公开(公告)号：US08109933B2

公开(公告)日：2012-02-07

申请号：US12062384

申请日：2008-04-03

申请人： Csaba Truckai ,  Robert Luzzi ,  John H. Shadduck

发明人： Csaba Truckai ,  Robert Luzzi ,  John H. Shadduck

IPC分类号： A61B17/58 ,  A61B17/60 ,  A61F2/00

CPC分类号： A61B17/8836 ,  A61B17/8822 ,  A61B2017/00022

摘要： Systems and methods for delivering bone cement into a bone can include a handle body defining a flow path, a thermal emitter in the handle body to apply energy to bone cement passing through the flow path, a source of bone cement and an injection cannula. The cannula can be in communication with the flow path such that inserting the cannula into a bone can allow a flow of bone cement therethrough to an opening at a distal end of the cannula. Other systems and methods for delivering bone cement into a bone can include an injector body with a handle portion, and a cannula, a bone cement container, a low pressure drive mechanism configured to effect a flow of bone cement from said container to the injector body and a high pressure drive mechanism configured to effect a flow of bone cement through the injector body into the bone.

摘要翻译： 用于将骨水泥输送到骨中的系统和方法可以包括限定流路的手柄主体，手柄主体中的热发射器，以将能量施加到通过流路的骨水泥，骨水泥源和注射套管。 套管可以与流动路径连通，使得将套管插入骨头可以允许骨水泥通过其穿过套管远端的开口。 用于将骨水泥输送到骨头中的其它系统和方法可以包括具有手柄部分的注射器主体和套管，骨水泥容器，低压驱动机构，其被配置为实现骨粘固剂从所述容器流到喷射器主体 以及高压驱动机构，其构造成使得骨水泥通过所述注射器主体流入所述骨中。

公开(公告)号：US20110308530A1

公开(公告)日：2011-12-22

申请号：US13113946

申请日：2011-05-23

申请人： Edward M. Gillis ,  John H. Shadduck ,  Csaba Truckai ,  Andrew Poutiatine ,  Paul J. Buscemi

发明人： Edward M. Gillis ,  John H. Shadduck ,  Csaba Truckai ,  Andrew Poutiatine ,  Paul J. Buscemi

IPC分类号： A61F5/56

CPC分类号： A61F2/00 ,  A61F5/566 ,  A61F2210/0004

摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body has first and second end portions and a medial portion. The implant body also includes a coupler configured to couple the end portions to one another such that the medial portion encircles targeted tissue. Methods of using such systems are also provided.

摘要翻译： 一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。 在一些实施例中，植入体具有第一和第二端部和中间部分。 植入体还包括耦合器，其被配置为将端部部分彼此耦合，使得内侧部分围绕目标组织。 还提供了使用这种系统的方法。

公开(公告)号：US20110054482A1

公开(公告)日：2011-03-03

申请号：US12942936

申请日：2010-11-09

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61B17/58

CPC分类号： A61B17/7095 ,  A61B17/68 ,  A61B17/686 ,  A61F2/28 ,  A61F2/30965 ,  A61F2/3662 ,  A61F2/44 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30006 ,  A61F2002/30011 ,  A61F2002/30023 ,  A61F2002/30069 ,  A61F2002/3008 ,  A61F2002/30092 ,  A61F2002/30224 ,  A61F2002/30583 ,  A61F2002/30677 ,  A61F2002/3085 ,  A61F2002/30957 ,  A61F2002/30971 ,  A61F2210/0014 ,  A61F2210/0085 ,  A61F2230/0069 ,  A61F2250/0015 ,  A61F2250/0018 ,  A61F2250/0023 ,  A61F2250/0034 ,  A61F2250/0098 ,  A61F2310/00353 ,  A61L27/50 ,  A61L2430/02

摘要： A system and method for treating bone abnormalities including vertebral compression fractures and the like. In one vertebroplasty method, a fill material is injected under high pressures into cancellous bone wherein the fill material includes a flowable bone cement component and an elastomeric polymer component that is carried therein. The elastomer component can further carry microscale or mesoscale reticulated elements. Under suitable injection pressures, the elastomeric component ultimately migrates within the flowable material to alter the apparent viscosity across the plume of fill material to accomplish multiple functions. For example, the differential in apparent viscosity across the fill material creates a broad load-distributing layer within cancellous bone for applying retraction forces to cortical bone endplates. The differential in apparent viscosity also transitions into a flow impermeable layer at the interface of cancellous bone and the flowable material to prevent extravasasion of the flowable bone cement component.

摘要翻译： 一种用于治疗包括椎骨压缩性骨折等骨骼异常的系统和方法。 在一种椎体成形术方法中，将填充材料在高压下注射到松质骨中，其中填充材料包括可流动的骨粘固剂组分和其中携带的弹性体聚合物组分。 弹性体组分可以进一步携带微米或中等尺寸的网状元件。 在合适的注射压力下，弹性体组分最终在可流动材料内迁移以改变穿过填充材料的羽流的表观粘度，以实现多种功能。 例如，穿过填充材料的表观粘度的差异在松质骨内产生宽的载荷分布层，用于将回缩力施加到皮质骨终板。 表观粘度的差异也转变为松质骨和可流动材料的界面处的不透水层，以防止可流动的骨水泥组分的外渗。

公开(公告)号：US07621952B2

公开(公告)日：2009-11-24

申请号：US11146893

申请日：2005-06-07

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61F2/44

CPC分类号： A61B17/8858 ,  A61B17/70 ,  A61B2017/00004 ,  A61F2/44 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2002/30062 ,  A61F2002/30289 ,  A61F2002/30579 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61F2230/0091

摘要： An orthopedic implant comprising a deformable, expandable implant body configured for treating abnormalities in bones, such as compression fractures of vertebra, necrosis of femurs and the like. An exemplary implant body comprises a small cross-section threaded element that is introduced into a bone region and thereafter is expanded into a larger cross-section, monolithic assembly to provide a bone support. In one embodiment, the implant body is at least partly fabricated of a magnesium alloy that is biodegradable to allow for later tissue ingrowth.

摘要翻译： 一种矫形植入物，包括可变形的，可扩张的植入体，其被配置用于治疗骨骼的异常，例如椎骨的压缩性骨折，股骨的坏死等。 示例性植入物主体包括被引入到骨区域中的小横截面的螺纹元件，然后被扩展成更大的横截面的整体式组件以提供骨支撑。 在一个实施例中，植入体至少部分地由可生物降解的镁合金制成，以允许稍后的组织向内生长。

公开(公告)号：US20080255570A1

公开(公告)日：2008-10-16

申请号：US12062345

申请日：2008-04-03

申请人： Csaba Truckai ,  Robert Luzzi ,  John H. Shadduck

发明人： Csaba Truckai ,  Robert Luzzi ,  John H. Shadduck

IPC分类号： A61B17/58 ,  A61B18/04

CPC分类号： A61B17/8836 ,  A61B17/8822 ,  A61B2017/00022

摘要： Systems and methods for delivering bone cement into a bone can include a handle body defining a flow path, a thermal emitter in the handle body to apply energy to bone cement passing through the flow path, a source of bone cement and an injection cannula. The cannula can be in communication with the flow path such that inserting the cannula into a bone can allow a flow of bone cement therethrough to an opening at a distal end of the cannula. Other systems and methods for delivering bone cement into a bone can include an injector body with a handle portion, and a cannula, a bone cement container, a low pressure drive mechanism configured to effect a flow of bone cement from said container to the injector body and a high pressure drive mechanism configured to effect a flow of bone cement through the injector body into the bone.

公开(公告)号：US20080132899A1

公开(公告)日：2008-06-05

申请号：US11130837

申请日：2005-05-17

申请人： John H. Shadduck ,  Csaba Truckai

发明人： John H. Shadduck ,  Csaba Truckai

IPC分类号： A61B17/58

CPC分类号： A61L27/12 ,  A61B17/7095 ,  A61B17/8836 ,  A61B90/39 ,  A61L27/04 ,  A61L27/16 ,  A61L27/425 ,  A61L27/446 ,  A61L27/50 ,  A61L2430/02 ,  C08L33/12

摘要： This invention relates to implantable bone fill materials, systems and methods of treating bone abnormalities such as compression fractures of vertebrae, bone necrosis, bone tumors, cysts and the like. In an exemplary embodiment, the bone abnormality is accessed and a space is created by bone removal or compaction. An exemplary implant of the invention has a substantially fluid impermeable surface portion and an interior portion including an in-situ hardenable bone cement. The method of the invention includes applying energy to the fill material to accelerate polymerization and hardening of the material for supporting the bone.

摘要翻译： 本发明涉及可植入骨填充材料，治疗骨骼异常的系统和方法，例如椎骨压缩性骨折，骨坏死，骨肿瘤，囊肿等。 在一个示例性实施例中，访问骨异常并且通过骨移除或压实产生空间。 本发明的示例性植入物具有基本上不透流体的表面部分和包括原位可硬化骨粘固剂的内部部分。 本发明的方法包括向填充材料施加能量以加速用于支撑骨的材料的聚合和硬化。

公开(公告)号：US20070233148A1

公开(公告)日：2007-10-04

申请号：US11469769

申请日：2006-09-01

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61F2/00

CPC分类号： A61B17/8836 ,  A61B17/8811 ,  A61B17/8822 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2090/064 ,  A61F2/44 ,  A61F2/4601

摘要： The present invention relates in certain embodiments to systems and methods for use in osteoplasty procedures, such as vertebral compression fractures. One system for injecting a bone fill material includes a container carrying a bone fill material. An elongated introducer configured for introduction into a vertebral body is coupleable to the container to allow a flow of the bone fill material therethrough. A cooling mechanism is coupled to the container and is configured to cool the bone fill material in the container to extend the working time of the bone fill material. One method for treating a vertebra includes providing a bone fill material, cooling the bone fill material to stall the polymerization of the bone fill material, heating the bone fill material to accelerate the polymerization of the bone fill material and delivering the bone fill material into a vertebral body.

摘要翻译： 本发明在某些实施例中涉及用于骨成形术程序（例如椎体压缩性骨折）的系统和方法。 一种用于注射骨填充材料的系统包括携带骨填充材料的容器。 构造成用于引入椎体的细长导引器可连接到容器以允许骨填充材料流过其中。 冷却机构联接到容器并且被配置为冷却容器中的骨填充材料以延长骨填充材料的工作时间。 治疗椎骨的一种方法包括提供骨填充材料，冷却骨填充材料以阻止骨填充材料的聚合，加热骨填充材料以加速骨填充材料的聚合并将骨填充材料输送到 椎体。

公开(公告)号：US07220261B2

公开(公告)日：2007-05-22

申请号：US11065180

申请日：2005-02-23

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61B18/18

CPC分类号： A61B17/22004 ,  A61B18/042 ,  A61B2017/22008 ,  A61B2018/1213

摘要： A medical instrument coupled to first and second energy means and a computer controller for the controlled volumetric removal of thin tissue layers. The system provides a source for introducing a gas to controllably form and capture transient gas volumes in a microchannel structure at the working surface of the instrument that interfaces with a targeted tissue site. Each of the microchannel features of the working surface carries an electrode element coupled to the electrical source. The energy may be applied to the targeted site in either of two modes of operation, depending in part on voltage and repetition rate of energy delivery. In one mode of energy application, electrical potential is selected to cause an intense electrical arc across the transient ionized gas volumes to cause an energy-tissue interaction characterized by tissue vaporization. In another preferred mode of energy delivery, the system applies selected levels of energy to the targeted site by means of an energetic plasma at the instrument working surface to cause molecular volatilization of surface macromolecules thus resulting in material removal. Both modes of operation limit collateral thermal damage to tissue volumes adjacent to the targeted site. Another preferred embodiment provides and an ultrasound source or other vibrational source coupled to the working end to cause cavitation in fluid about the working end.

摘要翻译： 耦合到第一和第二能量装置的医疗器械和用于受控体积移除薄组织层的计算机控制器。 该系统提供用于引入气体的源，以可控地形成并捕获与目标组织部位相接触的仪器工作表面处的微通道结构中的瞬态气体体积。 工作表面的每个微通道特征带有耦合到电源的电极元件。 能量可以以两种操作模式中的任一种施加到目标位置，部分取决于能量传递的电压和重复率。 在一种能量应用模式中，选择电势以在瞬态电离气体体积上引起强烈的电弧以引起以组织蒸发为特征的能量 - 组织相互作用。 在另一种优选的能量输送模式中，系统通过仪器工作表面上的能量等离子体将选择的能量施加到目标部位，从而导致表面大分子的分子挥发，从而导致材料去除。 两种操作模式都限制了与目标部位相邻的组织体积的附带热损伤。 另一个优选实施例提供了耦合到工作端的超声源或其他振动源，以在工作端周围引起流体中的空化。

公开(公告)号：US07070597B2

公开(公告)日：2006-07-04

申请号：US10643787

申请日：2003-08-19

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61B18/14

CPC分类号： A61B18/1442 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00148 ,  A61B2018/0063

摘要： An electrosurgical working end for automatic modulation of active Rf density in a targeted tissue volume. The working end of the probe of the present invention defines a tissue-engagement surface of an elastomeric material with conductive elements that extend therethrough. In one embodiment, the expansion of the elastomeric material can de-couple the conductive elements from an interior electrode based temperature to modulate current flow. In another embodiment, the elastomeric material can couple and de-couple the conductive elements from an interior electrode based engagement pressure to modulate current flow.

摘要翻译： 用于自动调节靶组织体积中的活性Rf密度的电外科工作端。 本发明的探针的工作端限定弹性体材料的组织接合表面，其中导电元件延伸穿过其中。 在一个实施例中，弹性体材料的膨胀可以将导电元件从基于内部电极的温度解耦，以调制电流。 在另一个实施例中，弹性体材料可以将导电元件从内部基于电极的接合压力耦合和解耦，以调制电流。

公开(公告)号：US06958061B2

公开(公告)日：2005-10-25

申请号：US10456149

申请日：2003-06-05

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61B17/12 ,  A61B18/18

CPC分类号： A61B17/12022 ,  A61B17/12045 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/12136 ,  A61B17/12168 ,  A61B17/12181 ,  A61B17/12186 ,  A61B2017/12068

摘要： A vaso-occlusive system comprising a catheter with a working end that carries a fluid media for introduction into an aneurysm. The fluid media carries a volume of microspheres, wherein each microsphere has a sacrificial shell or coating that surrounds an interior core portion of the microsphere. The core portions of the microspheres comprise either a first or second polymerizing composition, wherein interaction of such binary compositions will cause polymerization of the media into a gel or solid media that will occlude the aneurysm. An energy delivery means is provided within the catheter working end to cause removal of the sacrificial coatings of the volume of microspheres to thereby induce the polymerization process.

摘要翻译： 一种血管闭塞系统，包括具有工作端的导管，所述工作端承载用于引入动脉瘤的流体介质。 流体介质携带一定体积的微球体，其中每个微球体具有围绕微球体的内部核心部分的牺牲壳体或涂层。 微球的核心部分包括第一或第二聚合组合物，其中这种二元组合物的相互作用将引起培养基聚合成凝胶或固体培养基，其将闭塞动脉瘤。 在导管工作端内提供能量输送装置，以便移除体积的微球的牺牲涂层，从而引起聚合过程。