公开(公告)号：US11684296B2

公开(公告)日：2023-06-27

申请号：US16721527

申请日：2019-12-19

Applicant: Cercacor Laboratories, Inc.

Inventor： Hung The Vo ,  Kevin Hughes Pauley ,  Cristiano Dalvi ,  Sean Merritt ,  Jesse Chen ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Ruiqi Long

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/0242

Abstract: A noninvasive physiological sensor can include a first body portion and a second body portion coupled to each other and configured to at least partially enclose a user's finger. The sensor can further include a first probe coupled to one or more emitters and a second probe coupled to a detector. The first probe can direct light emitted from the one or more emitters toward tissue of the user's finger and the second probe can direct light attenuated through the tissue to the detector. The first and second probes can be coupled to the first and second body portions such that when the first and second body portions are rotated with respect to one another, ends of the first and second probes can be moved in a direction towards one another to compress the tissue of the user's finger.

公开(公告)号：US20200163597A1

公开(公告)日：2020-05-28

申请号：US16697814

申请日：2019-11-27

Applicant: Cercacor Laboratories, Inc.

Inventor： Cristiano Dalvi ,  Hung The Vo ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Jesse Chen ,  Kevin Hughes Pauley ,  Ruiqi Long ,  Stephen Leonard Monfre ,  Sean Merritt ,  Mohamed K. Diab ,  Massi Joe E. Kiani

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/053 ,  A61B5/01

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from the same tissue site. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus. The multi-sensor apparatus can orient the plurality of non-invasive, physiological sensors such that each of the plurality of non-invasive, physiological sensors obtains physiological data from the same or a similar location.

公开(公告)号：US20230233115A1

公开(公告)日：2023-07-27

申请号：US18158388

申请日：2023-01-23

Applicant: Cercacor Laboratories, Inc.

Inventor： Hung The Vo ,  Kevin Hughes Pauley ,  Cristiano Dalvi ,  Sean Merritt ,  Jesse Chen ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Ruiqi Long

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/6838 ,  A61B5/6826 ,  A61B2562/0242

Abstract: A noninvasive physiological sensor can include a first body portion and a second body portion coupled to each other and configured to at least partially enclose a user's finger. The sensor can further include a first probe coupled to one or more emitters and a second probe coupled to a detector. The first probe can direct light emitted from the one or more emitters toward tissue of the user's finger and the second probe can direct light attenuated through the tissue to the detector. The first and second probes can be coupled to the first and second body portions such that when the first and second body portions are rotated with respect to one another, ends of the first and second probes can be moved in a direction towards one another to compress the tissue of the user's finger.

公开(公告)号：US20240180451A1

公开(公告)日：2024-06-06

申请号：US18494585

申请日：2023-10-25

Applicant: Cercacor Laboratories, Inc.

Inventor： Mohamed K. Diab ,  Kevin Hughes Pauley ,  Jesse Chen ,  Cristiano Dalvi ,  Hung The Vo ,  Ferdyan Lesmana ,  Jeroen Poeze ,  Ruiqi Long ,  Venkatramanan Krishnamani ,  Frank Lee

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  G02B27/30

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  G02B27/30

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from essentially the same, overlapping, or proximate regions of tissue of a patient are disclosed. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus and can be oriented such that each sensor is directed towards, or can obtain a measurement from, the same or a similar location.

公开(公告)号：US11951186B2

公开(公告)日：2024-04-09

申请号：US17078843

申请日：2020-10-23

Applicant: Cercacor Laboratories, Inc.

Inventor： Venkatramanan Krishnamani ,  Sergei Petrovich Balashov ,  Kevin Hughes Pauley ,  Ruiqi Long ,  Hung The Vo

IPC: A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1477 ,  A61K49/00 ,  C07K14/245 ,  C07K14/435 ,  A61B5/145

CPC classification number: A61K49/0056 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/14735 ,  A61B5/1477 ,  A61K49/0045 ,  C07K14/245 ,  C07K14/43595 ,  A61B5/14532 ,  C07K2319/20 ,  C07K2319/60

Abstract: Some embodiments disclosed herein pertain to indicator compounds used to detect the presence of and/or an amount of an analyte. In some embodiments, the indicator compounds are fusion proteins. In some embodiments, when the analyte binds to the indicator compound, the indicator compound undergoes a conformational change. In some embodiments, the conformational change results in a luminescent signal that allows quantification of the amount of analyte present.

公开(公告)号：US11992311B2

公开(公告)日：2024-05-28

申请号：US17324396

申请日：2021-05-19

Applicant: Cercacor Laboratories, Inc.

Inventor： Jesse Chen ,  Sean Merritt ,  Cristiano Dalvi ,  Ferdyan Lesmana ,  Hung The Vo ,  Kevin Hughes Pauley ,  Jeroen Poeze ,  Ruiqi Long ,  Stephen L Monfre

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/026 ,  A61B5/0295 ,  A61B5/0531 ,  A61B5/107 ,  A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/0205 ,  A61B5/7203 ,  A61B5/7278 ,  A61B5/0066 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/0531 ,  A61B5/1075 ,  A61B5/1079 ,  A61B5/14551 ,  A61B5/442 ,  A61B5/443 ,  A61B2560/0223 ,  A61B2576/02

Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.

公开(公告)号：US20210378562A1

公开(公告)日：2021-12-09

申请号：US17324396

申请日：2021-05-19

Applicant: Cercacor Laboratories, Inc.

Inventor： Jesse Chen ,  Sean Merritt ,  Cristiano Dalvi ,  Ferdyan Lesmana ,  Hung The Vo ,  Kevin Hughes Pauley ,  Jeroen Poeze ,  Ruiqi Long ,  Stephen L. Monfre

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/0205

Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.

公开(公告)号：US11026604B2

公开(公告)日：2021-06-08

申请号：US16034743

申请日：2018-07-13

Applicant: Cercacor Laboratories, Inc.

Inventor： Jesse Chen ,  Sean Merritt ,  Cristiano Dalvi ,  Ferdyan Lesmana ,  Hung The Vo ,  Kevin Hughes Pauley ,  Jeroen Poeze ,  Ruiqi Long ,  Stephen L. Monfre

IPC: A61B5/02 ,  A61B5/145 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0295 ,  A61B5/0531 ,  A61B5/107 ,  A61B5/1455

Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.

公开(公告)号：US11832940B2

公开(公告)日：2023-12-05

申请号：US17004663

申请日：2020-08-27

Applicant: Cercacor Laboratories, Inc.

Inventor： Mohamed K. Diab ,  Kevin Hughes Pauley ,  Jesse Chen ,  Cristiano Dalvi ,  Hung The Vo ,  Ferdyan Lesmana ,  Jeroen Poeze ,  Ruiqi Long ,  Venkatramanan Krishnamani ,  Frank Lee

IPC: A61B5/145 ,  G02B27/30 ,  A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  G02B27/30

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from essentially the same, overlapping, or proximate regions of tissue of a patient are disclosed. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus and can be oriented such that each sensor is directed towards, or can obtain a measurement from, the same or a similar location.

公开(公告)号：US20210121582A1

公开(公告)日：2021-04-29

申请号：US17078843

申请日：2020-10-23

Applicant: Cercacor Laboratories, Inc.

Inventor： Venkatramanan Krishnamani ,  Sergei Petrovich Balashov ,  Kevin Hughes Pauley ,  Ruiqi Long ,  Hung The Vo

IPC: A61K49/00 ,  C07K14/435 ,  C07K14/245 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1477

Abstract: Some embodiments disclosed herein pertain to indicator compounds used to detect the presence of and/or an amount of an analyte. In some embodiments, the indicator compounds are fusion proteins. In some embodiments, when the analyte binds to the indicator compound, the indicator compound undergoes a conformational change. In some embodiments, the conformational change results in a luminescent signal that allows quantification of the amount of analyte present.