公开(公告)号：US20230257690A1

公开(公告)日：2023-08-17

申请号：US18018418

申请日：2021-07-28

Applicant: CORNING INCORPORATED

Inventor： Scott Matthew Bennett ,  Thomas Albert Cloutier ,  William Joseph Lacey ,  Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/12 ,  C12M3/00

CPC classification number: C12M23/50 ,  C12M41/44 ,  C12M25/06 ,  C12M23/48 ,  C12M29/06

Abstract: A cell culture system for culturing cells is provided. The cell culture system including a cell culture vessel with a cell culture chamber for culturing cells, an inlet through which liquid can flow for filling the cell culture vessel, and an outlet through which fluid can exit the cell culture vessel. The system also includes at least one fill sensor arranged to detect liquid within the cell culture vessel reaching a fill level at a predetermined position of the cell culture vessel during filling of the cell culture vessel, where the at least one fill sensor can generate a detection signal when liquid within the cell culture vessel reaches the fill level. Also included is an actuator to change an orientation of the cell culture vessel in response to the detection signal.

公开(公告)号：US11136540B2

公开(公告)日：2021-10-05

申请号：US16095452

申请日：2017-05-19

Applicant: Corning Incorporated

Inventor： William Joseph Lacey

IPC: C12M1/24 ,  C12M1/00 ,  C12M1/04 ,  B01L3/08

Abstract: A flask assembly that includes: an Erlenmeyer flask; and a liner bag comprising a single opening the bag sized to fit within the flask and having a thickness from about 0.0254 mm to about 0.508 mm. The liner bag is configured for cell culturing and ease of insertion of the bag into the flask. In addition, the liner bag comprises a gas-permeable, polymeric material. Further, the liner bag can include a pocket adapted to receive a removable flask insertion element and/or at least one foldable seam configured to facilitate insertion of the bag into the flask. The liner bag can also include a vent having a gas permeability that is greater than the gas permeability of the gas-permeable, polymeric material employed in the balance of the bag.

公开(公告)号：US20210230528A1

公开(公告)日：2021-07-29

申请号：US16629656

申请日：2018-07-13

Applicant: CORNING INCORPORATED

Inventor： William Joseph Lacey ,  Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/24 ,  C12M1/12 ,  C12M1/00

Abstract: A cell culture vessel includes a vessel body, support columns, and a stabilizer device. The vessel body defines a cell culture chamber enclosed between a bottom wall and a top wall. The support column is within the cell culture chamber and extends between the top wall and the bottom wall. The stabilizer device covers a width and length of the cell culture chamber and has a column engaging structure that is sized to slidingly engage the support column such that the stabilizer device is movable along the support column as a liquid culture medium is received in the cell culture chamber. The support column guides the stabilizer device along a length of the support column as the stabilizer device rises with rising liquid level in the cell culture chamber during a liquid culture medium filling operation.

公开(公告)号：US20190127674A1

公开(公告)日：2019-05-02

申请号：US16095452

申请日：2017-05-19

Applicant: Corning Incorporated

Inventor： William Joseph Lacey

IPC: C12M1/24 ,  C12M1/00 ,  C12M1/04

Abstract: A flask assembly that includes: an Erlenmeyer flask; and a liner bag comprising a single opening the bag sized to fit within the flask and having a thickness from about 0.0254 mm to about 0.508 mm. The liner bag is configured for cell culturing and ease of insertion of the bag into the flask. In addition, the liner bag comprises a gas-permeable, polymeric material. Further, the liner bag can include a pocket adapted to receive a removable flask insertion element and/or at least one foldable seam configured to facilitate insertion of the bag into the flask. The liner bag can also include a vent having a gas permeability that is greater than the gas permeability of the gas-permeable, polymeric material employed in the balance of the bag.

公开(公告)号：US20180242572A1

公开(公告)日：2018-08-30

申请号：US15774873

申请日：2016-11-03

Applicant: Corning Incorporated

Inventor： John Wilfred Coddaire ,  William Joseph Lacey ,  Gregory Roger Martin ,  Michael Kurt Schaefer ,  Paul Michael Szlosek ,  Allison Jean Tanner

IPC: A01N1/02 ,  B01L3/00 ,  B65D83/00

CPC classification number: A01N1/0268 ,  B01L3/5082 ,  B01L3/50825 ,  B01L3/5453 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2300/123 ,  B01L2400/0481 ,  B65D83/0005 ,  C12M45/22

Abstract: Vial assemblies comprising a tubular body and a flexible bottom or flexible liner are described herein, wherein the flexible bottom or liner is configured to compress at least partially upon the application of force. Methods for storing and removing frozen samples from such vial assemblies are also described herein.

公开(公告)号：US20170151561A1

公开(公告)日：2017-06-01

申请号：US15319993

申请日：2015-06-26

Applicant: CORNING INCORPORATED

Inventor： William Joseph Lacey ,  Gregory Roger Martin ,  Wai Kin Poon ,  Ramana Tadepalli ,  Joseph Christopher Wall ,  Hongming Wang

IPC: B01L3/00

CPC classification number: B01L3/50851 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0829

Abstract: A microplate is fitted with a reinforcing member that enhances the rigidity of the microplate and decreases the magnitude of thermally-induced deformation. An example reinforced microplate includes a deck including a plurality of wells formed therein, and a reinforcing member attached to an underside of the deck.

公开(公告)号：US20160144360A1

公开(公告)日：2016-05-26

申请号：US14950481

申请日：2015-11-24

Applicant: Corning Incorporated

Inventor： William Joseph Lacey ,  Paul Michael Szlosek ,  Allison Jean Tanner ,  Joseph Christopher Wall ,  Kathy Marie Youngbear

IPC: B01L3/00 ,  B29C51/00 ,  B29C51/10 ,  B29C45/00 ,  B29C51/42

CPC classification number: B01L3/50851 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/0858 ,  B29C45/0001 ,  B29C51/002 ,  B29C51/10 ,  B29C51/428 ,  B29K2023/12 ,  B29K2105/256 ,  B29K2995/0026 ,  B29L2031/752

Abstract: A method of forming microplate includes forming a preform microplate including a deck and a plurality of wells, and reforming at least one well of the plurality of wells to provide a microplate. Each well of the plurality of wells in the preform microplate has a first depth and a first wall thickness. At least one well of the microplate has a second depth and a second wall thickness, where the second depth is greater than the first depth and/or the second wall thickness is less than the first wall thickness.

Abstract translation: 形成微孔板的方法包括形成包括甲板和多个孔的预成型微孔板，以及重整多个孔中的至少一个孔以提供微孔板。 预成型微孔板中的多个孔的每个孔具有第一深度和第一壁厚度。 微孔板的至少一个孔具有第二深度和第二壁厚，其中第二深度大于第一深度和/或第二壁厚度小于第一壁厚度。

公开(公告)号：US20160144359A1

公开(公告)日：2016-05-26

申请号：US14950453

申请日：2015-11-24

Applicant: Corning Incorporated

Inventor： William Joseph Lacey ,  Paul Michael Szlosek ,  Allison Jean Tanner ,  Wai Kin Poon

IPC: B01L3/00 ,  B01L9/00

CPC classification number: B01L3/50851 ,  B01L2200/028 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0829

Abstract: A reinforced microplate includes a microplate main body having a deck and a plurality of wells, and a reinforcing member. The deck includes a first surface and a second surface. Each well of the plurality of wells extends from the second surface in a substantially perpendicular direction, and each well comprises an opening on the first surface. The reinforcing member is attached to at least one surface of the deck.

Abstract translation: 增强微孔板包括具有甲板和多个孔的微板主体和加强构件。 甲板包括第一表面和第二表面。 多个井中的每个井在基本上垂直的方向上从第二表面延伸，并且每个井包括在第一表面上的开口。 加强构件附接到甲板的至少一个表面。