD and other magnetic storage technologies.
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29.发明授权公开(公告)号：US06593731B1
公开(公告)日：2003-07-15
申请号：US09612828
申请日：2000-07-07
IPC分类号： G01B714
CPC分类号： G01D5/145
摘要： A displacement transducer in which relative displacement between a magnet and a Hall junction is sensed. Magnetic flux from the magnet is linked to the Hall junction in a direction perpendicular to the flow of current through the Hall junction. Relative displacement between the magnet and the Hall junction causes a change in the magnetic flux linked to the Hall junction which in turn causes a change in transverse voltage across the Hall junction. A signal representative of this voltage change is output from the transducer. The transducer may be part of a NEMS or MEMS.
摘要翻译： 一种位移传感器，其中检测到磁体和霍尔结之间的相对位移。 来自磁体的磁通量与垂直于通过霍尔连接点的电流的方向连接到霍尔接头。 磁体和霍尔连接点之间的相对位移导致与霍尔连接点相关联的磁通量的变化，这又导致霍尔连接点上横向电压的变化。 代表该电压变化的信号从换能器输出。 传感器可以是NEMS或MEMS的一部分。
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公开(公告)号：US10216698B2
公开(公告)日：2019-02-26
申请号：US13702790
申请日：2011-06-06
申请人： Thomas Ernst , Philippe Andreucci , Eric Colinet , Laurent Duraffourg , Edward B. Myers , Michael L. Roukes
发明人： Thomas Ernst , Philippe Andreucci , Eric Colinet , Laurent Duraffourg , Edward B. Myers , Michael L. Roukes
摘要： A device for analyzing a fluid, including a layer including a plurality of sensors of MEMS and/or NEMS type, a layer including a mechanism controlling the sensor and for processing information transmitted by the sensors, the control and processing mechanism being electrically connected to the detectors, and a layer positioned on the layer including the sensors on a side of a face including the sensors including a mechanism spatially and temporally distributing the fluid on the sensors.
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