公开(公告)号：US20130306539A1

公开(公告)日：2013-11-21

申请号：US13950646

申请日：2013-07-25

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

IPC: B01D25/12

CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

Abstract: The invention concerns a filtration device comprising a manifold (3) providing fluid connection and mechanical connection comprising a clamping plate (4) movably mounted relative to the manifold (3) and adapted to compress at least one cassette (2) against the manifold (3), means for driving and guiding the clamping plate comprising a rod (6) extending between the manifold (3) and the plate (4), an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold (3), and the member carrying the rod (6) and driving the plate (4) via the rod (6) to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

Abstract translation: 本发明涉及一种过滤装置，其包括提供流体连接的歧管（3）和包括相对于歧管（3）可移动地安装并适于将至少一个盒（2）压靠在歧管（3）上的夹板 ），用于驱动和引导夹持板的装置，其包括在歧管（3）和板（4）之间延伸的杆（6），致动器，其设置有主体和相对于主体可移动的构件，该构件适于 在延伸位置和缩回位置之间移动预定行程，主体由歧管（3）承载，并且承载杆（6）并且通过杆（6）驱动板（4）的构件被夹紧 其中构件处于其相对于其延伸位置移动经过比预定行程更短的行程的中间缩回位置的位置。

公开(公告)号：US11110373B2

公开(公告)日：2021-09-07

申请号：US16349791

申请日：2018-03-06

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Christine Abouayad El Idrissi

IPC: B01D15/04 ,  B01D15/00 ,  B01D15/08 ,  G01N30/88 ,  C12M1/00 ,  C12M3/00 ,  B01D15/14 ,  B01D15/18 ,  C12M1/12

Abstract: The invention concerns an installation for treating biological liquid by chromatography, extending in a longitudinal direction and comprising a supply valve (20b), a supply pump (30) downstream of the valve, instrument members downstream of the pump among which are at least one distribution valve (81a-c, 82a-c, 83a-c) and at least one device (78a-c, 85a-c, 86a-c) for measuring a physico-chemical parameter of the liquid, at least one chromatography column (99a-c) downstream of the instrument members and of the pipes connecting the valve, the pump, the instrument members and the column, instrument members being associated with the chromatography column and each mounted on at least one dedicated control and actuation platform (80a-c), which extends in a vertical direction relative to the generally longitudinal direction of extension of said installation, and which are disposed substantially above each other on said dedicated control and actuation platform.

公开(公告)号：US10766666B2

公开(公告)日：2020-09-08

申请号：US15848156

申请日：2017-12-20

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

IPC: B65D33/00 ,  A61M1/36 ,  B01D61/18 ,  B01D61/20 ,  F04B43/08

Abstract: The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first shell (16) disposed on a front face (5) of said base (2) and a second shell (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20).

公开(公告)号：US09259733B2

公开(公告)日：2016-02-16

申请号：US14413555

申请日：2013-07-18

Applicant: EMD Millipore Corporation

Inventor： Ronald Tuccelli ,  Sebastien Cirou ,  Virginie Buisson ,  Christine Abouayad El Idrissi ,  Jim Kelly

IPC: B01D61/30 ,  B01L3/00 ,  C12M1/12 ,  C12M1/00

CPC classification number: B01L3/561 ,  B01L3/565 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  C12M47/12 ,  Y10T137/9029

Abstract: The invention concerns a device comprising a circuit comprising a bag (10) comprising two flexible films (65, 66), a press (9) comprising a first shell (16) disposed upright on a front face of a base of the device and a second shell (17) mounted on said first shell, which shells clamp said bag to form conduits (13); said press is provided with a system (170) for jamming at the location of a treatment zone (67) of the bag, which comprises a jamming member (171) provided with at least one jamming nipple (173) and a complementary jamming member (172) provided with a jamming channel (174) configured to receive said nipple; said jamming member (171) and complementary jamming member (172) and said bag (10) being configured in order for the latter to have a portion (175) in said treatment zone in which said films are jammed between said nipple and said channel.

Abstract translation: 本发明涉及一种包括电路的装置，该电路包括包括两个柔性膜（65,66）的袋（10），压力机（9），包括直立设置在设备的基座的前面上的第一壳体（16）和 第二壳体（17），其安装在所述第一壳体上，所述壳体将所述袋子夹紧以形成管道（13）; 所述压机设置有用于在所述袋的处理区域（67）的位置处卡住的系统（170），所述系统包括设置有至少一个干扰接头（173）和互补干扰构件（172）的干扰构件（171） 172），其配置有接收所述乳头的干扰通道（174） 所述干扰构件（171）和互补的卡住构件（172），并且所述袋（10）构造成使得所述袋（10）在所述处理区域中具有一部分（175），在所述处理区域中所述膜被卡在所述接头和所述通道之间。

公开(公告)号：US20150008184A1

公开(公告)日：2015-01-08

申请号：US14493678

申请日：2014-09-23

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

IPC: B01D33/00 ,  B01D61/24 ,  A61M1/16 ,  B01D15/08

CPC classification number: B01D33/00 ,  A61M1/16 ,  B01D15/08 ,  B01D61/18 ,  B01D61/20 ,  B01D61/243 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/18 ,  B01D2313/58 ,  C12M47/12 ,  F04B43/08 ,  Y10T16/522 ,  Y10T137/8593 ,  Y10T137/86187 ,  Y10T137/86196

Abstract: The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first she (16) disposed on a front face (5) of said base (2) and a second shed (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20)

Abstract translation: 本发明涉及一种包括基座（2）和门（20）的装置，所述装置具有关闭的门位置，其中装置的电路（8）包括包括输送网络的两个柔性膜和连接器的袋，以及 包括设置在所述基座（2）的前表面（5）上的第一she（16）和设置在所述门（20）中的第二梭口（17）的按压机（9）。 以及铰链系统，其将所述门（20）相对于所述基座（2）铰接，并且仅设置在所述门（20）的一侧上，以便在所述门（20）和所述基座（2）之间形成横向间隙 所述门（20）的周边的其余部分

公开(公告)号：US20140299531A1

公开(公告)日：2014-10-09

申请号：US14311399

申请日：2014-06-23

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

IPC: B01D25/127

CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

Abstract translation: 本发明涉及一种过滤装置，其包括提供流体连接的歧管和机械连接，其包括相对于歧管可移动地安装的夹板，并且适于将至少一个盒压靠在歧管上，用于驱动和引导夹板的装置， 所述歧管和所述板，致动器，其设置有主体和可相对于所述主体移动的构件，所述构件适于在延伸位置和缩回位置之间移动通过预定行程，所述主体由所述歧管承载，并且所述主体 承载杆并且通过杆将板驱动到夹紧位置，在该夹紧位置处，构件处于中间缩回位置，在该夹紧位置中，其已经相对于其延伸位置移动比预定行程更短的行程。

公开(公告)号：US20140299530A1

公开(公告)日：2014-10-09

申请号：US14311395

申请日：2014-06-23

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

IPC: B01D25/127

CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

Abstract: The invention concerns a filtration device comprising a providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

Abstract translation: 本发明涉及一种过滤装置，包括提供流体连接和机械连接，其包括可相对于歧管可移动地安装的夹板，并且适于将至少一个盒体压靠在歧管上，用于驱动和引导夹板的装置， 歧管和板，致动器，其设置有主体和可相对于主体移动的构件，该构件适于在延伸位置和缩回位置之间移动通过预定行程，所述主体由歧管承载，并且构件 承载杆并经由杆驱动板到夹紧位置，在夹紧位置中，构件处于中间缩回位置，在夹紧位置中，其已经相对于其延伸位置移动经过比预定行程更短的行程。

公开(公告)号：US20130240065A1

公开(公告)日：2013-09-19

申请号：US13889616

申请日：2013-05-08

Applicant: EMD MILLIPORE CORPORATION

Inventor： Jean-Louis Weissenbach ,  Sebastien Cirou

IPC: B01D63/00

CPC classification number: B01D63/00 ,  B01D61/20 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/13 ,  B01D2313/18 ,  B01D2313/58 ,  B01D2313/90 ,  B01D2315/10 ,  Y10T137/6851 ,  Y10T137/8593

Abstract: The invention concerns a bag comprising a first conduit (13C) which extends longitudinally between a flow pump connector (11C) emerging on a first side (68) and a tangential filter connector (11M) emerging on a second side (69); a second conduit (13B) which extends longitudinally from a first side of said conduit (13C) between a supply container connector (11B) emerging on said first side (68), and another tangential flow connector (11N) emerging on said second side (69); a third conduit (13H) which extends from a second side of said conduit (13C), starting at a collecting container connector (11J), until it enters said first conduit (13C); and a fourth conduit (13A) which extends from the first side of said conduit (13C), starting at a transfer pump connector (11A), until it enters said second conduit (13B).

Abstract translation: 本发明涉及一种袋子，其包括在出现在第一侧面（68）上的流动泵连接器（11C）和出现在第二侧面（69）上的切向过滤器连接器（11M）之间纵向延伸的第一管道（13C）。 第二导管（13B），其从所述导管（13C）的第一侧沿着出现在所述第一侧（68）上的供应容器连接器（11B）和出现在所述第二侧（68）上的另一个切向流动连接器（11N） 69）; 从所述导管（13C）的第二侧延伸的第三导管（13H），从收集容器连接器（11J）开始，直至其进入所述第一导管（13C）; 以及从所述导管（13C）的第一侧从转移泵连接器（11A）开始直到其进入所述第二导管（13B）的第四导管（13A）。

公开(公告)号：US20130236130A1

公开(公告)日：2013-09-12

申请号：US13872248

申请日：2013-04-29

Applicant: EMD MILLIPORE CORPORATION

Inventor： Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

IPC: B65D33/00

CPC classification number: B65D33/00 ,  A61M1/36 ,  A61M2205/125 ,  A61M2209/088 ,  B01D61/18 ,  B01D61/20 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/58 ,  F04B43/08

Abstract: The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first shell (16) disposed on a front face (5) of said base (2) and a second shell (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20)

Abstract translation: 本发明涉及一种包括基座（2）和门（20）的装置，所述装置具有关闭的门位置，其中装置的电路（8）包括包括输送网络的两个柔性膜和连接器的袋，以及 包括设置在所述基座（2）的前表面（5）上的第一壳体（16）和设置在所述门（20）中的第二壳体（17）的压力机（9）。 以及铰链系统，其将所述门（20）相对于所述基座（2）铰接，并且仅设置在所述门（20）的一侧上，以便在所述门（20）和所述基座（2）之间形成横向间隙 所述门（20）的周边的其余部分