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    Automated interleaved spectral imaging calibration
    1.
    发明授权
    Automated interleaved spectral imaging calibration 失效
    自动交错光谱成像校准

    公开(公告)号：US07414723B2

    公开(公告)日：2008-08-19

    申请号：US11063051

    申请日：2005-02-22

    Applicant: E. Neil Lewis ,  Joseph William Schoppelrei ,  Eunah Lee

    Inventor： E. Neil Lewis ,  Joseph William Schoppelrei ,  Eunah Lee

    IPC: G01J3/46

    CPC classification number: G01J3/28 ,  G01J3/0267 ,  G01J3/2823 ,  G01J3/524

    Abstract: An imaging spectrometric instrument is disclosed. This instrument can include an imaging detector and one or more calibration standards having different optical properties. Portions of one or more actuators can move the calibration standards between the imaging detector and a sample. This instrument can use the actuator(s) to acquire an image of a sample and measure light and dark reference calibration values in quick succession at a given wavelength, before the instrument is tuned to another wavelength.

    Abstract translation: 公开了一种成像光谱仪。 该仪器可以包括成像检测器和具有不同光学性质的一个或多个校准标准。 一个或多个致动器的部分可以在成像检测器和样品之间移动校准标准。 在仪器调谐到另一波长之前，该仪器可以使用执行器来获取样品的图像，并在给定波长下快速连续测量光和暗参考校准值。

    Spectrometric investigation of heterogeneity
    2.
    发明申请
    Spectrometric investigation of heterogeneity 有权
    异质性光谱测量

    公开(公告)号：US20080180660A1

    公开(公告)日：2008-07-31

    申请号：US12006677

    申请日：2008-01-04

    Applicant: E. Neil Lewis

    Inventor： E. Neil Lewis

    IPC: G01J3/00

    CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0289 ,  G01J3/2823 ,  G01N15/1475 ,  G01N2015/1486 ,  G01N2015/1497

    Abstract: In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection.

    Abstract translation: 在一般的方面，公开了一种用于调查样品区域的异质性的分光装置。 所述装置包括：图像采集系统，用于采集所述采样区域中的多个子区域的图像;以及子区域选择接口，用于接收指定已获得图像的子区域之一的选择。 光谱仪具有视场，并且可操作以在其视野中获取一个子区域的至少一部分的光谱，并且定位机构响应于子区域选择界面并且可操作地定位场 基于接收到的选择，相对于样品区域的光谱仪的视图。

    Hybrid-imaging spectrometer
    4.
    发明申请
    Hybrid-imaging spectrometer 审中-公开
    混合成像光谱仪

    公开(公告)号：US20080130001A1

    公开(公告)日：2008-06-05

    申请号：US10996189

    申请日：2004-11-22

    Applicant: E. Neil Lewis ,  Kenneth S. Haber

    Inventor： E. Neil Lewis ,  Kenneth S. Haber

    IPC: G01N21/25

    CPC classification number: G01J3/51 ,  G01J3/2823 ,  G01J3/44 ,  G01J2003/1217 ,  G01J2003/1243

    Abstract: An imaging optical instrument for acquiring images of a sample area is disclosed. The instrument includes a spatial detector with aligned detector elements and a variable filter having filter characteristics that vary in at least one direction and are located in an optical path between the sample area and the spatial detector. An actuator is operatively connected between the variable filter and the spatial detector and is operative to move the variable filter along the direction in which the filter characteristics vary.

    Abstract translation: 公开了一种用于获取样本区域的图像的成像光学仪器。 仪器包括具有对准的检测器元件的空间检测器和具有在至少一个方向上变化并且位于样品区域和空间检测器之间的光路中的滤波器特性的可变滤波器。 致动器可操作地连接在可变滤波器和空间检测器之间，并且可操作以沿着滤波器特性变化的方向移动可变滤波器。

    SPECTROMETRIC INVESTIGATION OF HETEROGENEITY
    6.
    发明申请
    SPECTROMETRIC INVESTIGATION OF HETEROGENEITY 有权
    异质性的光谱研究

    公开(公告)号：US20130010105A1

    公开(公告)日：2013-01-10

    申请号：US13367359

    申请日：2012-02-06

    Applicant: E. Neil Lewis

    Inventor： E. Neil Lewis

    IPC: G01J3/00 ,  H04N7/18

    CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0289 ,  G01J3/2823 ,  G01N15/1475 ,  G01N2015/1486 ,  G01N2015/1497

    Abstract: In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection.

    Abstract translation: 在一般的方面，公开了一种用于调查样品区域的异质性的分光装置。 所述装置包括：图像采集系统，用于采集所述采样区域中的多个子区域的图像;以及子区域选择接口，用于接收指定已获得图像的子区域之一的选择。 光谱仪具有视场，并且可操作以在其视野中获取一个子区域的至少一部分的光谱，并且定位机构响应于子区域选择界面并且可操作地定位场 基于接收到的选择，相对于样品区域的光谱仪的视图。

    Pharmaceutical mixture evaluation
    7.
    发明授权
    Pharmaceutical mixture evaluation 有权
    药物混合物评价

    公开(公告)号：US08004662B2

    公开(公告)日：2011-08-23

    申请号：US11265796

    申请日：2005-10-17

    Applicant: E. Neil Lewis ,  Kenneth S. Haber

    Inventor： E. Neil Lewis ,  Kenneth S. Haber

    IPC: G01N21/00

    CPC classification number: A61K31/00 ,  G01N21/9508 ,  G01N33/15

    Abstract: A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.

    Abstract translation: 公开了获得有关异质药物混合物的信息的方法。 该方法包括将诸如污渍的图像增强剂施加到混合物。 然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

    Spectroscopic instruments and methods employing array detector and variable filtering
    9.
    发明授权
    Spectroscopic instruments and methods employing array detector and variable filtering 失效
    使用阵列检测器和可变滤波器的光谱仪器和方法

    公开(公告)号：US07399968B2

    公开(公告)日：2008-07-15

    申请号：US10776029

    申请日：2004-02-10

    Applicant: E. Neil Lewis ,  David J. Strachan ,  Linda H. Kidder

    Inventor： E. Neil Lewis ,  David J. Strachan ,  Linda H. Kidder

    IPC: G01J3/28

    CPC classification number: G01N21/31 ,  G01N21/253

    Abstract: Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.

    Abstract translation: 公开了药物剂量单位制造过程控制装置和方法。 这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供 关于基于加工步骤的药物剂量单位的流动的指示。

    High-volume on-line spectroscopic composition testing of manufactured pharmaceutical dosage units
    10.
    发明授权
    High-volume on-line spectroscopic composition testing of manufactured pharmaceutical dosage units 失效
    制造药物剂量单位的大容量在线光谱组成测试

    公开(公告)号：US06690464B1

    公开(公告)日：2004-02-10

    申请号：US09507293

    申请日：2000-02-18

    Applicant: E. Neil Lewis ,  David J. Strachan ,  Linda H. Kidder

    Inventor： E. Neil Lewis ,  David J. Strachan ,  Linda H. Kidder

    IPC: G01J328

    CPC classification number: G01N21/31 ,  G01N21/253

    Abstract: Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.

    Abstract translation: 公开了药物剂量单位制造过程控制装置和方法。 这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供 关于基于加工步骤的药物剂量单位的流动的指示。

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