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    CD40 splice variants, compositions for making and methods of using the same
    22.
    发明申请
    CD40 splice variants, compositions for making and methods of using the same 审中-公开
    CD40拼接变体，用于制备的组合物及其使用方法

    公开(公告)号：US20050272050A1

    公开(公告)日：2005-12-08

    申请号：US10924074

    申请日：2004-08-23

    申请人： Liat Mintz ,  Jeanne Bernstein ,  Dani Eshel ,  Amir Toporik ,  Aviva Chen

    发明人： Liat Mintz ,  Jeanne Bernstein ,  Dani Eshel ,  Amir Toporik ,  Aviva Chen

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C07K14/705 ,  C07K14/74 ,  C07K16/28 ,  C12N15/12 ,  C12Q1/68

    CPC分类号： C07K16/2878 ,  A61K48/00 ,  C07K14/70578 ,  C12N2799/026

    摘要： Provided are substantially pure CD40 splice variants that include altered internal sequences and unique tail sequences relative to previously described CD40 protein sequences. Also provided are fragments of the CD40 splice variants comprising at least 10 amino acids including at least 4 amino acids of the unique tail sequence; the unique tail sequences, and homologues thereof having at least 10 amino acids and 90% identity and antibodies which bind to an epitope on such proteins are disclosed. Pharmaceutical compositions comprising the protein, antibodies, isolated nucleic acid molecule that encode such proteins and pharmaceutical composition comprising such nucleic acid molecules are also disclosed. The present invention additionally relates to recombinant expression vectors that include the nucleic acid molecules and host cells which comprise such recombinant expression vectors are disclosed. In vitro methods of detecting in a sample the presence and/or quantity of such proteins or transcript which encodes such proteins are disclosed as are kits and reagents for performing the methods. Methods of modulating CD40-CD154 interactions in an individual are disclosed.

    摘要翻译： 提供基本上纯的CD40剪接变体，其包括相对于先前描述的CD40蛋白序列的改变的内部序列和唯一的尾部序列。 还提供了CD40剪接变体的片段，其包含至少10个氨基酸，包括唯一尾部序列的至少4个氨基酸; 公开了具有至少10个氨基酸和90％同一性的独特的尾部序列及其同源物，并且与这些蛋白质上的表位结合的抗体。 还公开了包含蛋白质，抗体，编码这种蛋白质的分离的核酸分子和包含此类核酸分子的药物组合物的药物组合物。 本发明还涉及包含核酸分子和包含这种重组表达载体的宿主细胞的重组表达载体。 在样本中检测体外的方法，公开了编码这种蛋白质的这些蛋白质或转录物的存在和/或数量，作为用于进行该方法的试剂盒和试剂。 公开了调节个体中CD40-CD154相互作用的方法。