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公开(公告)号：US06320039B1
公开(公告)日：2001-11-20
申请号：US09580517
申请日：2000-05-25
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A01K2217/05 , C12N9/1241 , C12N15/11 , C12N15/1137 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , C12N2310/3521
摘要： Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译： 包含哺乳动物端粒酶的RNA组分的核酸可用作药物，治疗和诊断试剂。
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22.发明授权Methods and reagents for the identification and regulation of senescence-related genes 失效用于鉴定和调控衰老相关基因的方法和试剂
公开(公告)号：US5744300A
公开(公告)日：1998-04-28
申请号：US332420
申请日：1994-10-31
申请人： Maarten H. K. Linskens , Kenneth S. Hirsch , Bryant Villeponteau , Junli Feng , Walter Funk , Michael David West
发明人： Maarten H. K. Linskens , Kenneth S. Hirsch , Bryant Villeponteau , Junli Feng , Walter Funk , Michael David West
IPC分类号： G01N33/566 , A61K38/00 , A61K47/48 , C12N5/00 , C12N15/09 , C12N15/113 , C12Q1/68 , C12Q1/70 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6883 , A61K31/70 , A61K47/48507 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12Q1/6809 , C12Y207/07049 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/158
摘要： Identification of senescence-related genes can be accomplished by comparing mRNA expression between young and senescent cells. Probes complementary to such genes can be used to detect senescent cells and distinguish between young and senescent cells as well as in screens to identify compounds that alter expression levels of senescence-related genes.
摘要翻译： 衰老相关基因的鉴定可以通过比较年轻和衰老细胞之间的mRNA表达来实现。 与这些基因互补的探针可用于检测衰老细胞，并区分年轻和衰老细胞以及屏幕，以鉴定改变衰老相关基因表达水平的化合物。
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公开(公告)号：US5583016A
公开(公告)日：1996-12-10
申请号：US330123
申请日：1994-10-27
CPC分类号： C12N15/113 , C12N15/11 , C12N15/1137 , C12N9/1241 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , A01K2217/05 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321
摘要： Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
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公开(公告)号：US20080300183A1
公开(公告)日：2008-12-04
申请号：US11805883
申请日：2007-05-24
申请人： Bryan J. Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Y. Tom Tang , Mikio Yagi , Kazuma Tomizuka
发明人： Bryan J. Boyle , Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Y. Tom Tang , Mikio Yagi , Kazuma Tomizuka
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译： 本发明涉及包含胃肠增生因子（GIPF）多核苷酸和多肽的药物组合物。 本发明还涉及GIPF用于预防或治疗与上皮粘膜变性相关的病症或病症的治疗用途。
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公开(公告)号：US06548298B2
公开(公告)日：2003-04-15
申请号：US09057351
申请日：1998-04-08
IPC分类号： C12Q168
CPC分类号： C12N15/11 , A01K2217/05 , A61L29/041 , A61L29/14 , A61M25/0045 , C12N9/1241 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Q2600/158 , C12Y207/07049 , C12N2310/3521 , C08L27/18
摘要： Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译： 包含哺乳动物端粒酶的RNA组分的核酸可用作药物，治疗和诊断试剂。
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公开(公告)号：US06216930B1
公开(公告)日：2001-04-17
申请号：US09423562
申请日：2000-01-14
申请人： Bernd Plocher , Friedrich Karrer , Walter Funk , Michael Schmidt
发明人： Bernd Plocher , Friedrich Karrer , Walter Funk , Michael Schmidt
IPC分类号： B60R700
摘要： The invention relates to a container (10) for storing a pair of spectacles (54) which can be inserted into the space between a spectacle holder (56) and a pivotable housing lid (20). When the housing lid (20) is closed, two rubber bands (28), which are held under tension in a housing (12) of the container (10) beneath the housing lid (20), press the spectacles (54) against an inner side of the housing lid (20) so that the spectacles (54) are held securely in the housing lid (20) so as not to rattle.
摘要翻译： 本发明涉及一种用于储存一对眼镜（54）的容器（10），该眼镜可插入到眼镜架（56）和可枢转的外壳盖（20）之间的空间中。 当壳体盖（20）关闭时，在壳体盖（20）下面的容器（10）的壳体（12）中被张紧地保持的两个橡胶带（28）将眼镜（54）压在一个 壳体盖（20）的内侧，使得眼镜（54）牢固地保持在壳体盖（20）中，以便不会发生咔嗒声。
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公开(公告)号：US5958680A
公开(公告)日：1999-09-28
申请号：US472802
申请日：1995-06-07
IPC分类号： A61L29/04 , A61L29/14 , A61M25/00 , C12N9/12 , C12N15/11 , C12N15/113 , C12Q1/68 , C07H21/02 , C12N5/08 , C12N15/63
CPC分类号： C12N15/11 , A61L29/041 , A61L29/14 , C12N15/113 , C12N15/1137 , C12N9/1241 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , A01K2217/05 , A61M25/0045 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q2600/158
摘要： Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
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公开(公告)号：US5776679A
公开(公告)日：1998-07-07
申请号：US482115
申请日：1995-06-07
CPC分类号： C12N15/11 , C12N15/113 , C12N15/1137 , C12N9/1241 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , A01K2217/05 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q2600/158
摘要： Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译： 包含哺乳动物端粒酶的RNA组分的核酸可用作药物，治疗和诊断试剂。
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