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1.发明申请公开(公告)号：US20140037549A1
公开(公告)日：2014-02-06
申请号：US13985468
申请日：2012-02-12
申请人： Akiva Pinchas , Sarit Edelheit-Flohr , Lily Bazak , Zurit Levine , Amir Toporik , Ofer Levy , Tomer Zekharya , Assaf Wool
发明人： Akiva Pinchas , Sarit Edelheit-Flohr , Lily Bazak , Zurit Levine , Amir Toporik , Ofer Levy , Tomer Zekharya , Assaf Wool
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention discloses markers useful in predicting the responsiveness of a subject having, or at risk of developing rheumatoid arthritis (RA) to treatment with anti-TNF agents. Particularly, the present invention discloses the allelic configuration of the CD6 gene and/or the STXBP6 gene which is indicative of the degree of responsiveness to anti-TNFα treatment of RA.
摘要翻译： 本发明公开了用于预测具有或具有发展类风湿性关节炎（RA）的风险的受试者对抗TNF剂治疗的反应性的标记物。 特别地，本发明公开了CD6基因和/或STXBP6基因的等位基因构型，其指示针对RA的抗TNFα治疗的反应程度。
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公开(公告)号：US20100184839A1
公开(公告)日：2010-07-22
申请号：US12598286
申请日：2008-04-30
申请人： Avishay Vaknin , Pini Akiva , Sarah Pollock , Lily Bazak , Erez Levanon , Tomer Zekharya , Alex Golubev , Gady Cojocaru , Liat Dassa , Sarit Edelheit-Flohr , Ronen Shemesh , Anat Amir , Yossi Cohen
发明人： Avishay Vaknin , Pini Akiva , Sarah Pollock , Lily Bazak , Erez Levanon , Tomer Zekharya , Alex Golubev , Gady Cojocaru , Liat Dassa , Sarit Edelheit-Flohr , Ronen Shemesh , Anat Amir , Yossi Cohen
IPC分类号： A61K31/7088 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The invention relates to the identification of allelic polymorphism in a diabetes associated gene, particularly in a gene encoding phosphofructokinase (PFK) and use thereof for diagnosing diabetes predisposition and state and for predicting the response to a therapeutic agent.
摘要翻译： 本发明涉及鉴定糖尿病相关基因中的等位基因多态性，特别是在编码磷酸果糖激酶（PFK）的基因中的等位基因多态性及其用于诊断糖尿病倾向和状态以及预测对治疗剂的应答的用途。
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3.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 有权核苷酸和氨基酸序列，以及用于诊断的测定及其使用方法公开(公告)号：US07842459B2
公开(公告)日：2010-11-30
申请号：US11051646
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
发明人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
摘要翻译： 新型剪接变体核酸序列。 根据本发明的新型剪接变体及其核酸序列可任选地用于诊断如本文所述的变体可检测的疾病。
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4.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 有权新型核苷酸和氨基酸序列，以及用于诊断的测定和方法公开(公告)号：US20100120022A1
公开(公告)日：2010-05-13
申请号：US11051646
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
发明人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
摘要翻译： 新型剪接变体核酸序列。 根据本发明的新型剪接变体及其核酸序列可任选地用于诊断如本文所述的变体可检测的疾病。
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5.发明申请NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND METHODS OF USE THEREOF FOR DIAGNOSIS 审中-公开新型核酸和氨基酸序列及其用于诊断的方法公开(公告)号：US20100184021A1
公开(公告)日：2010-07-22
申请号：US12161158
申请日：2007-01-16
申请人： Osnat Sella-Tavor , Sarah Pollack , Lily Bazak , Elena Tsypkin , Dan Sztybel , Shirley Sameah-Greenwald
发明人： Osnat Sella-Tavor , Sarah Pollack , Lily Bazak , Elena Tsypkin , Dan Sztybel , Shirley Sameah-Greenwald
CPC分类号： G01N33/57423
摘要： The present invention relates to diagnostic markers comprising novel splice variants of known proteins and polynucleotides encoding same, useful in the qualitative and/or quantitative detection of various diseases and/or pathological conditions in a subject, and to the use of known proteins and polynucleotides encoding same for diagnosis. Particularly, the invention relates to the diagnosis of a disease in a sample of body fluid or secretion obtained from the subject, and to the diagnosis of cancer.
摘要翻译： 本发明涉及包括已知蛋白质的新型剪接变体和编码其的多核苷酸的诊断标记物，其可用于定性和/或定量检测受试者的各种疾病和/或病理状况，以及编码已知蛋白质和多核苷酸的用途 相同的诊断。 特别地，本发明涉及从受试者获得的体液或分泌物的样品中的疾病的诊断以及癌症的诊断。
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6.发明申请NOVEL DIAGNOSTIC MARKERS, ESPECIALLY FOR IN VIVO IMAGING AND ASSAYS AND METHODS OF USE THEREOF 失效新型诊断标记，特别用于体检成像和测定及其使用方法公开(公告)号：US20090202991A1
公开(公告)日：2009-08-13
申请号：US11929570
申请日：2007-10-30
申请人： Sarah POLLOCK , Anat Cohen-Dayag , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach , Lily Bazak
发明人： Sarah POLLOCK , Anat Cohen-Dayag , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach , Lily Bazak
IPC分类号： C12Q1/68 , C12N15/11 , C07K14/00 , C12N15/00 , C12N5/06 , G01N33/574 , C12P21/04 , C07H21/00 , C07K16/18
CPC分类号： C12Y304/21109 , C12N9/6424 , C12Q1/6886 , C12Q2600/106
摘要： Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry.
摘要翻译： 新型剪接变体作为诊断标记，优选膜结合。 根据本发明的新型变体可任选地通过免疫组织化学方法用于本文所述的可标记可检测疾病的诊断。
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7.发明申请NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS 审中-公开新型核酸和氨基酸序列及其用于诊断的测定及其使用方法公开(公告)号：US20090275021A1
公开(公告)日：2009-11-05
申请号：US12095110
申请日：2006-11-27
申请人： Osnat Sella-Tavor , Sarah Pollock , Lily Bazak , Elena Tsypkin , Shira Wallach , Eve Montia , Shirley Sameah-Greenwald
发明人： Osnat Sella-Tavor , Sarah Pollock , Lily Bazak , Elena Tsypkin , Shira Wallach , Eve Montia , Shirley Sameah-Greenwald
IPC分类号： C12Q1/68 , C12N15/11 , C07K14/00 , C07K16/18 , C12N15/00 , C07H21/04 , C12N5/06 , C12P21/02 , G01N33/53
CPC分类号： C12Q1/6876 , C07K14/47 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.
摘要翻译： 新型剪接变体，氨基酸序列及其核苷酸序列及其使用方法。
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8.发明申请公开(公告)号：US20090215042A1
公开(公告)日：2009-08-27
申请号：US11913171
申请日：2006-06-08
申请人： Osnat Sella-Tavor , Sarah Pollock , Gad S. Cojocaru , Amit Novik , Lily Bazak , Elena Tsypkin , Shira Wallach , Shirley Sameah-Greenwald
发明人： Osnat Sella-Tavor , Sarah Pollock , Gad S. Cojocaru , Amit Novik , Lily Bazak , Elena Tsypkin , Shira Wallach , Shirley Sameah-Greenwald
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C12N9/6491 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/142
摘要： Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.
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9.发明申请公开(公告)号：US20090176217A1
公开(公告)日：2009-07-09
申请号：US12089051
申请日：2006-10-03
申请人： Osnat Sella-Tavor , Sarah Pollock , Gad S. Cojocaru , Amit Novik , Lily Bazak , Elena Tsypkin , Shira Wallach , Shirley Sameah-Greenwald
发明人： Osnat Sella-Tavor , Sarah Pollock , Gad S. Cojocaru , Amit Novik , Lily Bazak , Elena Tsypkin , Shira Wallach , Shirley Sameah-Greenwald
CPC分类号： G01N33/74 , C07K14/47 , C07K16/2863 , C07K16/40 , G01N33/574 , G01N33/57492 , G01N33/689 , G01N33/6893 , G01N2333/71 , G01N2800/52
摘要： Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.
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10.发明授权Diagnostic markers, especially for in vivo imaging and assays and methods of use thereof 失效诊断标记，特别是用于体内成像和测定及其使用方法公开(公告)号：US07741433B2
公开(公告)日：2010-06-22
申请号：US11929570
申请日：2007-10-30
申请人： Sarah Pollock , Anat Cohen-Dayag , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach , Lily Bazak
发明人： Sarah Pollock , Anat Cohen-Dayag , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach , Lily Bazak
IPC分类号： C07K5/00
CPC分类号： C12Y304/21109 , C12N9/6424 , C12Q1/6886 , C12Q2600/106
摘要： Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry.
摘要翻译： 新型剪接变体作为诊断标记，优选膜结合。 根据本发明的新型变体可任选地通过免疫组织化学方法用于本文所述的可标记可检测疾病的诊断。
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