公开(公告)号：US20110147581A1

公开(公告)日：2011-06-23

申请号：US12976543

申请日：2010-12-22

Applicant: Chung-Hsuan Chen ,  Jung-Lee Lin ,  Ming-Lee Chu

Inventor： Chung-Hsuan Chen ,  Jung-Lee Lin ,  Ming-Lee Chu

IPC: H01J49/26

CPC classification number: H01J49/0022 ,  H01J49/424 ,  H01J49/429

Abstract: Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 105, or analyte with a molecular weight of at least 105 Da, as well as mass spectra of small molecule analyte. In some embodiments, the methods comprise obtaining mass spectra with a portable apparatus described above.

Abstract translation: 公开了便携式质谱法的方法和装置。 该装置包括至少一个离子化分析物源，至少一个频率扫描子系统，至少一个检测器和可选的至少一个真空泵，并且是便携式的。 在一些实施方案中，装置包括多个电离分析物源和/或配置成获得大分析物的质谱，例如m / z比至少为105的分析物，或分子量至少为105的分析物 Da，以及小分子分析物的质谱。 在一些实施例中，所述方法包括使用上述便携式装置获得质谱。

公开(公告)号：US20100301199A1

公开(公告)日：2010-12-02

申请号：US12457064

申请日：2009-05-29

Applicant: Chung-Hsuan Chen ,  Chen-I Wu

Inventor： Chung-Hsuan Chen ,  Chen-I Wu

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/10 ,  H01J49/0454

Abstract: Methods and systems for ultrasound ionization mass spectrometry are provided. Analytes in a sample are ionized by subjecting them to ultrasound, facilitating their analysis by mass spectrometry. With these methods and systems, soft ionization of large analytes, including biological macromolecules and nanoparticles, can be achieved. Ionization efficiency can be improved by addition of chemicals such as, for example, organic solvents or acids to the sample.

Abstract translation: 提供了超声电离质谱法的方法和系统。 样品中的分析物通过对其进行超声波离子化，便于通过质谱法进行分析。 通过这些方法和系统，可以实现大分子的软电离，包括生物大分子和纳米颗粒。 通过向样品中加入化学物质，例如有机溶剂或酸，可以提高电离效率。

公开(公告)号：US07645987B2

公开(公告)日：2010-01-12

申请号：US11234051

申请日：2005-09-22

Applicant: Huan-Cheng Chang ,  Chung-Hsuan Chen

Inventor： Huan-Cheng Chang ,  Chung-Hsuan Chen

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/16 ,  H01J49/0454

Abstract: A method for producing gas phase molecules includes providing a sample of molecules, the sample being characterized by a charge distribution, and directing acoustic radiation at the sample of molecules to desorb at least some of the molecules from the sample such that the desorbed molecules have a charge distribution that is substantially the same as the charge distribution of the sample of molecules.

Abstract translation: 一种生产气相分子的方法包括提供分子样品，该样品的特征在于电荷分布，并引导分子样品上的声辐射以从样品解吸至少一些分子，使得解吸的分子具有 电荷分布基本上与分子样品的电荷分布相同。

公开(公告)号：US20080078928A1

公开(公告)日：2008-04-03

申请号：US11542568

申请日：2006-10-03

Applicant: Yi-Sheng Wang ,  Chung-Hsuan Chen ,  Shang-Ting Tsai ,  Chiu Wen Chen

Inventor： Yi-Sheng Wang ,  Chung-Hsuan Chen ,  Shang-Ting Tsai ,  Chiu Wen Chen

IPC: H01J49/40

CPC classification number: H01J49/40 ,  H01J49/0095

Abstract: A dual-polarity mass spectrometer includes an ion source, a negative ion mass analyzer, and a positive ion mass analyzer to measure both the negative and positive ion spectra of a sample material simultaneously. The ion source includes a sample surface on which the sample material is positioned, the sample material providing positive ions and negative ions when excited by a laser beam or an energetic particle stream. A first extraction electrode is connected to a voltage higher than the sample surface to attract the negative ions from the sample electrode. A second extraction electrode is connected to a voltage lower than the sample surface to attract the positive ions from the sample electrode. The negative and positive ions are analyzed simultaneously by the negative ion mass analyzer and the positive ion mass analyzer, respectively.

Abstract translation: 双极性质谱仪包括离子源，负离子质量分析仪和正离子质量分析仪，以同时测量样品材料的负离子和正离子光谱。 离子源包括其上放置样品材料的样品表面，当由激光束或能量粒子流激发时，样品材料提供正离子和负离子。 第一引出电极连接到高于样品表面的电压以吸引来自样品电极的负离子。 第二提取电极连接到低于样品表面的电压，以吸引来自样品电极的正离子。 负离子和正离子分别通过负离子质量分析仪和正离子质量分析仪同时分析。

公开(公告)号：US20070131871A1

公开(公告)日：2007-06-14

申请号：US11234051

申请日：2005-09-22

Applicant: Huan-Cheng Chang ,  Chung-Hsuan Chen

Inventor： Huan-Cheng Chang ,  Chung-Hsuan Chen

IPC: H01J27/00

CPC classification number: H01J49/16 ,  H01J49/0454

Abstract: A method for producing gas phase molecules includes providing a sample of molecules, the sample being characterized by a charge distribution, and directing acoustic radiation at the sample of molecules to desorb at least some of the molecules from the sample such that the desorbed molecules have a charge distribution that is substantially the same as the charge distribution of the sample of molecules.

Abstract translation: 一种生产气相分子的方法包括提供分子样品，该样品的特征在于电荷分布，并引导分子样品上的声辐射以从样品解吸至少一些分子，使得解吸的分子具有 电荷分布基本上与分子样品的电荷分布相同。