公开(公告)号：US08004662B2

公开(公告)日：2011-08-23

申请号：US11265796

申请日：2005-10-17

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/00

CPC分类号： A61K31/00 ,  G01N21/9508 ,  G01N33/15

摘要： A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.

摘要翻译： 公开了获得有关异质药物混合物的信息的方法。 该方法包括将诸如污渍的图像增强剂施加到混合物。 然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

公开(公告)号：US20100007877A1

公开(公告)日：2010-01-14

申请号：US12319817

申请日：2009-01-12

申请人： E. Neil Lewis ,  Linda K. Yarlott ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Linda K. Yarlott ,  Kenneth S. Haber

IPC分类号： G01J3/28

CPC分类号： G01J3/42 ,  G01J3/10 ,  G01N21/3563 ,  G01N2021/3133

摘要： Spectrometers and spectrometric measurement methods are disclosed. These employ narrow-band sources positioned in a circular array to perform spectrometric measurements that can employ Hadamard sequences.

摘要翻译： 公开了光谱仪和光谱测量方法。 这些采用位于圆形阵列中的窄带源进行可采用Hadamard序列的光谱测量。

公开(公告)号：US20140002662A1

公开(公告)日：2014-01-02

申请号：US13841721

申请日：2013-03-15

申请人： E. Neil Lewis ,  John McCaffrey ,  Kenneth S. Haber ,  Peter Bennett ,  Gerald Sando ,  Tomasz Sadowski

发明人： E. Neil Lewis ,  John McCaffrey ,  Kenneth S. Haber ,  Peter Bennett ,  Gerald Sando ,  Tomasz Sadowski

IPC分类号： G01N15/06

CPC分类号： G01N15/0612 ,  G01N15/1459 ,  G01N15/1463 ,  G01N2015/1043 ,  G01N2015/1493 ,  G01N2015/1497

摘要： In one general aspect, a particle characterization method is disclosed that includes suspending particles in a fluid, causing them to flow past a two-dimensional array detector, and illuminating them as they do so. The method also includes acquiring images of the particles as they flow past the two-dimensional array detector in the fluid, and applying a particle characterization function to the images for at least some of the suspended particles.

摘要翻译： 在一个一般方面，公开了一种颗粒表征方法，其包括将颗粒悬浮在流体中，使得它们流过二维阵列检测器，并照它们这样做。 该方法还包括当粒子流过流体中的二维阵列检测器时获取粒子的图像，以及对至少一些悬浮粒子的图像应用粒子表征功能。

公开(公告)号：US08456633B2

公开(公告)日：2013-06-04

申请号：US12387643

申请日：2009-05-05

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/25

CPC分类号： G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/42 ,  G01J3/51 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/651

摘要： Spectrometric apparatus that include an array of detector elements and exhibits a number of capabilities is disclosed. The elements can be responsive to incident radiation to produce an output signal that includes information from the incident radiation. A spectrally selective element can be located in an optical path between the radiation source and the array, with an analysis module responsive to the output signal operative to analyze spatial distribution of spectral information received by the array. The apparatus can also correct for differences in intensity and spectral variability for spectral image signals and/or compare the spectral image signals with a pattern in spatial-spectral coordinate space. Detector elements can be responsive to scattering, and spatial information in their output can be analyzed.

公开(公告)号：US20100097599A1

公开(公告)日：2010-04-22

申请号：US12387643

申请日：2009-05-05

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01J3/28 ,  G01N21/25

CPC分类号： G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/42 ,  G01J3/51 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/651

摘要： Spectrometric apparatus that include an array of detector elements and exhibits a number of capabilities is disclosed. The elements can be responsive to incident radiation to produce an output signal that includes information from the incident radiation. A spectrally selective element can be located in an optical path between the radiation source and the array, with an analysis module responsive to the output signal operative to analyze spatial distribution of spectral information received by the array. The apparatus can also correct for differences in intensity and spectral variability for spectral image signals and/or compare the spectral image signals with a pattern in spatial-spectral coordinate space. Detector elements can be responsive to scattering, and spatial information in their output can be analyzed.

摘要翻译： 公开了包括检测器元件阵列并展现多种能力的光谱仪。 这些元件可以响应于入射辐射以产生包括来自入射辐射的信息的输出信号。 光谱选择元件可以位于辐射源和阵列之间的光路中，分析模块响应于输出信号进行操作，以分析由阵列接收的光谱信息的空间分布。 该装置还可以校正光谱图像信号的强度和光谱变化的差异和/或将光谱图像信号与空间谱坐标空间中的图案进行比较。 检测器元件可以响应于散射，并且可以分析其输出中的空间信息。

公开(公告)号：US07528957B2

公开(公告)日：2009-05-05

申请号：US10328713

申请日：2002-12-23

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/25

CPC分类号： G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/42 ,  G01J3/51 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/651

摘要： Spectrometric apparatus that include an array of detector elements and exhibits a number of capabilities is disclosed. The elements can be responsive to incident radiation to produce an output signal that includes information from the incident radiation. A spectrally selective element can be located in an optical path between the radiation source and the array, with an analysis module responsive to the output signal operative to analyze spatial distribution of spectral information received by the array. The apparatus can also correct for differences in intensity and spectral variability for spectral image signals and/or compare the spectral image signals with a pattern in spatial-spectral coordinate space. Detector elements can be responsive to scattering, and spatial information in their output can be analyzed.

摘要翻译： 公开了包括检测器元件阵列并展现多种能力的光谱仪。 这些元件可以响应于入射辐射以产生包括来自入射辐射的信息的输出信号。 光谱选择元件可以位于辐射源和阵列之间的光路中，分析模块响应于输出信号进行操作以分析由阵列接收的光谱信息的空间分布。 该装置还可以校正光谱图像信号的强度和光谱变化的差异和/或将光谱图像信号与空间谱坐标空间中的图案进行比较。 检测器元件可以响应于散射，并且可以分析其输出中的空间信息。

公开(公告)号：US20090086200A1

公开(公告)日：2009-04-02

申请号：US11986548

申请日：2007-11-20

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01J3/00

CPC分类号： G01J3/06 ,  B01F9/04 ,  B01F15/00207 ,  B01F15/00214 ,  B01F2215/0032 ,  G01J3/0218 ,  G01J3/42 ,  G01N21/03 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/85 ,  G01N21/9508 ,  G01N2021/3595 ,  G01N2021/8592

摘要： In one general aspect, a spectroscopic method for monitoring heterogeneity of a sample is disclosed. In this method, sampled spectroscopic measurements are acquired over a range of different micro locations in a macro-sample of the sample. This step is repeated for micro-locations in further macro-samples of the sample, and a statistical measure of chemical heterogeneity is derived from the acquisitions. In another general aspect, differently sized samples are acquired, and a statistical measure of chemical heterogeneity is derived from these acquisitions.

摘要翻译： 在一般的方面，公开了一种用于监测样品异质性的光谱方法。 在该方法中，在样本的宏观样本中的不同微位置的范围上获取采样的光谱测量。 对于样品的其他宏观样品中的微位置重复此步骤，并且从采集中得出化学异质性的统计量度。 在另一个一般方面，获得不同大小的样品，并且从这些获取中得出化学异质性的统计量度。

公开(公告)号：US20080130001A1

公开(公告)日：2008-06-05

申请号：US10996189

申请日：2004-11-22

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/25

CPC分类号： G01J3/51 ,  G01J3/2823 ,  G01J3/44 ,  G01J2003/1217 ,  G01J2003/1243

摘要： An imaging optical instrument for acquiring images of a sample area is disclosed. The instrument includes a spatial detector with aligned detector elements and a variable filter having filter characteristics that vary in at least one direction and are located in an optical path between the sample area and the spatial detector. An actuator is operatively connected between the variable filter and the spatial detector and is operative to move the variable filter along the direction in which the filter characteristics vary.

摘要翻译： 公开了一种用于获取样本区域的图像的成像光学仪器。 仪器包括具有对准的检测器元件的空间检测器和具有在至少一个方向上变化并且位于样品区域和空间检测器之间的光路中的滤波器特性的可变滤波器。 致动器可操作地连接在可变滤波器和空间检测器之间，并且可操作以沿着滤波器特性变化的方向移动可变滤波器。

公开(公告)号：US08842266B2

公开(公告)日：2014-09-23

申请号：US13216038

申请日：2011-08-23

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/00 ,  G01N21/95 ,  A61K31/00 ,  G01N33/15

CPC分类号： A61K31/00 ,  G01N21/9508 ,  G01N33/15

摘要： A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.

摘要翻译： 公开了获得有关异质药物混合物的信息的方法。 该方法包括将诸如污渍的图像增强剂施加到混合物。 然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

公开(公告)号：US20120197541A1

公开(公告)日：2012-08-02

申请号：US13216038

申请日：2011-08-23

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01J3/44 ,  G06F19/00 ,  G01J3/00

CPC分类号： A61K31/00 ,  G01N21/9508 ,  G01N33/15

摘要： A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.

摘要翻译： 公开了获得有关异质药物混合物的信息的方法。 该方法包括将诸如污渍的图像增强剂施加到混合物。 然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。