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公开(公告)号:US07732402B2
公开(公告)日:2010-06-08
申请号:US10359935
申请日:2003-02-07
申请人: Bryant Villeponteau , Junli Feng , Walter Funk , William Andrews
发明人: Bryant Villeponteau , Junli Feng , Walter Funk , William Andrews
CPC分类号: C12N15/11 , A01K2217/05 , A61L29/041 , A61L29/14 , A61M25/0045 , C12N9/1241 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Q2600/158 , C12Y207/07049 , C12N2310/3521 , C08L27/18
摘要: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译: 包含哺乳动物端粒酶的RNA组分的核酸可用作药物,治疗和诊断试剂。
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公开(公告)号:US6013468A
公开(公告)日:2000-01-11
申请号:US520550
申请日:1995-08-29
申请人: William H. Andrews , Ariel Athena Avilion , Junli Feng , Walter Funk , Carol Greider , Maria Antonia Blasco Marhuenda , Bryant Villeponteau
发明人: William H. Andrews , Ariel Athena Avilion , Junli Feng , Walter Funk , Carol Greider , Maria Antonia Blasco Marhuenda , Bryant Villeponteau
IPC分类号: C12N9/12 , C12N15/11 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号: C12N15/11 , C12N15/113 , C12N15/1137 , C12N9/1241 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , A01K2217/05 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321
摘要: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译: 包含哺乳动物端粒酶的RNA组分的核酸可用作药物,治疗和诊断试剂。
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公开(公告)号:US5876979A
公开(公告)日:1999-03-02
申请号:US485778
申请日:1995-06-07
申请人: William H. Andrews , Ariel Athena Avilion , Junli Feng , Walter Funk , Carol Greider , Maria Antonia Blasco Marhuenda , Bryant Villeponteau
发明人: William H. Andrews , Ariel Athena Avilion , Junli Feng , Walter Funk , Carol Greider , Maria Antonia Blasco Marhuenda , Bryant Villeponteau
IPC分类号: C12N15/09 , A61K31/70 , A61K48/00 , A61P31/12 , A61P35/00 , C12N5/10 , C12N9/12 , C12N15/00 , C12N15/11 , C12N15/113 , C12Q1/68 , C12R1/91 , C07H21/04 , C12N5/16 , C12N15/52 , C12N15/85
CPC分类号: C12N9/1241 , C12N15/11 , C12N15/113 , C12N15/1137 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , A01K2217/05 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q2600/158
摘要: Nucleic acids comprising the RNA component of a mouse, rat, Chinese hamster and bovine telomerase are disclosed, as are recombinant expression plasmids comprising said nucleic acids and host cells transformed with said recombinant expression plasmids.
摘要翻译: 公开了包含小鼠,大鼠,中国仓鼠和牛端粒酶的RNA组分的核酸,重组表达质粒包含用所述重组表达质粒转化的所述核酸和宿主细胞。
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公开(公告)号:US06258535B1
公开(公告)日:2001-07-10
申请号:US09060523
申请日:1998-04-14
IPC分类号: C12Q168
CPC分类号: C12N15/113 , A01K2217/05 , C12N9/1241 , C12N15/11 , C12N15/1137 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , C12N2310/3521
摘要: This invention is directed to compositions enriched for telomerase and methods of preparing the same.
摘要翻译: 本发明涉及富集端粒酶的组合物及其制备方法。
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公开(公告)号:US06320039B1
公开(公告)日:2001-11-20
申请号:US09580517
申请日:2000-05-25
IPC分类号: C07H2104
CPC分类号: C12N15/113 , A01K2217/05 , C12N9/1241 , C12N15/11 , C12N15/1137 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , C12N2310/3521
摘要: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译: 包含哺乳动物端粒酶的RNA组分的核酸可用作药物,治疗和诊断试剂。
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6.Methods and reagents for the identification and regulation of senescence-related genes 失效
标题翻译: 用于鉴定和调控衰老相关基因的方法和试剂公开(公告)号:US5744300A
公开(公告)日:1998-04-28
申请号:US332420
申请日:1994-10-31
申请人: Maarten H. K. Linskens , Kenneth S. Hirsch , Bryant Villeponteau , Junli Feng , Walter Funk , Michael David West
发明人: Maarten H. K. Linskens , Kenneth S. Hirsch , Bryant Villeponteau , Junli Feng , Walter Funk , Michael David West
IPC分类号: G01N33/566 , A61K38/00 , A61K47/48 , C12N5/00 , C12N15/09 , C12N15/113 , C12Q1/68 , C12Q1/70 , C07H21/04 , C12P19/34
CPC分类号: C12Q1/6883 , A61K31/70 , A61K47/48507 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12Q1/6809 , C12Y207/07049 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/158
摘要: Identification of senescence-related genes can be accomplished by comparing mRNA expression between young and senescent cells. Probes complementary to such genes can be used to detect senescent cells and distinguish between young and senescent cells as well as in screens to identify compounds that alter expression levels of senescence-related genes.
摘要翻译: 衰老相关基因的鉴定可以通过比较年轻和衰老细胞之间的mRNA表达来实现。 与这些基因互补的探针可用于检测衰老细胞,并区分年轻和衰老细胞以及屏幕,以鉴定改变衰老相关基因表达水平的化合物。
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公开(公告)号:US5583016A
公开(公告)日:1996-12-10
申请号:US330123
申请日:1994-10-27
CPC分类号: C12N15/113 , C12N15/11 , C12N15/1137 , C12N9/1241 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , A01K2217/05 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321
摘要: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
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公开(公告)号:US6054575A
公开(公告)日:2000-04-25
申请号:US998443
申请日:1997-12-24
IPC分类号: C12N9/12 , C12N15/11 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号: C12N15/113 , C12N15/11 , C12N15/1137 , C12N9/1241 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , A01K2217/05 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321
摘要: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译: 包含哺乳动物端粒酶的RNA组分的核酸可用作药物,治疗和诊断试剂。
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9.Methods and reagents for regulating telomere length and telomerase activity 失效
标题翻译: 调节端粒长度和端粒酶活性的方法和试剂公开(公告)号:US5858777A
公开(公告)日:1999-01-12
申请号:US710249
申请日:1996-09-13
CPC分类号: C07K14/4703 , A61K38/00
摘要: Purified and recombinant proteins TPC2 and TPC3 and recombinant or synthetic oligonucleotides corresponding to those proteins or fragments thereof can be used to detect regulators of telomere length and telomerase activity in mammalian cells and for a variety of related diagnostic and therapeutic purposes.
摘要翻译: 纯化和重组蛋白质TPC2和TPC3以及对应于那些蛋白质或其片段的重组或合成寡核苷酸可用于检测哺乳动物细胞中端粒长度和端粒酶活性的调节剂以及各种相关诊断和治疗目的。
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公开(公告)号:US5837857A
公开(公告)日:1998-11-17
申请号:US660678
申请日:1996-06-05
IPC分类号: C12N9/12 , C12N15/11 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号: C12N15/113 , C12N15/11 , C12N15/1137 , C12N9/1241 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Y207/07049 , A01K2217/05 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321
摘要: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
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