公开(公告)号：US20050032209A1

公开(公告)日：2005-02-10

申请号：US10877269

申请日：2004-06-25

申请人： Darin Messina ,  Sanjay Mistry ,  Alexander Harmon ,  Ian Harris ,  Anthony Kihm ,  Agnieszka Seyda ,  Chin-Feng Yi ,  Anna Gosiewska

发明人： Darin Messina ,  Sanjay Mistry ,  Alexander Harmon ,  Ian Harris ,  Anthony Kihm ,  Agnieszka Seyda ,  Chin-Feng Yi ,  Anna Gosiewska

IPC分类号： C12N5/073 ,  C12N5/074 ,  C12N5/08 ,  C12N15/85

CPC分类号： A61K35/51 ,  A01N1/0226 ,  A61K35/12 ,  A61K35/50 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/19 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/27 ,  A61K45/06 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0607 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2509/00 ,  C12N2509/10 ,  C12N2533/50

摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.

摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞进行神经组织再生或修复的药物组合物，装置和方法。

公开(公告)号：US20060153818A1

公开(公告)日：2006-07-13

申请号：US11321864

申请日：2005-12-29

申请人： Sridevi Dhanaraj ,  Alexander Harmon ,  Darin Messina

发明人： Sridevi Dhanaraj ,  Alexander Harmon ,  Darin Messina

IPC分类号： A61K35/12 ,  C12N5/08

CPC分类号： A61K35/51 ,  A01N1/0226 ,  A61K35/12 ,  A61K35/50 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/19 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/27 ,  A61K45/06 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0607 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2509/00 ,  C12N2509/10 ,  C12N2533/50

摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

摘要翻译： 源自产后组织的细胞及其分离和诱导分化成软骨形成或成骨表型细胞的方法由本发明提供。 本发明进一步提供产后来源细胞的培养物和组合物及其相关的产品。 本发明的产后衍生细胞及其相关产品具有多种用途，包括但不限于研究，诊断和治疗应用，例如用于治疗骨和软骨病症。

公开(公告)号：US20060223177A1

公开(公告)日：2006-10-05

申请号：US11315897

申请日：2005-12-22

申请人： Ian Harris ,  Darin Messina ,  Anthony Kihm ,  Agnieszka Seyda ,  David Colter

发明人： Ian Harris ,  Darin Messina ,  Anthony Kihm ,  Agnieszka Seyda ,  David Colter

IPC分类号： C12N5/00 ,  C12N9/00 ,  C12N9/26

CPC分类号： C12N5/0607 ,  C12N5/0619 ,  C12N2500/32 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/135 ,  C12N2506/03

摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

摘要翻译： 公开了源自人脐带的细胞及其治疗用途的方法。 描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。

公开(公告)号：US20050125848A1

公开(公告)日：2005-06-09

申请号：US11036004

申请日：2005-01-14

申请人： Margot Mayer-Proschel ,  Mahendra Rao ,  Patrick Tresco ,  Darin Messina

发明人： Margot Mayer-Proschel ,  Mahendra Rao ,  Patrick Tresco ,  Darin Messina

IPC分类号： A61K35/12 ,  C12N5/0797 ,  A01K67/033 ,  C12N5/08 ,  A01K67/00

CPC分类号： A61K35/54 ,  A61K35/12 ,  C12N5/0623

摘要： A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.