-
公开(公告)号：US07910359B2
公开(公告)日：2011-03-22
申请号：US11185011
申请日：2005-07-20
申请人： Camillo Ricordi
发明人： Camillo Ricordi
IPC分类号： A61M5/14
CPC分类号： A61M5/14244 , A61M5/14276 , A61M2202/097
摘要： A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one of immunosuppressive and growth factor media to said space, and a pump structure operatively coupled to the manifold assembly. The device may comprise an additional plunger body for being disposed in said space and so as to define a peripheral gap between the plunger and the perforated wall of the device.
摘要翻译： 用于接收植入的生物材料的装置包括限定内部空间的多孔外壁，用于选择性地将免疫抑制和生长因子介质中的至少一种介入所述空间的流体歧管组件，以及可操作地联接到歧管组件的泵结构。 该装置可以包括附加的柱塞体，用于设置在所述空间中并且限定柱塞与装置的穿孔壁之间的周边间隙。
-
公开(公告)号：US20080168847A1
公开(公告)日：2008-07-17
申请号：US11653193
申请日：2007-01-12
IPC分类号： G01N1/00
CPC分类号： C12M41/36 , C12M23/12 , C12M29/10 , C12M33/10 , C12M35/04 , C12M41/00 , C12M41/14 , C12M41/46
摘要： A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
摘要翻译： 渗出装置包括用于细胞的至少一个样品容器，样品容器具有入口和出口。 容器通过入口接收测试液体，并通过出口排出液体。 插座壳体具有多个用于从样品容器的出口接收流体的容器。 驱动器连接到插座壳体以移动插座壳体，使得液体样品从样品容器的出口依次收集。 可以提供计算机以在预定时间控制插座壳体的运动，并且将识别液体样品的数据记录在容器中。 测试液体包括细胞的至少一种刺激，其可以是液体中化合物的存在，不存在或浓度，或液体的物理性质如温度。 分析收集在容器中的液体以确定细胞对刺激的反应。
-
公开(公告)号：US20060213802A1
公开(公告)日：2006-09-28
申请号：US11283951
申请日：2005-11-21
申请人： Ramon Poo , Camillo Ricordi
发明人： Ramon Poo , Camillo Ricordi
IPC分类号： B65D81/20
CPC分类号： B65D81/20 , Y10S435/809
摘要： A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas therebetween. A method for shipping items in an aircraft is also disclosed.
摘要翻译： 用于在飞行器中运输物品的容器包括运输舱和用于从运输隔间接收气体的可扩张室。 至少一个管道将可膨胀室连接到运输部门，以便允许其间的气体流动。 还公开了一种用于在飞行器中运送物品的方法。
-
24.发明授权Method and apparatus for bulk enrichment of a population or subpopulation of cells 失效用于大量富集细胞群体或亚群体的方法和装置
公开(公告)号：US6004743A
公开(公告)日：1999-12-21
申请号：US989124
申请日：1997-12-10
IPC分类号： G01N33/53 , C12N5/06 , G01N33/537 , G01N33/543 , G01N33/553 , G01N33/569 , A01N1/02 , G01N33/567
CPC分类号： G01N33/5375 , G01N33/54313 , G01N33/553 , G01N33/56966 , G01N33/56972
摘要： A cell population or subpopulation enrichment procedure for separating undesired populations or subpopulations from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have one or more reactants bound thereto which are specific to and will bind with the selected population or subpopulation to be eliminated from the sample. The particles preferably are mixed with the sample by repeatedly causing the particles to settle through a substantial portion of the sample to bind to the selected population. The particles with the bound selected population to be eliminated then are allowed to preferentially settle in the sample and the supernatant including the enriched population or subpopulation is separated from the particles with the population to be eliminated bound thereto. The enriched population supernatant can then be analyzed, utilized as is, have other populations or subpopulations removed or have additional amounts of remaining cells of the previously eliminated populations removed in additional steps.
摘要翻译： 使用相对重的致密颗粒和重力沉降从生物样品中分离不想要的种群或亚群体的细胞群或亚群富集程序。 颗粒具有一个或多个与其结合的反应物，其与所选择的群体或子群体特异并将与样品中的氨基酸结合。 颗粒优选通过重复使颗粒沉淀通过样品的大部分与样品结合而与样品混合。 将具有待排除的结合的选定群体的颗粒允许优先沉淀在样品中，并将包含富集群体或亚群体的上清液与要与其排除的群体结合的颗粒分离。 然后可以分析富集的群体上清液，按其他方式使用，除去其他群体或亚群体，或者在额外的步骤中除去先前消除的群体的额外量的剩余细胞。
-
公开(公告)号：US08785178B2
公开(公告)日：2014-07-22
申请号：US11653193
申请日：2007-01-12
CPC分类号： C12M41/36 , C12M23/12 , C12M29/10 , C12M33/10 , C12M35/04 , C12M41/00 , C12M41/14 , C12M41/46
摘要： A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
摘要翻译： 渗出装置包括用于细胞的至少一个样品容器，样品容器具有入口和出口。 容器通过入口接收测试液体，并通过出口排出液体。 插座壳体具有多个用于从样品容器的出口接收流体的容器。 驱动器连接到插座壳体以移动插座壳体，使得液体样品从样品容器的出口依次收集。 可以提供计算机以在预定时间控制插座壳体的运动，并且将识别液体样品的数据记录在容器中。 测试液体包括细胞的至少一种刺激，其可以是液体中化合物的存在，不存在或浓度，或液体的物理性质如温度。 分析收集在容器中的液体以确定细胞对刺激的反应。
-
26.发明申请公开(公告)号：US20120114729A1
公开(公告)日：2012-05-10
申请号：US13264140
申请日：2010-04-15
申请人： Cherie L. Stabler , Benjamin S. Harrisson , Christopher A. Fraker , Eileen Pedrada , Camillo Ricordi
发明人： Cherie L. Stabler , Benjamin S. Harrisson , Christopher A. Fraker , Eileen Pedrada , Camillo Ricordi
CPC分类号： A61L15/44 , A61L15/18 , A61L27/54 , A61L2300/11 , A61L2300/602 , A61L2300/63
摘要： A composite for delivering extended-release of oxygen is disclosed. The composite can include a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein. The polymer support can exhibit an oxygen tension value of at least 40 mmHg for a period of 14 days. The weight ratio of biocompatible polymeric support to solid peroxide particles can range from 1:1 to 99:1. Also disclosed is a method of using the composite to deliver oxygen to cells in both in vivo and in vitro environments.
摘要翻译： 公开了一种用于输送氧气延长释放的复合材料。 复合材料可以包括具有悬浮在其中的多个固体过氧化物颗粒的生物相容性聚合物载体。 聚合物载体可显示至少40mmHg的氧气张力值，持续14天。 生物相容性聚合物载体与固体过氧化物颗粒的重量比可以为1:1至99:1。 还公开了使用复合材料在体内和体外环境中将氧递送到细胞的方法。
-
27.发明申请AZO DYE RELATED SMALL MOLECULE MODULATORS OF PROTEIN-PROTEIN INTERACTIONS 审中-公开AZO DYE相关小分子蛋白质蛋白质相互作用的调节剂公开(公告)号：US20110065675A1
公开(公告)日：2011-03-17
申请号：US12991079
申请日：2009-05-05
IPC分类号： A61K31/655 , A61K31/185 , C12N5/071 , A61P35/00 , A61P3/10 , A61P29/00 , A61P19/04 , A61P3/00 , A61P17/00 , A61P17/06 , A61P37/02 , A61P37/06 , A61P25/28 , A61P9/10
CPC分类号： A61K31/517
摘要： Azo dyes and suramin-related small molecules are effective in inhibiting the CD40/CD154 protein-protein interaction, an important co-stimulatory interaction involved in the activation of immune responses mediated by T- and B-cells. The compounds were found to be active as indicated by their IC50 values both in a cell-free binding assay and in the inhibition of CD154-induced B-cell proliferation assay. The compounds may be used as therapeutic compounds for treatment of diseases and disorders related to immune or inflammatory responses. Methods of inhibiting the CD40/CD154 protein-protein interaction and treating diseases and disorders related to immune or inflammatory responses are described.
摘要翻译： 偶氮染料和苏拉明相关的小分子在抑制CD40 / CD154蛋白质 - 蛋白质相互作用中是有效的，这是参与由T细胞和B细胞介导的免疫应答活化的重要的共刺激相互作用。 发现这些化合物在无细胞结合测定和抑制CD154诱导的B细胞增殖测定中的IC 50值都是活性的。 该化合物可用作治疗与免疫或炎症反应有关的疾病和病症的治疗化合物。 描述了抑制CD40 / CD154蛋白质相互作用和治疗与免疫或炎症反应相关的疾病和病症的方法。
-
28.发明申请System and Method for Transmitting User Data Received by an Authorized Approver 失效用于发送由授权批准人接收的用户数据的系统和方法公开(公告)号：US20110021172A1
公开(公告)日：2011-01-27
申请号：US12834848
申请日：2010-07-12
IPC分类号： H04M11/04
CPC分类号： G06F19/3418 , G06F19/00 , G16H10/60 , Y02A90/26
摘要： This present invention relates to a system, method, and apparatus for an authorized approver (AA) to receive and transmit information to contacts of an end user or others. The authorized approvers may receive, for example, voice, data or video or a combination thereof from the end user. Said authorized approver may view the received information on a back-end server or on a telecommunications device including but not limited to a mobile device or mobile internet device. The authorized approvers may retransmit the end user data to one or more contacts of the end user. Before such retransmission, the authorized approver, may amend, summarize, modify, tag, or otherwise edit the end user information before sending it on to the end user contacts.
摘要翻译： 本发明涉及一种用于授权审批者（AA）向最终用户或其他人的联系人接收和发送信息的系统，方法和装置。 授权审批者可以从终端用户接收例如语音，数据或视频或其组合。 所述授权审批者可以在后端服务器或电信设备上查看所接收的信息，包括但不限于移动设备或移动互联网设备。 授权的审批者可以将最终用户数据重传到最终用户的一个或多个联系人。 在这种重传之前，授权的批准人可以在发送给最终用户的联系人之前修改，总结，修改，标记或以其他方式编辑最终用户信息。
-
29.发明申请System, Method, and Apparatus for Capturing, Securing, Sharing, Retrieving, and Searching Data 审中-公开用于捕获，保护，共享，检索和搜索数据的系统，方法和设备公开(公告)号：US20100333194A1
公开(公告)日：2010-12-30
申请号：US12495177
申请日：2009-06-30
CPC分类号： G06F21/32 , G06F16/90 , G06F2221/2103 , G06F2221/2111 , G06F2221/2133
摘要： This present invention relates to a system, method and apparatus for scientists and researchers and others to capture, secure, share, retrieve and search captured data. Said system and method is able to: fully-integrate hardware and software, required to seamlessly capture data inputs; combine edit and display functions from devices into one single edit and display platform; compile captured inputs from devices into text-searchable and tag-able data that can be displayed, edited and searched on one platform; compile captured inputs from devices into text-searchable and tag-able data that can be searchable by using free-text search, advanced search modules, or a combination thereof; provide advanced search modules that can search based on embedded text in files, tags tied to images or files, parallel image search and other intelligent parameter-based search formats; and can be provided as a hosted application, available via a wire line or wireless on-demand service, also referred to as Software as a Service (SaaS) delivery method.
摘要翻译： 本发明涉及一种用于科学家和研究人员以及其他人捕获，保护，共享，检索和搜索捕获的数据的系统，方法和装置。 所述系统和方法能够：完全集成硬件和软件，无缝捕获数据输入; 将设备的编辑和显示功能合并为一个单一的编辑和显示平台; 将设备中的捕获输入编译成可在一个平台上显示，编辑和搜索的文本可搜索和可标记数据; 编译从设备获取的输入到文本搜索和可标记数据，可以通过使用自由文本搜索，高级搜索模块或其组合进行搜索; 提供高级搜索模块，可以根据文件中嵌入的文本，绑定到图像或文件的标签，并行图像搜索和其他基于智能参数的搜索格式进行搜索; 并且可以作为托管应用程序提供，通过有线或无线点播服务（也称为软件即服务（SaaS））传递方法可用。
-
公开(公告)号：US07713686B2
公开(公告)日：2010-05-11
申请号：US11003808
申请日：2004-12-03
申请人： Ramon E. Poo , Camillo Ricordi
发明人： Ramon E. Poo , Camillo Ricordi
CPC分类号： A01N1/02 , A01N1/0263
摘要： An organ preservation container includes a gas impermeable housing for containing an organ. At least two liquids having different densities and forming a liquid-liquid interface are also contained in the housing. A closure for hermetically sealing the housing is provided. A structure is provided within the housing for engaging the organ and for maintaining a portion of the organ at the liquid-liquid interface such that the organ will be maintained partially in both of the liquids. A method for preserving the organ is also described.
摘要翻译： 器官保存容器包括用于容纳器官的不透气壳体。 至少两种具有不同密度并形成液 - 液界面的液体也包含在壳体中。 提供用于密封壳体的封闭件。 在壳体内设置有用于接合器官并用于将器官的一部分保持在液 - 液界面处的结构，使得器官部分地保持在两液体中。 还描述了保存器官的方法。
-
-
-
-
-
-
-
-
-
搜索结果
44 条记录 (耗时 0.025 秒)