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公开(公告)号：US08530420B2
公开(公告)日：2013-09-10
申请号：US12336209
申请日：2008-12-16
申请人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Chung-Hwan Chen
发明人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Chung-Hwan Chen
CPC分类号： A61K38/29 , A61K31/663 , A61K45/06 , A61K2300/00
摘要： A method for treating and/or inhibiting arthritis is provided. The method includes administering an effective amount of a composition including a parathyroid hormone and a pharmaceutically acceptable carrier or salt to a subject with arthritis. Additionally, a method for inhibiting and/or rescuing terminal differentiation of cells is also provided.
摘要翻译： 提供了治疗和/或抑制关节炎的方法。 该方法包括向患有关节炎的受试者施用有效量的包括甲状旁腺激素和药学上可接受的载体或盐的组合物。 此外，还提供了用于抑制和/或挽救细胞末端分化的方法。
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22.发明申请TOONA SINENSIS EXTRACT FOR SUPPRESSING PROLIFERATION AND INDUCING APOPTOSIS OF OSTEOSARCOMA CELLS 审中-公开TOONA SINENSIS提取物抑制卵母细胞增殖和诱导凋亡公开(公告)号：US20090169658A1
公开(公告)日：2009-07-02
申请号：US11965795
申请日：2007-12-28
申请人： Mei-Ling Ho , Hseng-Kuang Hsu , Gwo-Jaw Wang , Je-Ken Chang
发明人： Mei-Ling Ho , Hseng-Kuang Hsu , Gwo-Jaw Wang , Je-Ken Chang
CPC分类号： A61K36/58
摘要： Toona sinensis extract for suppressing the proliferation and inducing apoptosis of osteosarcoma, but not normal human osterblasts. The extraction process comprises: extracting Toona sinensis with water to obtain a first extract, and filtering the first extract by a membrane to obtain a filtrate, and the Toona sinensis extract of the invention does not cause biological damages of normal bone cells. In addition, the invention further provides a pharmaceutical composition comprising the Toona sinensis extract.
摘要翻译： 香椿提取物用于抑制骨肉瘤的增殖和诱导凋亡，但不是正常的人成骨细胞。 提取方法包括：用水提取香茅，得到第一提取物，用膜过滤第一提取物得到滤液，本发明的香椿提取物不会引起正常骨细胞的生物损伤。 此外，本发明还提供了包含香椿提取物的药物组合物。
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23.发明申请Three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, and preparation process and uses of the same 有权含有人关节软骨细胞的三维培养物诱导终末分化发生变化，其制备过程及用途相同公开(公告)号：US20080026362A1
公开(公告)日：2008-01-31
申请号：US11490860
申请日：2006-07-20
申请人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang
发明人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang
CPC分类号： C12N5/0655 , A61K2035/126 , C12N2501/06 , C12N2533/74 , G01N33/5044 , G01N2800/105
摘要： Disclosed herein is a three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, as well as a process for preparing the same. The three-dimensional culture, which was found to mimic the biological characteristics of articular chondrocytes that undergo terminal differentiation in vivo, can be used as a tool in the studies of the molecular and cellular mechanisms of osteoarthritis, and in the screening of candidate drugs for use in treatment of a disorder associated with articular chondrocytes.
摘要翻译： 本文公开了含有诱导末端分化改变的人关节软骨细胞的三维培养物及其制备方法。 被发现模仿体内终末分化的关节软骨细胞的生物学特性的三维培养物可用作骨关节炎分子和细胞机制研究中的工具，以及候选药物的筛选 用于治疗与关节软骨细胞相关的病症。
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公开(公告)号：US09173969B2
公开(公告)日：2015-11-03
申请号：US13443996
申请日：2012-04-11
申请人： Hui-Min Wang , Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yi-Ting Chou , Ching-Ying Wu , Su-Shin Lee
发明人： Hui-Min Wang , Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yi-Ting Chou , Ching-Ying Wu , Su-Shin Lee
CPC分类号： A61L15/28 , A61L15/32 , A61L15/325 , A61L15/425 , A61L27/3813 , A61L27/3886 , A61L27/60 , C08L5/08
摘要： The present invention provides a biomaterial comprising a scaffold consisting of collagen, hyaluronic acid, and gelatin, which are cross-linked via ethyl-3-[3-dimethylaminopropyl]carbodiimide (EDC) between any two of collagen, hyaluronic acid, and gelatin. The present invention further provides a method for preparing the biomaterial and a method for enhancing wound healing with the biomaterial.
摘要翻译： 本发明提供一种生物材料，其包含由胶原，透明质酸和明胶组成的支架，其通过任何两种胶原，透明质酸和明胶之间的乙基-3- [3-二甲基氨基丙基]碳二亚胺（EDC）进行交联。 本发明还提供了一种用于制备生物材料的方法和用生物材料增强伤口愈合的方法。
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25.发明授权Three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes and preparation process and uses of the same 有权含有人关节软骨细胞的三维培养物具有诱导的末端分化变化及其制备过程及用途公开(公告)号：US08470522B2
公开(公告)日：2013-06-25
申请号：US11490860
申请日：2006-07-20
申请人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang
发明人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang
CPC分类号： C12N5/0655 , A61K2035/126 , C12N2501/06 , C12N2533/74 , G01N33/5044 , G01N2800/105
摘要： Disclosed herein is a three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, as well as a process for preparing the same. The three-dimensional culture, which was found to mimic the biological characteristics of articular chondrocytes that undergo terminal differentiation in vivo, can be used as a tool in the studies of the molecular and cellular mechanisms of osteoarthritis, and in the screening of candidate drugs for use in treatment of a disorder associated with articular chondrocytes.
摘要翻译： 本文公开了含有诱导末端分化改变的人关节软骨细胞的三维培养物及其制备方法。 被发现模仿体内终末分化的关节软骨细胞的生物学特性的三维培养物可用作骨关节炎分子和细胞机制研究中的工具，以及候选药物的筛选 用于治疗与关节软骨细胞相关的病症。
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公开(公告)号：US20090170200A1
公开(公告)日：2009-07-02
申请号：US12106453
申请日：2008-04-21
申请人： Ching-Hua Yeh , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Chung-Hwan Chen
发明人： Ching-Hua Yeh , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Chung-Hwan Chen
IPC分类号： C12N5/06
CPC分类号： C12N5/0663 , C12N2500/12 , C12N2500/84 , C12N2501/11 , C12N2501/33 , C12N2501/39
摘要： A medium for culturing stem cell. The stem cell medium of the invention comprises a fetal bovine serum, one or plurality of amino acid, one or plurality of vitamin, one or plurality of growth factor, one or plurality of inorganic salt, one or plurality of antioxidant, wherein the stem cell medium has a calcium concentration of less than about 1.8 mM, and the fetal bovine serum is present in an amount of less than about 10% by volume of the medium. The stem cell medium of the invention can maintain the proliferative and self-renewal capacity of the stem cells and keep stem cells at a steady stage.
摘要翻译： 培养干细胞的培养基。 本发明的干细胞培养基包含胎牛血清，一种或多种氨基酸，一种或多种维生素，一种或多种生长因子，一种或多种无机盐，一种或多种抗氧化剂，其中所述干细胞 培养基具有小于约1.8mM的钙浓度，并且胎牛血清以小于培养基体积的约10体积％的量存在。 本发明的干细胞培养基可以维持干细胞的增殖和自我更新能力，并使干细胞保持稳定。
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公开(公告)号：US20090170177A1
公开(公告)日：2009-07-02
申请号：US12106436
申请日：2008-04-21
申请人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yan-Hsiung Wang
发明人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yan-Hsiung Wang
IPC分类号： C12N13/00
摘要： Stem cell transfection method. The stem cell infection method of the invention comprises providing a stem cell; positioning the stem cell at a buffer, wherein the buffer contains a foreign material; electroporating the stem cell in the buffer; and culturing the stem cell.
摘要翻译： 干细胞转染方法。 本发明的干细胞感染方法包括提供干细胞; 将干细胞定位在缓冲液中，其中缓冲液含有异物; 电穿孔缓冲液中的干细胞; 并培养干细胞。
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公开(公告)号：US5312409A
公开(公告)日：1994-05-17
申请号：US890780
申请日：1992-06-01
CPC分类号： A61B17/17 , A61B17/8847 , A61B17/1717 , A61B17/175 , A61F2/3662
摘要： An alignment apparatus for guiding a cutting element along a predetermined path, the apparatus including a frame for guiding the cutting element along the predetermined path; and an adjustable clamp assembly, connected to the frame, for clamping a bone such that an intramedullary canal of the clamped bone is disposed along the predetermined path.
摘要翻译： 一种用于沿预定路径引导切割元件的定位装置，该装置包括用于沿着预定路径引导切割元件的框架; 以及连接到所述框架的用于夹紧骨头的可调节的夹具组件，使得所述夹持的骨的髓内管沿着所述预定路径设置。
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公开(公告)号：US06082364A
公开(公告)日：2000-07-04
申请号：US990746
申请日：1997-12-15
申请人： Gary Balian , Gwo-Jaw Wang , David Diduch , Chang Hahn
发明人： Gary Balian , Gwo-Jaw Wang , David Diduch , Chang Hahn
IPC分类号： A61F2/28 , A61F2/30 , A61K35/12 , A61K38/00 , A61K48/00 , A61L27/38 , C12N5/077 , C12N5/0775 , A61B19/00
CPC分类号： A61L27/3821 , A61L27/3804 , A61L27/3817 , A61L27/3847 , A61L27/3852 , C12N5/0663 , A61F2/30756 , A61F2002/2817 , A61F2002/30677 , A61K2035/124 , A61K38/00 , A61K48/00 , C12N2501/39 , C12N2510/00
摘要： Pluripotent stem-like cells obtained from bone marrow differentiate into osteocytes, chondrocytes and adipocytes, depending on the environment encountered and treatment. If systemically administered, the cells "home", that is migrate, to bone marrow. The cells may be transformed with recombinant DNA for the expression of both reporter genes, and biological factors, such as growth factors. The cells may be systemically administered to treat osteoporosis, osteolysis, improve bone implant adherence, augment bone growth or bone repair, augment cartilage repair, augment fat production for, e.g., breast augmentation, and the like.
摘要翻译： 从骨髓获得的多能干细胞样细胞分化为骨细胞，软骨细胞和脂肪细胞，这取决于遇到的环境和治疗。 如果系统地施用，细胞“回家”，即迁移到骨髓。 可以用重组DNA转化细胞以表达两种报告基因，以及生物因子，如生长因子。 可以将细胞全身施用以治疗骨质疏松症，骨质溶解，改善骨植入物粘附，增加骨生长或骨修复，增强软骨修复，增加例如隆胸等的脂肪产生。
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