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37 条记录 (耗时 0.318 秒)

    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
    23.
    发明申请
    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby 有权
    生产蛋白质的方法是由此产生的酸性糖链和糖蛋白的还原

    公开(公告)号：US20070202569A1

    公开(公告)日：2007-08-30

    申请号：US11707737

    申请日：2007-02-16

    申请人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    发明人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    IPC分类号： C12P21/06 ,  C12P19/04 ,  C12N15/74 ,  C12N1/21 ,  C12N1/18

    CPC分类号： C12N9/1205 ,  C12P21/005

    摘要： The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia and provide a means of controlling the same. The present invention also intends to provide a process for producing a protein with reduction of an acidic sugar chain by using the thus controlled yeast strain belonging to the genus Pichia. Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene coding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genus Pichia having been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced.

    摘要翻译： 本发明意图将参与加入甘露糖磷酸酯的基因找到源自属于毕赤酵母属的酵母的糖蛋白的糖链，并提供对其进行控制的方法。 本发明还提供通过使用由此控制的属于毕赤酵母属的酵母菌株来制备具有酸性糖链还原性蛋白质的方法。 即，本发明包括参与向糖蛋白的糖链添加甘露糖磷酸的蛋白质; 编码该蛋白的基因; 该基因的突变体; 携带突变基因的载体; 已经通过该载体转化了属于毕赤酵母属的酵母菌株; 通过使用转化的酵母菌株来生产具有降低酸性糖链的蛋白质的方法; 和由此产生的糖蛋白。

    Process For Producing Protein With Reduction of Acidic Sugar Chain and Glycoprotein Produced Thereby
    25.
    发明申请
    Process For Producing Protein With Reduction of Acidic Sugar Chain and Glycoprotein Produced Thereby 有权
    通过减少酸性糖链和糖蛋白产生蛋白质的方法

    公开(公告)号：US20090004725A1

    公开(公告)日：2009-01-01

    申请号：US12184334

    申请日：2008-08-01

    申请人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    发明人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    IPC分类号： C12N1/19 ,  C07H21/04 ,  C12N15/64

    CPC分类号： C12N9/1205 ,  C12P21/005

    摘要： The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia and provide a means of controlling the same. The present invention also intends to provide a process for producing a protein with reduction of an acidic sugar chain by using the thus controlled yeast strain belonging to the genus Pichia. Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene coding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genus Pichia having been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced.

    摘要翻译： 本发明意图将参与加入甘露糖磷酸酯的基因找到源自属于毕赤酵母属的酵母的糖蛋白的糖链，并提供对其进行控制的方法。 本发明还提供通过使用由此控制的属于毕赤酵母属的酵母菌株来制备具有酸性糖链还原性蛋白质的方法。 即，本发明包括参与向糖蛋白的糖链添加甘露糖磷酸的蛋白质; 编码该蛋白的基因; 该基因的突变体; 携带突变基因的载体; 已经通过该载体转化了属于毕赤酵母属的酵母菌株; 通过使用转化的酵母菌株来生产具有降低酸性糖链的蛋白质的方法; 和由此产生的糖蛋白。

    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
    26.
    发明授权
    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby 有权
    生产蛋白质的方法是由此产生的酸性糖链和糖蛋白的还原

    公开(公告)号：US07198921B2

    公开(公告)日：2007-04-03

    申请号：US10276075

    申请日：2001-05-16

    申请人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    发明人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    IPC分类号： C12P19/04 ,  C12P21/02 ,  C12N1/18 ,  C07H21/04 ,  C12N14/39

    CPC分类号： C12N9/1205 ,  C12P21/005

    摘要： The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia and provide a means of controlling the same. The present invention also intends to provide a process for producing a protein with reduction of an acidic sugar chain by using the thus controlled yeast strain belonging to the genus Pichia. Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene encoding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genus Pichia having been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced.

    摘要翻译： 本发明意图将参与加入甘露糖磷酸酯的基因找到源自属于毕赤酵母属的酵母的糖蛋白的糖链，并提供对其进行控制的方法。 本发明还提供通过使用由此控制的属于毕赤酵母属的酵母菌株来制备具有酸性糖链还原性蛋白质的方法。 即，本发明包括参与向糖蛋白的糖链添加甘露糖磷酸的蛋白质; 编码该蛋白的基因; 该基因的突变体; 携带突变基因的载体; 已经通过该载体转化了属于毕赤酵母属的酵母菌株; 通过使用转化的酵母菌株来生产具有降低酸性糖链的蛋白质的方法; 和由此产生的糖蛋白。

    N-acyltetrahydroisoquinoline derivatives
    27.
    发明授权
    N-acyltetrahydroisoquinoline derivatives 失效
    N-酰基四氢异喹啉衍生物

    公开(公告)号：US06838465B2

    公开(公告)日：2005-01-04

    申请号：US10275712

    申请日：2001-04-27

    申请人： Koji Yamada ,  Masaaki Hirose ,  Hisashi Iwaasa

    发明人： Koji Yamada ,  Masaaki Hirose ,  Hisashi Iwaasa

    IPC分类号： A61K31/472 ,  A61K31/4725 ,  A61K31/506 ,  A61P3/04 ,  A61P25/20 ,  A61P43/00 ,  C07D217/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

    CPC分类号： C07D401/12 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/506 ,  C07D217/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

    摘要： This invention relates to novel compounds represented by the general formula [I]: (wherein, R1 and R4 are the same or different, and represent hydrogen atoms, lower alkyl groups or the like; R2 and R3 are the same or different, and represent lower alkoxy groups or lower alkyl groups; R5 represents a lower alkyl group or aralkyl group optionally having substituent(s); R6 represents a hydrogen atom or a lower alkyl group; X represents O, S or NH; m represents an integer of 0 to 3; n represents an integer of 0 or 1; and Ar represents a phenyl group or heteroaryl group optionally having substituent(s)). The compounds of the invention have an antagonistic action on orexin receptors, and are useful for treatment of appetite abnormality, obesity, sleeping disorder or the like.

    摘要翻译： 本发明涉及由通式[I]表示的新化合物:(其中R 1和R 4相同或不同，表示氢原子，低级烷基等; R 2和 R 3相同或不同，表示低级烷氧基或低级烷基; R 5表示任选具有取代基的低级烷基或芳烷基; R 6表示氢原子或低级烷基 烷基; X表示O，S或NH; m表示0至3的整数; n表示0或1的整数; Ar表示任选具有取代基的苯基或杂芳基） 本发明对食欲肽受体具有拮抗作用，可用于治疗食欲异常，肥胖，睡眠障碍等。

    Electric power supply system
    28.
    发明授权
    Electric power supply system 有权
    电力供应系统

    公开(公告)号：US06717386B1

    公开(公告)日：2004-04-06

    申请号：US09577010

    申请日：2000-05-24

    申请人： Katsumi Kanasugi ,  Atsushi Kurauchi ,  Masaaki Hirose

    发明人： Katsumi Kanasugi ,  Atsushi Kurauchi ,  Masaaki Hirose

    IPC分类号： H02H706

    CPC分类号： H02M7/217 ,  B60R16/03 ,  G05F1/66 ,  H02J7/1492 ,  Y02T10/92

    摘要： A rectifying section 2, and a DCDC converter 3 which lowers an input DC voltage and then outputs the voltage are disposed between an AC generator 1 and a load 4. When the output voltage Vt of the AC generator 1 is gradually lowered with starting from E0, the output power P is increased, and is maximum at Vt=V12. When the output voltage Vt is further lowered, the output power P is reduced. As an operating point at which the same output power P is obtained, there are a point of Vt=V11, and that of Vt=V13. The operation of the DCDC converter 3 is controlled so as to operate at the point of Vt=V13 where the output current I is lower.

    摘要翻译： 整流部分2和降低输入直流电压然后输出电压的DCDC转换器3设置在AC发电机1和负载4之间。当AC发电机1的输出电压Vt从E0开始逐渐降低时 ，输出功率P增加，并且在Vt = V12时最大。 当输出电压Vt进一步降低时，输出功率P减小。 作为获得相同输出功率P的工作点，存在Vt = V11，Vt = V13的点。 控制DCDC转换器3的操作，以便在输出电流I较低的Vt = V13的点处工作。

    Device for measuring the average value of pulse signals
    29.
    发明授权
    Device for measuring the average value of pulse signals 失效
    用于测量脉冲信号平均值的装置

    公开(公告)号：US5416798A

    公开(公告)日：1995-05-16

    申请号：US965272

    申请日：1993-08-20

    申请人： Masaaki Hirose ,  Kazuo Katoh ,  Yutaka Ueki ,  Yohei Hirakoso ,  Mitsunori Satoh ,  Takashi Kosuge

    发明人： Masaaki Hirose ,  Kazuo Katoh ,  Yutaka Ueki ,  Yohei Hirakoso ,  Mitsunori Satoh ,  Takashi Kosuge

    IPC分类号： G01R19/00 ,  G01R29/08 ,  G01R29/26 ,  H04B3/46 ,  H04B17/00

    CPC分类号： G01R19/003 ,  G01R29/0892 ,  G01R29/26

    摘要： The device of the present invention is used to measure the intensity of a disturbing wave and measures an average value of impulsive noise. The invention permits accurate and short-time measurements. Impulsive noise, which is input via a variable attenuator, a frequency converter, an intermediate-frequency amplifier and a band-pass filter of a 9 or 120 kHz pass frequency, is provided to a linear detector. The detected output is applied to a low-pass filter which is composed of CR elements and whose cut-off frequency is tens of kilohertz. By the low-pass filter, the peak value of the detected output is lowered and its width is increased. The filter output is converted by an A-D converter to a digital signal. Digital values at respective sample points in the digital signal of one frame are added by an arithmetic circuit, and the added value is divided by the number of samples to obtain an average value, which is displayed.

    摘要翻译： PCT No.PCT / JP92 / 00677 Sec。 371日期：1993年8月20日 102（e）日期1993年8月20日PCT提交1992年5月26日PCT公布。 第WO92 / 21984号公报 日本1992年12月10日。本发明的装置用于测量干扰波的强度并测量脉冲噪声的平均值。 本发明允许精确和短时间的测量。 通过可变衰减器，频率转换器，中频放大器和9或120kHz通过频率的带通滤波器输入的脉冲噪声被提供给线性检测器。 检测到的输出被施加到由CR元件组成并且截止频率为几十赫兹的低通滤波器。 通过低通滤波器，检测输出的峰值降低，其宽度增加。 滤波器输出由A-D转换器转换为数字信号。 通过算术电路将一帧的数字信号中的各采样点的数字值相加，并将该相加值除以采样数，得到显示的平均值。