公开(公告)号：US08842266B2

公开(公告)日：2014-09-23

申请号：US13216038

申请日：2011-08-23

Applicant: E. Neil Lewis ,  Kenneth S. Haber

Inventor： E. Neil Lewis ,  Kenneth S. Haber

IPC: G01N21/00 ,  G01N21/95 ,  A61K31/00 ,  G01N33/15

CPC classification number: A61K31/00 ,  G01N21/9508 ,  G01N33/15

Abstract: A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.

Abstract translation: 公开了获得有关异质药物混合物的信息的方法。 该方法包括将诸如污渍的图像增强剂施加到混合物。 然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

公开(公告)号：US20120197541A1

公开(公告)日：2012-08-02

申请号：US13216038

申请日：2011-08-23

Applicant: E. Neil Lewis ,  Kenneth S. Haber

Inventor： E. Neil Lewis ,  Kenneth S. Haber

IPC: G01J3/44 ,  G06F19/00 ,  G01J3/00

CPC classification number: A61K31/00 ,  G01N21/9508 ,  G01N33/15

Abstract: A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.

Abstract translation: 公开了获得有关异质药物混合物的信息的方法。 该方法包括将诸如污渍的图像增强剂施加到混合物。 然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

公开(公告)号：US07864316B2

公开(公告)日：2011-01-04

申请号：US11986548

申请日：2007-11-20

Applicant: E. Neil Lewis ,  Kenneth S. Haber

Inventor： E. Neil Lewis ,  Kenneth S. Haber

IPC: G01J3/28

CPC classification number: G01J3/06 ,  B01F9/04 ,  B01F15/00207 ,  B01F15/00214 ,  B01F2215/0032 ,  G01J3/0218 ,  G01J3/42 ,  G01N21/03 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/85 ,  G01N21/9508 ,  G01N2021/3595 ,  G01N2021/8592

Abstract: In one general aspect, a spectroscopic method for monitoring heterogeneity of a sample is disclosed. In this method, sampled spectroscopic measurements are acquired over a range of different micro locations in a macro-sample of the sample. This step is repeated for micro-locations in further macro-samples of the sample, and a statistical measure of chemical heterogeneity is derived from the acquisitions. In another general aspect, differently sized samples are acquired, and a statistical measure of chemical heterogeneity is derived from these acquisitions.

Abstract translation: 在一般的方面，公开了一种用于监测样品异质性的光谱方法。 在该方法中，在样本的宏观样本中的不同微位置的范围上获取采样的光谱测量。 对于样品的其他宏观样品中的微位置重复此步骤，并且从采集中得出化学异质性的统计量度。 在另一个一般方面，获得不同大小的样品，并且从这些获取中得出化学异质性的统计量度。

公开(公告)号：US20090294673A1

公开(公告)日：2009-12-03

申请号：US12218504

申请日：2008-07-15

Applicant: E. Neil Lewis ,  David J. Strachan ,  Linda H. Kidder

Inventor： E. Neil Lewis ,  David J. Strachan ,  Linda H. Kidder

IPC: G01J5/02

CPC classification number: G01N21/31 ,  G01N21/253

Abstract: Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.

Abstract translation: 公开了药物剂量单位制造过程控制装置和方法。 这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供 关于基于加工步骤的药物剂量单位的流动的指示。

公开(公告)号：US20080032412A1

公开(公告)日：2008-02-07

申请号：US11499390

申请日：2006-08-04

Applicant: E. Neil Lewis ,  Kenneth S. Haber

Inventor： E. Neil Lewis ,  Kenneth S. Haber

IPC: G01N21/00

CPC classification number: G01N21/6428 ,  G01N21/3563 ,  G01N21/6456 ,  G01N21/65 ,  G01N21/78 ,  G01N21/9508 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/7773 ,  G01N2021/7786

Abstract: A method for obtaining information about a heterogeneous pharmaceutical mixture is disclosed. The method includes beginning to apply an image enhancement agent to the mixture. A plurality of images of the mixture can then be obtained over time, with at least one image being obtained after the step of beginning to apply an image enhancement agent. This allows information to be derived about a distribution of components of the mixture, based on differences between spatial information in different images.

Abstract translation: 公开了一种获取有关异质药物混合物的信息的方法。 该方法包括开始向混合物施加图像增强剂。 然后可以随着时间获得混合物的多个图像，其中在开始施加图像增强剂的步骤之后获得至少一个图像。 这允许基于不同图像中的空间信息的差异来获得关于混合物的分量的分布的信息。

公开(公告)号：US06483112B1

公开(公告)日：2002-11-19

申请号：US09353325

申请日：1999-07-14

Applicant: E. Neil Lewis

Inventor： E. Neil Lewis

IPC: G02B523

CPC classification number: G01J3/42 ,  G01J3/02 ,  G01J3/0291 ,  G01N21/03 ,  G01N21/35 ,  G01N21/3563

Abstract: A spectrometer includes an infrared source, a spectrally selective element, and a cell array. The cell array includes walls that define a number of cavities. The spectrometer also includes an infrared spatial detector responsive to infrared radiation travelling from the infrared source through contents of at least two of the cavities as well as through the spectrally selective element.

Abstract translation: 光谱仪包括红外源，光谱选择元件和单元阵列。 电池阵列包括限定多个空腔的壁。 光谱仪还包括红外空间检测器，其响应于从红外源通过至少两个空腔的内容以及通过光谱选择性元件传播的红外辐射。