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    System and methods for optical sensing and drug delivery using microneedles
    21.
    发明授权
    System and methods for optical sensing and drug delivery using microneedles 失效
    使用微针的光学感应和药物输送的系统和方法

    公开(公告)号：US08560059B2

    公开(公告)日：2013-10-15

    申请号：US11716145

    申请日：2007-03-09

    申请人： Carine Hoarau ,  Li Li ,  Keith Batchelder ,  Shannon E. Campbell

    发明人： Carine Hoarau ,  Li Li ,  Keith Batchelder ,  Shannon E. Campbell

    IPC分类号： A61N1/30 ,  A61M5/32 ,  A61B17/20

    CPC分类号： A61B5/0059 ,  A61B5/412 ,  A61B5/4839 ,  A61B2562/0233 ,  A61B2562/046

    摘要： The current techniques provide a system for monitoring a physiological parameter of a patient using microneedles that are coupled to an optical system, allowing spectroscopic measurements to be made immediately below the outer layer of the epidermis. In embodiments of the present invention, the results of the spectroscopic measurements are used to control the administration of a drug through an intravenous tube. In other embodiments, the microneedles may be coated with a drug for administration to the patient. In other embodiments, the microneedles may be mounted in a probe, wherein an actuator is used to move the needles into contact with the skin, and a drug delivery system is used to infuse the drug into the patient. A method for making needles is also provided.

    摘要翻译： 目前的技术提供了一种用于使用耦合到光学系统的微针来监测患者的生理参数的系统，允许在表皮的外层的正下方进行光谱测量。 在本发明的实施方案中，光谱测量的结果用于通过静脉内管来控制药物的给药。 在其它实施方案中，可以用用于给患者给药的药物涂覆微针。 在其他实施例中，微针可以安装在探针中，其中致动器用于将针移动到与皮肤接触，并且药物递送系统用于将药物注入患者体内。 还提供了制造针的方法。

    Medical sensor for reducing signal artifacts and technique for using the same
    22.
    发明授权
    Medical sensor for reducing signal artifacts and technique for using the same 有权
    用于减少信号伪影的医疗传感器及其使用技术

    公开(公告)号：US08396527B2

    公开(公告)日：2013-03-12

    申请号：US11525693

    申请日：2006-09-22

    申请人： Carine Hoarau

    发明人： Carine Hoarau

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/14552 ,  A61B5/02416 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7207 ,  A61B2562/222

    摘要： A sensor may be adapted to reduce motion artifacts by mitigating the effects of the tissue moving within the sensor. A sensor is provided with an elastomeric sensor body adapted to accommodate patient motion. Further, a sensor is provided in which the sensor cable is arranged to mitigate its pressure on a patient's tissue.

    摘要翻译： 传感器可以适于通过减轻在传感器内移动的组织的影响来减少运动伪影。 传感器设置有适于容纳患者运动的弹性传感器主体。 此外，提供了一种传感器，其中传感器电缆布置成减轻其对患者组织的压力。

    Pulse oximetry signal correction using near infrared absorption by water
    24.
    发明授权
    Pulse oximetry signal correction using near infrared absorption by water 有权
    使用近红外吸收水的脉搏血氧饱和度信号校正

    公开(公告)号：US08175670B2

    公开(公告)日：2012-05-08

    申请号：US11521960

    申请日：2006-09-15

    申请人： Clark R. Baker, Jr. ,  Edward Karst ,  Carine Hoarau

    发明人： Clark R. Baker, Jr. ,  Edward Karst ,  Carine Hoarau

    IPC分类号： A61B5/1455 ,  A61B5/02

    CPC分类号： A61B5/7207 ,  A61B5/02416 ,  A61B5/14551

    摘要： A method and system for measuring a physiological parameter, comprising collecting a first absorbance at a first wavelength, chosen to be primarily absorbed by water; collecting a second absorbance at a second wavelength, chosen to be primarily absorbed by hemoglobin; and combining the first signal and the second signal to generate a combined plethysmograph signal which is proportionate lower in noise caused by motion-related interference.

    摘要翻译： 一种用于测量生理参数的方法和系统，包括收集被选择为主要被水吸收的第一波长的第一吸光度; 收集第二波长的第二吸光度，其被选择为主要由血红蛋白吸收; 以及组合第一信号和第二信号以产生由运动相关干扰引起的噪声相对较低的组合体积描记器信号。

    Method and apparatus for spectroscopic tissue analyte measurement
    25.
    发明授权
    Method and apparatus for spectroscopic tissue analyte measurement 有权
    用于光谱组织分析物测量的方法和装置

    公开(公告)号：US08175665B2

    公开(公告)日：2012-05-08

    申请号：US11716482

    申请日：2007-03-09

    申请人： Clark R. Baker, Jr. ,  Nicholas J. Durr ,  Murtaza Mogri ,  Carine Hoarau ,  Rafael Ostrowski ,  Martin P. Debreczeny

    发明人： Clark R. Baker, Jr. ,  Nicholas J. Durr ,  Murtaza Mogri ,  Carine Hoarau ,  Rafael Ostrowski ,  Martin P. Debreczeny

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/0059 ,  A61B5/4869 ,  A61B5/4878

    摘要： Methods and systems for calculating body fluid metrics are provided. In accordance with an exemplary embodiment of the present technique, there is provided a method for calculating body fluid metrics by acquiring an absorbance spectrum of a subject's tissue over a range of near-infrared light, performing a multi-linear regression of the absorbance spectrum of the subject's tissue in relation to absorbance spectra of tissue constituents, and calculating body fluid metrics based on the results of the multi-linear regression. A system is provided having a sensor for emitting the light into the subject's tissue and detecting reflected, scattered, or transmitted light, a spectrometer for processing the detected light and generating the absorbance spectrum of the subject's tissue, memory for storing absorbance spectra of the tissue constituents and a multi-linear regression model, and a processor for performing the multi-linear regression and calculating the body fluid metrics.

    摘要翻译： 提供了用于计算体液量度的方法和系统。 根据本技术的示例性实施例，提供了一种通过在近红外光范围内获取受试者组织的吸收光谱来计算体液量度的方法，执行吸收光谱的多线性回归 相关于组织成分的吸收光谱的受试者组织，以及基于多线性回归的结果计算体液量度。 提供一种具有用于将光发射到被检体的组织中并检测反射，散射或透射光的传感器的系统，用于处理检测到的光并产生受试者组织的吸收光谱的光谱仪，用于存储组织的吸收光谱的存储器 成分和多线性回归模型，以及用于执行多线性回归和计算体液量度的处理器。

    MEDICAL SENSOR FOR REDUCING MOTION ARTIFACTS AND TECHNIQUE FOR USING THE SAME
    26.
    发明申请
    MEDICAL SENSOR FOR REDUCING MOTION ARTIFACTS AND TECHNIQUE FOR USING THE SAME 有权
    用于减少运动用品的医疗传感器和使用它们的技术

    公开(公告)号：US20120035443A1

    公开(公告)日：2012-02-09

    申请号：US13267681

    申请日：2011-10-06

    申请人： Carine Hoarau ,  Clark R. Baker, JR. ,  Edward Karst

    发明人： Carine Hoarau ,  Clark R. Baker, JR. ,  Edward Karst

    IPC分类号： A61B5/1455 ,  B23P11/00

    CPC分类号： A61B5/6886 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/6844 ,  Y10T29/49826

    摘要： A sensor for pulse oximetry or other applications utilizing spectrophotometry may be adapted to reduce motion artifacts by fixing the optical distance between an emitter and detector. A flexible sensor is provided with a stiffening member to hold the emitter and detector of the sensor in a relatively fixed position when applied to a patient. Further, an annular or partially annular sensor is adapted to hold an emitter and detector of the sensor in a relatively fixed position when applied to a patient. A clip-style sensor is provided with a spacer that controls the distance between the emitter and detector.

    摘要翻译： 用于脉搏血氧饱和度测定的传感器或利用分光光度法的其它应用可适用于通过固定发射器和检测器之间的光学距离来减少运动伪影。 柔性传感器设置有加强构件，以在应用于患者时将传感器的发射器和检测器保持在相对固定的位置。 此外，环形或部分环形的传感器适于在施加到患者时将传感器的发射器和检测器保持在相对固定的位置。 夹式传感器设置有间隔器，该间隔件控制发射器和检测器之间的距离。

    SYSTEM AND METHOD FOR MITIGATING INTERFERENCE IN PULSE OXIMETRY
    29.
    发明申请
    SYSTEM AND METHOD FOR MITIGATING INTERFERENCE IN PULSE OXIMETRY 失效
    用于减少脉冲OXIMETRY干扰的系统和方法

    公开(公告)号：US20110124991A1

    公开(公告)日：2011-05-26

    申请号：US13021441

    申请日：2011-02-04

    申请人： Carine Hoarau

    发明人： Carine Hoarau

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/6838 ,  A61B5/062 ,  A61B5/064 ,  A61B5/14551 ,  A61B5/6826

    摘要： A pulse oximetry sensor adapted to emit light from an emitter proximate to a patient's tissue and detect a portion of the emitted light on a detector proximate to the tissue. The pulse oximetry system is adapted to acquire position data for the emitter and for the detector with one or more position indicators. The pulse oximetry system is adapted to process the position data to obtain a change in position of the emitter and the detector; and to process pulse oximetry measurements using the change in position to obtain a motion-corrected pulse oximetry data.

    摘要翻译： 一种脉搏血氧饱和度传感器，其适于从靠近患者组织的发射器发射光并且检测靠近组织的检测器上的发射光的一部分。 脉搏血氧饱和度测量系统适于采用一个或多个位置指示器来获取发射器和检测器的位置数据。 脉搏血氧饱和度系统适于处理位置数据以获得发射器和检测器的位置变化; 并使用位置变化来处理脉搏血氧饱和度测量，以获得运动校正的脉搏血氧饱和度数据。