公开(公告)号：US20240079226A1

公开(公告)日：2024-03-07

申请号：US18268649

申请日：2021-12-21

Applicant: Atomic Energy Of Canada Limited / Énergie Atomique Du Canada Limitée

Inventor： Ankur Chaudhuri ,  Liqian Li ,  James Johnston ,  Martin-Lee Cusick

IPC: H01J49/40 ,  H01J49/00 ,  H01J49/16 ,  H01J49/24

CPC classification number: H01J49/408 ,  H01J49/0022 ,  H01J49/164 ,  H01J49/24

Abstract: An apparatus for and a method of analyzing a sample. A laser section may include a laser arranged to direct a laser beam in a first direction towards the sample. The laser beam ablating and ionizing at least a portion of the sample to generate ions. An ion source section may include a sample holder for holding the sample. At least one component is arranged to apply an electric field for extracting at least a portion of the ions to form an ion beam traveling in a second direction. A time-of-flight section may include a detector arranged to receive the ion beam.

公开(公告)号：US09947524B2

公开(公告)日：2018-04-17

申请号：US14727941

申请日：2015-06-02

Applicant: Micromass UK Limited

Inventor： Steven Derek Pringle ,  Michael Raymond Morris ,  Stephen Smith ,  Michael McCullagh

IPC: H01J49/16 ,  H01J49/00 ,  H01J49/10 ,  H01J49/04 ,  H01J49/06 ,  A61B17/32 ,  A61B17/3203 ,  A61B18/00 ,  A61B18/14 ,  A61B18/18

CPC classification number: H01J49/16 ,  A61B17/320068 ,  A61B17/3203 ,  A61B18/14 ,  A61B2018/00994 ,  A61B2018/1412 ,  A61B2018/1807 ,  A61B2218/008 ,  H01J49/0022 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0459 ,  H01J49/049 ,  H01J49/06 ,  H01J49/10

Abstract: A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analyzed by contacting the substrate with a diathermy knife. An electric current is applied to the diathermy knife such that the diathermy knife vaporizes a portion of the substrate. The vapor is aspirated via a sampling tube pumped by a venturi pump into a vacuum chamber of a mass spectrometer. Analyte molecules are aspirated into the vacuum chamber whereupon they impact a surface of the vacuum chamber and are ionized to form analyte ions which are then mass analyzed.

公开(公告)号：US09558924B2

公开(公告)日：2017-01-31

申请号：US14564746

申请日：2014-12-09

Applicant: MORPHO DETECTION, LLC

Inventor： Jack A. Syage

IPC: H01J49/40 ,  H01J49/04 ,  H01J49/00 ,  H01J49/24 ,  H01J49/16

CPC classification number: H01J49/24 ,  H01J49/0022 ,  H01J49/0031 ,  H01J49/0495 ,  H01J49/162 ,  H01J49/40

Abstract: A mass spectrometer system includes a pulsed ion source configured to generate ionized molecules and neutral molecules. The system also includes a first enclosure coupled in flow communication with the pulsed ion source. The first enclosure defines a first vacuum chamber and an ion inlet aperture. The system further includes a detector positioned within said first enclosure and a plurality of ion transmission devices positioned within the first vacuum chamber and aligned with the ion inlet aperture. The plurality of ion transmission devices is configured to channel and accelerate ionized molecules through a first transmission path such that the ionized molecules and the neutral molecules are physically separated in space and temporally separated.

Abstract translation: 质谱仪系统包括配置成产生电离分子和中性分子的脉冲离子源。 该系统还包括与脉冲离子源流动连通的第一外壳。 第一外壳限定第一真空室和离子入口孔。 该系统还包括位于所述第一外壳内的检测器和位于第一真空室内并与离子入口孔对准的多个离子传递装置。 多个离子传输装置被配置为通过第一传输路径引导和加速电离分子，使得离子化分子和中性分子在空间中物理分离并在时间上分离。

公开(公告)号：US09443705B2

公开(公告)日：2016-09-13

申请号：US14851401

申请日：2015-09-11

Applicant: Korea Basic Science Institute

Inventor： Seung Yong Kim ,  Mo Yang ,  Hyun Sik Kim

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/42

CPC classification number: H01J49/0022 ,  H01J49/022 ,  H01J49/427 ,  H03F3/19 ,  H03F2200/451

Abstract: Provided is a multiple frequency Radio Frequency (RF) amplifier. The multiple frequency RF amplifier includes a waveform generation circuit configured to generate an RF signal by amplitude and frequency-modulating a reference waveform signal, a drive amplifier circuit configured to drive-amplify the RF signal, and a power amplifier circuit configured to generate a multiple frequency RF voltage signal through a power amplification of the drive-amplified RF signal and output the multiple frequency RF voltage signal to an ion trap for a mass spectrometry.

Abstract translation: 提供了一种多频射频（RF）放大器。 多频RF放大器包括：波形发生电路，被配置为通过幅度产生RF信号并对参考波形信号进行频率调制;驱动放大器电路，被配置为驱动放大RF信号;以及功率放大器电路，被配置为产生多个 通过驱动放大的RF信号的功率放大来输出频率RF电压信号，并将多频RF电压信号输出到用于质谱的离子阱。

公开(公告)号：US09406489B2

公开(公告)日：2016-08-02

申请号：US14496126

申请日：2014-09-25

Applicant: The Boeing Company

Inventor： Cheryl E. Bick ,  Joe M. Baratto

IPC: H01J49/00 ,  H01J49/26 ,  G01N30/00

CPC classification number: H01J49/0031 ,  G01N30/00 ,  G01N30/7206 ,  H01J49/0022 ,  H01J49/26

Abstract: A method and apparatus for investigating a chemical-based event inside a vehicle without significant delay. A number of samples of air are collected at a number of locations inside the vehicle in response to a detection of the chemical-based event inside the vehicle. A number of chemical profiles for the number of samples are generated on-site using a portable chemical profiling device. A probable cause of the chemical-based event is identified using at least one of the number of chemical profiles.

Abstract translation: 一种用于在没有显着延迟的情况下调查车辆内基于化学物质的事件的方法和装置。 响应于车辆内部基于化学物质的事件的检测，在车辆内的多个位置处收集多个空气样本。 使用便携式化学分析装置，在现场生成多个样品数量的化学分布。 基于化学物质事件的可能原因是使用化学特性数量中的至少一个来确定的。

公开(公告)号：US20160163530A1

公开(公告)日：2016-06-09

申请号：US14564746

申请日：2014-12-09

Applicant: MORPHO DETECTION, LLC

Inventor： Jack A. Syage

IPC: H01J49/40 ,  H01J49/04

CPC classification number: H01J49/24 ,  H01J49/0022 ,  H01J49/0031 ,  H01J49/0495 ,  H01J49/162 ,  H01J49/40

Abstract: A mass spectrometer system includes a pulsed ion source configured to generate ionized molecules and neutral molecules. The system also includes a first enclosure coupled in flow communication with the pulsed ion source. The first enclosure defines a first vacuum chamber and an ion inlet aperture. The system further includes a detector positioned within said first enclosure and a plurality of ion transmission devices positioned within the first vacuum chamber and aligned with the ion inlet aperture. The plurality of ion transmission devices is configured to channel and accelerate ionized molecules through a first transmission path such that the ionized molecules and the neutral molecules are physically separated in space and temporally separated.

Abstract translation: 质谱仪系统包括配置成产生电离分子和中性分子的脉冲离子源。 该系统还包括与脉冲离子源流动连通的第一外壳。 第一外壳限定第一真空室和离子入口孔。 该系统还包括位于所述第一外壳内的检测器和位于第一真空室内并与离子入口孔对准的多个离子传递装置。 多个离子传输装置被配置为通过第一传输路径引导和加速电离分子，使得离子化分子和中性分子在空间中物理分离并在时间上分离。

公开(公告)号：US09093253B2

公开(公告)日：2015-07-28

申请号：US13732218

申请日：2012-12-31

Applicant: 908 Devices Inc.

Inventor： Andrew J. Bartfay-Szabo ,  Christopher D. Brown ,  Michael Jobin ,  Kevin J. Knopp ,  Evgeny Krylov ,  Scott Miller

IPC: H01J49/26 ,  H01J49/00 ,  H01J49/24

CPC classification number: H01J49/0022 ,  H01J49/24

Abstract: Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed.

Abstract translation: 公开了使用质谱法测量样品信息的质谱仪和方法。

公开(公告)号：US20150108341A1

公开(公告)日：2015-04-23

申请号：US14396228

申请日：2013-04-22

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Tsukasa Shishika ,  Hidetoshi Morokuma ,  Masuyoshi Yamada ,  Hiroyuki Inoue

IPC: H01J49/00 ,  G08B21/24 ,  G06Q10/00 ,  H01J49/26 ,  H01J49/02

CPC classification number: H01J49/0022 ,  G01N33/493 ,  G06Q10/20 ,  G08B21/24 ,  H01J49/0027 ,  H01J49/025 ,  H01J49/26

Abstract: A portable mass spectrometer that is carried to a sampling site to conduct analysis incorporates measures against erroneous operation. To prevent erroneous operation, when a measurement sample cannot be accurately analyzed because of contamination in the measurement sample, a criterion for aborting the sample measurement is provided and mass spectrometer control maintenance is performed. When urine is measured, the mass spectrometer detects the substances contained in the urine and automatically determines whether the sample is urine. The mass spectrometer then automatically selects an analysis condition specific to urine samples to make a measurement. Also with respect to sweat and saliva, the mass spectrometer similarly selects a specific analysis condition. The mass spectrometer automatically determines whether a sample, which is an internal standard sample contained in a sample case, is being measured on a measurement-by-measurement basis and automatically displays any error, interrupts the measurement, or carries out other processing.

Abstract translation: 携带到采样点进行分析的便携式质谱仪包括防止错误操作的措施。 为了防止错误的操作，由于测量样品中的污染导致测量样品不能被精确地分析，因此提供了用于中止样品测量的标准，并进行质谱仪控制维护。 当测量尿液时，质谱仪检测尿液中含有的物质，并自动确定样品是否为尿液。 然后质谱仪自动选择特定于尿样的分析条件进行测量。 此外，关于汗液和唾液，质谱仪也类似地选择特定的分析条件。 质谱仪自动确定是否在逐个测量的基础上测量作为样品箱中包含的内标样品的样品，并自动显示任何错误，中断测量或执行其他处理。

公开(公告)号：US08927943B2

公开(公告)日：2015-01-06

申请号：US14125491

申请日：2011-12-16

Applicant: Mo Yang ,  Seung Yong Kim ,  Hyun Sik Kim

Inventor： Mo Yang ,  Seung Yong Kim ,  Hyun Sik Kim

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/08 ,  H01J49/42

CPC classification number: H01J49/10 ,  H01J49/0022 ,  H01J49/08 ,  H01J49/424

Abstract: The present invention relates to a device for obtaining the ion source of a mass spectrometer using an ultraviolet diode and a CEM module, having the purpose of inducing initial electron emission using a CEM module and by radiating ultraviolet photons emitted from the ultraviolet diode to the entrance of the CEM module to obtain a large amount of amplified electron beams from the exit and to produce electron beams the emission times of which are accurately controlled at low temperature and at low power. The present invention is characterized by a device for obtaining the ion source of a mass spectrometer using an ultraviolet diode and a CEM module, the device consisting essentially of: an ultraviolet diode emitting ultraviolet rays by means of supplied power; an electron multiplier inducing and amplifying the initial electron emission of ultraviolet photons from the ultraviolet diode and obtaining a large amount of electron beams from the exit; an electron condenser lens condensing the electron beams amplified by the electron multiplier; an ion trap mass separator ionizing gas sample molecules by the electron beams injected through the electron xondensing lens; and an ion detector detecting ions separated from the ion trap mass separator by mass spectrum, wherein the electron multiplier is a CEM module.

Abstract translation: 本发明涉及一种使用紫外二极管和CEM模块获得质谱仪的离子源的装置，其目的是使用CEM模块诱发初始电子发射，并且将从紫外线二极管发射的紫外光子辐射到入口 的CEM模块，以从出口获得大量的放大电子束，并产生其发射时间在低温和低功率下精确控制的电子束。 本发明的特征在于一种用于使用紫外二极管和CEM模块获得质谱仪的离子源的装置，该装置基本上由以下部分组成：紫外线二极管，通过供电供给紫外线; 电子倍增器，从紫外二极管感应并放大紫外光子的初始电子发射，并从出口获得大量的电子束; 电子聚光透镜，聚合由电子倍增器放大的电子束; 离子阱质量分离器通过电子透射透镜注入的电子束离子化气体样品分子; 以及离子检测器，通过质谱检测离子阱质量分离器分离的离子，其中电子倍增器是CEM模块。

公开(公告)号：US08829425B1

公开(公告)日：2014-09-09

申请号：US14228379

申请日：2014-03-28

Applicant: William (Wei) Yang ,  Charlie Zhang ,  Ming Chai ,  Yongqiang Qiu ,  Doneil Hoekman

Inventor： William (Wei) Yang ,  Charlie Zhang ,  Ming Chai ,  Yongqiang Qiu ,  Doneil Hoekman

IPC: H01J49/26 ,  H01J49/10 ,  B01D59/44 ,  H01J49/00 ,  H01J49/24

CPC classification number: H01J49/24 ,  H01J49/0022

Abstract: A portable or handheld mass spectrometer making use of a cryogenic pumping, ion pumping or getter pumping system. The portable mass spectrometer contains a cryopump, ion pump, or getter pump, and operates in conjunction with a fixed docking station. The docking station contains a backing pump to bring the mass spectrometer manifold down to operating pressure prior to being placed into portable operation using the cryopump, ion pump, or getter pump. The individual pumps may be operated either separately or simultaneously. This configuration permits the portable mass spectrometer module to be small, lightweight and rugged, and yet be easily and quickly recharged and regenerated for use in either a field or laboratory environment.

Abstract translation: 使用便携式或手持式质谱仪，利用低温泵送，离子泵送或吸气剂泵送系统。 便携式质谱仪包含一个低温泵，离子泵或吸气泵，并与一个固定的对接站配合使用。 对接站包含背衬泵，以便在使用低温泵，离子泵或吸气泵进入便携式操作之前将质谱仪歧管降至工作压力。 单独的泵可以单独地或同时地操作。 该配置允许便携式质谱模块小型，重量轻且坚固，并且容易且快速地再充电和再生以用于现场或实验室环境中。