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    Antibodies, production method of the antibodies, hybridomas which produce the antibodies, production method the hybirdomas and antigen proteins recognized by the antibodies
    21.
    发明授权
    Antibodies, production method of the antibodies, hybridomas which produce the antibodies, production method the hybirdomas and antigen proteins recognized by the antibodies 有权
    抗体，抗体的制备方法，产生抗体的杂交瘤，生产方法由抗体识别的hybirdomas和抗原蛋白

    公开(公告)号：US06258564B1

    公开(公告)日：2001-07-10

    申请号：US09363787

    申请日：1999-07-29

    申请人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi

    发明人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi

    IPC分类号： C12N1502

    CPC分类号： C07K14/705 ,  C07K16/28

    摘要： The invention is related to antibodies which specifically react with connective tissue type-human mast cells, a production method of the antibodies, hybridomas which produce the antibodies, a production method of the hybridomas and antigen proteins recognized by the antibodies. After cord blood cells were cultured in the presence of SCF and IL-6, they were further cocultured with primary culture of human skin fibroblasts, and connective tissue type-human mast cells were thus obtained. A rat was immunized using the cells, hybridomas were prepared and selected by an ordinary method, and novel monoclonal antibodies were harvested from the culture supernatant of the selected hybridomas. The monoclonal antibodies specifically reacted with connective tissue type-human mast cells.

    摘要翻译： 本发明涉及与结缔组织型 - 人肥大细胞特异性反应的抗体，抗体的制备方法，产生抗体的杂交瘤，由抗体识别的杂交瘤和抗原蛋白的制备方法。 在SCF和IL-6存在下培养脐带血细胞后，与人皮肤成纤维细胞的原代培养物进一步共培养，得到结缔组织型人类肥大细胞。 使用细胞免疫大鼠，通过常规方法制备杂交瘤并选择，并从所选择的杂交瘤的培养上清液中收获新的单克隆抗体。 单克隆抗体与结缔组织型 - 人类肥大细胞特异性反应。

    Vehicle suspension mechanism
    24.
    发明授权
    Vehicle suspension mechanism 失效
    车辆悬挂机构

    公开(公告)号：US4466635A

    公开(公告)日：1984-08-21

    申请号：US469416

    申请日：1983-02-24

    申请人： Tadashi Okada ,  Yuji Furukawa ,  Makoto Murata

    发明人： Tadashi Okada ,  Yuji Furukawa ,  Makoto Murata

    IPC分类号： B60G3/06 ,  B60G7/00 ,  B62D17/00

    CPC分类号： B62D17/00 ,  B60G7/008 ,  B60G2200/142 ,  B60G2200/46 ,  B60G2200/462 ,  B60G2204/148 ,  B60G2204/4402 ,  Y10T403/12

    摘要： A suspension mechanism for a wheeled vehicle, comprising a suspension arm having a pair of arm portions aligned with each other in a lateral direction of the vehicle body and pivotally connected to the vehicle body for being rockable about a first axis fixed with respect to the vehicle body and transverse to the vehicle body; a wheel axle which is pivotally connected to the suspension arm and rockable about a second axis fixed with respect to the suspension arm and perpendicular to the first axis and which has a spindle portion having a center axis about which a wheel-and-tire assembly is rotatable; and angle adjusting means engaging the suspension arm and the wheel axle and adapted to permit adjustment of the angular position of the wheel axle with respect to the suspension arm about the second axis.

    摘要翻译： 一种用于轮式车辆的悬挂机构，包括悬架臂，所述悬架臂具有在车身的横向方向上彼此对准的一对臂部，并且枢转地连接到车身，用于围绕相对于车辆固定的第一轴线摇摆 车身横向; 轮轴，其枢转地连接到所述悬架臂并围绕相对于所述悬架臂固定并且垂直于所述第一轴线固定的第二轴线摇摆，并且所述轮轴具有主轴部分，所述心轴部分具有轮毂和轮胎组件所围绕的中心轴线 可旋转的 以及角度调节装置，其接合所述悬架臂和所述轮轴并且适于允许相对于所述悬架臂围绕所述第二轴线调整所述轮轴的角位置。

    Phase control system
    25.
    发明授权
    Phase control system 失效
    相位控制系统

    公开(公告)号：US4099205A

    公开(公告)日：1978-07-04

    申请号：US735134

    申请日：1976-10-26

    申请人： Hajime Hattori ,  Eiji Usui ,  Takashi Oya ,  Kaneyoshi Sugawa ,  Eiji Kezuka ,  Tadashi Okada ,  Toshiro Watanabe

    发明人： Hajime Hattori ,  Eiji Usui ,  Takashi Oya ,  Kaneyoshi Sugawa ,  Eiji Kezuka ,  Tadashi Okada ,  Toshiro Watanabe

    IPC分类号： G09G5/02 ,  G09G5/12 ,  H04N5/073 ,  H04N5/265 ,  H04N9/475 ,  H04N5/04

    CPC分类号： H04N5/0736

    摘要： A television signal is encoded by the use of a sampling pulse synchronized with a color subcarrier frequency included in an input television signal, the encoded signal is compressed and recorded in a memory for later reproduction of a desired compressed picture image having a desired size and center position, the recorded signal is reproduced under the control of a clock pulse signal produced in synchronism with a sync signal obtained in a studio, for example, and the reproduced signal is corrected by inverting the polarity of the chroma component according to frame information at the time of recording of said reproduced signal.Thus, it is possible to freely obtain phase coupling of different synchronizing signals; for instance, it is possible to bring the phase of a different television signal of a different synchronization system into coincidence with the phase of a central synchronization signal and it is possible to reproduce an object image optionally compressed on a TV display screen.

    摘要翻译： 电视信号通过使用与输入电视信号中包含的彩色副载波频率同步的采样脉冲进行编码，编码信号被压缩并记录在存储器中，用于稍后再现具有期望尺寸和中心的所需压缩图像图像 例如，在与在演播室中获得的同步信号同步产生的时钟脉冲信号的控制下再现记录的信号，并且通过根据帧信息将色度分量的极性反转来校正再现信号 记录所述再现信号的时间。

    Method for promoting carnitine palmitoyltransferase activity using green coffee bean extract
    26.
    发明授权
    Method for promoting carnitine palmitoyltransferase activity using green coffee bean extract 有权
    使用绿咖啡豆提取物促进肉碱棕榈酰转移酶活性的方法

    公开(公告)号：US08802164B2

    公开(公告)日：2014-08-12

    申请号：US13038513

    申请日：2011-03-02

    申请人： Hiroshi Shimoda ,  Michio Aitani ,  Tomoko Sugishita ,  Tadashi Okada ,  Hiromichi Murai ,  Emi Yamada

    发明人： Hiroshi Shimoda ,  Michio Aitani ,  Tomoko Sugishita ,  Tadashi Okada ,  Hiromichi Murai ,  Emi Yamada

    IPC分类号： A61K36/74

    CPC分类号： A61Q19/00 ,  A23F5/02 ,  A61K8/97 ,  A61K36/74 ,  A61Q19/06

    摘要： (PROBLEMS) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes. (MEANS FOR SOLVING PROBLEMS) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt/wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.

    摘要翻译： （问题）提供源自绿咖啡豆的高度安全的饮食组合，通过该饮食组合可以获得优异的饮食效果，并且有助于预防和治疗诸如糖尿病的生活方式相关疾病。 （解决问题的手段）一种饮食组合物，其特征在于，含有脱脂生咖啡豆的极性溶剂提取物作为活性成分。 优选上述极性溶剂提取物是通过使用含水乙醇，更优选乙醇浓度为40〜90％（wt / wt）的含水乙醇得到的提取物。 优选上述脱脂生咖啡豆是通过用N-己烷萃取生咖啡豆而得到的咖啡豆，从而分离出油性成分。 建议将上述饮食组合物与选自沙拉提取物，月见草提取物，芝麻素和藤黄的一种或多种组合物组合。 这种饮食组合物可用作食品，饮料，药物或外用皮肤制剂的材料。

    Single screw compressor
    27.
    发明授权
    Single screw compressor 有权
    单螺杆压缩机

    公开(公告)号：US08348648B2

    公开(公告)日：2013-01-08

    申请号：US12672196

    申请日：2008-08-07

    申请人： Harunori Miyamura ,  Tadashi Okada ,  Takayuki Takahashi ,  Kaname Ohtsuka ,  Toshihiro Susa ,  Hiromichi Ueno ,  Takanori Murono

    发明人： Harunori Miyamura ,  Tadashi Okada ,  Takayuki Takahashi ,  Kaname Ohtsuka ,  Toshihiro Susa ,  Hiromichi Ueno ,  Takanori Murono

    IPC分类号： F01C1/08 ,  F01C1/24 ,  F03C2/00 ,  F03C4/00 ,  F04C2/00 ,  F04C18/00 ,  F16N13/20

    CPC分类号： F04C18/52 ,  F04C18/084 ,  F04C2270/17

    摘要： In a single screw compressor, gates (51) of gate rotors (50) are to be engaged with spiral grooves (41) of a screw rotor (40). In each spiral groove (41) of the screw rotor (40), an area extending from a start point of the spiral groove (41) to a position in a compression stroke is a suction-side portion (45), and the remaining portion (portion up to a terminal point of the spiral groove (41)) is a discharge-side portion (46). In the discharge-side portion (46), a clearance between a wall surface (42, 43, 44) therein and the gate (51) is substantially “0 (zero).” A clearance between the wall surface (42, 43, 44) in the suction-side portion (45) and the gate (51) is wider than that between the wall surface (42, 43, 44) in the discharge-side portion (46) and the gate (51), and is gradually narrowed from the start point toward the terminal point in the spiral groove (41).

    摘要翻译： 在单螺杆式压缩机中，门转子（50）的门（51）将与螺杆转子（40）的螺旋槽（41）接合。 在螺杆转子40的螺旋形槽41中，从螺旋槽41的起点延伸到压缩行程的位置为吸入侧部45，其余部分 （直到螺旋槽41的终点的部分）是排出侧部分（46）。 在排出侧部分（46）中，其中的壁表面（42,43,44）和浇口（51）之间的间隙大致为零（零）。 吸入侧部分（45）中的壁表面（42,43,44）和浇口（51）之间的间隙比排出侧部分的壁表面（42,43,44）之间的间隙宽 46）和栅极（51）之间，从螺旋槽（41）的起点向终点逐渐变细。

    Dietetic composition
    28.
    发明申请
    Dietetic composition 审中-公开
    饮食组成

    公开(公告)号：US20090274777A1

    公开(公告)日：2009-11-05

    申请号：US10569970

    申请日：2004-10-05

    申请人： Hiroshi Shimoda ,  Michio Aitani ,  Tomoko Sugishita ,  Tadashi Okada ,  Hiromichi Murai ,  Emi Yamada

    发明人： Hiroshi Shimoda ,  Michio Aitani ,  Tomoko Sugishita ,  Tadashi Okada ,  Hiromichi Murai ,  Emi Yamada

    IPC分类号： A61K36/74 ,  A61P3/04

    CPC分类号： A61Q19/00 ,  A23F5/02 ,  A61K8/97 ,  A61K36/74 ,  A61Q19/06

    摘要： (Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes.(Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt/wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.

    摘要翻译： （问题）提供源自绿咖啡豆的高度安全的饮食组合，通过该饮食组合可以获得优异的饮食效果，并且有助于预防和治疗诸如糖尿病的生活方式相关疾病。 （解决问题的手段）一种饮食组合物，其特征在于，含有脱脂生咖啡豆的极性溶剂提取物作为活性成分。 优选上述极性溶剂提取物是通过使用含水乙醇，更优选乙醇浓度为40〜90％（wt / wt）的含水乙醇得到的提取物。 优选上述脱脂生咖啡豆是通过用N-己烷萃取生咖啡豆而得到的咖啡豆，从而分离出油性成分。 建议将上述饮食组合物与选自沙拉提取物，月见草提取物，芝麻素和藤黄的一种或多种组合物组合。 这种饮食组合物可用作食品，饮料，药物或外用皮肤制剂的材料。

    Antibody against a mast cell surface antigen
    30.
    发明申请
    Antibody against a mast cell surface antigen 审中-公开
    针对肥大细胞表面抗原的抗体

    公开(公告)号：US20060276631A1

    公开(公告)日：2006-12-07

    申请号：US11415575

    申请日：2006-05-02

    申请人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi ,  Masao Shibata ,  Motoki Kuhara

    发明人： Makoto Kawai ,  Tadashi Okada ,  Fukiko Atsumi ,  Masao Shibata ,  Motoki Kuhara

    IPC分类号： C07K14/74 ,  C07K16/28 ,  C07H21/04

    CPC分类号： C07K14/705 ,  C07K16/28

    摘要： A mast cell surface antigen, DNA thereof and an antibody against the antigen are provided. The amino acid sequence of this mast cell surface antigen is the translation of the coding region of its DNA. The base sequence of this DNA has been clarified in the following manner. Namely, mast cells obtained by incubating cord blood monocular cells are co-incubated with primary culture of fibroblasts to give connective tissue type mast cells (MC-TC). Then mRNA is extracted from this MC-TC cell extraction and a cDNA library is constructed therefrom. Immunological screening is carried out with the use of anti-MC-TC antiserum and the base sequence of the positive clone thus obtained is identified. Owing to the clarification of the amino acid sequence of this mast cell antigen, it becomes possible to reveal the role of mast cells in the pathology of allergic diseases and thus an antibody against mast cells can be easily obtained.

    摘要翻译： 提供肥大细胞表面抗原，其DNA和针对抗原的抗体。 该肥大细胞表面抗原的氨基酸序列是其DNA编码区的翻译。 该DNA的碱基序列已经以下述方式进行了说明。 即，将通过孵育脐带血单核细胞获得的肥大细胞与成纤维细胞的原代培养物共温育以产生结缔组织型肥大细胞（MC-TC）。 然后从该MC-TC细胞提取中提取mRNA，并由其构建cDNA文库。 使用抗MC-TC抗血清进行免疫筛选，鉴定得到的阳性克隆的碱基序列。 由于这种肥大细胞抗原的氨基酸序列的澄清，可以揭示肥大细胞在过敏性疾病的病理学中的作用，因此可以容易地获得抗肥大细胞的抗体。