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公开(公告)号：US07101984B2
公开(公告)日：2006-09-05
申请号：US10033167
申请日：2001-12-27
Applicant: David Botstein , Luc Desnoyers , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Austin L. Gurney , James Pan , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood
Inventor： David Botstein , Luc Desnoyers , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Austin L. Gurney , James Pan , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07098312B2
公开(公告)日：2006-08-29
申请号：US10006130
申请日：2001-12-06
Applicant: Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
Inventor： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
CPC classification number: C07K14/47 , C07K14/705
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07070979B2
公开(公告)日：2006-07-04
申请号：US09906838
申请日：2001-07-16
Applicant: David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , William I. Wood
Inventor： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , William I. Wood
CPC classification number: C07K14/47
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07034123B2
公开(公告)日：2006-04-25
申请号：US10007236
申请日：2001-12-06
Applicant: Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
Inventor： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
CPC classification number: C07K14/47
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07033786B2
公开(公告)日：2006-04-25
申请号：US10015715
申请日：2001-12-12
Applicant: Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
Inventor： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
CPC classification number: C07K14/47
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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Patent Agency Ranking
公开(公告)号：US20060078964A1
公开(公告)日：2006-04-13
申请号：US10216161
申请日：2002-08-09
Applicant: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
Inventor： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC classification number: C07K14/705
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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27.发明授权Nucleic acids encoding secreted polypeptides that stimulate release of proteoglycans from cartilage 有权编码分泌的多肽的核酸，其刺激蛋白聚糖从软骨释放公开(公告)号：US07018837B2
公开(公告)日：2006-03-28
申请号：US09944884
申请日：2001-08-31
Applicant: Kevin P. Baker , David Botstein , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Mary A. Napier , Margaret Ann Roy , Daniel Tumas , William I. Wood
Inventor： Kevin P. Baker , David Botstein , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Mary A. Napier , Margaret Ann Roy , Daniel Tumas , William I. Wood
CPC classification number: C07K14/47 , C07H21/04 , C07K2319/00
Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07018811B2
公开(公告)日：2006-03-28
申请号：US09989726
申请日：2001-11-19
Applicant: David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , William I. Wood
Inventor： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , William I. Wood
CPC classification number: C07H21/04 , C07K14/395 , C07K14/47
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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29.发明申请Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors 审中-公开分类，诊断，分层和治疗癌症患者及其肿瘤的方法公开(公告)号：US20060040302A1
公开(公告)日：2006-02-23
申请号：US11200822
申请日：2005-08-10
Applicant: David Botstein , Patrick Brown , Charles Perou , Brian Ring , Douglas Ross , Rob Seitz , Jan van de Rijn
Inventor： David Botstein , Patrick Brown , Charles Perou , Brian Ring , Douglas Ross , Rob Seitz , Jan van de Rijn
IPC: C12Q1/68 , G01N33/574
CPC classification number: C07K14/4748 , A61K38/00 , C07K16/18
Abstract: The invention provides a variety of reagents for use in the diagnosis and management of cancer, particularly breast cancer. cDNA microarray technology was used to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of cancer and for identification of therapies for cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.
Abstract translation: 本发明提供用于诊断和治疗癌症，特别是乳腺癌的各种试剂。 cDNA微阵列技术用于鉴定跨越大量肿瘤样本的表达谱与细胞角蛋白5和细胞角蛋白17（正常乳腺泌乳腺基底细胞的标记）相关的基因。 本发明表明，表达细胞角蛋白5/6和/或17的肿瘤总体上相对于肿瘤的预后差。 本发明提供了基础标记基因及其表达产物和这些基因用于诊断癌症和用于鉴定癌症疗法的用途。 特别地，本发明提供了包括钙粘蛋白3，基质金属蛋白酶14和钙粘蛋白EGF LAG七通G型受体2的基础标记基因。本发明提供了由这些基因表达的多肽的抗体及其使用方法。
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公开(公告)号：US06965011B2
公开(公告)日：2005-11-15
申请号：US09905449
申请日：2001-07-13
Applicant: David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Margaret Ann Roy , William I. Wood
Inventor： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Margaret Ann Roy , William I. Wood
IPC: C07K14/435 , C07K14/47 , C07K14/705 , C07K19/00
CPC classification number: C07K14/705 , C07K14/47
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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