公开(公告)号：US09591975B2

公开(公告)日：2017-03-14

申请号：US13888266

申请日：2013-05-06

Applicant: CERCACOR LABORATORIES, INC.

Inventor： Cristiano Dalvi ,  Marcelo Lamego ,  Sean Merritt ,  Hung Vo ,  Johannes Bruinsma ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Greg Olsen ,  Massi Joe E. Kiani

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/024 ,  A61B5/145

CPC classification number: A61B5/02427 ,  A61B5/02416 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/4875 ,  A61B5/6816 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6838 ,  A61B5/6843 ,  A61B5/70 ,  A61B5/7275 ,  A61B2562/146

Abstract: A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.

Abstract translation: 用于测量医疗患者的一个或多个生理参数的无创生理传感器可以包括插入在光源和光电检测器之间的凸块。 凸起可以放置成与患者的身体组织接触，从而减少身体组织的厚度。 结果，可以减少光源和光电检测器之间的光程。 此外，传感器可以包括可将热量远离光源引导的散热器。 此外，传感器可以包括在光源和光电检测器之间的光路中的屏蔽。 屏蔽可以降低由光电检测器接收的噪声。

公开(公告)号：US20140275872A1

公开(公告)日：2014-09-18

申请号：US14204708

申请日：2014-03-11

Applicant: Cercacor Laboratories, Inc.

Inventor： Sean Merritt ,  Kevin Pauley ,  Jesse Chen ,  Justin Mathew Paul ,  Marcelo M. Lamego

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14551 ,  A61B5/1495 ,  A61B5/6826 ,  A61B2560/0233 ,  G01N21/278

Abstract: A quality control system for patient monitors is disclosed. The quality control system can include a quality check insert having optical properties. In an embodiment, the insert is placed within a sensor, irradiated with light, and then the light is detected after attenuation by the insert. The detected light is processed using the same or different processing methodologies typically used to determine measurement values for physiological parameters of a monitored patient. When a patient monitor is functioning properly, the results of the processing provide values within a predetermined range of values. When the patient monitor is not functioning properly, the results of the processing provide values outside the predetermined range of values. The quality control system can include quality control parameters indicative of a properly functioning active pulse motor of the sensor, emitters of the sensor, detectors of the sensor, accelerometers of the sensors, and/or temperature sensors of the system.

Abstract translation: 公开了一种患者监护仪的质量控制系统。 质量控制系统可以包括具有光学特性的质量检查插件。 在一个实施例中，将插入物放置在传感器内，用光照射，然后在插入物衰减之后检测光。 使用通常用于确定被监测患者的生理参数的测量值的相同或不同的处理方法来处理检测到的光。 当患者监视器正常工作时，处理结果提供在预定值范围内的值。 当病人监护仪不能正常工作时，处理结果提供超出预定范围值的值。 质量控制系统可以包括指示传感器的正常工作的有源脉冲电机，传感器的发射器，传感器的检测器，传感器的加速度计和/或系统的温度传感器的质量控制参数。

公开(公告)号：US20140155712A1

公开(公告)日：2014-06-05

申请号：US14153895

申请日：2014-01-13

Applicant: CERCACOR LABORATORIES, INC.

Inventor： Marcelo M. Lamego ,  Sean Merritt ,  Cristiano Dalvi ,  Hung Vo ,  Johannes Bruinsma ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Massi Joe E. Kiani

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/6816 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6838 ,  A61B5/6843 ,  A61B2562/0233 ,  A61B2562/04 ,  A61B2562/046 ,  A61B2562/146

Abstract: The present disclosure relates to an interface for a noninvasive glucose sensor that comprises a front-end adapted to receive an input signals from optical detectors and provide corresponding digital signals. In one embodiment, the front-end comprises switched capacitor circuits that are capable of handling multiple streams signals from the optical detectors. In another embodiment, the front-end comprises transimpedance amplifiers that are capable of handling multiple streams of input signals. In this embodiment, the transimpedance amplifier may be configured based on its own characteristics, such as its impedance, the impedance of the photodiodes to which it is coupled, and the number of photodiodes to which it is coupled.

Abstract translation: 本公开涉及一种用于非侵入式葡萄糖传感器的接口，其包括适于接收来自光学检测器的输入信号并提供相应数字信号的前端。 在一个实施例中，前端包括能够处理来自光学检测器的多个流信号的开关电容器电路。 在另一个实施例中，前端包括能够处理多个输入信号流的跨阻放大器。 在该实施例中，跨阻抗放大器可以基于其自身的特性，例如其阻抗，与其耦合的光电二极管的阻抗以及与其耦合的光电二极管的数量来配置。

公开(公告)号：US20140114199A1

公开(公告)日：2014-04-24

申请号：US14056615

申请日：2013-10-17

Applicant: Cercacor Laboratories, Inc.

Inventor： Marcelo M. Lamego ,  Hung Vo ,  Cristiano Dalvi ,  Sean Merritt

IPC: A61B5/00 ,  A61B5/024

CPC classification number: A61B5/6838 ,  A61B5/02422 ,  A61B5/14551 ,  A61B5/6826 ,  A61B2562/0238

Abstract: A magnetic-flap optical sensor has an emitter activated so as to transmit light into a fingertip inserted between an emitter pad and a detector pad. The sensor has a detector responsive to the transmitted light after attenuation by pulsatile blood flow within fingertip so as to generate a detector signal. Flaps extend from the emitter pad and along the sides of a detector shell housing the detector pad. Flap magnets are disposed on the flap ends and shell magnets are disposed on the detector shell sides. A spring urges the emitter shell and detector shell together, so as to squeeze the fingertip between its fingernail and its finger pad. The flap magnets have opposite north and south orientations from the shell magnets, urging the flaps to the detector shell sides and squeezing the fingertip sides. These spring and magnet squeezing forces occlude the fingertip blood flow and accentuate a detector signal responsive to an active pulsing of the fingertip.

Abstract translation: 磁瓣光学传感器具有被激活的发射器，以将光透射到插入在发射器焊盘和检测器焊盘之间的指尖中。 传感器具有响应于通过指尖中的脉动血流衰减的透射光的检测器，以便产生检测器信号。 襟翼从发射极焊盘延伸，并沿壳体检测器焊盘的检测器外壳的侧面延伸。 翼片磁体设置在翼片端部，壳体磁铁设置在检测器壳体侧。 弹簧将发射器壳体和探测器壳体一起推动，以将指尖挤压在其指甲和指垫之间。 翼片磁体具有与壳体磁体相反的北和南取向，将翼片推向检测器壳体侧并挤压指尖侧。 这些弹簧和磁铁挤压力阻挡指尖血流，并响应于指尖的主动脉冲强化检测器信号。

公开(公告)号：US20140066783A1

公开(公告)日：2014-03-06

申请号：US14069974

申请日：2013-11-01

Applicant: CERCACOR LABORATORIES, INC.

Inventor： Massi Joe E. Kiani ,  Marcelo Lamego ,  Sean Merritt ,  Cristiano Dalvi ,  Hung Vo ,  Johannes Bruinsma ,  Jeroen Poeze ,  Ferydan Lesmana ,  Greg Olsen

IPC: A61B5/024 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/02427 ,  A61B5/02416 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/4875 ,  A61B5/6816 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6838 ,  A61B5/6843 ,  A61B5/70 ,  A61B5/7275 ,  A61B2562/146

Abstract: A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.

Abstract translation: 用于测量医疗患者的一个或多个生理参数的无创生理传感器可以包括插入在光源和光电检测器之间的凸块。 凸起可以放置成与患者的身体组织接触，从而减少身体组织的厚度。 结果，可以减少光源和光电检测器之间的光程。 此外，传感器可以包括可将热量远离光源引导的散热器。 此外，传感器可以包括在光源和光电检测器之间的光路中的屏蔽。 屏蔽可以降低由光电检测器接收的噪声。

公开(公告)号：US20230233115A1

公开(公告)日：2023-07-27

申请号：US18158388

申请日：2023-01-23

Applicant: Cercacor Laboratories, Inc.

Inventor： Hung The Vo ,  Kevin Hughes Pauley ,  Cristiano Dalvi ,  Sean Merritt ,  Jesse Chen ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Ruiqi Long

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/6838 ,  A61B5/6826 ,  A61B2562/0242

Abstract: A noninvasive physiological sensor can include a first body portion and a second body portion coupled to each other and configured to at least partially enclose a user's finger. The sensor can further include a first probe coupled to one or more emitters and a second probe coupled to a detector. The first probe can direct light emitted from the one or more emitters toward tissue of the user's finger and the second probe can direct light attenuated through the tissue to the detector. The first and second probes can be coupled to the first and second body portions such that when the first and second body portions are rotated with respect to one another, ends of the first and second probes can be moved in a direction towards one another to compress the tissue of the user's finger.

公开(公告)号：US20230181068A1

公开(公告)日：2023-06-15

申请号：US18066118

申请日：2022-12-14

Applicant: Cercacor Laboratories, Inc.

Inventor： Cristiano Dalvi ,  Ferdyan Lesmana ,  Hung Vo ,  Jeroen Poeze ,  Jesse Chen ,  Kevin Pauley ,  Mathew Paul ,  Sean Merritt ,  Thomas B. Blank ,  Massi Joe E. Kiani

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14552 ,  A61B5/0075 ,  A61B5/6838 ,  A61B2562/0238

Abstract: An optical physiological sensor configured to perform high speed spectral sweep analysis of sample tissue being measured to non-invasively predict an analyte level of a patient. An emitter of the optical physiological sensor can be regulated to operate at different temperatures to emit radiation at different wavelengths. Variation in emitter drive current, duty cycle, and forward voltage can also be used to cause the emitter to emit a range of wavelengths. Informative spectral data can be obtained during the sweeping of specific wavelength regions of sample tissue.

公开(公告)号：US11540729B2

公开(公告)日：2023-01-03

申请号：US16984057

申请日：2020-08-03

Applicant: Cercacor Laboratories, Inc.

Inventor： Marcelo M. Lamego ,  Massi Joe E. Kiani ,  Jeroen Poeze ,  Cristiano Dalvi ,  Sean Merritt ,  Hung Vo ,  Gregory A. Olsen ,  Ferdyan Lesmana

IPC: A61B5/1455 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/021 ,  A61B5/08

Abstract: The present disclosure includes a handheld processing device including medical applications for minimally and noninvasive glucose measurements. In an embodiment, the device creates a patient specific calibration using a measurement protocol of minimally invasive measurements and noninvasive measurements, eventually creating a patient specific noninvasive glucometer. Additionally, embodiments of the present disclosure provide for the processing device to execute medical applications and non-medical applications.

公开(公告)号：US20210186338A1

公开(公告)日：2021-06-24

申请号：US16984057

申请日：2020-08-03

Applicant: Cercacor Laboratories, Inc.

Inventor： Marcelo M. Lamego ,  Massi Joe E. Kiani ,  Jeroen Poeze ,  Cristiano Dalvi ,  Sean Merritt ,  Hung Vo ,  Gregory A. Olsen ,  Ferdyan Lesmana

IPC: A61B5/0205 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/00 ,  A61B5/1459

Abstract: The present disclosure includes a handheld processing device including medical applications for minimally and noninvasive glucose measurements. In an embodiment, the device creates a patient specific calibration using a measurement protocol of minimally invasive measurements and noninvasive measurements, eventually creating a patient specific noninvasive glucometer. Additionally, embodiments of the present disclosure provide for the processing device to execute medical applications and non-medical applications.

公开(公告)号：US20210085228A1

公开(公告)日：2021-03-25

申请号：US16985497

申请日：2020-08-05

Applicant: Cercacor Laboratories, Inc.

Inventor： Kevin Pauley ,  Cristiano Dalvi ,  Hung Vo ,  Jesse Chen ,  Ferdyan Lesmana ,  Jeroen Poeze ,  Sean Merritt

IPC: A61B5/1455 ,  A61B5/145 ,  G01J1/16 ,  G01N21/47 ,  G01N21/31 ,  G01N21/49 ,  A61B5/00 ,  G01N21/59

Abstract: An optical measurement device includes a light source, a first detector, and a second detector. The light source emits light to a measurement site of a patient and one or more detectors detect the light from the light source. At least a portion of a detector is translucent and the light passes through the translucent portion prior to reaching the measurement site. A detector receives the light after attenuation and/or reflection or refraction by the measurement site. A processor determines a light intensity of the light source, a light intensity through a tissue site, or a light intensity of reflected or refracted light based on light detected by the one or more detectors. The processor can estimate a concentration of an analyte at the measurement site or an absorption or reflection at the measurement site.