公开(公告)号：US10759874B2

公开(公告)日：2020-09-01

申请号：US15550109

申请日：2016-03-08

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr

IPC: C08B13/00 ,  C08B11/20 ,  A61K9/14 ,  A23P10/30 ,  A23L33/125 ,  A61K9/10 ,  A61K9/48 ,  A61K47/38

Abstract: An esterified cellulose comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.03 to 0.38, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 20° C.

公开(公告)号：US20200255547A1

公开(公告)日：2020-08-13

申请号：US16651159

申请日：2018-07-26

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Robert Appell ,  Jorg Theuerkauf ,  Matthias S Ober ,  Matthias Knarr

IPC: C08B11/08

Abstract: A process for preparing cellulose ether includes (a) alkylation and etherification of cellulose to form an initial cellulose ether, (b) washing and filtering of the initial cellulose ether; (c) optionally granulating the cellulose ether; (d) compounding the cellulose ether to form a dough; (e) optionally disposing the cellulose ether into a buffer tank; and (f) drying the cellulose ether dough to obtain a final cellulose ether with a lower viscosity than the initial cellulose ether; where the process is characterized by introducing an aqueous catalyst and a peroxy-containing oxidizer to the cellulose ether during at least one of steps (c)-(f), introducing an aqueous enhancer during at least one of steps (c)-(e) and wherein the process is free of drying an isolating cellulose ether after (a) and before drying the final cellulose ether.

公开(公告)号：US10272156B2

公开(公告)日：2019-04-30

申请号：US15292914

申请日：2016-10-13

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Nicholas S. Grasman ,  Mark J. Hall ,  Steven J. Guillaudeu ,  Robert L. Schmitt ,  Matthias Knarr

IPC: A61K9/10 ,  A61K47/38 ,  A61K9/16 ,  A61K9/28 ,  C08L1/28 ,  A61K9/14 ,  A61K31/343 ,  A61K31/4166

Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period.The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying.Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.

公开(公告)号：US20190075811A1

公开(公告)日：2019-03-14

申请号：US16083179

申请日：2017-03-27

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Alexandra Hild ,  Matthias Knarr ,  Britta Huebner-Keese ,  Roja Ergun

IPC: A23D9/007 ,  A23D9/02 ,  A23L29/262 ,  A23L29/00

Abstract: Provided is a method of making an ethylcellulose oleogel comprising cooling a mixture of ethylcellulose polymer and oil from 100° C. to 35° C. at a rate of 0.6° C./min or slower.

公开(公告)号：US20180282526A1

公开(公告)日：2018-10-04

申请号：US15764498

申请日：2016-09-29

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr ,  Meinolf Brackhagen

IPC: C08L1/32 ,  C08B13/00 ,  A61K47/38 ,  A61K9/48 ,  A23L33/10 ,  A23P10/30 ,  B29C41/14

Abstract: An aqueous composition which is useful for producing coatings and capsule shells comprises a) dispersed particles of an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent hydrocarbon group and A is hydrogen or a cation, and the total degree of ester substitution is more than 0.70, and b) an esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, wherein I) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, II) the total degree of ester substitution is from 0.03 to 0.70, and III) the esterified cellulose ether b) has a solubility in water of at least 2.0 weight percent at 2° C.

公开(公告)号：US20160120990A1

公开(公告)日：2016-05-05

申请号：US14888119

申请日：2014-07-16

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Jaime L. Curtis-Fisk ,  Susan L. Jordan ,  True L. Rogers ,  Robert B. Appell ,  Matthias Knarr ,  Roland Adden

IPC: A61K47/38 ,  A61K31/167 ,  A61K9/00 ,  A61K47/02

CPC classification number: A61K47/38 ,  A61K9/0043 ,  A61K9/08 ,  A61K31/167 ,  A61K47/02

Abstract: A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a hydroxyalkyl methylcellulose and a liquid diluent, wherein the hydroxyalkyl methylcellulose has a DS of from 1.6 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, and at least 55 weight percent of the liquid diluent is water. When the composition comprises additionally a physiologically active agent, the composition may be used for transmucosal administration of the physiologically active agent to an individual.

Abstract translation: 设计用于粘膜的组合物包括张力调节剂，羟烷基甲基纤维素和液体稀释剂，其中羟烷基甲基纤维素的DS为1.6至2.7，MS为0.40至1.30，其中DS为 甲氧基和MS的取代是羟基烷氧基的摩尔取代，至少55重量％的液体稀释剂是水。 当该组合物另外包含生理活性剂时，该组合物可以用于生理活性剂向个体的经粘膜施用。

公开(公告)号：US20160015058A1

公开(公告)日：2016-01-21

申请号：US14771932

申请日：2014-04-08

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Puspendu Deo ,  Roland Adden ,  Matthias Knarr ,  Robert L. Sammler ,  Kathryn Brown

IPC: A23L1/0534 ,  A23L1/308 ,  A61K31/717 ,  A23L1/29

CPC classification number: A23L33/24 ,  A23L29/262 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/717

Abstract: An aqueous solution comprising (a) one or more mono-, di- and/or oligosaccharides and (b) a methylcellulose, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, is produced by i) mixing the methylcellulose with an aqueous liquid comprising one or more mono-, di- and/or oligosaccharides at a shear rate of at least 1000 s−1 or ii) mixing one or more mono-, di- and/or oligosaccharides with the methylcellulose and/or an aqueous liquid before, simultaneously with or after mixing the methylcellulose with the aqueous liquid at a shear rate of at least 1000 s−1.

Abstract translation: 一种水溶液，其包含（a）一种或多种单糖，二糖和/或寡糖和（b）甲基纤维素，其中所述甲基纤维素具有通过1-4键连接的脱水葡萄糖单元，其中脱水葡萄糖单元的羟基被甲基取代， s23 / s26为0.36以下，通过i）以至少1000s -1的剪切速率将甲基纤维素与包含一种或多种单糖，二糖和/或寡糖的水性液体混合，或ii）将一 或更多的单 - ，二 - 和/或寡糖与甲基纤维素和/或水性液体在混合甲基纤维素与水性液体之前，同时或之后以至少1000s -1的剪切速率混合。

公开(公告)号：US20150320869A1

公开(公告)日：2015-11-12

申请号：US14804489

申请日：2015-07-21

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Robert L. Schmitt ,  Matthias Knarr

IPC: A61K47/38 ,  A61K9/50

CPC classification number: A61K47/38 ,  A61K9/146 ,  A61K9/2866 ,  A61K9/5047 ,  A61K9/5089

Abstract: A liquid composition which comprises an organic liquid diluent and at least one hydroxypropyl methylcellulose having 28 to 30 weight percent of methoxyl groups, 7 to 12 weight percent of hydroxypropoxyl groups and a sum of methoxyl groups and hydroxypropoxyl groups of from 38.5 to 42 weight percent is stable over an extended time period.The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one hydroxypropyl methylcellulose by spray-drying.Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one hydroxypropyl methylcellulose described above and optionally one or more adjuvants.

Abstract translation: 一种液体组合物，其包含有机液体稀释剂和至少一种羟乙基甲基纤维素，其具有甲氧基28-30重量％，羟丙氧基7-12重量％，甲氧基和羟基丙氧基之和为38.5至42重量％ 在延长的时间内稳定。 液体组合物可用于通过喷雾干燥制备包含至少一种羟丙基甲基纤维素中的至少一种活性成分的固体分散体。 或者，可以通过共混和挤出至少一种活性成分，至少一种上述羟丙基甲基纤维素和任选的一种或多种佐剂来制备固体分散体。

公开(公告)号：US20220056157A1

公开(公告)日：2022-02-24

申请号：US17394458

申请日：2021-08-05

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Oliver Petermann ,  Matthias Knarr ,  Meinolf Brackhagen ,  Matthias Sprehe

IPC: C08B11/20 ,  C08B13/00 ,  A61K9/14 ,  C08L1/26

Abstract: A process for fractionating an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, comprises the steps of a) blending the esterified cellulose ether comprising groups of the formula —C(O)—R—COOH with an aqueous liquid and setting the temperature of the resulting blend to less than 10° C. to dissolve a portion of the esterified cellulose ether in the aqueous liquid, b) separating the non-dissolved portion of the esterified cellulose ether from the remainder of the blend, and c) recovering or disposing of the esterified cellulose ether that is dissolved in the aqueous liquid.

公开(公告)号：US11142633B2

公开(公告)日：2021-10-12

申请号：US15764498

申请日：2016-09-29

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr ,  Meinolf Brackhagen

IPC: C08L1/32 ,  A23L33/10 ,  A61K9/48 ,  A61K47/38 ,  A23P10/30 ,  B29C41/14 ,  C08B13/00 ,  C08B1/00 ,  B29K1/00 ,  B29L31/00

Abstract: An aqueous composition which is useful for producing coatings and capsule shells comprises a) dispersed particles of an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent hydrocarbon group and A is hydrogen or a cation, and the total degree of ester substitution is more than 0.70, and b) an esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, wherein I) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, II) the total degree of ester substitution is from 0.03 to 0.70, and III) the esterified cellulose ether b) has a solubility in water of at least 2.0 weight percent at 2° C.