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21.发明授权Substituted benzyl derivatives of polyalkylene polyamines and their use in cosmetic and pharmaceutical compositions 失效聚亚烷基多胺的取代苄基衍生物及其在化妆品和药物组合物中的用途
公开(公告)号：US5910513A
公开(公告)日：1999-06-08
申请号：US876585
申请日：1997-06-16
申请人： Jean-Baptiste Galey
发明人： Jean-Baptiste Galey
IPC分类号： A61K8/30 , A61K8/00 , A61K8/20 , A61K8/23 , A61K8/24 , A61K8/41 , A61K31/13 , A61K31/135 , A61K31/315 , A61K31/55 , A61K38/44 , A61P17/00 , A61P43/00 , A61Q17/00 , A61Q19/00 , A61Q19/08 , C07C211/14 , C07C215/76 , C07C217/54 , C07C217/58 , C07C217/84 , C07C211/13
CPC分类号： A61Q19/08 , A61K8/41 , A61Q17/00 , C07C217/58 , A61K2800/522 , A61K2800/58
摘要： A compound being a substituted benzyl derivative of polyalkylene polyamine and corresponding to the following formula: ##STR1## in which: n and m=2, 3 or 4, p=2 or 3, x=0, 1 or 2, R.sub.1 and R.sub.4, which may be identical or different, represent(i) a linear or branched C.sub.1 -C.sub.4 alkyl radical or(ii) a radical of the following formula: ##STR2## in which: Z.sub.1 represents OH or OR, Z.sub.2 and Z.sub.3 represent H, OH or OR, R being a linear or branched C.sub.1 -C.sub.8 alkyl radical,R.sub.2 and R.sub.3, which may be identical or different, represent H, a linear or branched C.sub.1 -C.sub.4 alkyl radical, a radical of formula (A) or a radical of the following formula (B): ##STR3## R'.sub.1, R'.sub.4 and R'.sub.5 represent H or a linear or branched C.sub.1 -C.sub.4 alkyl radical, and R.sub.5 represents a linear or branched C.sub.1 -C.sub.4 alkyl radical or a radical of formula (A),with the proviso that at least one of the radicals R.sub.1, R.sub.2, R.sub.3, R.sub.4 or R.sub.5 represents a radical of formula (A), and that when R.sub.1 and R.sub.4, being identical, represent a radical of formula (A), x being 0 or 1, then Z.sub.1 or Z.sub.1 and Z.sub.2, being identical, cannot represent OR, R being a C.sub.1 -C.sub.6 alkyl radical,and their salts and metal complexes.Use in cosmetic and pharmaceutical compositions in order to protect the body against oxidative stress.
摘要翻译： 化合物是聚亚烷基多胺的取代苄基衍生物，对应于下式：其中：n和m = 2,3或4，p = 2或3，x = 0,1或2，R 1和R 4，其可以 相同或不同，表示（i）直链或支链C 1 -C 4烷基或（ii）下式的基团：其中：Z1表示OH或OR，Z2和Z3表示H，OH或OR，R为 直链或支链C1-C8烷基，R2和R3可以相同或不同，代表H，直链或支链C 1 -C 4烷基，式（A）基团或下式（B ）：R'1，R'4和R'5表示H或直链或支链C1-C4烷基，R5表示直链或支链C1-C4烷基或式（A）的基团，条件是 基团R 1，R 2，R 3，R 4或R 5中的至少一个表示式（A）的基团，当R 1和R 4相同时，表示式（A）的基团，x为0或1， 那么Z1或Z1和Z2就是i 齿状，不能表示OR，R为C1-C6烷基，以及它们的盐和金属络合物。 用于化妆品和药物组合物，以保护身体免受氧化应激。
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22.发明授权Use of N,N'-dibenzylethylenediamine-N,N'-diacetic acid derivatives as depigmenting agents 失效使用N，N'-二苄基乙二胺-N，N'-二乙酸衍生物作为脱色剂
公开(公告)号：US5834518A
公开(公告)日：1998-11-10
申请号：US897946
申请日：1997-07-24
CPC分类号： A61Q19/02 , A61K8/44 , A61K2800/58 , A61K2800/782
摘要： Human skin is depigmented or bleached by applying thereto a compound of formula (1): ##STR1## wherein X represents COOH or the ring: ##STR2## wherein Z.sub.1, Z.sub.2 and Z.sub.3, independently of each other, are H, OR or R, R representing an optionally substituted saturated or unsaturated, linear or branched C.sub.1 -C.sub.8 -alkyl radical, or a salt, a metal complex or an ester of the compound.
摘要翻译： 通过施用式（1）化合物，人皮肤脱色或漂白：其中X表示COOH或环：其中Z1，Z2和Z3彼此独立地为H，OR 或R，R表示任选取代的饱和或不饱和的直链或支链C 1 -C 8烷基或化合物的盐，金属络合物或酯。
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23.发明授权Derivatives of N'N'-di(aralkyl)-N,N'-di(2-azaaralkyl)alkylene diamine and the use thereof in pharmaceutical and cosmetic compostions 失效N'N'-二（芳烷基）-N，N'-二（2-氮杂烷基）亚烷基二胺的衍生物及其在药物和化妆品组合物中的用途
公开(公告)号：US5760037A
公开(公告)日：1998-06-02
申请号：US681414
申请日：1996-07-23
IPC分类号： C07D249/02 , A61K8/00 , A61K8/20 , A61K8/23 , A61K8/24 , A61K8/49 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/44 , A61K31/4402 , A61K45/06 , A61P9/00 , A61P17/00 , A61P25/00 , A61P43/00 , A61Q19/00 , A61Q19/08 , C07D213/38 , C07D235/14 , C07D235/20 , C07D239/42 , C07D251/42 , C07D257/04 , C07D277/28 , A61K31/53 , A61K31/505
CPC分类号： C07D277/28 , A61K45/06 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4946 , A61Q19/00 , A61Q19/08 , C07D213/38 , C07D235/14 , C07D257/04 , A61K2800/522 , A61K2800/58
摘要： These compounds correspond to the following general formula: ##STR1## where: n is 0, 1, or 2, m is are 1, 2, or 3, R, R.sub.1, R.sub.2, and R.sub.3, whether identical or different, represent an atom of hydrogen or a linear or branched alkyl radical at C.sub.1 -C.sub.4, R.sub.1 and R.sub.2, or R.sub.2 and R.sub.3 taken together can form a 5- or 6-group cycle, X and Y, whether identical or different, represent a nitrogenous aromatic heterocycle in position 2, Z.sub.1, Z.sub.2, and Z.sub.3, whether identical or different, represent an atom of hydrogen, a linear or branched alkyl radical at C.sub.1 -C.sub.4, the radical --OR.sub.4 or --NR.sub.4 R'.sub.4, R.sub.4 and R'.sub.4 represent an atom of hydrogen or a linear or branched alkyl radical at C.sub.1 -C.sub.4, and the metallic salts and complexes thereof. Use in pharmaceutical and cosmetic compositions to protect the organism from oxidizing stress situations linked to certain pathological states.
摘要翻译： 这些化合物对应于以下通式：其中：n为0,1或2，m为1,2或3，R，R1，R2和R3，无论相同或不同， 代表氢原子或C1-C4，R1和R2的直链或支链烷基，或R2和R3一起可以形成5-或6-基团的周期，X和Y是否相同或不同，代表含氮 位置2，Z 1，Z 2和Z 3上的芳族杂环，无论相同或不同，表示氢原子，C1-C4，基团-OR4或-NR4R'4，R4和R4'上的直链或支链烷基 表示C1-C4上的氢原子或直链或支链烷基，及其金属盐和络合物。 用于药物和化妆品组合物以保护生物免受与某些病理状态相关的压力情况的氧化。
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24.发明授权Diamine alkylene diacetic or triacetic acid derivatives, preparation method, use in cosmetic and pharmaceutical compositions and compositions containing them 失效二亚烷基二乙酸或三乙酸衍生物，制备方法，用于化妆品和药物组合物以及含有它们的组合物公开(公告)号：US06482855B2
公开(公告)日：2002-11-19
申请号：US09779737
申请日：2001-02-09
IPC分类号： A01N3710
CPC分类号： A61K8/44 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C229/16 , C07C235/06
摘要： Novel alkylenediaminediacetic acid or alkylenediaminetriacetic derivatives of formula (I): or an organic or inorganic salt thereof, their process of preparation, and their use in cosmetic and pharmaceutical compositions, such as for protecting the body against oxidative stress are discussed.
摘要翻译： 讨论式（I）的新型亚烷基二胺二乙酸或亚烷基二胺三乙酸衍生物：或其有机或无机盐，其制备方法及其在化妆品和药物组合物中的用途，例如用于保护身体免受氧化应激。
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25.发明授权Use of N-aryl-2-hydroxyalkylamides for stimulating or inducing hair growth and/or arresting hair loss 失效使用N-芳基-2-羟烷基酰胺刺激或诱导毛发生长和/或阻止脱发公开(公告)号：US06291532B1
公开(公告)日：2001-09-18
申请号：US09142473
申请日：1998-12-07
申请人： Lionel Breton , Jean-Baptiste Galey
发明人： Lionel Breton , Jean-Baptiste Galey
IPC分类号： A61K7135
CPC分类号： A61Q7/00 , A61K8/42 , Y10S514/88
摘要： Methods and compositions for induction or stimulation of hair growth and retardation of hair loss are provided. Preferably, these compounds will include a perhalogenated alkyl radical having 1 to 4 carbon atoms.
摘要翻译： 提供了用于诱导或刺激毛发生长和减少脱发的方法和组合物。 优选地，这些化合物将包括具有1至4个碳原子的全卤代烷基。
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26.发明授权Diamine alkylene diacetic or triacetic acid derivatives, preparation method, use in cosmetic and pharmaceutical compositions and compositions containing them 失效二亚烷基二乙酸或三乙酸衍生物，制备方法，用于化妆品和药物组合物以及含有它们的组合物公开(公告)号：US06218432B1
公开(公告)日：2001-04-17
申请号：US09297748
申请日：1999-07-14
IPC分类号： A01N3710
CPC分类号： A61K8/44 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C229/16 , C07C235/06
摘要： Novel alkylenediaminediacetic acid or alkylenediaminetriacetic derivatives of formula (I): or an organic or inorganic salt thereof, their process of preparation, and their use in cosmetic and pharmaceutical compositions, such as for protecting the body against oxidative stress are discussed.
摘要翻译： 讨论式（I）的新型亚烷基二胺二乙酸或亚烷基二胺三乙酸衍生物：或其有机或无机盐，其制备方法及其在化妆品和药物组合物中的用途，例如用于保护身体免受氧化应激。
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27.发明授权Compounds of the 3-aryl 2,4 dioxo oxazolidine family and use thereof in cosmetic and pharmaceuticals 失效3-芳基2,4-二氧代恶唑烷系的化合物及其在化妆品和药物中的应用
公开(公告)号：US6057351A
公开(公告)日：2000-05-02
申请号：US230762
申请日：1999-04-05
IPC分类号： A61K8/00 , A61K8/49 , A61K31/42 , A61K31/421 , A61P17/08 , A61P17/10 , A61P17/14 , A61P29/00 , A61P31/10 , A61P31/12 , A61P33/10 , A61Q5/00 , A61Q7/00 , A61Q19/00 , C07D263/44 , C07D263/06
CPC分类号： C07D263/44 , A61K8/49 , A61Q19/00 , A61Q7/00
摘要： Novel compounds of the aryl 2,4 dioxo oxazolidine family, a method for synthesizing same, compositions containing said compounds, and the use of an effective amount of at least one of said compounds as an active principle in a physiologically acceptable medium in a cosmetic composition or for preparing a pharmaceutical composition, are disclosed. Said compound or said compositions are useful for inducing and/or stimulating hair growth and/or controlling hair loss and/or treating hyperseborrhea and/or acne.
摘要翻译： PCT No.PCT / FR97 / 01289第 371日期1999年4月5日 102（e）1999年4月5日PCT 1997年7月11日PCT公布。 公开号WO98 / 05654 日期1998年2月12日芳基2,4-二氧代恶唑烷族的新型化合物，其合成方法，含有所述化合物的组合物，以及有效量的至少一种所述化合物作为生理学可接受的活性成分 公开了化妆品组合物中的培养基或制备药物组合物。 所述化合物或所述组合物可用于诱导和/或刺激毛发生长和/或控制脱发和/或治疗过度脂肪和/或痤疮。
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28.发明授权Method of depigmenting or bleaching mammalian skin using L-2-oxothiazolidine-4-carboxylic acid 失效使用L-2-氧代噻唑烷-4-羧酸脱色或漂白哺乳动物皮肤的方法
公开(公告)号：US6007827A
公开(公告)日：1999-12-28
申请号：US773514
申请日：1996-12-23
IPC分类号： C07D277/14 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/36 , A61K8/37 , A61K8/49 , A61K8/86 , A61K31/425 , A61K31/426 , A61P17/00 , A61Q19/00 , A61Q19/02 , A61K6/00 , A61K7/00 , A61K7/04
摘要： A cosmetic composition for depigmenting or bleaching mammalian skin or both, which contains:a) an amount of L-2-oxothiazolidine-4-carboxylic acid effective to depigment or bleach mammalian skin or both, andb) a topically-acceptable carrier.
摘要翻译： 用于脱色或漂白哺乳动物皮肤或两者的化妆品组合物，其包含：a）一定量的有效去除或漂白哺乳动物皮肤或两者的L-2-氧代噻唑烷-4-羧酸，和b）局部可接受的载体。
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29.发明授权
公开(公告)号：US5709848A
公开(公告)日：1998-01-20
申请号：US528653
申请日：1995-09-07
IPC分类号： A61K9/06 , A61K8/00 , A61K8/30 , A61K8/40 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/90 , A61K9/70 , A61K31/185 , A61K31/22 , A61K31/47 , A61P17/00 , A61P43/00 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C219/22 , C07D215/26 , C07D215/30 , C09K3/00 , A61K7/42
CPC分类号： A61K8/40 , A61K8/44 , A61K8/466 , A61K8/4926 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q5/00 , C07D215/30 , A61K2800/51 , Y02P20/55
摘要： Chelating agents for a transition metal, which exhibit the special feature of being photocleavable, that is containing a chelating functional group blocked by a photocleavable protecting group such that the chelating functional group is released only on exposure to luminous, specially ultraviolet, radiation, trap the transition metals released by the action of the luminous radiation, without exhibiting the side effects observed with conventional chelating agents. Compositions, especially cosmetic and/or dermatological ones, containing at least one such chelating agent are useful for protecting the skin, the mucosa, and/or the hair against ultraviolet radiation.
摘要翻译： 过渡金属螯合剂，其具有可光洁蛋白的特征，其包含被可光致发光保护基团封闭的螯合官能团，使得螯合官能团仅在暴露于发光，特别是紫外线，辐射下才释放 通过发光辐射的作用释放的过渡金属，而不表现出用常规螯合剂观察到的副作用。 含有至少一种此类螯合剂的组合物，特别是化妆品和/或皮肤病学组合物可用于保护皮肤，粘膜和/或毛发抵抗紫外线辐射。
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30.发明授权Use of N-arylmethylene ethylenediaminetriacetates N-arylmethylene iminodiacetates or N,N'-diarylmethylene ethylenediamineacetates against oxidative stress 失效N-芳基亚甲基亚乙基二胺三乙酸酯N-芳基亚甲基亚氨基二乙酸盐或N，N'-二芳基亚甲基乙二胺乙酸盐对氧化应激的应用
公开(公告)号：US5629436A
公开(公告)日：1997-05-13
申请号：US469751
申请日：1995-06-06
IPC分类号： A61K8/00 , A61K8/30 , A61K8/33 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/58 , A61K8/64 , A61K8/66 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/215 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/444 , A61K45/06 , A61P3/00 , A61P29/00 , A61P35/00 , A61P43/00 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C229/16 , C07C229/76 , C07D213/38 , C07F15/02 , C07C229/24
CPC分类号： C07D213/38 , A61K31/195 , A61K31/198 , A61K31/4406 , A61K31/444 , A61K45/06 , A61K8/44 , A61Q17/00 , A61Q19/00 , A61Q5/00 , C07C229/16 , A61Q19/08
摘要： N-arylmethylene ethylenediaminetriacetate, N-arylmethylene iminodiacetate or N,N'-diarylmethylene ethylenediaminediacetate type compounds and their use in combatting oxidative stress, and pharmaceutical and cosmetic compositions comprising said compounds. The invention also concerns a process for the preparation of said compounds.
摘要翻译： N-芳基亚甲基亚乙基二胺三乙酸酯，N-芳基亚甲基亚氨基二乙酸酯或N，N'-二芳基亚甲基亚乙基二乙酸酯类化合物及其在抵抗氧化应激中的用途，以及包含所述化合物的药物和化妆品组合物。 本发明还涉及制备所述化合物的方法。
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