公开(公告)号：US07604703B2

公开(公告)日：2009-10-20

申请号：US11417856

申请日：2006-05-03

申请人： Torsten Scheuermann ,  Eckhard Alt

发明人： Torsten Scheuermann ,  Eckhard Alt

IPC分类号： C23C8/06 ,  A61F2/06 ,  C22F1/18

CPC分类号： A61L31/18 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2310/00598 ,  A61L31/022 ,  A61L31/088

摘要： In a process of fabricating a stent composed primarily of niobium alloyed with a trace amount of zirconium, tantalum, or titanium for hardening, the stent is annealed under vacuum in a substantially oxygen-free environment. The vacuum is preferably maintained at pressure less than 10−4 millibars, oxygen-content less than about 80 parts per million, and the annealing temperature exceeds 400° C. for at least one hour, and is preferably kept in a range from about 1100-1200° C. for several hours. This may be followed by applying a surface layer of oxide, such as iridium oxide, with a thickness of 299-300 nm to the stent.

摘要翻译： 在制造主要由铌合金化的用于硬化的锆，钽或钛的支架的制造过程中，支架在基本上无氧的环境中在真空下退火。 真空优选保持在小于10-4毫巴的压力，含氧量小于约百万分之八十，退火温度超过400℃至少一小时，优选保持在约1100 -1200℃几个小时。 然后可以向支架施加厚度为299-300nm的氧化物表面层，例如氧化铱。

公开(公告)号：US07335229B2

公开(公告)日：2008-02-26

申请号：US10841113

申请日：2004-05-07

申请人： Eckhard Alt ,  Torsten Scheuermann ,  Michael Kühling

发明人： Eckhard Alt ,  Torsten Scheuermann ,  Michael Kühling

IPC分类号： A61F2/06

CPC分类号： A61L31/18 ,  A61B5/055 ,  A61B5/411 ,  A61F2/88 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2250/0043 ,  A61L31/022 ,  A61L31/082 ,  G01R33/285 ,  G01R33/34046 ,  G01R33/34053 ,  G01R33/34069 ,  G01R33/34076 ,  G01R33/34084

摘要： A stent is adapted to be implanted in a duct of a human body to maintain an open lumen at the implant site, and to allow viewing body tissue and fluids by magnetic resonance imaging (MRI) energy applied external to the body. The stent constitutes a metal scaffold. An electrical circuit resonant at the resonance frequency of the MRI energy is fabricated integral with the scaffold structure of the stent to promote viewing body properties within the lumen of the stent.

摘要翻译： 支架适于植入人体的管道中，以在植入部位保持开放的腔，并且允许通过在身体外部施加的磁共振成像（MRI）能量观察体内组织和流体。 支架构成金属支架。 在MRI能量的共振频率下共振的电路与支架的支架结构一体制成，以促进支架内腔内的观察体特性。

公开(公告)号：US20070010870A1

公开(公告)日：2007-01-11

申请号：US11505640

申请日：2006-08-17

申请人： Eckhard Alt ,  Thilo Fliedner ,  Robert Alert ,  Axel Stemberger

发明人： Eckhard Alt ,  Thilo Fliedner ,  Robert Alert ,  Axel Stemberger

IPC分类号： A61F2/06

CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2240/001 ,  A61F2250/0036 ,  A61F2250/0098 ,  C21D1/773 ,  Y10S623/901

摘要： An expandable tubular endoluminal prosthesis for maintaining the patency of a bodily vessel has a plurality of axially spaced serpentine bands. Each serpentine band has a proximal and distal end and a plurality of interconnected struts. Serpentine bands which are adjacent one another are connected one to the other. The prosthesis has a flow path therethrough and is capable of radial outward expansion from a first diameter to a second enlarged diameter. In a cross-section perpendicular to the flowpath, the struts have thicker portions with a narrower portion therebetween and have a greater width than thickness.

摘要翻译： 用于维持身体血管通畅的可扩张管状腔内假体具有多个轴向间隔开的蛇形带。 每个蛇形带具有近端和远端以及多个相互连接的支柱。 彼此相邻的蛇形带彼此连接。 假体具有穿过其的流动路径，并且能够从第一直径向第二扩大直径的径向向外膨胀。 在垂直于流路的横截面中，支柱具有较厚部分，其间具有较窄部分，并且具有比厚度更大的宽度。

公开(公告)号：US20060122690A1

公开(公告)日：2006-06-08

申请号：US11338452

申请日：2006-01-23

申请人： Eckhard Alt

发明人： Eckhard Alt

IPC分类号： A61F2/82 ,  A61F2/90

CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2250/0067 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/0076 ,  A61L2300/416 ,  A61L2300/606 ,  C08L67/04

摘要： A stent for delivering a therapeutic dose of the immnuosupressant tacrolimus is disclosed.

公开(公告)号：US20050137480A1

公开(公告)日：2005-06-23

申请号：US11007046

申请日：2004-12-07

申请人： Eckhard Alt ,  John Brinkmann

发明人： Eckhard Alt ,  John Brinkmann

IPC分类号： A61B5/00 ,  A61B5/04 ,  A61B5/053 ,  A61B5/08 ,  A61N1/362 ,  A61N1/365 ,  A61B5/02

CPC分类号： A61B5/04012 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/0537 ,  A61B5/0809 ,  A61B5/7232 ,  A61B2560/0271 ,  A61B2562/0219 ,  A61N1/3627 ,  A61N1/36521

摘要： A system and method for communicating data and signals through the Medical Implant Communication Service Band using a repeater or base station in the proximity to an implantable device within a patient is disclosed. In a preferred embodiment, the device is capable for early detection and monitoring of congestive heart failure in a patient. Impedance measurements, or other health parameters depending on the type of implantable device or sensor used, are sent using a bi-directional low-power radio operating in the MICS band to a nearby base station which may provide signal processing and analysis. The base station may have an interface to one or more communications networks to connect to a remote location. The system and method of the present invention permits a healthcare professional to monitor an ambulatory patient's condition at a remote location and to program the implanted device.

摘要翻译： 公开了一种用于通过医疗植入物通信服务频带通过在患者体内可植入装置附近的中继器或基站来传送数据和信号的系统和方法。 在优选实施例中，该装置能够早期检测和监测患者的充血性心力衰竭。 根据所使用的可植入装置或传感器的类型，阻抗测量或其他健康参数使用在MICS频带中操作的双向低功率无线电发送到可提供信号处理和分析的附近基站。 基站可以具有到一个或多个通信网络的接口以连接到远程位置。 本发明的系统和方法允许保健专业人员监视远程位置处的步行病人的状况并对植入的设备进行编程。

公开(公告)号：US20050079161A1

公开(公告)日：2005-04-14

申请号：US10955403

申请日：2004-09-30

申请人： Eckhard Alt

发明人： Eckhard Alt

IPC分类号： A61K35/12 ,  A61K45/00 ,  A61M25/00 ,  C12N5/077 ,  A61M31/00

CPC分类号： A61M25/0023 ,  A61K35/12

摘要： A method is described for repairing tissue of a selected organ from among heart, brain, liver, pancreas, kidney, glands, and muscles in a patient's body. In the method, adult stem cells that have the capability to repair tissue of the selected organ are recovered by harvesting from the patient's body. The harvested stem cells are then intraluminally applied through a designated natural body vessel or duct leading to a predetermined target site of the tissue of the selected organ to be repaired. During the time the stem cells are being applied to the targeted tissue downstream, the designated vessel or duct is selectively occluded to increase concentration and pressure of the applied adult stem cells at the target site of the organ tissue.

摘要翻译： 描述了用于修复来自患者体内的心脏，脑，肝，胰腺，肾，腺体和肌肉中的所选器官的组织的方法。 在该方法中，具有修复所选器官组织的能力的成体干细胞通过从患者体内收获而回收。 然后将经收获的干细胞通过指定的天然体血管或导管进行内膜施用，导致待修复的所选器官的组织的预定靶位点。 在将干细胞施用于下游的靶组织的期间，选择性地闭塞指定的血管或管道，以增加在器官组织的靶位点处施用的成体干细胞的浓度和压力。

公开(公告)号：US06805860B1

公开(公告)日：2004-10-19

申请号：US09968739

申请日：2001-09-30

申请人： Eckhard Alt

发明人： Eckhard Alt

IPC分类号： A01N6500

CPC分类号： C12N5/0657 ,  A61K35/12 ,  C12N2501/165

摘要： A process is described for cellular repair of failing tissue of an organ if a patient's body. In the process, a catheter is positioned to provide an entry point for stem cell injection at the proximal end of the central lumen of the catheter external to the body and an exit point from the central lumen at the distal end proximate the site of the failing tissue. Stem cells are then injected through the catheter to invade the failing tissue at the site, while local forces at the site are quelled from disrupting migration of the stem cells into the failing tissue, to enhance the concentration of the stem cells and the pressure arising from the injection at the site and thereby overcome any barrier between the site of the injection and the failing tissue. Preferably, autologous adult stem cells are used in the procedure.

摘要翻译： 描述了如果患者的身体，器官的失败组织的细胞修复的过程。 在该过程中，定位导管以提供用于干细胞注射的入口点，其在身体外部的导管的中心腔的近端处，以及离开远端处的中心腔的出口点，靠近失败部位 组织。 然后通过导管注射干细胞以侵入现场的失败组织，同时在该部位的局部力量被破坏以破坏干细胞向失败组织的迁移，以增强干细胞的浓度和由 在该部位进行注射，从而克服了注射部位与失败组织之间的任何障碍。 优选地，在该程序中使用自体成体干细胞。

公开(公告)号：US06398805B1

公开(公告)日：2002-06-04

申请号：US09544780

申请日：2000-04-07

申请人： Eckhard Alt

发明人： Eckhard Alt

IPC分类号： A61F206

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/061 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0018

摘要： A vascular or endoluminal stent has low surface friction for ease of navigating a vessel, duct or tract of a patient. The stent is configured as a tubular element of biocompatible material having a longitudinal axis, open ends and a multiplicity of openings of generally common shape and size through its wall throughout its length. The openings are bounded by a network of tangentially interconnected, continuous, predominantly longitudinally oriented curvilinear struts, without discontinuity, forming a sidewall of the tubular element. The stent is adapted to be deployed by exertion of outward radial pressure on the tubular element, and when deployed, at least a segment of each strut undergoes a transition to a predominantly transverse orientation relative to the longitudinal axis of the stent.

摘要翻译： 血管或腔内支架具有低表面摩擦，便于导航患者的血管，导管或道。 支架构造为生物相容性材料的管状元件，其具有纵向轴线，开口端和通过其整个长度通过其壁的通常形状和尺寸的多个开口。 开口由切线互连的，连续的，主要是纵向定向的曲线支柱的网络界定，而不间断地形成管状元件的侧壁。 支架适于通过在管状元件上施加向外的径向压力来展开，并且当展开时，每个支柱的至少一段经历相对于支架的纵向轴线以主要横向取向的过渡。

公开(公告)号：US06238340B1

公开(公告)日：2001-05-29

申请号：US09081953

申请日：1998-05-19

申请人： Eckhard Alt ,  D. F. Regulla

发明人： Eckhard Alt ,  D. F. Regulla

IPC分类号： A61B600

CPC分类号： A61M25/0108 ,  A61B6/12 ,  A61B90/39

摘要： An unwanted effect of secondary radiation enhancement from backscatter of incident ionizing radiation on a relatively extensive metallic portion of an instrument to be inserted into a human body under x-ray fluoroscopy is minimized by coating the metallic surface thereof with a biocompatible material having the characteristic of shielding the secondary radiation enhancement effect from reaching body tissue. The depth of penetration of the secondary radiation enhancement is dependent on the atomic number of the metallic portion in conjunction with the expected radiation characteristics and energy level of the radiation incident on the metallic surface. The coating material is selected according to the atomic number of the metallic portion, and the coating has a thickness at least equal to the anticipated depth of penetration of the secondary radiation enhancement, as the shielding characteristic of the coating material, so that the secondary radiation enhancement effect will dissipate before reaching the body tissue.

摘要翻译： 通过使用具有以下特征的生物相容性材料将其金属表面涂覆在金属表面上，从而将入射电离辐射的后向散射的二次辐射增强的不期望的效果通过用X射线荧光透视法插入人体的仪器的相对广泛的金属部分来最小化 屏蔽二次辐射增强效果到达身体组织。 次级辐射增强的穿透深度取决于金属部分的原子序数，结合入射在金属表面上的辐射的预期辐射特性和能量水平。 涂层材料根据金属部分的原子序数来选择，并且涂层具有至少等于预期的二次辐射增强的穿透深度的厚度作为涂层材料的屏蔽特性，使得二次辐射 增强效果会在到达身体组织之前消散。

公开(公告)号：US6027510A

公开(公告)日：2000-02-22

申请号：US999737

申请日：1997-12-08

申请人： Eckhard Alt

发明人： Eckhard Alt

IPC分类号： A61F2/06 ,  A61F2/84 ,  A61M25/10 ,  A61F11/00

CPC分类号： A61F2/958 ,  A61F2002/9583 ,  A61M25/10

摘要： A stent delivery system includes a catheter having a balloon mounted at its distal end for advancement into and withdrawal from a patient's vascular system by manipulation of the catheter from a point external to the patient's body, a lumen extending through the catheter into the balloon to allow the balloon to be selectively inflated and deflated from a pressurizing medium external to the patient's body, and spaced-apart radiopaque projections on the catheter adjacent the proximal and distal ends of the balloon to receive and retain a stent therebetween in overlying relation to the balloon and to provide x-ray markers thereof. The stent is deployed at a designated target site by selectively inflating the balloon to radially expand the diameter of the stent against the vascular wall. The projections are shaped (i) to protect the stent from being dislodged during travel through the vessel, but not to interfere with radial expansion of the stent during balloon inflation and (ii) to avoid injury to tissue of the vascular wall during movement of the catheter through the vessel. A method of fabricating such a stent delivery system includes providing a catheter with an elongate flexible body of size and shape suitable for traversing the vascular system and with a selectively inflatable balloon located distally on the catheter; and employing spaced-apart projections on the catheter at the ends of the balloon to retain a stent which, after the catheter is inserted through the stent, is tightly crimped onto the balloon between the projections, in readiness for radial expansion when delivered to the target site and the balloon inflated. The catheter diameter may be greater between than outside the projections, for tight crimping of the stent on the balloon, and the projections are integral with the catheter including its region of greater diameter.

摘要翻译： 支架输送系统包括导管，其具有安装在其远端处的气囊，用于通过从患者身体外部的位置操纵导管来进入患者的血管系统并从患者的血管系统中撤出;将腔室延伸穿过导管以允许 气球被选择性地从患者身体外部的加压介质膨胀和放气，并且邻近球囊的近端和远端的导管上的间隔开的不透射线的突起，以在其之间以与气囊相重叠的方式接纳和保持支架， 以提供其X射线标记。 支架通过选择性地使气囊膨胀而部署在指定的靶位置，以将支架的直径径向扩张抵靠血管壁。 这些突起的形状（i）成形为（i）保护支架免于在穿过血管的行进过程中脱落，但不会妨碍支架在球囊膨胀期间的径向膨胀，并且（ii）避免在移动过程中对血管壁的组织造成伤害 导管穿过血管。 一种制造这种支架递送系统的方法包括提供导管，其具有适于横穿血管系统的尺寸和形状的细长柔性体，以及位于远端位于导管上的选择性充气气囊; 并且在球囊的端部处在导管上采用间隔开的突起，以保持支架，其在导管插入穿过支架之后被紧紧地压接在突起之间的球囊上，以便当被递送到靶时准备径向膨胀 场地和气球膨胀。 导管直径可以在突出部外侧更大，用于气囊上的支架的紧密卷曲，并且突起与导管成一体，包括其直径较大的区域。